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1. 发明申请

WO2011059609A3 DENDRIMER COMPOSITIONS AND METHODS OF SYNTHESIS 审中-公开
标题翻译： DENDRIMER组合物和合成方法
公开(公告)号：WO2011059609A3
公开(公告)日：2011-05-19
申请号：PCT/US2010/051835
申请日：2010-10-07
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , BAKER JR., James, R. , HUANG, Baohua
发明人： BAKER JR., James, R. , HUANG, Baohua
IPC分类号： A61K31/16 , A61K31/195 , A61K31/185 , A61K31/13 , A61K49/10 , A61P29/00
摘要： The present invention relates to novel dendrimer compounds and methods of synthesizing the same. In particular, the present invention is directed to novel polyamidoamine (PAMAM) dendrimers, novel dendrimer branching units, methods for synthesizing such novel PAMAM dendrimers and functionalized dendrimers, as well as systems and methods utilizing the dendrimers (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease diagnosis and/or therapy, etc.))).
摘要翻译：本发明涉及新颖的树枝状大分子化合物及其合成方法。特别地，本发明涉及新型聚酰胺胺（PAMAM）树枝状聚合物，新型树枝状聚合物分支单元，合成这种新型PAMAM树枝状聚合物和官能化树枝状聚合物的方法，以及利用树状聚合物的系统和方法（例如诊断和/或治疗设置（例如，用于递送治疗剂，成像和/或靶向剂（例如在疾病诊断和/或治疗等中）））。

2. 发明申请

WO2011028334A3 SYNTHESIS AND ISOLATION OF DENDRIMER SYSTEMS 审中-公开
公开(公告)号：WO2011028334A3
公开(公告)日：2011-03-10
申请号：PCT/US2010/043109
申请日：2010-07-23
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , BAKER, JR., James R. , BANASZAK HOLL, Mark M. , MULLEN, Douglas Gurnett , ORR, Bradford G. , DESAI, Ankur , SANDER, Leonard M. , WADDELL, Jack Neel
发明人： BAKER, JR., James R. , BANASZAK HOLL, Mark M. , MULLEN, Douglas Gurnett , ORR, Bradford G. , DESAI, Ankur , SANDER, Leonard M. , WADDELL, Jack Neel
IPC分类号： A61K31/74 , A61K47/48 , A61K47/34 , A61K31/4985 , A61K9/20 , A61P35/00
摘要： The present invention relates to novel methods of synthesis and isolation of dendrimer systems. In particular, the present invention is directed to novel dendrimer conjugates with defined and limited numbers of ligand conjugates and high levels of structural uniformity, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)).

3. 发明申请

WO2009151687A3 DENDRIMER CONJUGATES 审中-公开
标题翻译： DENDRIMER共轭物
公开(公告)号：WO2009151687A3
公开(公告)日：2010-03-04
申请号：PCT/US2009036992
申请日：2009-03-12
申请人： UNIV MICHIGAN , CHENG XUE-MIN , BAKER JR JAMES R , THOMAS P THOMMEY , HUANG BAOHUA MARK
发明人： CHENG XUE-MIN , BAKER JR JAMES R , THOMAS P THOMMEY , HUANG BAOHUA MARK
IPC分类号： A61K47/48 , A61K49/00
CPC分类号： C07D305/08
摘要： The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.
摘要翻译：本发明涉及新的治疗和诊断树枝状大分子。具体而言，本发明涉及树枝状聚合物 - 接头偶联物，其合成方法，包含偶联物的组合物，以及利用偶联物的系统和方法（例如，在诊断和/或治疗设置中（例如用于递送（例如，在疾病（例如癌症）诊断和/或治疗，疼痛治疗等中）的治疗剂，成像和/或靶向剂的组合物）因此，本发明的树状聚合物 - 接头缀合物可以进一步包含一种或多种用于靶向，成像，感测和/或提供对治疗的治疗或诊断材料和/或监测响应的组件。

4. 发明申请

WO2009151687A2 DENDRIMER CONJUGATES 审中-公开
标题翻译： DENDRIMER联合
公开(公告)号：WO2009151687A2
公开(公告)日：2009-12-17
申请号：PCT/US2009/036992
申请日：2009-03-12
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , CHENG, Xue-min , BAKER, Jr., James R. , THOMAS, P., Thommey , HUANG, Baohua, Mark
发明人： CHENG, Xue-min , BAKER, Jr., James R. , THOMAS, P., Thommey , HUANG, Baohua, Mark
IPC分类号： A61K47/48 , A61K49/00
CPC分类号： C07D305/08
摘要： The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.
摘要翻译：本发明涉及新的治疗和诊断树枝状大分子。特别地，本发明涉及树枝状大分子 - 连接体缀合物，其合成方法，包含缀合物的组合物，以及利用缀合物的系统和方法（例如，在诊断和/或治疗设置（例如，用于递送治疗，成像和/或靶向剂（例如，在疾病（例如癌症）诊断和/或治疗，疼痛治疗等中））。因此，本发明的树枝状大分子 - 接头缀合物还可包含一种或多种用于靶向，成像，感测和/或提供治疗或诊断材料和/或监测对治疗的响应的组分。

