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1. 发明申请

WO2005019269A3 TECHNIQUES AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF CANCER (MUC1) 审中-公开
标题翻译：用于诊断和治疗癌症的技术和组合（MUC1）
公开(公告)号：WO2005019269A3
公开(公告)日：2005-05-12
申请号：PCT/US2004027954
申请日：2004-08-26
申请人： MINERVA BIOTECHNOLOGIES CORP , BAMDAD CYNTHIA C
发明人： BAMDAD CYNTHIA C
IPC分类号： A61P35/00 , C07K14/71 , C07K16/28 , C12N15/13 , G01N33/574 , C07K16/30 , A61K39/395 , C12N5/10 , C12N15/63 , G01N33/53
CPC分类号： C07K14/71 , A61K2039/505 , B82Y30/00 , C07K14/4727 , C07K16/2863 , C07K2319/21
摘要： The invention provides a series of compositions, methods, kits, articles and species associated primarily with the diagnosis and/or treatment of cell proliferation, specifically cancer. Cell proliferation associated with aberrant expression of MUC1 is particularly focused upon. Mechanisms associated with MUC1cell proliferation are discussed.
摘要翻译：本发明提供了主要与细胞增殖的诊断和/或治疗特别是癌症相关的一系列组合物，方法，试剂盒，制品和物种。与MUC1异常表达相关的细胞增殖特别关注于。讨论与MUC1细胞增殖相关的机制。

2. 发明申请

WO2005019269A2 TECHNIQUES AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF CANCER (MUC1) 审中-公开
标题翻译：用于诊断和治疗癌症的技术和组合物（MUC1）
公开(公告)号：WO2005019269A2
公开(公告)日：2005-03-03
申请号：PCT/US2004/027954
申请日：2004-08-26
申请人： MINERVA BIOTECHNOLOGIES CORPORATION , BAMDAD, Cynthia, C.
发明人： BAMDAD, Cynthia, C.
IPC分类号： C07K16/30
CPC分类号： C07K14/71 , A61K2039/505 , B82Y30/00 , C07K14/4727 , C07K16/2863 , C07K2319/21
摘要： The invention provides a series of compositions, methods, kits, articles and species associated primarily with the diagnosis and/or treatment of cell proliferation, specifically cancer. Cell proliferation associated with aberrant expression of MUC1 is particularly focused upon. Mechanisms associated with MUC1cell proliferation are discussed.
摘要翻译：本发明提供了主要与细胞增殖，特别是癌症的诊断和/或治疗相关的一系列组合物，方法，试剂盒，物品和物种。与MUC1异常表达相关的细胞增殖特别集中于。讨论了与MUC1细胞增殖有关的机制。

3. 发明申请

WO2004059347A2 OPTICAL DEVICES AND METHODS INVOLVING NANOPARTICLES 审中-公开
标题翻译：涉及纳米颗粒的光学器件和方法
公开(公告)号：WO2004059347A2
公开(公告)日：2004-07-15
申请号：PCT/US0341258
申请日：2003-12-22
申请人： MINERVA BIOTECHNOLOGIES CORP , BAMDAD CYNTHIA C
发明人： BAMDAD CYNTHIA C
IPC分类号： G02B1/10 , G02B5/20 , G02B
CPC分类号： B82Y30/00 , B82Y10/00 , B82Y20/00 , G02B1/10 , G02B1/11 , G02B5/20 , G02B5/206 , G02F1/17 , G02F2203/10 , G11B7/242
摘要： The present invention relates generally to optical materials and applications of optical materials and, more particularly, to optical materials incorporating particles such as nanoparticles, methods of forming such materials, and applications of such materials in various devices, for example, for filters, displays, coatings for glare reduction, and the like. The present invention can provide control over fabrication dimensions at very small scale, for example, at the molecular scale rather than at a macroscopic scale. The invention also involves, in some cases, controlling the interaction of many wavelengths of electromagnetic radiation with these materials. The optical materials and devices of the invention may be constructed and arranged for a response to, control of, and/or interaction with essentially any electromagnetic radiation, electric field, and/or magnetic field.
摘要翻译：本发明一般涉及光学材料的光学材料和应用，更具体地说，涉及纳入颗粒的光学材料，例如纳米颗粒，形成这种材料的方法，以及这些材料在各种装置中的应用，例如用于过滤器，显示器，用于减少眩光的涂层等。本发明可以以非常小的尺度提供对制造尺寸的控制，例如在分子尺度而不是宏观尺度。在一些情况下，本发明还涉及控制许多波长的电磁辐射与这些材料的相互作用。本发明的光学材料和器件可以构造和布置成对基本上任何电磁辐射，电场和/或磁场的响应，控制和/或相互作用。

