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1. 发明申请

WO2006135786A2 METHODS FOR SYNTHESIS OF ENCODED LIBRARIES 审中-公开
标题翻译：编码图书馆的合成方法
公开(公告)号：WO2006135786A2
公开(公告)日：2006-12-21
申请号：PCT/US2006/022555
申请日：2006-06-09
申请人： PRAECIS PHARMACEUTICALS, INC. , MORGAN, Barry , HALE, Stephen , ARICO-MUENDEL, Christopher, C. , CLARK, Matthew , WAGNER, Richard , KAVARANA, Malcolm, J. , CREASER, Steffen, Phillip , FRANKLIN, George, J. , CENTRELLA, Paolo, A. , ISRAEL, David, I. , GEFTER, Malcolm, L. , BENJAMIN, Dennis , HANSEN, Nils, Jakob, Vest , ACHARYA, Raksha, A.
发明人： MORGAN, Barry , HALE, Stephen , ARICO-MUENDEL, Christopher, C. , CLARK, Matthew , WAGNER, Richard , KAVARANA, Malcolm, J. , CREASER, Steffen, Phillip , FRANKLIN, George, J. , CENTRELLA, Paolo, A. , ISRAEL, David, I. , GEFTER, Malcolm, L. , BENJAMIN, Dennis , HANSEN, Nils, Jakob, Vest , ACHARYA, Raksha, A.
IPC分类号： C12N15/10 , C07B61/00 , C07H21/00
CPC分类号： C07H21/00 , C12N15/1068
摘要： The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
摘要翻译：本发明提供合成包含编码寡核苷酸标签的分子文库的方法。

2. 发明申请

WO2012019165A3 METHODS OF INHIBITION OF PROTEIN FUCOSYLATION IN VIVO USING FUCOSE ANALOGS 审中-公开
公开(公告)号：WO2012019165A3
公开(公告)日：2012-02-09
申请号：PCT/US2011/046857
申请日：2011-08-05
申请人： SEATTLE GENETICS, INC. , SENTER, Peter , ALLEY, Stephen , BENJAMIN, Dennis
发明人： SENTER, Peter , ALLEY, Stephen , BENJAMIN, Dennis
IPC分类号： A61K31/70
摘要： The invention provides methods and compositions for the inhibition of fucosylation of proteins, including antibodies, in vivo by administration of a fucose analog.

3. 发明申请

WO2012019165A2 METHODS OF INHIBITION OF PROTEIN FUCOSYLATION IN VIVO USING FUCOSE ANALOGS 审中-公开
标题翻译：使用FUCOSE模拟抑制蛋白质纤维蛋白的方法
公开(公告)号：WO2012019165A2
公开(公告)日：2012-02-09
申请号：PCT/US2011046857
申请日：2011-08-05
申请人： SEATTLE GENETICS INC , SENTER PETER , ALLEY STEPHEN , BENJAMIN DENNIS
发明人： SENTER PETER , ALLEY STEPHEN , BENJAMIN DENNIS
IPC分类号： A61K31/7042
CPC分类号： A61K31/7004 , A61K9/0053 , A61K31/7024 , A61K31/7042 , A61K31/7048 , A61K31/706 , A61K39/0011 , A61K45/06 , A61K2039/5152 , A61K2039/545 , C07K16/00 , C07K16/18 , C07K2317/41
摘要： The invention provides methods and compositions for the inhibition of fucosylation of proteins, including antibodies, in vivo by administration of a fucose analog.
摘要翻译：本发明提供通过施用岩藻糖类似物在体内抑制蛋白质包括抗体的岩藻糖基化的方法和组合物。

4. 发明申请

WO2010111018A1 ANTIBODY DRUG CONJUGATES (ADC) THAT BIND TO 24P4C12 PROTEINS 审中-公开
标题翻译：与24P4C12蛋白质结合的抗体药物联合（ADC）
公开(公告)号：WO2010111018A1
公开(公告)日：2010-09-30
申请号：PCT/US2010/026429
申请日：2010-03-05
申请人： AGENSYS, INC. , SEATTLE GENETICS, INC. , GUDAS, Jean , JAKOBOVITS, Aya , AN, Zili , MORRISON, Robert, Kendall , MORRISON, Karen, Jene Meyrick , JIA, Xiao-Chi , BENJAMIN, Dennis , MOSER, Ruth , SENTER, Peter
发明人： GUDAS, Jean , JAKOBOVITS, Aya , AN, Zili , MORRISON, Robert, Kendall , MORRISON, Karen, Jene Meyrick , JIA, Xiao-Chi , BENJAMIN, Dennis , MOSER, Ruth , SENTER, Peter
IPC分类号： A61K39/00 , C12P21/08
CPC分类号： C07K16/30 , A61K45/06 , A61K47/6803 , A61K47/6851 , A61K47/6863 , A61K2039/505 , C07K16/3046
摘要： Antibody drug conjugates (ADC's) that bind to 24P4C12 protein and variants thereof are described herein. 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
摘要翻译：本文描述了结合24P4C12蛋白及其变体的抗体药物偶联物（ADC）。 24P4C12在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，本发明的ADC提供了用于治疗癌症的治疗组合物。

