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1. 发明申请

WO2009112488A3 POLYETHER POLYOL DENDRON CONJUGATES WITH EFFECTOR MOLECULES FOR BIOLOGICAL TARGETING 审中-公开
标题翻译：聚醚多元醇与生物靶向分子共轭物的共轭物
公开(公告)号：WO2009112488A3
公开(公告)日：2009-12-10
申请号：PCT/EP2009052786
申请日：2009-03-10
申请人： MIVENION GMBH , LICHA KAI , SCHIRNER MICHAEL , BAHNER MALTE , HAAG RAINER , HEEK TIMM , WYSZOGRODZKA MONIKA
发明人： LICHA KAI , SCHIRNER MICHAEL , BAHNER MALTE , HAAG RAINER , HEEK TIMM , WYSZOGRODZKA MONIKA
IPC分类号： A61K49/00 , A61K51/00 , A61P29/00 , A61P35/00
CPC分类号： A61K49/0036 , A61K41/0057 , A61K41/0071 , A61K49/0021 , A61K49/0032 , A61K49/0054 , A61K49/0056 , C08G83/004
摘要： Subject of the present invention are polyether polyol dendron conjugates comprising a specific polyether polyol dendron moiety, at least one certain fluorescent effector molecule (E). Such polyether polyol dendron conjugates may be used for diagnostic and therapeutic purposes, whereby the optical properties of the at least one certain fluorescent effector molecule are enhanced due to the attachment to the polyether polyol dendron conjugate.
摘要翻译：本发明的主题是包含特定聚醚多元醇树枝状大分子部分的聚醚多元醇树枝状大分子结合物，至少一种特定的荧光效应分子（E）。此类聚醚多元醇树枝状分子偶联物可用于诊断和治疗目的，由此至少一种某些荧光效应分子的光学性质由于与聚醚多元醇树枝状分子偶联物的连接而增强。

2. 发明申请

WO2009034177A2 DIAGNOSTIC SUBSTANCES FOR OPTICAL IMAGING TESTING ON THE BASIS OF NANOPARTICULAR FORMULATIONS 审中-公开
标题翻译：用于基于纳米制剂的光学成像测试的诊断物质
公开(公告)号：WO2009034177A2
公开(公告)日：2009-03-19
申请号：PCT/EP2008062193
申请日：2008-09-12
申请人： MIVENION GMBH , BAHNER MALTE
发明人： BAHNER MALTE
IPC分类号： A61K49/00
CPC分类号： A61K49/0034 , A61K49/0032 , A61K49/0082
摘要： The present invention relates to the provision of nanoparticular formulations comprising a PEG-alkyl block copolymer and a near infrared fluorescent dye, the preparation of these nanoparticular formulations, pharmaceutical compositions comprising the nanoparticular formulations of the present invention, as well as their use as contrast medium.
摘要翻译：本发明涉及提供包含PEG-烷基嵌段共聚物和近红外荧光染料的纳米颗粒制剂，这些纳米颗粒制剂的制备，包含本发明的纳米颗粒制剂的药物组合物以及它们作为造影剂的用途。

3. 发明申请

WO2009112488A4 POLYETHER POLYOL DENDRON CONJUGATES WITH EFFECTOR MOLECULES FOR BIOLOGICAL TARGETING 审中-公开
标题翻译：聚醚多糖与生物指标效应分子结合
公开(公告)号：WO2009112488A4
公开(公告)日：2010-02-18
申请号：PCT/EP2009052786
申请日：2009-03-10
申请人： MIVENION GMBH , LICHA KAI , SCHIRNER MICHAEL , BAHNER MALTE , HAAG RAINER , HEEK TIMM , WYSZOGRODZKA MONIKA
发明人： LICHA KAI , SCHIRNER MICHAEL , BAHNER MALTE , HAAG RAINER , HEEK TIMM , WYSZOGRODZKA MONIKA
IPC分类号： A61K49/00 , A61K51/00 , A61P29/00 , A61P35/00
CPC分类号： A61K49/0036 , A61K41/0057 , A61K41/0071 , A61K49/0021 , A61K49/0032 , A61K49/0054 , A61K49/0056 , C08G83/004
摘要： Subject of the present invention are polyether polyol dendron conjugates comprising a specific polyether polyol dendron moiety, at least one certain fluorescent effector molecule (E). Such polyether polyol dendron conjugates may be used for diagnostic and therapeutic purposes, whereby the optical properties of the at least one certain fluorescent effector molecule are enhanced due to the attachment to the polyether polyol dendron conjugate.
摘要翻译：本发明的主题是包含特定聚醚多元醇树枝状部分，至少一种某种荧光效应分子（E）的聚醚多元醇树枝状缀合物。这种聚醚多元醇树突缀合物可用于诊断和治疗目的，由此由于与聚醚多元醇树枝状结合物的连接，至少一种某些荧光效应分子的光学性质得到增强。