4. 发明申请

WO2002076248A3 CUSTOMIZED THERAPEUTICS AND IN SITU DIAGNOSTICS 审中-公开
公开(公告)号：WO2002076248A3
公开(公告)日：2002-10-03
申请号：PCT/US2002/008809
申请日：2002-03-22
申请人： MINERVA BIOTECHNOLOGIES CORPORATION , BAMDAD, Cynthia, C. , BAMDAD, R., Shoshana
发明人： BAMDAD, Cynthia, C. , BAMDAD, R., Shoshana
IPC分类号： A61K49/04
摘要： Customized therapeutics and in situ diagnostics for patient therapy and diagnosis takes advantage of tools including techniques for derivatizing colloids with self-assembled monolayers. This provides the capability of a wide variety of assays including chemical or biochemical agent/agent interaction studies. Bio-derivatized colloids, with or without signaling entities, are used to probe interactions with species on non-colloidal structures. The invention provides techniques for immobilizing colloidal particles on a wide variety of non-colloidal structures. Included is the ability to decorate a variety of non-colloidal structures including beads, with colloids as a detectable assay. This allows, in many cases, assays detectable via the unaided human eye, as well as assays detectable via automated determination of a change of interaction of electromagnetic radiation with the colloids, e.g., absorption, light-scattering, and the like.

5. 发明申请

WO2002076248A2 CUSTOMIZED THERAPEUTICS AND IN SITU DIAGNOSTICS 审中-公开
标题翻译：定制的治疗方法和原位诊断
公开(公告)号：WO2002076248A2
公开(公告)日：2002-10-03
申请号：PCT/US2002/008809
申请日：2002-03-22
申请人： MINERVA BIOTECHNOLOGIES CORPORATION , BAMDAD, Cynthia, C. , BAMDAD, R., Shoshana
发明人： BAMDAD, Cynthia, C. , BAMDAD, R., Shoshana
IPC分类号： A41B
CPC分类号： G01N33/585 , A61K47/6923 , B82Y5/00 , B82Y15/00 , B82Y30/00 , G01N33/5438 , G01N2610/00
摘要： Customized therapeutics and in situ diagnostics for patient therapy and diagnosis takes advantage of tools including techniques for derivatizing colloids with self-assembled monolayers. This provides the capability of a wide variety of assays including chemical or biochemical agent/agent interaction studies. Bio-derivatized colloids, with or without signaling entities, are used to probe interactions with species on non-colloidal structures. The invention provides techniques for immobilizing colloidal particles on a wide variety of non-colloidal structures. Included is the ability to decorate a variety of non-colloidal structures including beads, with colloids as a detectable assay. This allows, in many cases, assays detectable via the unaided human eye, as well as assays detectable via automated determination of a change of interaction of electromagnetic radiation with the colloids, e.g., absorption, light-scattering, and the like.
摘要翻译：用于患者治疗和诊断的定制治疗和原位诊断利用工具，包括用自组装单层衍生胶体的技术。这提供了各种测定的能力，包括化学或生物化学试剂/药物相互作用研究。具有或不具有信号传导实体的生物衍生胶体用于探测与非胶体结构物质的相互作用。本发明提供了将胶体颗粒固定在各种非胶体结构上的技术。包括装饰各种非胶体结构（包括珠粒）的能力，胶体作为可检测的测定法。这在许多情况下允许通过无辅助人眼可检测的测定，以及通过自动测定电磁辐射与胶体的相互作用变化（例如吸收，光散射等）可检测的测定。

6. 发明申请

WO2006105448A3 PROLIFERATION OF MUC1 EXPRESSING CELLS 审中-公开
公开(公告)号：WO2006105448A3
公开(公告)日：2006-10-05
申请号：PCT/US2006/012092
申请日：2006-03-30
申请人： MINERVA BIOTECHNOLOGIES CORPORATION , BAMDAD, Cynthia, C.
发明人： BAMDAD, Cynthia, C.
IPC分类号： G01N33/567 , A01N37/18 , A61K38/00 , C07K1/00 , C07K4/00 , C07K17/00
摘要： The present application discloses a method for stimulating or enhancing proliferation of a population of cells by activating MUC1 receptor on the cells.

