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1. 发明申请

WO2012119907A1 METHOD OF PROTECTING BIOLOGICALLY ACTIVE SUBSTANCES AGAINST DENATURATION 审中-公开
标题翻译：保护生物活性物质防止破坏的方法
公开(公告)号：WO2012119907A1
公开(公告)日：2012-09-13
申请号：PCT/EP2012/053454
申请日：2012-02-29
申请人： BIEMANS, Rogier
发明人： BIEMANS, Rogier
IPC分类号： A61K9/16 , A61K9/70 , A61K9/00 , B41J2/005 , A61M37/00
CPC分类号： A61L26/0061 , A61K9/0021 , A61K9/1623 , A61K9/1652 , A61K9/7007 , A61M37/00 , B41J2/14274
摘要： A method of protecting a biologically active substance against denaturation, wherein a liquid (14) containing the active substance and a matrix-forming substance is deposited on a target surface (18) and dried so as to form a solid amorphous matrix (26) with the molecules of the active substance embedded therein, wherein an ink jet printer (10) is used for depositing the liquid (14) on the target surface (16) in the form of droplets (12) having a volume small enough to cause the liquid to dry when it impinges on the target surface (16) and to be held on the target surface through adhesion.
摘要翻译：一种保护生物活性物质免受变性的方法，其中将含有活性物质和基质形成物质的液体（14）沉积在目标表面（18）上并干燥以形成固体无定形基质（26），其具有嵌入其中的活性物质的分子，其中喷墨打印机（10）用于以液滴（12）的形式将液体（14）沉积在目标表面（16）上，液滴体积足够小以使液体当其撞击在目标表面（16）上时被干燥并通过粘附保持在目标表面上。

2. 发明申请

WO1988006865A1 ENDOVASCULAR CONNECTOR 审中-公开
标题翻译：内镜连接器
公开(公告)号：WO1988006865A1
公开(公告)日：1988-09-22
申请号：PCT/NL1988000010
申请日：1988-03-17
申请人： BIEMANS, Rogier, Guido, Marie
IPC分类号： A61B11/00
CPC分类号： A61B17/11 , A61B17/12009 , A61B2017/1107 , A61B2017/1135 , A61F2002/30217 , A61F2002/30233 , A61F2002/30235 , A61F2002/30329 , A61F2002/30354 , A61F2002/30461 , A61F2220/0025 , A61F2220/0033 , A61F2220/0075 , A61F2230/0067 , A61F2230/0069
摘要： Endovascular connector (1) for interconnecting the lumina of blood vessels (3, 9) and/or grafts, comprising a tube-shaped coupling part with a first end (2), destined to be inserted into the vessel (3) and a second end, destined to accept the open end of the other vessel (9) and/or graft.
摘要翻译：用于互连血管（3,9）和/或移植物的管腔的血管内连接器（1），包括具有第一端（2）的管状联接部分，目的是插入血管（3）和第二终止，注定接受另一个血管（9）的开放端和/或移植物。

3. 发明申请

WO2009092703A1 METHOD FOR LYOPHILISING PARTICLES HAVING A PHARMACEUTICAL COMPOUND CONTAINED THEREIN AND A PHARMACEUTICAL PACK CONTAINING SUCH PARTICLES 审中-公开
标题翻译：用于含有含有药物化合物的颗粒和含有这种颗粒的药物包装的方法
公开(公告)号：WO2009092703A1
公开(公告)日：2009-07-30
申请号：PCT/EP2009/050584
申请日：2009-01-20
申请人： INTERVET INTERNATIONAL B.V. , MIDDELBEEK, Hans Almer , KIRKELS, Monique , BIEMANS, Rogier
发明人： MIDDELBEEK, Hans Almer , KIRKELS, Monique , BIEMANS, Rogier
IPC分类号： A61K9/19
CPC分类号： A61K9/19 , A61K9/1694
摘要： The present invention pertains to a method for lyophilising particles comprising frozen liquid having a pharmaceutical compound contained therein, comprising providing a heat conducting container having a bottom and side walls, filling the container with a bed of the particles, the bed comprising multiple layers of the particles and having an aspect ratio of not less than 1, providing a heat source above a top layer of the particles, the heat source having a surface directed to a top layer of the bed, which surface has an emissivity coefficient of at least 0.4, subjecting the particles filled in the container to a reduced pressure, heating at least the bottom of the container and the said surface to provide heat to the particles to support sublimation of the frozen liquid at the reduced pressure, and after the frozen liquid is sublimated, stopping the provision of heat to the particles. The invention also pertains to a pharmaceutical pack comprising a container having contained therein at least one particle obtained via this method.
摘要翻译：本发明涉及一种用于冻干颗粒的方法，所述方法包括其中含有药物化合物的冷冻液体，包括提供具有底壁和侧壁的导热容器，用该颗粒填充容器，该床包含多层颗粒并且具有不小于1的纵横比，在所述颗粒的顶层上方提供热源，所述热源具有指向所述床的顶层的表面，所述表面的发射系数为至少0.4，将填充在容器中的颗粒进行减压，至少加热容器的底部和所述表面以向颗粒提供热量以在减压下支撑冷冻液体的升华，并且在冷冻液体升华之后，停止向颗粒提供热量。本发明还涉及一种药物包装，其包含容器，其中含有通过该方法获得的至少一种颗粒。

4. 发明申请

WO2009068545A1 CARRIER PARTICLE FOR A MICROORGANISM OR SUBUNIT THEREOF, PHARMACEUTICAL COMPOSITION COMPRISING SUCH PARTICLES, METHOD FOR PREPARATION OF THIS COMPOSITION AND ITS USE IN THE TREATMENT OF ANIMALS 审中-公开
标题翻译：用于微生物或其子的载体颗粒，包含这种颗粒的药物组合物，该组合物的制备方法及其在动物处理中的用途
公开(公告)号：WO2009068545A1
公开(公告)日：2009-06-04
申请号：PCT/EP2008/066188
申请日：2008-11-26
申请人： INTERVET INTERNATIONAL B.V. , MOMBARG, Erwin , BIEMANS, Rogier
发明人： MOMBARG, Erwin , BIEMANS, Rogier
IPC分类号： A61K9/50 , A61K39/00
CPC分类号： A61K9/5015 , A61K39/0275 , A61K39/102 , A61K39/12 , A61K39/385 , A61K39/39 , A61K2039/521 , A61K2039/5252 , A61K2039/552 , A61K2039/55505 , A61K2039/55566 , A61K2039/70 , C12N2710/10234 , C12N2750/10034 , C12N2760/18134 , C12N2760/18334 , C12N2770/20034 , Y02A50/482
摘要： The invention pertains to a carrier particle comprising a hydrophilic phase containing a micro-organism and/or subunit thereof, the hydrophilic phase being dispersed in a hydrophobic continuous phase being solid at room temperature, wherein the hydrophobic phase is constituted to undergo a solid-to-liquid conversion at a temperature above room temperature, the conversion comprising a first order transition. The invention also pertains to a pharmaceutical composition comprising said particles, a method for preparation the pharmaceutical composition and the use of this composition in the treatment of an animal.
摘要翻译：本发明涉及包含含有微生物和/或其亚单位的亲水相的载体颗粒，所述亲水相分散在室温下为固体的疏水性连续相中，其中所述疏水相构成为进行固 - - 在高于室温的温度下的液体转化，转化包括一级转变。本发明还涉及包含所述颗粒的药物组合物，制备药物组合物的方法和该组合物在动物治疗中的用途。

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