4. 发明申请

WO2009034177A3 DIAGNOSTIC SUBSTANCES FOR OPTICAL IMAGING TESTING ON THE BASIS OF NANOPARTICULAR FORMULATIONS 审中-公开
公开(公告)号：WO2009034177A3
公开(公告)日：2009-03-19
申请号：PCT/EP2008/062193
申请日：2008-09-12
申请人： MIVENION GMBH , BAHNER, Malte
发明人： BAHNER, Malte
IPC分类号： A61K49/00
摘要： The present invention relates to the provision of nanoparticular formulations comprising a PEG-alkyl block copolymer and a near infrared fluorescent dye, the preparation of these nanoparticular formulations, pharmaceutical compositions comprising the nanoparticular formulations of the present invention, as well as their use as contrast medium.

5. 发明申请

WO2009022003A1 DEVICE AND PROCEDURE FOR THE DIAGNOSIS OR DIAGNOSTIC PREPARATION AND/OR THERAPY MONITORING OF INFLAMMATORY DISEASES SUCH AS RHEUMATOID ARTHRITIS 审中-公开
标题翻译：用于诊断或诊断和/或治疗如炎症性疾病的炎症性疾病的诊断和/或治疗方法的设备和程序
公开(公告)号：WO2009022003A1
公开(公告)日：2009-02-19
申请号：PCT/EP2008/060726
申请日：2008-08-14
申请人： MIVENION GMBH , BAHNER, Malte
发明人： BAHNER, Malte
IPC分类号： A61B5/00 , A61K49/00
CPC分类号： A61B5/0059 , A61B5/4528
摘要： A first aspect of the invention relates to a device for a diagnosis and/or therapy monitoring of inflammatory diseases, such as rheumatoid arthritis. It comprises at least a rest or support device (1) for holding at least one extremity (11) of a person. Thereby, the support device has the task of facilitating the at least one extremity, preferably two extremities, for instance the two hands to be comfortably and immovably placed as long as possible. This support device can be provided with a rest with several accessories, such as indentations, bowl-like recesses, ridges, elastic or non-elastic straps and/or loops, etc.. Furthermore, at least an excitation source (2) for at least partially illuminating one extremity at least with a radiation of defined excitation wavelength. Furthermore, at least an image sensor (3) is incorporated for capturing at least a reference signal from the extremity as well as several signals from the regions of medical interest (ROI) of the extremity (11). Moreover, a device according to the invention comprises a comparator for comparing the reference signal with the signals from the regions of medical interest (ROI).
摘要翻译：本发明的第一方面涉及用于诊断和/或治疗炎症性疾病如类风湿性关节炎的装置。它至少包括用于保持人的至少一个肢体（11）的休息或支撑装置（1）。因此，支撑装置具有促进至少一个肢体，优选两个末端的任务，例如两只手可以尽可能地舒适地和不可移动地放置。该支撑装置可以设置有诸如凹痕，碗状凹部，脊，弹性或非弹性带和/或环等的多个附件的休息。此外，至少一个用于在至少部分地用定义的激发波长的辐射照明一个末端。此外，还包括至少一个图像传感器（3），用于至少捕获来自末端的参考信号以及来自末端（11）的医疗感兴趣区域（ROI）的几个信号。此外，根据本发明的装置包括用于将参考信号与来自医疗感兴趣区域（ROI）的信号进行比较的比较器。

