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1. 发明申请

WO2011161641A3 ADDUCTS WITH PERFLUOROPOLYETHER PHOSPHATE AND USES THEREOF 审中-公开
标题翻译：具有全氟磷酸氢盐的添加剂及其用途
公开(公告)号：WO2011161641A3
公开(公告)日：2012-11-22
申请号：PCT/IB2011052756
申请日：2011-06-23
申请人： GIULIANI SPA , GIULIANI GIAMMARIA , BENEDUSI ANNA , PANTINI GIOVANNI , MASCOLO ANTONIO , BARONI SERGIO
发明人： GIULIANI GIAMMARIA , BENEDUSI ANNA , PANTINI GIOVANNI , MASCOLO ANTONIO , BARONI SERGIO
IPC分类号： A61K8/19 , A61K8/24 , A61K8/27 , A61K8/365 , A61K8/67 , A61K8/70 , A61K8/73 , A61K8/81 , A61Q17/04 , A61Q19/00
CPC分类号： C08G65/00 , A61K8/19 , A61K8/24 , A61K8/27 , A61K8/365 , A61K8/676 , A61K8/70 , A61K8/732 , A61K8/8111 , A61Q17/04 , A61Q19/00
摘要： The present invention relates, in one aspect, to an adduct of formula O-PF-A, in which O is an oil; PF is a perfluoropolyether phosphate (PFPE phosphate); A is at least one substance selected from: (X) a water-soluble polyhydroxylated substance and (Y) a water-insoluble inorganic substance and to topical applications thereof in particular in the cosmetic and pharmaceutical field.
摘要翻译：本发明一方面涉及式O-PF-A的加合物，其中O是油; PF是全氟聚醚磷酸盐（PFPE磷酸盐）; A是选自：（X）水溶性多羟基化物质和（Y）水不溶性无机物质中的至少一种物质，特别是在化妆品和药物领域中的局部应用。

2. 发明申请

WO2012007572A1 COMPOUNDS WITH A SKIN PIGMENTING ACTIVITY AND PHARMACEUTICAL OR COSMETIC COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：具有皮肤致密活性的化合物和含有它们的药物或化妆品组合物
公开(公告)号：WO2012007572A1
公开(公告)日：2012-01-19
申请号：PCT/EP2011/062129
申请日：2011-07-15
申请人： GIULIANI S.P.A. , GIULIANI, Giammaria , PAUS, Ralf , RAMOT, Yuval , BECKER, Astrid , BARONI, Sergio
发明人： GIULIANI, Giammaria , PAUS, Ralf , RAMOT, Yuval , BECKER, Astrid , BARONI, Sergio
IPC分类号： A61K31/202 , A61K31/232 , A61K8/36 , A61K8/37 , A61Q19/04 , A61P17/00 , A61P17/16
CPC分类号： A61K31/232 , A61K8/361 , A61K8/37 , A61K31/192 , A61K31/202 , A61Q17/04 , A61Q19/04
摘要： The present invention relates to compounds having general formula (I): CH3-(CH=CH)n-R (I) where: n = 3, 5, 7; R is chosen from -CH 2 -O-CO-R', -CO-OR' or -CO-O (-) , R' is chosen from H, C 1 -C 22 alkyl or alkenyl, aryl or aralkyl, or sugars; and their pharmaceutically acceptable salts, such as sodium, potassium and lysine salts, for use as the active ingredient in pharmaceutical or cosmetic compositions for improving the pigmentation of the human skin, treating pigmentation disorders and/or improve both the photoprotective capacity of the skin and the intensity of its suntan.
摘要翻译：本发明涉及具有通式（I）的化合物：CH 3 - （CH = CH）n -R（I）其中：n = 3,5,7; R选自-CH 2 -O-CO-R'，-CO-OR'或-CO-O（ - ），R'选自H，C 1 -C 22烷基或链烯基，芳基或芳烷基或糖; 和其药学上可接受的盐，例如钠，钾和赖氨酸盐，用作药物或化妆品组合物中的活性成分，用于改善人皮肤的色素沉着，治疗色素沉着紊乱和/或改善皮肤的光保护能力和其防晒的强度。

