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1. 发明申请

WO2011067569A1 BIODEGRADABLE STENT COMPRISING AN ACID SCAVENGING AGENT 审中-公开
标题翻译：包含酸性助洗剂的生物可降解的固体
公开(公告)号：WO2011067569A1
公开(公告)日：2011-06-09
申请号：PCT/GB2010/002219
申请日：2010-12-02
申请人： ARTERIUS LIMITED , AL-LAMEE, Kadem, Gayad
发明人： AL-LAMEE, Kadem, Gayad
IPC分类号： A61L31/06 , A61L31/14 , A61L31/16
CPC分类号： A61L31/16 , A61L31/06 , A61L31/148 , A61L2300/216 , A61L2300/604 , C08L67/04
摘要： A biodegradable stent comprising a biodegradable material having dissolved therein an acid scavenging agent. The biodegradable material may be PLLA or PLGA. The acid scavenging agent may be also a pharmaceutical agent, for example an antiproliferative agent, coronary vasodilator agent and/or a bronchodilator. Preferably the acid scavenging agent is dipyridamole and/or mopidamol. The invention also provides a method of preparing a biodegradable material for use in the stent of the invention comprising: (i) preparing a formulation of the biodegradable material and the acid scavenging agent; (ii) heating the formulation to melt the biodegradable material and the acid scavenging agent so as to dissolve the agent in the material; and (iii) collecting and cooling the formulation of step (ii).
摘要翻译：一种可生物降解的支架，其包括其中溶解有酸清除剂的可生物降解的材料。可生物降解材料可以是PLLA或PLGA。酸清除剂也可以是药剂，例如抗增生剂，冠状血管舒张剂和/或支气管扩张剂。优选地，除酸剂是双嘧达莫和/或莫匹达莫泊。本发明还提供了一种制备用于本发明支架的可生物降解材料的方法，包括：（i）制备可生物降解材料和除酸剂的制剂; （ii）加热制剂以熔化可生物降解材料和除酸剂，以将试剂溶解在材料中; 和（iii）收集和冷却步骤（ii）的制剂。

2. 发明申请

WO2012143731A1 A STENT 审中-公开
标题翻译：一个STENT
公开(公告)号：WO2012143731A1
公开(公告)日：2012-10-26
申请号：PCT/GB2012/050882
申请日：2012-04-20
申请人： ARTERIUS LIMITED , BRESSLOFF, Neil W. , PANT, Sanjay , AL-LAMEE, Kadem Gayad
发明人： BRESSLOFF, Neil W. , PANT, Sanjay , AL-LAMEE, Kadem Gayad
IPC分类号： A61F2/90
CPC分类号： A61F2/86 , A61F2/915 , A61F2002/91508 , A61F2002/91525 , A61F2002/91541 , A61F2002/91558 , A61F2230/0054 , A61F2250/0067 , F04C2270/041
摘要： A tubular stent (1) has first and second ends (2,3) and a longitudinal axis (4) therebetween. The tubular stent (1) is formed from a network of struts which defines a cylindrical surface about the longitudinal axis (4), the struts delineating a plurality of cells {23, 30, 31, 32, 33) within the network, there being rows of cells parallel to the longitudinal axis (4). At least one cell in each row is a nodal cell (23). There is an increase in the maximum length parallel to the longitudinal axis (4) of cells from the at (east one nodal cell (23) to a first distal cell (30) in the row that is closer to the first or second end (2, 3) of the tubular stent (1). There is a second distal cell (31) in the row which has a different maximum length parallel to the longitudinal axis (4) from the nodal cell (23) and the first distal cell (30). The network of struts comprises a plurality of circumferential rings (6, 6', 9, 9', 13, 13', 16, 16', 17, 17'). Each ring (6, 6', 9, 9', 13, 13', 16, 16', 17, 17') extends perpendicularly to the longitudinal axis (4) and the rings are located adjacent to each other parallel to the longitudinal axis (4) to define the cylindrical surface. The circumferential rings (6, 6', 9, 9', 13, 13', 16, 16', 17, 17') are of a wave form. Each circumferential ring (6, 6', 9, 9', 13, 13', 16, 16', 17, 17') has an amplitude parallel to the longitudinal axis (4), such that each wave form comprises a plurality of peaks (7, 10, 14, 18, 20) which extend towards the axial centre (5) of the tubular stent (1) and a plurality of troughs (8, 12, 29, 21, 36) which extend away from the axial centre (5) of the tubular stent (1).
摘要翻译：管状支架（1）在其间具有第一和第二端（2,3）和纵向轴线（4）。管状支架（1）由支撑网构成，该网架限定围绕纵向轴线（4）的圆柱形表面，支柱描绘网络内的多个单元（23,30,31,32,33），其中行的细胞平行于纵向轴线（4）。每行中至少有一个单元格是节点单元（23）。平行于从（在一个一个节点（23））到靠近第一或第二末端的行中的第一远端细胞（30）的细胞的平行于细胞的纵向轴线（4）的最大长度增加管状支架（1）中的第二远端细胞（31）具有平行于来自节细胞（23）和第一远端细胞（4）的纵向轴线（4）的不同最大长度（30），支柱网包括多个周向环（6,6'，9,9'，13,13'，16,16'，17,17'），每个环（6,6'，9 ，9'，13,13'，16,16'，17,17'）垂直于纵向轴线（4）延伸，并且环彼此相邻地平行于纵向轴线（4）定位，以限定圆柱形表面周向环（6,6'，9,9'，13,13'，16,16'，17,17'）为波浪形状，每个周向环（6,6'，9'，9“ 13,13'，16,16'，17,17'）具有平行于纵轴（4）的振幅，使得每个波形上升多个向管状支架（1）的轴向中心（5）延伸的峰（7,10,14,18,20）和多个槽（8,12,29,21,36），其延伸远离管状支架（1）的轴向中心（5）。

