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1. 发明申请

WO2007002080A3 EYA2S AS MODIFIERS OF THE PTEN/AKT PATHWAY AND METHODS OF USE 审中-公开
标题翻译： EYA2S作为PTEN / AKT途径的修改者和使用方法
公开(公告)号：WO2007002080A3
公开(公告)日：2009-04-30
申请号：PCT/US2006023970
申请日：2006-06-20
申请人： EXELIXIS INC , BRACE ARTHUR , BJERKE LYNN MARGARET , NIETO-BERGMAN SUSANA , FRIEDMAN LORI S , WARD KEVIN , BLAKE ROBERT A
发明人： BRACE ARTHUR , BJERKE LYNN MARGARET , NIETO-BERGMAN SUSANA , FRIEDMAN LORI S , WARD KEVIN , BLAKE ROBERT A
IPC分类号： A61K39/395 , C12Q1/68 , G01N33/574
CPC分类号： C12N9/14 , G01N33/574 , G01N33/6872 , G01N2333/4704 , G01N2333/9121 , G01N2500/04 , G01N2500/10 , G01N2510/00
摘要： Human EYA2 genes are identified as modulators of the PTEN/AKT pathway, and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT, comprising screening for agents that modulate the activity of EYA2 are provided.
摘要翻译：人EYA2基因被鉴定为PTEN / AKT途径的调节剂，因此是与缺陷型PTEN / AKT功能相关的病症的治疗靶标。提供了用于鉴定PTEN / AKT调节剂的方法，包括筛选调节EYA2活性的试剂。

2. 发明申请

WO2007002131A3 GALK1S AS MODIFIERS OF THE PTEN/AKT PATHWAY AND METHODS OF USE 审中-公开
标题翻译： GALK1S作为PTEN / AKT途径的修饰者及其使用方法
公开(公告)号：WO2007002131A3
公开(公告)日：2007-10-04
申请号：PCT/US2006024053
申请日：2006-06-20
申请人： EXELIXIS INC , BRACE ARTHUR , BJERKE LYNN MARGARET , NIETO-BERGMAN SUSANA , FRIEDMAN LORI S , WARD KEVIN , BLAKE ROBERT A
发明人： BRACE ARTHUR , BJERKE LYNN MARGARET , NIETO-BERGMAN SUSANA , FRIEDMAN LORI S , WARD KEVIN , BLAKE ROBERT A
IPC分类号： A61K39/395
CPC分类号： C12N9/14 , G01N33/574 , G01N33/6872 , G01N2333/4704 , G01N2333/9121 , G01N2500/04 , G01N2500/10 , G01N2510/00
摘要： Human GALKl genes are identified as modulators of the PTEN/AKT pathway, and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT, comprising screening for agents that modulate the activity of GALKl are provided.
摘要翻译：人GALK1基因被鉴定为PTEN / AKT途径的调节剂，因此是与缺陷型PTEN / AKT功能相关的病症的治疗靶点。提供了用于鉴定PTEN / AKT调节剂的方法，包括筛选调节GALK1活性的试剂。

3. 发明申请

WO2006099181A3 EEF2K AS MODIFIERS OF THE PTEN/AKT PATHWAY AND METHODS OF USE 审中-公开
标题翻译： EEF2K作为PTEN / AKT路径的修改器和使用方法
公开(公告)号：WO2006099181A3
公开(公告)日：2007-04-05
申请号：PCT/US2006008675
申请日：2006-03-10
申请人： EXELIXIS INC , BRACE ARTHUR , BLAKE ROBERT A , FRIEDMAN LORI S , BJERKE LYNN MARGARET , WARD KEVIN M , NIETO-BERGMAN SUSANA
发明人： BRACE ARTHUR , BLAKE ROBERT A , FRIEDMAN LORI S , BJERKE LYNN MARGARET , WARD KEVIN M , NIETO-BERGMAN SUSANA
IPC分类号： G01N33/53
CPC分类号： G01N33/5041
摘要： Human EEF2K genes are identified as modulators of the PTEN/AKT pathway and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT comprising screening for agents that modulate the activity of EEF2K are provided.
摘要翻译：人EEF2K基因被鉴定为PTEN / AKT途径的调节剂，因此是与缺陷型PTEN / AKT功能相关的疾病的治疗靶标。提供了用于鉴定PTEN / AKT调节剂的方法，其包括筛选调节EEF2K活性的试剂。