6. 发明申请

WO0041135A3 METHOD AND DEVICE FOR DETERMINING VOLUMINA IN THE HUMAN OR ANIMAL BODY 审中-公开
标题翻译：用于确定人体和动物体内VOLUMINA的方法和装置
公开(公告)号：WO0041135A3
公开(公告)日：2000-09-28
申请号：PCT/DE0000038
申请日：2000-01-05
申请人： DEUTSCHES KREBSFORSCH , MAHR ANDREAS , BAHNER MALTE , LEVEGRUEN SABINE
发明人： MAHR ANDREAS , BAHNER MALTE , LEVEGRUEN SABINE
IPC分类号： A61B5/107 , G06T7/60
CPC分类号： A61B5/107
摘要： According to known methods and devices, a suitable image-producing method detects the image data of a volume of interest, segments the detected image data manually, semi-automatically or fully automatically and automatically determines dimensional information about the volume of interest on the basis of the segmented image data. The aim of the invention is to improve the suitability of the automatically detected dimensional information, especially to improve their reliability. To this end, at least one characteristic value is allocated to the steps of detecting image data and segmenting image data. Said characteristic value represents a measure of error of said steps. An error value is determined on the basis of the allocated characteristic value for any error in determining the dimensional information. Said error can be displayed or output.
摘要翻译：已知的方法和感兴趣的体积的装置由一个适当的成像处理的图像数据的装置检测，半自动地或全自动地手动分割所获取的图像数据和从所述感兴趣体积的分割的图像数据尺寸的信息自动确定。为了提高自动确定的信息大小的可用性，特别是增加它们的意义，是所述方法包括：获取图像数据和分割与至少一个特征值，这是这些过程中的步骤的误差的测量相关联的图像数据。然后，根据相关的特征值，将误差值确定为在可以显示或输出的尺寸指示的确定中的误差的度量。

7. 发明申请

WO2009112488A2 POLYETHER POLYOL DENDRON CONJUGATES WITH EFFECTOR MOLECULES FOR BIOLOGICAL TARGETING 审中-公开
标题翻译：聚醚多糖与生物指标效应分子结合
公开(公告)号：WO2009112488A2
公开(公告)日：2009-09-17
申请号：PCT/EP2009/052786
申请日：2009-03-10
申请人： MIVENION GMBH , LICHA, Kai , SCHIRNER, Michael , BAHNER, Malte , HAAG, Rainer , HEEK, Timm , WYSZOGRODZKA, Monika
发明人： LICHA, Kai , SCHIRNER, Michael , BAHNER, Malte , HAAG, Rainer , HEEK, Timm , WYSZOGRODZKA, Monika
IPC分类号： A61K49/00 , A61K51/00
CPC分类号： A61K49/0036 , A61K41/0057 , A61K41/0071 , A61K49/0021 , A61K49/0032 , A61K49/0054 , A61K49/0056 , C08G83/004
摘要： Subject of the present invention are polyether polyol dendron conjugates comprising a specific polyether polyol dendron moiety, at least one certain fluorescent effector molecule (E). Such polyether polyol dendron conjugates may be used for diagnostic and therapeutic purposes, whereby the optical properties of the at least one certain fluorescent effector molecule are enhanced due to the attachment to the polyether polyol dendron conjugate.
摘要翻译：本发明的主题是包含特定的聚醚多元醇树枝状部分，至少一种特定的荧光效应分子（E）的聚醚多元醇树枝状缀合物。这种聚醚多元醇树突缀合物可以用于诊断和治疗目的，由此由于与聚醚多元醇树突缀合物的连接，至少一种某种荧光效应分子的光学性质得到增强。

8. 发明申请

WO2006072580A1 USE OF CYANINE DYES FOR THE DIAGNOSIS OF PROLIFERATIVE DISEASES 审中-公开
标题翻译：用于诊断增殖性疾病的氰基染料的使用
公开(公告)号：WO2006072580A1
公开(公告)日：2006-07-13
申请号：PCT/EP2006/000058
申请日：2006-01-05
申请人： SCHERING AG , LICHA, Kai , PESSEL, Martin , BAHNER, Malte
发明人： LICHA, Kai , PESSEL, Martin , BAHNER, Malte
IPC分类号： A61K49/00
CPC分类号： A61K49/0032 , A61K49/0034 , A61K49/0058
摘要： The present invention concerns the use of the cyanine dye SF64 for the diagnosis of proliferative diseases upon administration of less than 5 mg/kg body weight.
摘要翻译：本发明涉及花青染料SF64在施用小于5mg / kg体重时用于诊断增殖性疾病的用途。

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