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1. 发明申请

WO2021231237A2 ANTIBODIES FOR SARS-COV-2 AND USES THEREOF 审中-公开
公开(公告)号：WO2021231237A2
公开(公告)日：2021-11-18
申请号：PCT/US2021/031460
申请日：2021-05-09
申请人： AUGMENTA BIOWORKS, INC.
发明人： CHRISTOPHER, J., Emig , ROSANNA, Man, Wah Chau , PAYAM, Shahi , KIM-XUAN, Nguyen , YUSHUAN, Lai , ROBIN, Emig , JOHN, Beaber , STEVEN, Henry , MARCO, Antonio, Mena
IPC分类号： C07K16/10 , A61K39/12 , A61P31/14 , C07K2317/21 , C07K2317/34 , C07K2317/76 , C07K2317/92
摘要： The disclosure relates generally to the field of immune binding proteins and method for obtaining immune binding proteins from genomic or other sources. The disclosure also relates to anti-SARS-CoV-2 antibodies that have been obtained from subjects who became immune to this coronavirus, and to methods of using these anti-SARS-CoV-2 antibodies. Methods for neutralizing SARS-CoV-2 are disclosed, as well treatments for SARS-COV-2 using the anti-SARS-CoV-2 antibodies.

2. 发明申请

WO2020033332A1 METHODS FOR MAKING GEL BEADS AND CORE AND SHELL BEADS WITH A CELL 审中-公开
公开(公告)号：WO2020033332A1
公开(公告)日：2020-02-13
申请号：PCT/US2019/045163
申请日：2019-08-05
申请人： AUGMENTA BIOWORKS, INC.
发明人： MENA, Marco, Antonio , EMIG, Christopher, J. , HALIBURTON, John , SHAHI, Pyam
IPC分类号： C12Q1/68 , C12Q1/6804 , C12Q1/6806 , C12N5/02 , C12N5/04 , C12N5/07 , C12N15/05 , C12N15/06 , C12N15/07 , C12N15/09 , C12N15/10
摘要： The present invention relates generally to the field of immune binding proteins and method for obtaining immune binding proteins from genomic or other sources. The present invention also relates to nucleic acids encoding the immune binding proteins in which the natural multimeric association of chains is maintained in the nucleic acids and the immune binding proteins made therefrom. For example, nucleic acids encoding antibodies that are amplified from a B-cell using the methods of the invention maintain the natural pairing of heavy and light chains from the B-cell. This maintenance of pairing (or multimerization) produces libraries and/or repertoires of immune binding proteins that are enriched for useful binding molecules.

3. 发明申请

WO2023064717A2 ANTIBODIES FOR SARS-COV-2 AND USES THEREOF 审中-公开
公开(公告)号：WO2023064717A2
公开(公告)日：2023-04-20
申请号：PCT/US2022/077810
申请日：2022-10-07
申请人： AUGMENTA BIOWORKS, INC.
发明人： EMIG, Christopher, J. , CHAU, Rosanna , SHAHI, Payam , NGUYEN, Kim-Xuan , LAI, YuShuan , EMIG, Robin , BEABER, John , HENRY, Steven , MENA, Marco
摘要： The disclosure relates generally to the field of immune binding proteins and method for obtaining immune binding proteins from genomic or other sources. The disclosure also relates to anti-SARS-CoV-2 antibodies that have been obtained from subjects who became immune to this coronavirus, and to methods of using these anti-SARS-CoV-2 antibodies. Methods for neutralizing SARS-CoV-2 are disclosed, as well treatments for SARS-COV-2 using the anti-SARS-CoV-2 antibodies.

4. 发明申请

WO2020077017A2 METHODS FOR ISOLATING IMMUNE BINDING PROTEINS 审中-公开
公开(公告)号：WO2020077017A2
公开(公告)日：2020-04-16
申请号：PCT/US2019/055484
申请日：2019-10-09
申请人： AUGMENTA BIOWORKS, INC.
发明人： MENA, Marco , EMIG, Christopher , JOHN, Haliburton , SHAHI, Payam
IPC分类号： C12Q1/68
摘要： Described herein are immune binding proteins and method for obtaining immune binding proteins from genomic or other sources. Also described herein are nucleic acids encoding the immune binding proteins in which the natural multimeric association of chains is maintained in the nucleic acids and the immune binding proteins made therefrom. For example, nucleic acids encoding antibodies that are amplified from a B-cell using the methods described herein maintain the natural pairing of heavy and light chains from the B-cell. This maintenance of pairing (or multimerization) produces libraries and/or repertoires of immune binding proteins that are enriched for useful binding molecules.

5. 发明申请

WO2018053119A3 IMMUNE REPERTOIRE SEQUENCE AMPLIFICATION METHODS AND APPLICATIONS 审中-公开
公开(公告)号：WO2018053119A3
公开(公告)日：2018-03-22
申请号：PCT/US2017/051549
申请日：2017-09-14
申请人： AUGMENTA BIOWORKS, INC.
发明人： EMIG, Christopher J. , MENA, Marco
IPC分类号： C12Q1/68 , C07K16/00 , C12N15/10 , C40B50/06 , G01N33/52
摘要： The present invention relates generally to the field of immune binding proteins and method for obtaining immune binding proteins from genomic or other sources. The present invention also relates to nucleic acids encoding the immune binding proteins in which the natural multimeric association of chains is maintained in the nucleic acids and the immune binding proteins made therefrom. For example nucleic acids encoding antibodies that are amplified from a B-cell using the methods of the invention maintain the natural pairing of heavy and light chains from the B-cell. This maintenance of pairing (or multimerization) produces libraries and/or repertoires of immune binding proteins that are enriched for useful binding molecules.