3. 发明申请

WO2010091894A3 METHODS OF TREATING HAIR RELATED CONDITIONS 审中-公开
标题翻译：治疗头发相关条件的方法
公开(公告)号：WO2010091894A3
公开(公告)日：2010-11-11
申请号：PCT/EP2010000939
申请日：2010-02-16
申请人： GIULIANI INT LTD , BARONI SERGIO , BELLINVIA SALVATORE , VITI FRANCESCA
发明人： BARONI SERGIO , BELLINVIA SALVATORE , VITI FRANCESCA
IPC分类号： A61P17/14 , A61K8/42 , A61K31/196 , A61Q7/02
CPC分类号： A61K31/196 , A61K8/42 , A61K2800/78 , A61Q5/00 , A61Q7/00 , A61Q19/02 , A61Q19/06 , A61Q19/08 , C07C233/54 , C07C235/38 , C07D307/79 , C07D319/08
摘要： Disclosed herein are methods for treating hair related disorders, including compounds of formula I as defined in claim 1, that may be specific or modulate PPAR receptors.
摘要翻译：本文公开了治疗毛发相关病症的方法，包括权利要求1中定义的式I化合物，其可以是特异性或调节PPAR受体。

4. 发明申请

WO2010060729A1 THERAPEUTIC, DIETARY, OR COSMETIC USE OF COMPOUNDS WITH SPECIFIC ANTI-APOPTOTIC ACTIVITY TOWARD CASPASE-3, AND COMPOSITIONS CONTAINING THESE COMPOUNDS 审中-公开
标题翻译：具有针对CASPASE-3特异性抗病毒活性的化合物的治疗，膳食或化妆品使用，以及含有这些化合物的组合物
公开(公告)号：WO2010060729A1
公开(公告)日：2010-06-03
申请号：PCT/EP2009/064368
申请日：2009-10-30
申请人： GIULIANI S.P.A. , GIULIANI, Giammaria , BENEDUSI, Anna , BARONI, Sergio
发明人： GIULIANI, Giammaria , BENEDUSI, Anna , BARONI, Sergio
IPC分类号： A61K31/047 , A61K31/7048 , A61K31/13 , A61P17/14 , A61P17/16
CPC分类号： C07H17/07
摘要： This invention regards the use of zeaxanthin and/or rutin, as such or further combined with spermidine, as the active principle in a pharmaceutical, dietary, or cosmetic composition, acting to inhibit caspase-3 and therefore to control apoptosis by preventing programmed cell death. The indication for this composition according to the invention is primarily the treatment of scalp disorders characterized by excessive cellular turnover including chemotherapy-induced alopecia, alopecia areata, androgenetic alopecia and telogen effluvium.
摘要翻译：本发明涉及玉米黄质和/或芦丁本身或与亚精胺进一步组合的用途，作为药物，膳食或化妆品组合物中的活性成分，用于抑制胱天蛋白酶-3，因此通过预防程序性细胞死亡来控制凋亡。根据本发明的该组合物的适应症主要是治疗特征在于过度细胞周转的头皮疾病，包括化疗诱导的脱发，斑秃，雄激素性脱发和休止期脱落。

5. 发明申请

WO2010054826A1 ANTISENSE COMPOSITIONS AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：抗菌组合物及其制备方法和使用方法
公开(公告)号：WO2010054826A1
公开(公告)日：2010-05-20
申请号：PCT/EP2009/008087
申请日：2009-11-13
申请人： GIULIANI INTERNATIONAL LIMITED , BARONI, Sergio , BELLINVIA, Salvatore , VITI, Francesca
发明人： BARONI, Sergio , BELLINVIA, Salvatore , VITI, Francesca
IPC分类号： C12N15/113 , A61K31/7088
CPC分类号： C12N15/1136 , A61K9/0053 , A61K9/2846 , A61K31/7105 , A61K31/7125 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2320/32
摘要： The present invention provides pharmaceutical formulations for oral administration of antisense oligonucleotides, such as antisense oligonucleotides against SMAD7. The pharmaceutical formulations can be used to treat Crohn's disease, ulcerative colitis and chronic inflammatory bowel disease.
摘要翻译：本发明提供了用于口服给予反义寡核苷酸的药物制剂，例如针对SMAD7的反义寡核苷酸。药物制剂可用于治疗克罗恩病，溃疡性结肠炎和慢性炎症性肠病。