5. 发明申请

WO2013115885A3 SYNTHESIZING FUNCTIONALIZED DENDRIMERS WITHIN BIOLOGICAL SETTINGS 审中-公开
标题翻译：在生物环境中合成功能化的DENDRIMERS
公开(公告)号：WO2013115885A3
公开(公告)日：2013-11-07
申请号：PCT/US2012065252
申请日：2012-11-15
申请人： UNIV MICHIGAN , BAKER JR JAMES R , GOONEWARDENA SASCHA NILU , ZONG HONG
发明人： BAKER JR JAMES R , GOONEWARDENA SASCHA NILU , ZONG HONG
IPC分类号： G01N33/53 , G01N33/48 , G01N33/543
CPC分类号： A61K31/655 , A61K47/595 , G01N33/502
摘要： The present invention relates to compositions (e.g., dendrimer scaffolds) capable of click chemistry for use in synthesis of functionalized dendrimers within biological settings, and methods of use of the same.
摘要翻译：本发明涉及能够用于在生物环境中合成官能化树枝状大分子的点击化学的组合物（例如树状聚合物支架），以及其使用方法。

6. 发明申请

WO2011059609A9 DENDRIMER COMPOSITIONS AND METHODS OF SYNTHESIS 审中-公开
标题翻译： DENDRIMER组合物和合成方法
公开(公告)号：WO2011059609A9
公开(公告)日：2011-10-13
申请号：PCT/US2010051835
申请日：2010-10-07
申请人： UNIV MICHIGAN , BAKER JR JAMES R , HUANG BAOHUA
发明人： BAKER JR JAMES R , HUANG BAOHUA
IPC分类号： A61K31/16 , A61K31/13 , A61K31/185 , A61K31/195 , A61K49/10 , A61P29/00
CPC分类号： A61K47/48207 , A61K47/595 , A61K49/0002 , A61K49/0043 , A61K49/0054 , A61K49/124 , A61K51/065 , C08G73/028
摘要： The present invention relates to novel dendrimer compounds and methods of synthesizing the same. In particular, the present invention is directed to novel polyamidoamine (PAMAM) dendrimers, novel dendrimer branching units, methods for synthesizing such novel PAMAM dendrimers and functionalized dendrimers, as well as systems and methods utilizing the dendrimers (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease diagnosis and/or therapy, etc.))).
摘要翻译：本发明涉及新颖的树枝状大分子化合物及其合成方法。特别地，本发明涉及新型聚酰胺胺（PAMAM）树枝状聚合物，新型树枝状聚合物分支单元，合成这种新型PAMAM树枝状聚合物和官能化树枝状聚合物的方法，以及利用树状聚合物的系统和方法（例如诊断和/或治疗设置（例如，用于递送治疗剂，成像和/或靶向剂（例如用于疾病诊断和/或治疗等）））。

7. 发明申请

WO2011011384A9 SYNTHESIS OF DENDRIMER CONJUGATES 审中-公开
标题翻译： DENDRIMER结合物的合成
公开(公告)号：WO2011011384A9
公开(公告)日：2011-07-21
申请号：PCT/US2010042556
申请日：2010-07-20
申请人： UNIV MICHIGAN , BAKER JR JAMES R , ZHANG YUEHUA , THOMAS THOMMEY P , DESAI ANKUR MAHESH
发明人： BAKER JR JAMES R , ZHANG YUEHUA , THOMAS THOMMEY P , DESAI ANKUR MAHESH
IPC分类号： A61K49/10 , A61K38/20 , A61K39/395 , A61K49/08 , A61P29/00 , A61P35/00
CPC分类号： A61K49/0054 , A61K47/551 , A61K47/595 , A61K49/0043
摘要： The present invention relates to novel methods of synthesis of therapeutic and diagnostic dendrimers. In particular, the present invention is directed to novel dendrimer conjugates, novel methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer, inflammatory disease) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer conjugates of the present invention may further comprise at least two different components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. Furthermore, the novel synthesis methods of certain embodiments of the present invention provide significant advantages with regard to total reaction time and simplicity.
摘要翻译：本发明涉及合成治疗和诊断树枝状大分子的新方法。特别地，本发明涉及新颖的树枝状大分子缀合物，其合成方法，包含缀合物的组合物，以及利用缀合物的系统和方法（例如，在诊断和/或治疗设置中（例如用于递送治疗，成像和/或靶向剂（例如，在疾病（例如癌症，炎性疾病）诊断和/或治疗，疼痛治疗等中））。因此，本发明的树枝状大分子缀合物可以进一步包含至少用于靶向，成像，感测和/或提供治疗或诊断材料和/或监测对治疗的响应的两种不同组分。此外，本发明某些实施方案的新型合成方法在总反应时间和简单。

