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1. 发明申请

WO2020161450A1 SEA LICE VACCINES 审中-公开
公开(公告)号：WO2020161450A1
公开(公告)日：2020-08-13
申请号：PCT/GB2019/050295
申请日：2019-02-04
申请人： BENCHMARK ANIMAL HEALTH LIMITED
发明人： BARKER, Sarah Elizabeth
IPC分类号： A61K39/00 , C07K14/435 , A61P33/14
摘要： Proteins derived from secretory/excretory products of Lepeophtheirus salmonis , including recombinant proteins, DNA encoding the proteins, vaccines and antigens comprising the proteins or the DNA, and uses thereof for the prevention or treatment of sea lice ( Lepeophtheirus salmonis or Caligus rogercresseyi ) in fish, and related methods of treatment.

2. 发明申请

WO2018051071A9 DETECTION AND TREATMENT OF MICROSPORIDIAN INFECTION 审中-公开
公开(公告)号：WO2018051071A9
公开(公告)日：2018-03-22
申请号：PCT/GB2017/052676
申请日：2017-09-12
申请人： BENCHMARK ANIMAL HEALTH LIMITED
发明人： SCHOLZ, Felix , RODGER, Hamish
IPC分类号： A61K39/395 , C12Q1/68 , C12N15/11 , G01N33/53
摘要： An isolated or synthetic nucleic acid from having a sequence selected from the group consisting of SEQ ID NOs: 9, 13 and 1-8, or a homologues thereof, an isolated or synthetic nucleic acid complementary to a sequence selected from the group consisting of SEQ ID NOs: 1-14, or a homologues thereof, an isolated polypeptide encoded by the nucleic acid, or an antibody that binds thereto, may be used as an immunogenic composition or diagnostic, or in a method of treatment or prevention, in respect of a microsporidian infection, in particular a Tetramicra brevifilum infection in animals, particularly fish. Additionally, methods of testing an agent for the prevention and/or treatment of a microsporidian infection, preferably a Tetramicra brevifilum infection, and kits for screening for a microsporidian infection, are provided.

3. 发明申请

WO2018051071A1 DETECTION AND TREATMENT OF MICROSPORIDIAN INFECTION 审中-公开
标题翻译：微小隐孢子虫感染的检测与治疗
公开(公告)号：WO2018051071A1
公开(公告)日：2018-03-22
申请号：PCT/GB2017/052676
申请日：2017-09-12
申请人： BENCHMARK ANIMAL HEALTH LIMITED
发明人： SCHOLZ, Felix , RODGER, Hamish
IPC分类号： A61K39/395 , C12Q1/68 , C12N15/11 , G01N33/53
CPC分类号： G01N33/56961 , A61K39/00 , A61K2039/552 , C12Q1/6895 , G01N2500/10
摘要： An isolated or synthetic nucleic acid from having a sequence selected from the group consisting of SEQ ID NOs: 9, 13 and 1-8, or a homologues thereof, an isolated or synthetic nucleic acid complementary to a sequence selected from the group consisting of SEQ ID NOs: 1-14, or a homologues thereof, an isolated polypeptide encoded by the nucleic acid, or an antibody that binds thereto, may be used as an immunogenic composition or diagnostic, or in a method of treatment or prevention, in respect of a microsporidian infection, in particular a Tetramicra brevifilum infection in animals, particularly fish. Additionally, methods of testing an agent for the prevention and/or treatment of a microsporidian infection, preferably a Tetramicra brevifilum infection, and kits for screening for a microsporidian infection, are provided.
摘要翻译：具有选自SEQ ID NO：9,13和1-8的序列的分离的或合成的核酸，或其同源物，分离的或合成的核酸，其与选自SEQ ID NO：1-14的序列或其同源物，由该核酸编码的分离的多肽或与其结合的抗体可以用作免疫原性组合物或诊断剂，或在方法中对微孢子虫感染，特别是在动物特别是鱼类中感染的Tetramicra brevifilum感染的治疗或预防。此外，还提供了用于预防和/或治疗微孢子虫感染的试剂的方法，优选地为Tetramicra brevifilum感染，以及用于筛选微孢子虫感染的试剂盒。