4. 发明申请

WO2007002087A2 CDC6S AS MODIFIERS OF THE PTEN/AKT PATHWAY AND METHODS OF USE 审中-公开
标题翻译： CDC6S作为PTEN / AKT途径的修改者及其使用方法
公开(公告)号：WO2007002087A2
公开(公告)日：2007-01-04
申请号：PCT/US2006023979
申请日：2006-06-20
申请人： EXELIXIS INC , BRACE ARTHUR , BJERKE LYNN MARGARET , NIETO-BERMAN SUSANA , FRIEDMAN LORI S , WARD KEVIN , BLAKE ROBERT A
发明人： BRACE ARTHUR , BJERKE LYNN MARGARET , NIETO-BERMAN SUSANA , FRIEDMAN LORI S , WARD KEVIN , BLAKE ROBERT A
IPC分类号： A61K38/54
CPC分类号： C12N9/14 , G01N33/574 , G01N33/6872 , G01N2333/4704 , G01N2333/9121 , G01N2500/04 , G01N2500/10 , G01N2510/00
摘要： Human CDC6 genes are identified as modulators of the PTEN/AKT pathway, and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT, comprising screening for agents that modulate the activity of CDC6 are provided.
摘要翻译：人CDC6基因被鉴定为PTEN / AKT途径的调节剂，因此是与缺陷型PTEN / AKT功能相关的病症的治疗靶点。提供了用于鉴定PTEN / AKT调节剂的方法，包括筛选调节CDC6活性的试剂。

5. 发明申请

WO2006099185A3 BRSK1S AS MODIFIERS OF THE PTEN/AKT PATHWAY AND METHODS OF USE 审中-公开
公开(公告)号：WO2006099185A3
公开(公告)日：2006-09-21
申请号：PCT/US2006/008679
申请日：2006-03-10
申请人： EXELIXIS, INC , BRACE, Arthur , BLAKE, Robert, A. , FRIEDMAN, Lori, S. , BJERKE, Lynn, Margaret , WARD, Kevin , NIETO-BERGMAN, Susana
发明人： BRACE, Arthur , BLAKE, Robert, A. , FRIEDMAN, Lori, S. , BJERKE, Lynn, Margaret , WARD, Kevin , NIETO-BERGMAN, Susana
IPC分类号： G01N33/53
摘要： Human BRSK1 genes are identified as modulators of the PTEN/AKT pathway, and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT, comprising screening for agents that modulate the activity of BRSK1 are provided.

6. 发明申请

WO2006099182A2 MPTENAKTS AS MODIFIERS OF THE PTEN/AKT PATHWAY AND METHODS OF USE 审中-公开
标题翻译： MPTENAKTS作为PTEN / AKT途径的修改者和使用方法
公开(公告)号：WO2006099182A2
公开(公告)日：2006-09-21
申请号：PCT/US2006/008676
申请日：2006-03-10
申请人： EXELIXIS, INC. , BRACE, Arthur , BLAKE, Robert, A. , FRIEDMAN, Lori, S. , BJERKE, Lynn, Margaret , WARD, Kevin, M. , NIETO-BERGMAN, Susana
发明人： BRACE, Arthur , BLAKE, Robert, A. , FRIEDMAN, Lori, S. , BJERKE, Lynn, Margaret , WARD, Kevin, M. , NIETO-BERGMAN, Susana
IPC分类号： G01N33/53
CPC分类号： G01N33/5041
摘要： Human MPTENAKT genes are identified as modulators of the PTEN/AKT pathway, and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT, comprising screening for agents that modulate the activity of MPTENAKT are provided.
摘要翻译：人类MPTENAKT基因被鉴定为PTEN / AKT途径的调节剂，因此是与缺陷型PTEN / AKT功能相关的病症的治疗靶点。提供了用于鉴定PTEN / AKT调节剂的方法，包括筛选调节MPTENAKT活性的试剂。

7. 发明申请

WO2005046932A2 APPARATUS AND METHOD FOR INSPECTING GRINDING WHEELS 审中-公开
标题翻译：用于检查磨轮的装置和方法
公开(公告)号：WO2005046932A2
公开(公告)日：2005-05-26
申请号：PCT/US2004005764
申请日：2004-02-24
申请人： ALCOA INC , BLAKE ROBERT A , WHITTLE NEVILLE C , TEICHMAN MICHELLE M
发明人： BLAKE ROBERT A , WHITTLE NEVILLE C , TEICHMAN MICHELLE M
IPC分类号： B24B20060101 , G01N9/24 , G01N29/06 , G01N29/11 , G01N29/22 , G01N29/27 , G01N29/44 , B24B
CPC分类号： G01N29/223 , G01N9/24 , G01N29/0609 , G01N29/11 , G01N29/27 , G01N29/4427 , G01N2291/02818 , G01N2291/048 , G01N2291/2696
摘要： An ultrasonic inspection system (10) is used to inspect grinding wheels used to prepare work rolls used in metal sheet production. The ultrasonic inspection system (10) includes a test stand (12) adapted to rotatably support a grinding wheel (14). An ultrasonic transmitting and receiving apparatus (20) passes sound waves through the body of the grinding wheel. The attenuation of the sound waves passed through the grinding wheel (14) is recorded in a recording device (38) and analyzed in a computer (34). The recording device (38), which may be the computer (34), preferably records amplitude attenuation of the sound waves. The computer (34) analyzes the amplitude attenuation, records the amplitude attenuation as an indicated density profile (40), and displays the indicated density profile (40) on a computer screen (36) for inspection. The indicated density profile (40) of the inspected grinding wheel may be compared with indicated density profiles of other grinding wheels, particularly those with known operational characteristics.
摘要翻译：超声波检测系统（10）用于检查用于制备用于金属板生产的工作辊的磨轮。超声波检查系统（10）包括适于可旋转地支撑研磨轮（14）的测试台（12）。超声波发射和接收装置（20）使声波穿过砂轮的主体。通过磨轮（14）的声波的衰减被记录在记录装置（38）中并在计算机（34）中分析。可以是计算机（34）的记录装置（38）优选地记录声波的振幅衰减。计算机（34）分析幅度衰减，将幅度衰减记录为指示的密度分布（40），并将指示的密度分布（40）显示在计算机屏幕（36）上以供检查。检查的砂轮的指示密度分布图（40）可以与其他砂轮的指定密度分布图进行比较，特别是具有已知操作特性的那些。