6. 发明申请

WO2009080828A3 COMPOUNDS FOR THE SELECTIVE TREATMENT OF THE INTESTINAL IMMUNO-INFLAMMATORY COMPONENT OF THE CELIAC DISEASE 审中-公开
标题翻译：选择性治疗CELIAC疾病肠道免疫炎症组分的化合物
公开(公告)号：WO2009080828A3
公开(公告)日：2009-10-01
申请号：PCT/EP2008068265
申请日：2008-12-23
申请人： GIULIANI INT LTD , BARONI SERGIO , BELLINVIA SALVATORE
发明人： BARONI SERGIO , BELLINVIA SALVATORE
IPC分类号： A61K31/196 , A61K31/606 , A61P1/00
CPC分类号： A61K31/606 , A61K31/196
摘要： In one aspect, the present invention relates to amino-salicylic - aminophenylpropionic compounds for the use in the treatment of the inflammatory component of the celiac disease. These compounds act by blocking the cytokines released in the celiac disease and are specifically useful in the treatment of cases refractory to the diet, in dietary errors and in the reduction of the celiac disease remission time.
摘要翻译：一方面，本发明涉及用于治疗乳糜泻炎症成分的氨基 - 水杨酸 - 氨基苯基丙酸化合物。这些化合物通过阻断乳糜泻中释放的细胞因子起作用，并特别用于治疗难治性病例，饮食错误和减少乳糜泻缓解时间。

7. 发明申请

WO2007010516A2 COMPOUNDS AND THEIR SALTS SPECIFIC TO THE PPAR RECEPTORS AND THE EGF RECEPTORS AND THEIR USE IN THE MEDICAL FIELD 审中-公开
标题翻译： PPAR受体和EGF受体特异性化合物及其盐类及其在医疗领域的应用
公开(公告)号：WO2007010516A2
公开(公告)日：2007-01-25
申请号：PCT/IE2006/000078
申请日：2006-07-24
申请人： GIULIANI INTERNATIONAL LIMITED , NACCARI, Giancarlo , BARONI, Sergio
发明人： NACCARI, Giancarlo , BARONI, Sergio
CPC分类号： A61K31/196 , C07C229/42
摘要： The present invention relates to compounds comprising the general formula (I), in which R 1 and R 2 , which may be identical or different, are selected from the group comprising -H or a linear or branched alkyl group having from 1 to 6 carbon atoms or together form an aromatic or aliphatic ring with 5 or 6 atoms; Y and Z, which may be identical or different, are selected from the group comprising -H, -OH, -COOH, -OR 3 , -CH(OR 3 )COOH, in which R 3 is selected from H, phenyl, benzyl , -CF 3 or -CF 2 CF 3 , vinyl, allyl and a linear or branched alkyl group having from 1 to 6 carbon atoms.
摘要翻译：本发明涉及包含通式（I）的化合物，其中R 1和R 2可以相同或不同选自-H或具有1至6个碳原子的直链或支链烷基或一起形成具有5或6个原子的芳族或脂族环; Y和Z可以相同或不同，选自-H，-OH，-COOH，-OR 3，-CH（OR 3） COOH，其中R 3选自H，苯基，苄基，-CF 3或-CF 2 CF 3，乙烯基，烯丙基和具有1至6个碳原子的直链或支链烷基。

8. 发明申请

WO2007010515A1 IMPROVEMENTS TO ANALOGOUS COMPOUNDS OF 6-THIOGUANOSINE TRIPHOSPHATE, THEIR USE IN MEDICAL FIELDS AND PROCESSES FOR THEIR PREPARATION 审中-公开
标题翻译：六硫代磷酸三磷酸酯类似物化合物的改进，其在医疗领域的应用及其制备方法
公开(公告)号：WO2007010515A1
公开(公告)日：2007-01-25
申请号：PCT/IE2006/000077
申请日：2006-07-24
申请人： GIULIANI INTERNATIONAL LIMITED , NACCARI, Giancarlo , BARONI, Sergio
发明人： NACCARI, Giancarlo , BARONI, Sergio
IPC分类号： C07H19/16 , C07H19/20 , A61K31/7076 , A61K31/708 , A61P37/06
CPC分类号： C07H19/20 , C07H19/16
摘要： The invention relates to analogous compounds of 6-thioguanosine triphosphate of general formula (I). A compound of the general formula (I); wherein the dashed bond in the sugar moiety can be either single or double and wherein R1 , R2, R3, R4 or R5, equal or different between each other, have general formula -(Int) m -Ter , wherein m is between 0 and 12 and lnt and Ter are Int ernal and Ter minal building blocks, wherein lnt is selected from the group consisting of formula (II); and Ter is selected from the group consisting of formula (III). And wherein X represents either carbon or nitrogen atom within aromatic ring, Y represents either oxygen or sulphur atom and an additional group Q, group Qi or groups Qi (Qi indicates that the group or several groups may be bound to any unsaturated moiety of the ring) are selected from the group consisting of -OH, -COOH, -N(CH 3 ) 2 , -N(CH 2 -CH 3 ) 2 | -CO-CH 3 , -CO-O-CH 3 , -O-CH 3 , -S-CH 3 ,-SO 2 -CH 3 , -CN, -NO 2 or -Halogen elements, and wherein R5 may be formula (IV) and metal and ammonium salts thereof, wherein n is between O and 5, or oxygen or phosphorus is partially or completely replaced by nitrogen, sulphur, methyleno groups or their derivatives. The invention also concerns the uses of the above mentioned compounds in medical field and the process for their preparation.
摘要翻译：本发明涉及通式（I）的6-硫代鸟嘌呤三磷酸的类似化合物。通式（I）的化合物; 其中所述糖部分中的虚线键可以是单或双，并且其中R 1，R 2，R 3，R 4或R 5彼此相同或不同，具有通式 - （Int）