4. 发明申请

WO2020152467A1 SEA LICE ANTIGENS AND VACCINES 审中-公开
公开(公告)号：WO2020152467A1
公开(公告)日：2020-07-30
申请号：PCT/GB2020/050154
申请日：2020-01-23
申请人： BENCHMARK ANIMAL HEALTH LIMITED , UNIVERSITY OF MAINE SYSTEM BOARD OF TRUSTEES
发明人： BRICKNELL, Ian Robert , BARKER, Sarah Elizabeth , PIESZ, Jessica Lynn
IPC分类号： A61K39/00
摘要： Isolated proteins from caligid copepods, mutant protein from caligid copepods, polynucleotides encoding the same, and antigens and vaccines comprising the same, in particular for the treatment or prevention of caligid copepod infection in fish. Proteins are a mutant of fructose bisphosphate aldolase (FBP), a mutant of glutathione S-transferase 1, isoform D (GST), peptidyl prolyl cis-trans isomerase 5-precursor (PPIase), glutathione S-transferase 1, isoform D (GST), a mutant of triosephosphate isomerase (TIM) and cystathionine gamma-lyase (CSE).

5. 发明申请

WO2019145730A1 SEA LICE ANTIGENS AND VACCINES 审中-公开
公开(公告)号：WO2019145730A1
公开(公告)日：2019-08-01
申请号：PCT/GB2019/050216
申请日：2019-01-25
申请人： BENCHMARK ANIMAL HEALTH LIMITED , FVG, INC. , UNIVERSITY OF MAINE SYSTEM BOARD OF TRUSTEES
发明人： BARKER, Sarah Elizabeth , PIESZ, Jessica Lynn , BRICKNELL, Ian Robert
IPC分类号： A61K39/00 , C07K14/435 , A61P33/14
CPC分类号： C07K14/43509 , A61K39/0003 , A61K2039/552
摘要： Isolated proteins from caligid copepods, polynucleotides encoding the same, and antigens and vaccines comprising the same, in particular for the treatment or prevention of caligid copepod infection in fish. Proteins are peroxiredoxin-2 (Prx-2), fructose bisphosphate aldolase (FBP); enolase, transitionally-controlled tumour protein homolog (TCTP) and triosephosphate isomerase (TIM).

6. 发明申请

WO2017216541A1 TREATMENT. OF MARINE PARASITE INFECTION 审中-公开
标题翻译：治疗。海洋寄生虫感染
公开(公告)号：WO2017216541A1
公开(公告)日：2017-12-21
申请号：PCT/GB2017/051715
申请日：2017-06-13
申请人： BENCHMARK ANIMAL HEALTH LIMITED
发明人： REILLY, Robert , MARSHALL, John
IPC分类号： A01N57/16 , A01N51/00 , A01N25/00 , A01P1/00
CPC分类号： A01N57/16 , A01N25/00 , A01N51/00
摘要： A combination of an anti-parasitic agent, such as azamethiphos, and fresh water for use in the treatment or prevention of a marine parasite infection in a fish, wherein the use is sequential, separate and/or simultaneous. Typically, the use is sequential, and the anti- parasitic agent is applied after an initial period in the fresh water. The treatment is suitable for a variety of fish, for example Salmo salar , sea bass, sea bream, and is effective against parasitic infections such as those mediated by Lepeophtheirus salmonis , Caligus rogercresseyi , Caligus clemensi and amoebic gill disease, The combination also provides methods of enhancing the effectiveness of an anti-marine parasitic agent, reducing the resistance of marine parasites to an anti-marine parasitic agent, treating a marine parasite infection in a fish, and preventing re-infection of a fish with a marine parasite.
摘要翻译：用于治疗或预防鱼类中的海生寄生虫感染的抗寄生虫剂如阿美利西泊（azamethiphos）和淡水的组合，其中所述用途是连续的，分开的和/或同时。典型地，使用是顺序的，并且在淡水中的初始阶段之后应用抗寄生虫剂。该处理适用于各种鱼类，例如Salmo salar，鲈鱼，鲷鱼，并且对寄生虫感染例如由鲑鱼疮疱病毒介导的寄生虫感染是有效的， Caligus rogercresseyi，Caligus clemensi和阿米巴鳃疾病，该组合还提供了增强抗海洋寄生物剂的有效性的方法，其降低了抗性将海洋寄生虫转化为抗海洋寄生虫剂，治疗鱼类中的海洋寄生虫感染，以及防止海洋寄生虫再次感染鱼类。