3. 发明申请

WO2023079290A1 DRUG COATED BALLOON 审中-公开
公开(公告)号：WO2023079290A1
公开(公告)日：2023-05-11
申请号：PCT/GB2022/052777
申请日：2022-11-03
申请人： ARTERIUS LIMITED
发明人： AL-LAMEE, Kadem , BULLETT, Nial , SMITH, Lydia , AHMED, Naveed , GROVE, William
IPC分类号： A61L29/08 , A61L29/16
摘要： A coating composition for application to an expandable medical device comprising a polymeric compound comprising a central portion and two end portions wherein either the central portion is hydrophobic and the end portions are hydrophilic or the central portion is hydrophilic and the end portions are hydrophobic; at least one active agent wherein at least one active agent is hydrophobic when the central portion of the polymeric compound is hydrophobic and at least one active agent is hydrophilic when the central portion of the polymeric compound is hydrophilic; and a solvent; wherein, in use the at least one active agent is encapsulated by the polymeric compound; and wherein at least one active agent is a vasodilator and/or an anti-platelet agent. The invention extends to a coating composition system comprising the coating composition.

4. 发明申请

WO2021209747A1 A BONE CEMENT 审中-公开
公开(公告)号：WO2021209747A1
公开(公告)日：2021-10-21
申请号：PCT/GB2021/050891
申请日：2021-04-14
申请人： ARTERIUS LIMITED
发明人： AL-LAMEE, Kadem , BALMER, William , BULLETT, Nial
IPC分类号： A61L24/00
摘要： The invention relates to a two part hardenable composition comprising a solid first part and a storage stable liquid second part. The parts are operable to form a resorbable and injectable bone cement which hardens to a solid mass upon mixing of the parts together. The solid first part comprises a filler and/or polymer particles, wherein each of the filler and the polymer particles, when present, have an average particle size of up to 200 µm and wherein the polymer particles, when present, have a weight-average molecular weight (Mw) of at least 10,000 Da; and 0.01 to 15 wt% of an initiator based on the total weight of the solid first part. The storage stable liquid second part comprises a monomer component, wherein the monomer component is operable to undergo free radical polymerisation in the presence of the initiator to form a polymer upon mixing of the parts together; and 0.5 to 50 wt% of a crosslinker material based on the total weight of the storage stable liquid part. Each of the polymer particles, when present, and the polymer formed from the free radical polymerisation of the monomer component are resorbable. The invention extends to a two part hardenable composition for use in the treatment of human or animal bone and a kit of parts comprising the two part hardenable composition and a syringe or caulking gun.

5. 发明申请

WO2014045068A1 METHOD OF PRODUCING A TUBE FOR USE IN THE FORMATION OF A STENT, AND SUCH TUBE 审中-公开
标题翻译：制造用于形成支架的管的方法和这种管
公开(公告)号：WO2014045068A1
公开(公告)日：2014-03-27
申请号：PCT/GB2013/052499
申请日：2013-09-24
申请人： ARTERIUS LIMITED
发明人： AL-LAMEE, Kadem , KELLY, Adrian , COATES, Philip D , THOMPSON, Glen P , CATON-ROSE, Phil
IPC分类号： B29C55/26 , A61F2/82
CPC分类号： B29C55/26 , B29K2995/006
摘要： Bioresorbable polymeric tubes suitable for use in a stent have been produced by a using a die drawing technique, comprising: - deforming an orientable, thermoplastic polymer tubing (4) in the solid phase by drawing it over a mandrel (1) and/or through a die (3), where the mandrel (1) has a lead end and an exit end and the die (3) has an entry side and an exit side, wherein a drawing mechanism applies a drawing tension to the tubing (4) from the exit end of the mandrel (1) and/or the exit side of the die (3), said tension being insufficient to cause tensile failure of the tubing but sufficient to deform the tubing, thereby drawing the tubing over the mandrel (1) and/or through the die (3) in the solid phase to induce uniaxial or biaxial orientation of the polymer; and - collecting the deformed tubing from the exit end of the mandrel (1) and/or the exit side of the die (3).
摘要翻译：适用于支架的可生物再吸收的聚合物管已经通过使用模具拉拔技术生产，其包括： - 使可固化的热固性聚合物管（4）在固相中拉伸，使其穿过心轴（1）和/或通过模具（3），其中心轴（1）具有引线端和出口端，并且模具（3）具有入口侧和出口侧，其中拉伸机构将拉伸张力施加到管道（4）上，心轴（1）的出口端和/或模具（3）的出口侧，所述张力不足以引起管道的拉伸破坏，但足以使管道变形，从而将管道拉过心轴（1）和/或通过模具（3）在固相中引发聚合物的单轴或双轴取向; 以及 - 从所述心轴（1）的出口端和/或所述模具（3）的出口侧收集变形的管道。

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