9. 发明申请

WO2007010514A2 COMPOUNDS AND THEIR SALTS SPECIFIC TO THE PPAR RECEPTORS AND THE EGF RECEPTORS AND THEIR USE IN THE MEDICAL FIELD 审中-公开
标题翻译： PPAR受体和EGF受体特异性化合物及其盐类及其在医疗领域的应用
公开(公告)号：WO2007010514A2
公开(公告)日：2007-01-25
申请号：PCT/IE2006/000076
申请日：2006-07-24
申请人： GIULIANI INTERNATIONAL LIMITED , NACCARI, Giancarlo , BARONI, Sergio
发明人： NACCARI, Giancarlo , BARONI, Sergio
CPC分类号： C07D307/79 , C07C229/64 , C07C233/54 , C07C259/10 , C07D319/08
摘要： Therefore the present invention relates specifically to the compounds of general formula (I), in which R 1 and R 2 , which may be identical or different, are selected from the group comprising H , -C n H 2n-1 , a linear or branched alkyl group having from 1 to 6 carbon atoms, or together form an aromatic or aliphatic ring with 5 or 6 atoms; R 3 is selected from -CO-CH 3 , -NHOH, -OH, -OR 6 in which R 6 is a linear or branched alkyl group having from 1 to 6 carbon atoms; R 4 is selected from H, a linear or branched alkyl group having from 1 to 6 carbon atoms, phenyl, benzyl, -CF 3 or -CF 2 CF 3 , vinyl or allyl; R 5 , R 7 , R 8 are hydrogen atoms; or R 3 and R 4 , R 4 and R 5 , or R 7 and R 8 together form a ring, fused to the benzene, aromatic or aliphatic ring with 5 or 6 atoms comprising from 1 to 2 heteroatoms selected independently from the group comprising N, O. and use thereof in the medical field.
摘要翻译：因此，本发明具体涉及通式（I）的化合物，其中R 1和R 2可以是相同的或不同的，选自包括H 1，-C≡N2n-1，直链或支链烷基的具有1至 6个碳原子，或一起形成具有5或6个原子的芳族或脂族环; R 3选自-CO-CH 3，-NHOH，-OH，-OR 6，其中R 6，是具有1至6个碳原子的直链或支链烷基; R 4选自H，具有1至6个碳原子的直链或支链烷基，苯基，苄基，-CF 3或-CF 2， CF 3，乙烯基或烯丙基; R 5，R 7，R 8是氢原子; 或者R 3和R 4，R 4和R 5或R 7 7 和R 8一起形成稠合至具有5或6个原子的苯，芳族或脂族环，所述环包含1至2个独立地选自N，O的杂原子及其在医疗领域。

10. 发明申请

WO2012140609A3 SYSTEM FOR PROLONGED RELEASE OF COSMETIC AGENTS 审中-公开
公开(公告)号：WO2012140609A3
公开(公告)日：2012-10-18
申请号：PCT/IB2012/051826
申请日：2012-04-13
申请人： GIULIANI S.P.A. , GIULIANI, Giammaria , BENEDUSI, Anna , BARONI, Sergio , MASCOLO, Antonio
发明人： GIULIANI, Giammaria , BENEDUSI, Anna , BARONI, Sergio , MASCOLO, Antonio
IPC分类号： A61K8/55 , A61K8/73 , A61K8/87 , A61Q7/00
摘要： The present invention relates to a system for the release of cosmetic agents comprising at least one phospholipid, hyaluronic acid or derivatives thereof and a cationic polyurethane derivative. The system of the invention may be used in the formulation of cosmetic preparations for obtaining the protracted release of cosmetic agents or active substances to the epidermis or the keratinic structures of the human body, with a simultaneous reduction in the frequency of application.

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