7. 发明申请

WO2017134441A1 METHODS OF PRODUCING VIRUSES 审中-公开
标题翻译：生产病毒的方法
公开(公告)号：WO2017134441A1
公开(公告)日：2017-08-10
申请号：PCT/GB2017/050259
申请日：2017-02-02
申请人： BENCHMARK ANIMAL HEALTH LIMITED
发明人： TOON, Lindsey Ann , HOFFMANN, Ralf
IPC分类号： A61K39/12 , C12N5/071
CPC分类号： C12N5/0602 , C12N2510/02 , C12N2700/00
摘要： Methods of producing, propagating and multiplying viruses, methods of identifying the presence of a virus in a sample, specifically methods using Japanese eel cell cultures. Also provided are an isolated Japanese eel cell culture, optionally infected with a virus, vaccines comprising viruses grown according to the methods of the invention, and a kit for propagating viruses comprising the Japanese eel cell culture. The virus may be a fish virus such as nodavirus, Infectious Pancreatic Necrosis Virus (IPNV) and Salmon Pancreas Disease Virus (SPDV).
摘要翻译：产生，繁殖和繁殖病毒的方法，鉴定样品中病毒存在的方法，特别是使用日本鳗cell细胞培养物的方法。还提供了任选感染病毒的分离的日本鳗cell细胞培养物，包含根据本发明方法生长的病毒的疫苗，以及用于繁殖包含日本鳗cell细胞培养物的病毒的试剂盒。该病毒可以是鱼病毒，例如诺达病毒，传染性胰腺坏死病毒（IPNV）和鲑鱼胰腺疾病病毒（SPDV）。

8. 发明申请

WO2019234396A1 TREATMENT FOR REMOVING ECTOPARASITES FROM FISH 审中-公开
公开(公告)号：WO2019234396A1
公开(公告)日：2019-12-12
申请号：PCT/GB2019/051519
申请日：2019-05-31
申请人： BENCHMARK ANIMAL HEALTH LIMITED
发明人： MARSHALL, John , LONGSHAW, Matthew , APPLEYARD, Elizabeth
IPC分类号： A01N37/18 , A01N43/40 , A01N43/86 , A01N47/40 , A01N51/00 , A61K31/426 , A01P15/00
摘要： A method for removing ectoparasites, such as sea lice, from a fish in water, comprising: (i) administering a neonicotinoid to remove the ectoparasites from the fish; and (ii) exchanging the water comprising the removed ectoparasites with replacement water, thereby separating the removed ectoparasites and the fish. The neonicotinoid is not imidacloprid, and is not configured or formulated for in-feed administration. The fish may be a salmonid, char, or cleaner fish, and the neonicotinoid may be applied at a sublethal dose and/or for a sublethal time, at a lethal dose and/or for a lethal time, or at a dose that knocks down the ectoparasites. The method may further comprise the step of preventing release of the removed ectoparasites into the environment, for example by collecting the ectoparasites from a sample of water comprising the removed ectoparasites, for example by passing the sample through a filter, preferably a mesh filter. A neonicotinoid for use in the method is also provided.

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