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1. 发明申请

WO2003053255A1 SURGICAL STAPLER APPARATUS 审中-公开
标题翻译：手术装置
公开(公告)号：WO2003053255A1
公开(公告)日：2003-07-03
申请号：PCT/US2002/041127
申请日：2002-12-20
申请人： TYCO HEALTHCARE GROUP LP , BECK, Joachim
发明人： BECK, Joachim
IPC分类号： A61B17/115
CPC分类号： A61B17/115 , A61B17/1155
摘要： The present disclosure relates to circular staplers for performing rectal mucosectomies and other surgical procedures. The circular staplers include a shaft having a proximal and distal end, a cartridge assembly having a plurality of staples and operatively coupled to the distal end of the shaft, the cartridge assembly having a housing and a distal end defining an inner chamber, an anvil assembly operatively coupled to the cartridge assembly, and a channel adapted to communicate with a source of vacuum and the cartridge assembly to transmit a vacuum to the inner chamber of the cartridge assembly for drawing tissue into the inner chamber of the cartridge assembly.
摘要翻译：本公开涉及用于进行直肠粘膜切除术和其它外科手术的圆形缝合器。圆形订书机包括具有近端和远端的轴，具有多个订书钉并且可操作地联接到轴的远端的盒组件，盒组件具有壳体和限定内室的远端，砧座组件可操作地耦合到盒组件，以及适于与真空源和盒组件通信的通道，以将真空传送到盒组件的内室，用于将组织吸入盒组件的内腔中。

2. 发明申请

WO0192567A3 NOVEL TARGET GENES FOR DISEASES OF THE HEART 审中-公开
标题翻译：心脏疾病的新目标基因
公开(公告)号：WO0192567A3
公开(公告)日：2003-02-13
申请号：PCT/EP0106165
申请日：2001-05-30
申请人： MEDIGENE AG , BUNK DANIELA , REUNER BIRGIT , BECK JOACHIM , HENKEL THOMAS
发明人： BUNK DANIELA , REUNER BIRGIT , BECK JOACHIM , HENKEL THOMAS
IPC分类号： A01K67/027 , A61K38/00 , A61K45/00 , A61K48/00 , A61P9/00 , A61P9/02 , A61P9/04 , A61P9/10 , A61P9/12 , C07K14/47 , C12N15/09 , C12N15/85 , C12Q1/50 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , A61K49/00 , C07K16/18
CPC分类号： C12N15/8509 , A01K2217/05 , A01K2217/075 , A01K2267/03 , A01K2267/0375 , C07K14/47 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to a variety of genes abnormally expressed in heart tissue as well as to fragments of such genes. Assessment of the expression level of these genes may be used for testing the predisposition of mammals and preferably humans for a heart disease or for an acute state of such a disease. Preferred diseases in accordance with the invention are congestive heart failure, dilative cardiomyopathy, hypertrophic cardiomyopathy and ischemic cardiomyopathy. The present invention further relates to methods of identifying compounds capable of normalizing the expression level of the aforementioned genes and of further genes affected by the abnormal expression. The identified compounds may be used for formulating compositions, preferably pharmaceutical compositions for preventing or treating diseases. They may also be used as lead compounds for the development of medicaments having an improved efficiency, a longer half-life, a decreased toxicity etc. and to be employed in the treatment of heart diseases. Included in the invention are also somatic gene therapy methods comprising the introduction of at least one functional copy of any of the above-mentioned genes into a suitable cell. Finally, the invention relates to non-human transgenic animals comprising at least one of the aforementioned genes in their germ line. The transgenic animals of the invention may be used for the development of medicaments for the treatment of heart diseases.
摘要翻译：本发明涉及在心脏组织中异常表达的各种基因以及这些基因的片段。这些基因的表达水平的评估可以用于测试哺乳动物和优选人心脏病或这种疾病的急性状态的倾向。根据本发明的优选疾病是充血性心力衰竭，扩张性心肌病，肥厚性心肌病和缺血性心肌病。本发明还涉及鉴定能够使上述基因的表达水平正常化的化合物和受异常表达影响的其它基因的方法。鉴定的化合物可用于配制组合物，优选用于预防或治疗疾病的药物组合物。它们也可以用作开发具有改善的效率，更长的半衰期，降低的毒性等等并且用于治疗心脏病的药物的铅化合物。本发明还包括体细胞基因治疗方法，其包括将任何上述基因的至少一个功能拷贝引入合适的细胞中。最后，本发明涉及在其种系中包含至少一个上述基因的非人转基因动物。本发明的转基因动物可用于开发用于治疗心脏病的药物。

3. 发明申请

WO2003025579A3 USE OF HEART FATTY ACID BINDING PROTEIN 审中-公开
公开(公告)号：WO2003025579A3
公开(公告)日：2003-03-27
申请号：PCT/EP2002/010488
申请日：2002-09-18
申请人： MEDIGENE AG , RÖNICKE, Volker , NAVÉ, Barbara , HENKEL, Thomas , BECK, Joachim
发明人： RÖNICKE, Volker , NAVÉ, Barbara , HENKEL, Thomas , BECK, Joachim
IPC分类号： G01N33/68
摘要： The present invention relates to methods of identifying and/or obtaining a compound which is suspected to be an inhibitor or antagonist of H-FABP. Furthermore, pharmaceutical and diagnostic compositions are disclosed which are, inter alia, to be employed in diseases related to hypertrophy of cells.

4. 发明申请

WO2003025579A2 USE OF HEART FATTY ACID BINDING PROTEIN 审中-公开
标题翻译：心脏脂肪酸结合蛋白的用途
公开(公告)号：WO2003025579A2
公开(公告)日：2003-03-27
申请号：PCT/EP2002/010488
申请日：2002-09-18
申请人： MEDIGENE AG , RÖNICKE, Volker , NAVÉ, Barbara , HENKEL, Thomas , BECK, Joachim
发明人： RÖNICKE, Volker , NAVÉ, Barbara , HENKEL, Thomas , BECK, Joachim
IPC分类号： G01N33/68
CPC分类号： G01N33/5091 , A61K38/00 , C07K14/70567 , C12N2799/022 , C12Q1/6883 , C12Q2600/158 , G01N33/5008 , G01N33/5041 , G01N33/5061 , G01N33/92 , G01N2800/044
摘要： The present invention relates to methods of identifying and/or obtaining a compound which is suspected to be an inhibitor or antagonist of H-FABP. Furthermore, pharmaceutical and diagnostic compositions are disclosed which are, inter alia, to be employed in diseases related to hypertrophy of cells.
摘要翻译：本发明涉及鉴定和/或获得怀疑是H-FABP抑制剂或拮抗剂的化合物的方法。此外，公开了药物和诊断组合物，其尤其用于与细胞肥大有关的疾病。

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