8. 发明申请

WO2007002188A3 MPTENAKTS AS MODIFIERS OF THE PTEN/AKT PATHWAY AND METHODS OF USE 审中-公开
公开(公告)号：WO2007002188A3
公开(公告)日：2007-05-18
申请号：PCT/US2006024131
申请日：2006-06-20
申请人： EXELIXIS INC , BRACE ARTHUR , BJERKE LYNN MARGARET , NIETO-BERGMAN SUSANA , FRIEDMAN LORI S , WARD KEVIN , BLAKE ROBERT A
发明人： BRACE ARTHUR , BJERKE LYNN MARGARET , NIETO-BERGMAN SUSANA , FRIEDMAN LORI S , WARD KEVIN , BLAKE ROBERT A
IPC分类号： C12N5/00 , G01N33/53
CPC分类号： C12N9/14 , G01N33/574 , G01N33/6872 , G01N2333/4704 , G01N2333/9121 , G01N2500/04 , G01N2500/10 , G01N2510/00
摘要： Human MPTENAKT genes are identified as modulators of the PTEN/AKT pathway, and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT, comprising screening for agents that modulate the activity of MPTENAKT are provided.

9. 发明申请

WO2007002131A2 GALK1S AS MODIFIERS OF THE PTEN/AKT PATHWAY AND METHODS OF USE 审中-公开
标题翻译： GALK1S作为PTEN / AKT途径的修饰物和使用方法
公开(公告)号：WO2007002131A2
公开(公告)日：2007-01-04
申请号：PCT/US2006/024053
申请日：2006-06-20
申请人： EXELIXIS, INC. , BRACE, Arthur , BJERKE, Lynn, Margaret , NIETO-BERGMAN, Susana , FREIDMAN, Lori, S. , WARD, Kevin , BLAKE, Robert, A.
发明人： BRACE, Arthur , BJERKE, Lynn, Margaret , NIETO-BERGMAN, Susana , FREIDMAN, Lori, S. , WARD, Kevin , BLAKE, Robert, A.
IPC分类号： A61K38/52
CPC分类号： C12N9/14 , G01N33/574 , G01N33/6872 , G01N2333/4704 , G01N2333/9121 , G01N2500/04 , G01N2500/10 , G01N2510/00
摘要： Human GALKl genes are identified as modulators of the PTEN/AKT pathway, and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT, comprising screening for agents that modulate the activity of GALKl are provided.
摘要翻译：人GALK1基因被鉴定为PTEN / AKT途径的调节剂，因此是与缺陷PTEN / AKT功能相关的病症的治疗靶标。提供了鉴定PTEN / AKT调节剂的方法，包括筛选调节GALK1活性的试剂。

10. 发明申请

WO2007002080A2 EYA2S AS MODIFIERS OF THE PTEN/AKT PATHWAY AND METHODS OF USE 审中-公开
标题翻译： EYA2S作为PTEN / AKT途径的修改者和使用方法
公开(公告)号：WO2007002080A2
公开(公告)日：2007-01-04
申请号：PCT/US2006/023970
申请日：2006-06-20
申请人： EXELIXIS, INC. , BRACE, Arthur , BJERKE, Lynn, Margaret , NIETO-BERGMAN, Susana , FRIEDMAN, Lori, S. , WARD, Kevin , BLAKE, Robert, A.
发明人： BRACE, Arthur , BJERKE, Lynn, Margaret , NIETO-BERGMAN, Susana , FRIEDMAN, Lori, S. , WARD, Kevin , BLAKE, Robert, A.
IPC分类号： A61K38/55
CPC分类号： C12N9/14 , G01N33/574 , G01N33/6872 , G01N2333/4704 , G01N2333/9121 , G01N2500/04 , G01N2500/10 , G01N2510/00
摘要： Human EYA2 genes are identified as modulators of the PTEN/AKT pathway, and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT, comprising screening for agents that modulate the activity of EYA2 are provided.
摘要翻译：人EYA2基因被鉴定为PTEN / AKT途径的调节剂，因此是与缺陷型PTEN / AKT功能相关的病症的治疗靶标。提供了用于鉴定PTEN / AKT调节剂的方法，包括筛选调节EYA2活性的试剂。

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