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1. 发明申请

WO2003078990A1 COMPOSITE MATERIALS FOR SENSING APPLICATIONS AND CHEMICAL SENSOR COMPRISING SAID MATERIALS 审中-公开
标题翻译：用于传感应用的复合材料和包含材料的化学传感器
公开(公告)号：WO2003078990A1
公开(公告)日：2003-09-25
申请号：PCT/IB2003/001056
申请日：2003-03-18
申请人： INFM ISTITUTO NAZIONALE PER LA FISICA DELLA MATERIA , SARTORE, Luciana , PENCO, Maurizio , BIGNOTTI, Fabio , SBERVEGLIERI, Giorgio
发明人： SARTORE, Luciana , PENCO, Maurizio , BIGNOTTI, Fabio , SBERVEGLIERI, Giorgio
IPC分类号： G01N27/12
CPC分类号： G01N27/126 , G01N27/125 , G01N33/0027 , Y10T428/31725
摘要： A chemical sensor for detecting an analyte in a fluid, useful for the production of an apparatus for the analysis of odours (an electronic nose), comprises a film of composite material formed by a matrix of a non-conductive polymer constituted by a polyamidoamine and a conductive filler, eg. carbon black. In preferred embodiments, the polyamidoamine is formed as the adduct of bisacrylamidoacetic (BAC) and N, N’ -dimethylethylenediamide (DMEDA) else N, N’ -ethlenediaminoaceticacid (EDDA), and can include copper or cobalt ions as complexes.
摘要翻译：一种用于检测流体中的分析物的化学传感器，用于生产用于气味分析的装置（电子鼻）），包括由聚酰胺胺构成的非导电聚合物基质和导电填料，例如碳黑。在优选的实施方案中，聚酰胺胺形成为双丙烯酰氨基乙酸（BAC）和N，N'-二甲基乙二胺（DMEDA）或N，N'-亚乙基二氨基乙酸（EDDA）的加合物，并且可以包括铜或钴离子作为络合物。

2. 发明申请

WO1997025067A2 POLYMERS 审中-公开
标题翻译：聚合物
公开(公告)号：WO1997025067A2
公开(公告)日：1997-07-17
申请号：PCT/GB1997000022
申请日：1997-01-06
申请人： THE UNIVERSITY OF NOTTINGHAM , GARNETT, Martin, Charles , MACLAUGHLIN, Fiona, Caroline , DAVIS, Stanley, Stewart , BIGNOTTI, Fabio , FERRUTI, Paolo
发明人： THE UNIVERSITY OF NOTTINGHAM
IPC分类号： A61K47/48
CPC分类号： A61K47/645 , A61K47/59 , A61K47/593 , A61K47/595 , A61K47/60
摘要： A composition for delivering a biologically active polyanionic molecule comprising a linear polymer with a backbone comprising amido and tertiary amino groups arranged regularly on the said backbone and said biologically active polyanionic molecule bound to said polymer. Preferably the linear polymer comprises a poly(amidoamine). Preferably the biologically active polyanionic molecule is a nucleic acid, more preferably DNA. The compositions are useful for delivering nucleic acids to a cell, for example in cell transformation or transfection and in gene therapy.
摘要翻译：一种用于递送生物活性聚阴离子分子的组合物，其包含线性聚合物，所述主链包含在所述骨架上规则排列的酰胺基和叔氨基，所述生物活性聚阴离子分子与所述聚合物结合。优选地，线性聚合物包含聚（酰氨基胺）。优选地，生物活性聚阴离子分子是核酸，更优选DNA。组合物可用于将核酸递送至细胞，例如在细胞转化或转染和基因治疗中。

3. 发明申请

WO9725067A3 POLYMERS 审中-公开
标题翻译：聚合物
公开(公告)号：WO9725067A3
公开(公告)日：1997-09-18
申请号：PCT/GB9700022
申请日：1997-01-06
申请人： UNIV NOTTINGHAM , GARNETT MARTIN CHARLES , MACLAUGHLIN FIONA CAROLINE , DAVIS STANLEY STEWART , BIGNOTTI FABIO , FERRUTI PAOLO
发明人： GARNETT MARTIN CHARLES , MACLAUGHLIN FIONA CAROLINE , DAVIS STANLEY STEWART , BIGNOTTI FABIO , FERRUTI PAOLO
IPC分类号： A61K9/00 , A61K31/70 , A61K47/34 , A61K47/48 , A61K48/00
CPC分类号： A61K47/645 , A61K47/59 , A61K47/593 , A61K47/595 , A61K47/60
摘要： A composition for delivering a biologically active polyanionic molecule comprising a linear polymer with a backbone comprising amido and tertiary amino groups arranged regularly on the said backbone and said biologically active polyanionic molecule bound to said polymer. Preferably the linear polymer comprises a poly(amidoamine). Preferably the biologically active polyanionic molecule is a nucleic acid, more preferably DNA. The compositions are useful for delivering nucleic acids to a cell, for example in cell transformation or transfection and in gene therapy. 00000
摘要翻译：一种用于递送生物活性聚阴离子分子的组合物，其包含线性聚合物，所述主链包含在所述骨架上规则排列的酰氨基和叔氨基，所述生物活性聚阴离子分子与所述聚合物结合。优选地，线性聚合物包含聚（酰氨基胺）。优选地，生物活性聚阴离子分子是核酸，更优选DNA。组合物可用于将核酸递送至细胞，例如在细胞转化或转染和基因治疗中。 00000