6. 发明申请

WO2018053119A2 IMMUNE REPERTOIRE SEQUENCE AMPLIFICATION METHODS AND APPLICATIONS 审中-公开
标题翻译：免疫重复序列扩增方法和应用
公开(公告)号：WO2018053119A2
公开(公告)日：2018-03-22
申请号：PCT/US2017/051549
申请日：2017-09-14
申请人： AUGMENTA BIOWORKS, INC.
发明人： EMIG, Christopher J. , MENA, Marco
IPC分类号： C12N15/10 , C07K16/00
摘要： The present invention relates generally to the field of immune binding proteins and method for obtaining immune binding proteins from genomic or other sources. The present invention also relates to nucleic acids encoding the immune binding proteins in which the natural multimeric association of chains is maintained in the nucleic acids and the immune binding proteins made therefrom. For example nucleic acids encoding antibodies that are amplified from a B-cell using the methods of the invention maintain the natural pairing of heavy and light chains from the B-cell. This maintenance of pairing (or multimerization) produces libraries and/or repertoires of immune binding proteins that are enriched for useful binding molecules.
摘要翻译：本发明一般涉及免疫结合蛋白领域和从基因组或其他来源获得免疫结合蛋白的方法。本发明还涉及编码免疫结合蛋白的核酸，其中链中的天然多聚体结合维持在核酸中，并且免疫结合蛋白由其制成。例如，使用本发明的方法从B细胞扩增的编码抗体的核酸维持来自B细胞的重链和轻链的天然配对。配对（或多聚化）的这种维持产生富含有用结合分子的免疫结合蛋白的文库和/或库。

7. 发明申请

WO2023064770A1 DRY FORMULATIONS OF ANTI-SARS-COV-2 VIRUS ANTIBODIES AND COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2023064770A1
公开(公告)日：2023-04-20
申请号：PCT/US2022/077909
申请日：2022-10-11
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , AUGMENTA BIOWORKS, INC. , TFF PHARMACEUTICALS, INC.
发明人： EMIG, Christopher, J. , HENRY, Steven, J. , VITUG, Adela, Anne , CHRISTENSEN, Dale, J. , CUI, Zhengrong , XU, Haiyue , WILLIAMS, Robert, O., III
IPC分类号： C07K16/10 , A61K47/00 , A61P31/12
摘要： The invention generally encompasses a human-derived monoclonal antibody compositions and methods comprising a dry powder formulation for neutralizing SARS-CoV- 2 and known variants thereof in a patient, comprising administering to the patient a dry powder formulation comprising the human-derived monoclonal antibody. The invention further encompasses compositions and methods comprising a dry powder formulation for treating or preventing COVID-19 and/or at least one symptom associated with COVID-19 in a patient, comprising administering to the patient a dry powder formulation comprising the human- derived monoclonal antibody.

8. 发明申请

WO2020198080A1 ISOLATION OF SINGLE CELLS AND USES THEREOF 审中-公开
公开(公告)号：WO2020198080A1
公开(公告)日：2020-10-01
申请号：PCT/US2020/024074
申请日：2020-03-21
申请人： AUGMENTA BIOWORKS, INC.
发明人： MENA, Marco, Antonio , EMIG, Christopher, J. , NGUYEN, Kim-Xuan
IPC分类号： B01L3/00 , C07K16/00 , C12Q1/6869 , G01N33/50
摘要： The present invention relates generally to the field of immune binding proteins and method for obtaining immune binding proteins from genomic or other sources. The present invention also relates to methods and apparati for obtaining single cells that express immune binding proteins. The single cells expressing the immune binding proteins can be obtained from a patient that has had an effective immune response to a disease state (e.g., cancer or an infectious agent). The methods and apparati of the disclosure can be used to obtain immune cells that produce immune binding proteins responsible for the effective immune response. The methods and apparati of the disclosure can also be used to obtain cells that express a polypeptide (e.g., a receptor, a secreted protein, a cytokine, or a recombinant protein) or other factor of interest.

9. 发明申请

WO2020077017A3 METHODS FOR ISOLATING IMMUNE BINDING PROTEINS 审中-公开
公开(公告)号：WO2020077017A3
公开(公告)日：2020-04-16
申请号：PCT/US2019/055484
申请日：2019-10-09
申请人： AUGMENTA BIOWORKS, INC.
发明人： MENA, Marco , EMIG, Christopher , JOHN, Haliburton , SHAHI, Payam
IPC分类号： G01N33/53 , C12Q1/68 , C12Q1/60
摘要： Described herein are immune binding proteins and method for obtaining immune binding proteins from genomic or other sources. Also described herein are nucleic acids encoding the immune binding proteins in which the natural multimeric association of chains is maintained in the nucleic acids and the immune binding proteins made therefrom. For example, nucleic acids encoding antibodies that are amplified from a B-cell using the methods described herein maintain the natural pairing of heavy and light chains from the B-cell. This maintenance of pairing (or multimerization) produces libraries and/or repertoires of immune binding proteins that are enriched for useful binding molecules.

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