7. 发明申请

WO2006105448A2 PROLIFERATION OF MUC1 EXPRESSING CELLS 审中-公开
标题翻译： MUC1表达细胞的增殖
公开(公告)号：WO2006105448A2
公开(公告)日：2006-10-05
申请号：PCT/US2006012092
申请日：2006-03-30
申请人： MINERVA BIOTECHNOLOGIES CORP , BAMDAD CYNTHIA C
发明人： BAMDAD CYNTHIA C
IPC分类号： A61K38/48 , A61K31/711 , A61K38/22 , A61K38/54 , A61K45/00 , A61K48/00 , A61P35/00 , A61P35/02 , A61P43/00 , C07K14/705 , C12N5/07 , C12N5/074 , C12N15/09
CPC分类号： C07K16/3092 , A61K38/1709 , A61K38/193 , A61K38/45 , A61K38/488 , A61K38/4886 , A61K48/00 , C07K16/2863 , C07K16/468 , C07K2317/31 , C07K2317/35 , C07K2317/75 , A61K2300/00
摘要： The present application discloses a method for stimulating or enhancing proliferation of a population of cells by activating MUC1 receptor on the cells.
摘要翻译：本申请公开了通过激活细胞上的MUC1受体来刺激或增强细胞群体增殖的方法。

8. 发明申请

WO0201225A3 TANDEM SIGNALING ASSAY 审中-公开
标题翻译： TANDEM信号测定
公开(公告)号：WO0201225A3
公开(公告)日：2003-10-23
申请号：PCT/US0119968
申请日：2001-06-25
申请人： MINERVA BIOTECHNOLOGIES CORP , BAMDAD CYNTHIA C , BAMDAD R SHOSHANA
发明人： BAMDAD CYNTHIA C , BAMDAD R SHOSHANA
IPC分类号： G01N33/543 , G01N33/569 , G01N33/58 , G01N33/78 , G01N33/53
CPC分类号： B82Y30/00 , B82Y15/00 , G01N33/54326 , G01N33/5438 , G01N33/56966 , G01N33/585 , G01N33/78 , G01N2458/30 , G01N2500/00
摘要： Chemical, biological, and/or biochemical assays of the invention utilize intermediate binding entities for binding interactions. For example, a colloid particle carrying a species that could harm a component in the assay is allowed to binding interact in the assay only after other, more sensitive components have finished their binding interactions. In another example, multi-step binding interactions are used where single-step interactions could be used, so as to reduce false positives.
摘要翻译：本发明的化学，生物和/或生物化学测定利用中间结合实体来结合相互作用。例如，只有在其他更敏感的组分完成了其结合相互作用之后，才允许携带可能损害测定中组分的物质的胶体颗粒在测定中结合相互作用。在另一个实例中，使用多步结合相互作用，其中可以使用单步相互作用，以便减少误报。

9. 发明申请

WO0237109A3 DETECTION OF BINDING SPECIES WITH COLLOIDAL AND NON-COLLOIDAL STRUCTURES 审中-公开
标题翻译：用胶结和非胶结构检测结合物种
公开(公告)号：WO0237109A3
公开(公告)日：2003-04-17
申请号：PCT/US0144964
申请日：2001-11-01
申请人： MINERVA BIOTECHNOLOGIES CORP , BAMDAD CYNTHIA C , BAMDAD R SHOSHANA
发明人： BAMDAD CYNTHIA C , BAMDAD R SHOSHANA
IPC分类号： G01N33/53 , C12Q1/28 , G01N21/27 , G01N21/78 , G01N27/27 , G01N27/327 , G01N33/483 , G01N33/543 , G01N33/566 , G01N33/58 , C12Q1/68 , G01N30/02 , G01N33/68
CPC分类号： B82Y30/00 , G01N33/54313 , G01N33/585 , G01N33/586
摘要： The invention provides novel techniques for determining the interaction between binding partners. The first binding partner is immobilized to a surface or a colloid and a second binding partner immobilized to a surface or a colloid. Non-specific binding techniques, including a SAM, provide for the immobilization of a wide variety of species. A mixture may be separated into various componens and these components may then be fastened to either the colloids or the surfaces. Binding interaction between the binding partners may be determined through a variety of assays.
摘要翻译：本发明提供用于确定结合配偶体之间相互作用的新技术。第一结合配偶体固定在固定在表面或胶体上的表面或胶体和第二结合配偶体上。包括SAM在内的非特异性结合技术提供了多种物种的固定。混合物可以分成各种组分，然后这些组分可以被固定到胶体或表面。结合配偶体之间的结合相互作用可以通过多种测定来确定。

10. 发明申请

WO2007053135A1 METHODS FOR DIAGNOSIS AND TREATMENT OF CANCER 审中-公开
标题翻译：癌症诊断和治疗方法
公开(公告)号：WO2007053135A1
公开(公告)日：2007-05-10
申请号：PCT/US2005/032821
申请日：2005-09-14
申请人： MINERVA BIOTECHNOLOGIES CORPORATION , BAMDAD, Cynthia, C.
发明人： BAMDAD, Cynthia, C.
IPC分类号： A01N43/54 , A61K31/517 , C07D419/00 , C07D239/72 , A61K31/495 , C07D209/00 , C07D209/48
CPC分类号： A61K31/495 , A61K31/517 , B82Y30/00
摘要： The present application discloses methods of detecting and treating cancer which express MUC1 aberrantly.
摘要翻译：本申请公开了一种异常表达MUC1的癌症检测方法。

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