5. 发明申请

WO2009052431A3 CD19 BINDING AGENTS AND USES THEREOF 审中-公开
标题翻译： CD19结合剂及其用途
公开(公告)号：WO2009052431A3
公开(公告)日：2010-01-14
申请号：PCT/US2008080373
申请日：2008-10-17
申请人： SEATTLE GENETICS INC , MCDONAGH CHARLOTTE , CERVENY CHARLES G , BENJAMIN DENNIS , CARTER PAUL , GERBER HANS PETER , FRANCISCO LEIGH
发明人： MCDONAGH CHARLOTTE , CERVENY CHARLES G , BENJAMIN DENNIS , CARTER PAUL , GERBER HANS PETER , FRANCISCO LEIGH
IPC分类号： A61K39/395
CPC分类号： A61K47/6803 , A61K38/05 , A61K47/6811 , A61K47/6849 , A61K47/6867 , A61K2039/505 , C07K16/2803 , C07K16/3061 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77
摘要： This invention, inter alia, relates to CD19 binding agents and methods of using such CD19 binding agents for treating disease.
摘要翻译：本发明尤其涉及CD19结合剂和使用这种CD19结合剂来治疗疾病的方法。

6. 发明申请

WO2007087587A3 CHEMICAL DEFUNCTIONALIZATION OF POLYMERIC ALKYLENEDIOXYHETEROCYCLICS 审中-公开
标题翻译：聚合物烷基二氧杂环己酮的化学分解
公开(公告)号：WO2007087587A3
公开(公告)日：2007-11-15
申请号：PCT/US2007061016
申请日：2007-01-25
申请人： UNIV FLORIDA , REYNOLDS JOHN ROBERT , REEVES BENJAMIN DENNIS
发明人： REYNOLDS JOHN ROBERT , REEVES BENJAMIN DENNIS
IPC分类号： H01B1/12 , C08G61/00 , H01L51/30
CPC分类号： C08G61/122 , C08G61/124 , C08G61/125 , C08G61/126 , C08G2261/1426 , C08G2261/3223 , C08G2261/80 , H01B1/127 , H01L51/0037
摘要： A method for preparing a defunctionalized alkylenedioxyheterocycle polymer or copolymer involves providing a polycarboxylic acid derivative functionalizcd alkylenedioxyheterocycle polymer or copolymer and transforming the polymer or copolymer into a defunctionalized alkylenedioxyheterocycle polymer or copolymer which is a polyhydroxy, polythiol, polyamino, or polycarboxylic acid functionalizcd alkylenedioxyheterocycle polymer or copolymer. The monomers, homopolymers and copolymers for use in the method are new compositions of matter. The polymers containg polycarboxylic acid derivative functionalized alkylenedioxyheterocycle units are soluble polymers which are defunctionalized to yield insoluble polyhydroxy, polythiol, polyamino, or polycarboxylic acid functionalized alkylenedioxyheterocycle polymers. These polymers can be cast as films for use as: hole transport layers in organic light emitting diodes; active electrochrome in electrochromic windows, mirrors and displays; field effect transistors, supercapacitors, batteries, photovoltaic cells, and other electronic components; electronic paper; anti-stat conductors; and transparent conductors.
摘要翻译：制备去官能化的亚烷基二氧杂环聚合物或共聚物的方法包括提供可聚酰亚胺官能化的亚烷基二氧杂环聚合物或共聚物，并将该聚合物或共聚物转化成去官能化的亚烷基二氧杂环聚合物或共聚物，其为多羟基，多硫醇，聚氨基或多官能亚烷基二氧杂环聚合物或共聚物。用于该方法的单体，均聚物和共聚物是新的物质组合物。含有多元羧酸衍生物官能化的亚烷基二氧杂环单元的聚合物是可溶性聚合物，其被去官能化以产生不溶性多羟基，多硫醇，聚氨基或多元羧酸官能化的亚烷基二氧杂环聚合物。这些聚合物可以铸造成薄膜用于：有机发光二极管中的空穴传输层; 电致变色窗户，镜子和显示器中的活性电子色素; 场效应晶体管，超级电容器，电池，光伏电池和其他电子组件; 电子纸; 反导体; 和透明导体。

