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    • 3. 发明申请
    • PROCESS FOR THE PREPARATION OF ASTAXANTHIN
    • 制备ASTAXANTHIN的方法
    • WO2007128574A1
    • 2007-11-15
    • PCT/EP2007/004071
    • 2007-05-08
    • DSM IP ASSETS B.V.BERG, MichaelESSL, StefanHUGENTOBLER, Max
    • BERG, MichaelESSL, StefanHUGENTOBLER, Max
    • C07C403/24
    • C07C403/24
    • The invention therefore relates to a process for the preparation of astaxanthin of the formula I by reacting 2 mol of the triphenylphosphonium salt of the general formula II in which X represents chlorine, bromine or the (HSO 4 ) radical, preferably bromine, in a Wittig reaction with one mol of the C 10 -dialdehyde of the formula III which is characterized in that a) the starting compounds of the formulae II and III are taken up in a solvent, the mixture is cooled to a temperature of not more than 10°C, preferably -18°C to +5°C, b) about 0.9 to 1.5, preferably 0.9 to 1.2, mol of a base per mole of triphenylphosphonium salt are added to the resulting reaction mixture at a temperature of not more than 10°C, preferably -18°C to +5°C, c) the base is metered and mixed in over a predetermined reaction time T so that at least a ½ base equivalent is added to the reaction mixture continuously or quasicontinuously within a timespan T'
    • 因此,本发明涉及通过使2摩尔通式II的三苯基鏻盐(其中X表示氯,溴或(HSO 4))基团,制备式I的虾青素的方法 ,优选溴,在与一摩尔式III的C 10-20二甲醛的Wittig反应中,其特征在于a)将式II和III的起始化合物溶于溶剂 ,将混合物冷却至不高于10℃,优选-18℃至+ 5℃的温度,b)加入每摩尔三苯基鏻盐约0.9至1.5摩尔,优选0.9至1.2摩尔的碱 在不高于10℃,优选-18℃至+ 5℃的温度下将所得反应混合物加入到所得反应混合物中,c)将碱在预定的反应时间T内进行计量和混合,使得至少1/2碱基当量 在时间段T'<3T内连续或准连续加入到反应混合物中,剩余的碱 在剩余的反应时间内。