4. 发明申请

WO1995012629A1 HIGH MOLECULAR WEIGHT POLYESTERPOLYCARBONATES AND THE USE THEREOF FOR THE PREPARATION OF BIOEROSIBLE MATRICES 审中-公开
标题翻译：高分子量聚异戊烯碳酸酯及其制备生物可食性基质的用途
公开(公告)号：WO1995012629A1
公开(公告)日：1995-05-11
申请号：PCT/EP1994003560
申请日：1994-10-28
申请人： MEDIOLANUM FARMACEUTICI S.P.A. , FERRUTI, Paolo , PENCO, Maurizio , RANUCCI, Elisabetta , BIGNOTTI, Fabio
发明人： MEDIOLANUM FARMACEUTICI S.P.A.
IPC分类号： C08G63/64
CPC分类号： A61K9/1647 , C08G63/64
摘要： Polyesterpolycarbonates of formula (I), wherein a is an integer 2 to 300; R1 and R2, which can be the same or different, are each a polyester residue of formula (II), wherein x and y are integers from 0 to 100, the ratio (x/x+y)*100, being comprised between 0 and 100, with the proviso that x and y are not 0 at the same time; R3 and R4, which can be the same or different, are each a straight or branched chain C1-C4 aliphatic hydrocarbon residue; R5 is a straight or branched chain C2-C18 aliphatic hydrocarbon residue or a C3-C8 cycloaliphatic hydrocarbon residue, optionally bearing one or more straight or branched alkyl substituents; or it is a polyoxyalkylene residue of formula (III), wherein R6 is hydrogen or methyl, n is an integer from 1 to 3 and m is an integer from 1 to 200; the two -R3-COO and -R4-COO groups being randomly distributed in the polyester residue; are valuable for use as bioerosible matrices for the controlled release of drugs.
摘要翻译：式（I）的聚酯聚碳酸酯，其中a为2至300的整数; R 1和R 2可以相同或不同，分别为式（II）的聚酯残基，其中x和y为0至100的整数，比率（x / x + y）* 100包含在0 和100，条件是x和y不同时为0; R 3和R 4可以相同或不同，分别为直链或支链C 1 -C 4脂族烃残基; R5是直链或支链C 2 -C 18脂族烃残基或任选带有一个或多个直链或支链烷基取代基的C 3 -C 8脂环族烃残基; 或者它是式（III）的聚氧化烯残基，其中R6是氢或甲基，n是1至3的整数，m是1至200的整数; 两个-R3-COO和-R4-COO基团随机分布在聚酯残基中; 对于用作药物受控释放的生物可吸收基质是有价值的。

5. 发明申请

WO1992022600A1 POLYCARBONATES AND THE USE THEREOF FOR THE PREPARATION OF BIOEROSIBLE MATRICES 审中-公开
标题翻译：聚碳酸酯及其制备生物可食性基质的用途
公开(公告)号：WO1992022600A1
公开(公告)日：1992-12-23
申请号：PCT/EP1992001262
申请日：1992-06-05
申请人： MEDIOLANUM FARMACEUTICI S.P.A. , FERRUTI, Paolo , RANUCCI, Elisabetta , BIGNOTTI, Fabio
发明人： MEDIOLANUM FARMACEUTICI S.P.A.
IPC分类号： C08G64/02
CPC分类号： C08G63/64 , A61K9/204 , C08G64/0208 , C08G64/183 , C08G64/38
摘要： Polycarbonates of formula (I) wherein a is an integer from 2 to 300; R and R , which can be the same or different, are an aliphatic or alicyclic straight or branched chain having from 2 to 18 carbon atoms, or R and R are a polyoxyalkylene residue of formula (II) in which R is hydrogen or methyl, n is an integer from 1 to 3 and m is an integer from 1 to 200, or a polyester residue of formula (III), wherein x and y are integers from 1 to 50, R and R , which can be the same or different, are aliphatic straight or branched hydrocarbon chains having from 1 to 4 carbon atoms, R is an aliphatic or alicyclic straight or branched chain having from 2 to 18 carbon atoms, or a polyoxyalkylene residue of formula (II), being intended that the two groups -R -COO and -R -COO are randomly distributed in the polyester residue, x and y being in any possible ratio from 0 to 100, are synthesized by reacting (the) dihydroxy compounds with 1,1'-carbonyldiimidazole. They are useful for the preparation of bioerodible matrices for biologically active compounds.
摘要翻译：式（I）的聚碳酸酯，其中a为2至300的整数; R 1和R 2可以相同或不同，是具有2至18个碳原子的脂族或脂环族直链或支链，或R 1和R 2是聚氧化烯残基式（II）其中R 3为氢或甲基，n为1至3的整数，m为1至200的整数，或式（III）的聚酯残基，其中x和y为 1至50，R 4和R 5可以相同或不同，是具有1至4个碳原子的脂族直链或支链烃链，R 6是脂族或脂环族直链或支链具有2至18个碳原子或式（II）的聚氧化烯残基，旨在使两个基团-R 4 -COO和-R 5 -COO随机分布在聚酯残基中，x和y 通过（（））二羟基化合物与1,1'-羰基二咪唑反应来合成0至100的任何可能的比例。它们可用于制备用于生物活性化合物的生物可蚀解基质。

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