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1. 发明申请

WO2018102584A1 IMMUNOGENIC COMPOSITIONS TARGETING RECURRENT CANCER MUTATIONS AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2018102584A1
公开(公告)日：2018-06-07
申请号：PCT/US2017/064015
申请日：2017-11-30
申请人： ADVAXIS, INC. , PETIT, Robert , PRINCIOTTA, Michael F. , CODER, Brandon , BALLI, David
发明人： PETIT, Robert , PRINCIOTTA, Michael F. , CODER, Brandon , BALLI, David
IPC分类号： C12N15/74 , C07K14/47 , A61K35/74 , A61K39/00 , A61K48/00
摘要： Provided herein are recombinant fusion polypeptides comprising one or more antigenic peptides (e.g., fused to a PEST-containing peptide) from cancer-associated proteins. The antigenic peptides can comprise one or more or all of an antigenic peptide comprising a recurrent cancer mutation, an antigenic peptide comprising a heteroclitic mutation, or an antigenic peptide fused to a ubiquitin protein. For example, provided herein are recombinant fusion polypeptides comprising two or more antigenic peptides (e.g., fused to a PEST-containing peptide), wherein each antigenic peptide comprises a recurrent cancer mutation, and wherein at least two of the antigenic peptides are fragments of the same cancer-associated protein. Also provided are nucleic acids encoding such fusion polypeptides, recombinant bacteria or Listeria strains comprising such fusion polypeptides or such nucleic acids, and cell banks comprising such recombinant bacteria or Listeria strains. Also provided herein are methods of generating such fusion polypeptides, such nucleic acids, and such recombinant bacteria or Listeria strains. Also provided are immunogenic compositions, pharmaceutical compositions, and vaccines comprising such fusion polypeptides, such nucleic acids, or such recombinant bacteria or Listeria strains. Also provided are methods of inducing an anti-tumor-associated-antigen immune response in a subject, methods of inducing an anti-tumor or anti-cancer immune response in a subject, methods of treating a tumor or cancer in a subject, methods of preventing a tumor or cancer in a subject, and methods of protecting a subject against a tumor or cancer using such recombinant fusion polypeptides, nucleic acids, recombinant bacteria or Listeria strains, immunogenic compositions, pharmaceutical compositions, or vaccines.

2. 发明申请

WO2018102585A1 PERSONALIZED IMMUNOTHERAPY IN COMBINATION WITH IMMUNOTHERAPY TARGETING RECURRENT CANCER MUTATIONS 审中-公开
公开(公告)号：WO2018102585A1
公开(公告)日：2018-06-07
申请号：PCT/US2017/064016
申请日：2017-11-30
申请人： ADVAXIS, INC. , PETIT, Robert , PERRY, Kyle , PRINCIOTTA, Michael F. , O'CONNOR, Daniel J. , CODER, Brandon , BALLI, David
发明人： PETIT, Robert , PERRY, Kyle , PRINCIOTTA, Michael F. , O'CONNOR, Daniel J. , CODER, Brandon , BALLI, David
IPC分类号： A61K35/74 , A61K39/00 , A61K48/00 , C12N15/74 , C07K14/47
CPC分类号： A61K39/0011 , A61K35/74 , A61K2039/523 , A61K2039/545 , A61K2039/55544 , A61K2039/55594 , A61K2039/64 , A61K2039/645 , C07K14/47 , C07K14/4746 , C07K14/4748 , C07K14/71
摘要： Provided herein are systems comprising recurrent cancer mutation immunotherapy compositions and personalized neoepitope immunotherapy compositions. Also provided are recurrent cancer mutation immunotherapy compositions comprising a recombinant Listeria strain comprising a nucleic acid comprising a nucleic acid comprising an open reading frame encoding a recombinant fusion polypeptide comprising one or more antigenic peptides (e.g., fused to a PEST-containing peptide) from cancer-associated proteins. The antigenic peptides can comprise one or more or all of an antigenic peptide comprising a recurrent cancer mutation, an antigenic peptide comprising a heteroclitic mutation, or an antigenic peptide fused to a ubiquitin protein. Also provided are recurrent cancer mutation immunotherapy compositions comprising a recombinant Listeria strain comprising a nucleic acid comprising an open reading frame encoding a fusion polypeptide, wherein the fusion polypeptide comprises a PEST-containing peptide fused to two or more antigenic peptides, wherein each of the antigenic peptides comprises a recurrent cancer mutation, and wherein at least two of the antigenic peptides comprise different recurrent cancer mutations and are fragments of the same cancer-associated protein. Also provided are personalized immunotherapy compositions comprising a recombinant Listeria strain comprising a nucleic acid comprising an open reading frame encoding a fusion polypeptide, wherein the fusion polypeptide comprises a PEST-containing peptide fused to one or more antigenic peptides, wherein each of the antigenic peptides comprises a cancer-specific neoepitope comprising a cancer-specific mutation found in a cancer sample from a subject but not in a healthy biological sample from the subject. Also provided are recombinant fusion polypeptides, nucleic acids encoding fusion polypeptides, and methods of generating such compositions. Also provided are methods of inducing an anti-tumor-associated-antigen immune response in a subject, methods of inducing an anti-tumor or anti-cancer immune response in a subject, methods of treating a tumor or cancer in a subject, methods of preventing a tumor or cancer in a subject, and methods of protecting a subject against a tumor or cancer using such immunotherapy compositions, recombinant fusion polypeptides, nucleic acids, or recombinant bacteria or Listeria strains.

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