7. 发明申请

WO2005058479A3 METHODS FOR SYNTHESIS OF ENCODED LIBRARIES 审中-公开
标题翻译：编码图书馆的合成方法
公开(公告)号：WO2005058479A3
公开(公告)日：2005-10-13
申请号：PCT/US2004042964
申请日：2004-12-17
申请人： PRAECIS PHARM INC , MORGAN BARRY , HALE STEPHEN , ARICO-MUENDEL CHRISTOPHER C , CLARK MATHEW , WAGNER RICHARD , ISRAEL DAVIDE I , GEFTER MALCOLM L , BENJAMIN DENNIS , HANSEN NILS JACOB VEST , KAVARNA MALCOLM J , CREASER STEFFAN PHILLIP , FRANKLIN GEORGE J , CLARK MATHEW A , CENTRELLA PAOLO A , ACHARYA RAKSHA A
发明人： MORGAN BARRY , HALE STEPHEN , ARICO-MUENDEL CHRISTOPHER C , CLARK MATHEW , WAGNER RICHARD , ISRAEL DAVIDE I , GEFTER MALCOLM L , BENJAMIN DENNIS , HANSEN NILS JACOB VEST , KAVARNA MALCOLM J , CREASER STEFFAN PHILLIP , FRANKLIN GEORGE J , CLARK MATHEW A , CENTRELLA PAOLO A , ACHARYA RAKSHA A
IPC分类号： C07B61/00 , C07H21/00 , C07H21/04 , C07K1/00 , C12N15/10 , C12P19/34 , C12Q1/68 , A61K38/00
CPC分类号： C07H21/00 , C12N15/1068 , C40B50/10
摘要： The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
摘要翻译：本发明提供合成包含编码寡核苷酸标签的分子文库的方法。

8. 发明申请

WO2004092728A3 METHODS OF MEASURING THE ABILITY OF A TEST COMPOUND TO INACTIVATE A BIOLOGICAL TARGET IN CELLS OF A SUBJECT 审中-公开
标题翻译：测试化合物能够使主体细胞中的生物学目标失活的方法
公开(公告)号：WO2004092728A3
公开(公告)日：2005-06-02
申请号：PCT/US2004010941
申请日：2004-04-07
申请人： PRAECIS PHARM INC , BENJAMIN DENNIS , THOMPSON CHARLES , WANG BRYAN , WAKEFIELD JAMES , GEFTER MALCOLM L , ARICO-MUENDEL CHRISTOPHER C
发明人： BENJAMIN DENNIS , THOMPSON CHARLES , WANG BRYAN , WAKEFIELD JAMES , GEFTER MALCOLM L , ARICO-MUENDEL CHRISTOPHER C
IPC分类号： C12Q1/37 , G01N33/50 , G01N33/53 , G01N33/567 , G01N33/573 , G01N33/574
CPC分类号： G01N33/573 , G01N33/5032 , G01N33/57496
摘要： The present invention provides a method of assessing the ability of a compound (the "test compound") which is an inhibitor of a biological target to inhibit the biological target in a biological compartment of interest when administered to a subject in vivo.
摘要翻译：本发明提供了当在体内施用于受试者时，评估作为生物靶标抑制剂的化合物（“测试化合物”）在感兴趣的生物区室中抑制生物靶标的能力的方法。

9. 发明申请

WO2011109308A1 METHODS FOR SCREENING ANTIBODIES 审中-公开
标题翻译：筛选抗体的方法
公开(公告)号：WO2011109308A1
公开(公告)日：2011-09-09
申请号：PCT/US2011/026534
申请日：2011-02-28
申请人： SEATTLE GENETICS, INC. , LYON, Robert , BENJAMIN, Dennis , RYAN, Maureen
发明人： LYON, Robert , BENJAMIN, Dennis , RYAN, Maureen
IPC分类号： C07K16/00 , A61K39/395
CPC分类号： C07K16/00 , A61K47/6803 , C07K1/04 , C07K2317/24 , G01N33/5014 , G01N33/533
摘要： The invention provides methods for making antibody conjugates for use in antibody screening assays and antibody conjugates produced by the claimed methods.
摘要翻译：本发明提供用于制备用于抗体筛选测定的抗体缀合物的方法和通过所要求保护的方法产生的抗体缀合物。

10. 发明申请

WO2010008799A1 CORDLESS BATTERY OPERATED HANDHELD STEAMER AND METHODS OF OPERATION 审中-公开
标题翻译：无电池电池操作的手持式蒸汽器及其操作方法
公开(公告)号：WO2010008799A1
公开(公告)日：2010-01-21
申请号：PCT/US2009/048156
申请日：2009-06-22
申请人： ANTIMICROBIAL TEST LABORATORIES, LLC , TANNER, Benjamin, Dennis , HILLSAMER, Timothy, Richard
发明人： TANNER, Benjamin, Dennis , HILLSAMER, Timothy, Richard
IPC分类号： D06F75/18
CPC分类号： D06F73/00
摘要： A cordless handheld steamer comprising an interior chamber containing a steam generation unit and a water reservoir. The water reservoir generally encompasses the steam generation unit and the steam generation unit contains a heating element. A precise temperature control unit monitors the heating element's temperature to maintain an optimum steam producing temperature without overheating. The heating element is powered only by an on-board battery pack. A user determined amount of water is pumped from the water reservoir to the flash boiler chamber where the water is converted to steam and the steam travels through a plenum to a target area.
摘要翻译：一种无绳手持式蒸笼，包括含有蒸汽发生单元和储水器的内部室。储水器通常包括蒸汽发生单元，蒸汽发生单元包含加热元件。精确的温度控制单元监测加热元件的温度，以保持最佳的蒸汽产生温度而不会过热。加热元件仅由板载电池组供电。用户确定的水量从储水器被泵送到闪蒸锅炉室，其中水被转换成蒸汽，并且蒸汽通过增压室行进到目标区域。

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