8. 发明申请

WO2012003361A2 NANOEMULSION VACCINES 审中-公开
公开(公告)号：WO2012003361A2
公开(公告)日：2012-01-05
申请号：PCT/US2011/042658
申请日：2011-06-30
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , NANOBIO CORPORATION , BAKER, Jr., James R. , HAMOUDA, Tarek , CIOTTI, Susan M.
发明人： BAKER, Jr., James R. , HAMOUDA, Tarek , CIOTTI, Susan M.
IPC分类号： A61K39/145 , A61K47/48 , A61K9/10 , A61K9/107 , A61P31/00
CPC分类号： A61K9/1075 , A61K39/39 , A61K2039/55566 , C12N2760/16134 , Y02A50/394 , Y02A50/403 , Y02A50/469
摘要： The present invention provides methods and compositions for the stimulation of immune responses. Specifically, the present invention provides nanoemulsion compositions harboring one or more immunogens within the oil phase of the nanoemulsion and methods of using the same for the induction of immune responses (e.g., innate and/or adaptive immune responses (e.g., for generation of host immunity against an environmental pathogen)). Compositions and methods of the invention find use in, among other things, clinical (e.g., therapeutic and preventative medicine (e.g., vaccination)) and research applications.
摘要翻译：本发明提供了用于刺激免疫应答的方法和组合物。具体地说，本发明提供在纳米乳液的油相中含有一种或多种免疫原的纳米乳液组合物及其用于诱导免疫应答的方法（例如，天然和/或适应性免疫应答（例如用于产生宿主免疫）针对环境病原体））。本发明的组合物和方法尤其可用于临床（例如治疗和预防性药物（例如疫苗接种））和研究应用。

9. 发明申请

WO2011011384A3 SYNTHESIS OF DENDRIMER CONJUGATES 审中-公开
标题翻译： DENDRIMER共轭物的合成
公开(公告)号：WO2011011384A3
公开(公告)日：2011-06-03
申请号：PCT/US2010042556
申请日：2010-07-20
申请人： UNIV MICHIGAN , BAKER JR JAMES R , ZHANG YUEHUA , THOMAS THOMMEY P , DESAI ANKUR MAHESH
发明人： BAKER JR JAMES R , ZHANG YUEHUA , THOMAS THOMMEY P , DESAI ANKUR MAHESH
IPC分类号： A61K49/10 , A61K38/20 , A61K39/395 , A61K49/08 , A61P29/00 , A61P35/00
CPC分类号： A61K49/0054 , A61K47/551 , A61K47/595 , A61K49/0043
摘要： The present invention relates to novel methods of synthesis of therapeutic and diagnostic dendrimers. In particular, the present invention is directed to novel dendrimer conjugates, novel methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer, inflammatory disease) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer conjugates of the present invention may further comprise at least two different components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. Furthermore, the novel synthesis methods of certain embodiments of the present invention provide significant advantages with regard to total reaction time and simplicity.
摘要翻译：本发明涉及合成治疗和诊断树枝状大分子的新方法。特别地，本发明涉及新型树枝状聚合物缀合物，合成其的新方法，包含缀合物的组合物，以及利用缀合物的系统和方法（例如，在诊断和/或治疗设置中（例如，递送（例如，在疾病（例如癌症，炎症性疾病）诊断和/或治疗，疼痛治疗等）中的治疗剂，成像和/或靶向剂的组合物）因此，本发明的树状聚合物缀合物可以进一步包含用于靶向，成像，感测和/或提供对治疗的治疗或诊断材料和/或监测响应的两种不同组分。此外，本发明的某些实施方案的新合成方法在总反应时间方面提供显着优点，简单。

10. 发明申请

WO2011028334A2 SYNTHESIS AND ISOLATION OF DENDRIMER SYSTEMS 审中-公开
标题翻译： DENDRIMER系统的合成和分离
公开(公告)号：WO2011028334A2
公开(公告)日：2011-03-10
申请号：PCT/US2010043109
申请日：2010-07-23
申请人： UNIV MICHIGAN , BAKER JR JAMES R , BANASZAK HOLL MARK M , MULLEN DOUGLAS GURNETT , ORR BRADFORD G , DESAI ANKUR , SANDER LEONARD M , WADDELL JACK NEEL
发明人： BAKER JR JAMES R , BANASZAK HOLL MARK M , MULLEN DOUGLAS GURNETT , ORR BRADFORD G , DESAI ANKUR , SANDER LEONARD M , WADDELL JACK NEEL
IPC分类号： A61K31/74 , A61K9/20 , A61K31/4985 , A61K47/34 , A61K47/48 , A61P35/00
CPC分类号： C08G83/004
摘要： The present invention relates to novel methods of synthesis and isolation of dendrimer systems. In particular, the present invention is directed to novel dendrimer conjugates with defined and limited numbers of ligand conjugates and high levels of structural uniformity, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)).
摘要翻译：本发明涉及树枝状大分子体系的合成和分离的新方法。特别地，本发明涉及具有限定数量和限定数量的配体缀合物和高水平结构均匀性的新型树状聚合物缀合物，其合成方法，包含缀合物的组合物以及利用缀合物的系统和方法（例如，在诊断和/或治疗设置（例如，用于递送治疗剂，成像和/或靶向剂（例如，在疾病（例如，癌症）诊断和/或治疗，疼痛治疗等中））。

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