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1. 发明申请

WO2011139478A2 HIGH SHEAR APPLICATION IN MEDICAL THERAPY 审中-公开
标题翻译：医疗治疗中的高剪切应用
公开(公告)号：WO2011139478A2
公开(公告)日：2011-11-10
申请号：PCT/US2011/031725
申请日：2011-04-08
申请人： H R D CORPORATION , HASSAN, Abbas , HASSAN, Aziz , ANTHONY, Rayford G.
发明人： HASSAN, Abbas , HASSAN, Aziz , ANTHONY, Rayford G.
IPC分类号： A61M5/14 , A61M5/142 , A61M5/168 , A61J3/00 , A61K9/10
CPC分类号： A61J3/00 , A61K9/0019 , A61M5/142 , B01F7/00766 , B01F7/008 , B01F13/1016
摘要： In this disclosure, a method is described wherein the method comprises mixing a therapeutic gas or a therapeutic liquid or a combination thereof and a liquid carrier in a high shear device to produce a dispersion; and administering the produced dispersion intravenously to a patient; wherein the produced dispersion contains nanobubbles of the therapeutic gas or droplets of the therapeutic liquid with a mean diameter of less than about 1.5 μm. In this disclosure, a system is also described wherein the system comprises a therapeutic gas source or a therapeutic liquid source or a combination thereof; a liquid carrier source; a high shear device (HSD) having an inlet, an outlet, at least one rotor, and at least one stator separated by a shear gap; and a pump configured to control the flow rate and residence time of a fluid passing through the high shear device.
摘要翻译：在本公开中，描述了一种方法，其中所述方法包括在高剪切装置中混合治疗气体或治疗液体或其组合和液体载体以产生分散体; 并将产生的分散体静脉内施用于患者; 其中所制备的分散体含有平均直径小于约1.5μm的治疗液体的治疗气体或液滴的纳米气泡。在本公开中，还描述了一种系统，其中系统包括治疗气体源或治疗液体源或其组合; 液体载体源; 具有入口，出口，至少一个转子和由剪切间隔分开的至少一个定子的高剪切装置（HSD）; 以及构造成控制通过高剪切装置的流体的流速和停留时间的泵。

2. 发明申请

WO2011062737A3 BITUMEN EXTRACTION AND ASPHALTENE REMOVAL FROM HEAVY CRUDE USING HIGH SHEAR 审中-公开
公开(公告)号：WO2011062737A3
公开(公告)日：2011-05-26
申请号：PCT/US2010/054496
申请日：2010-10-28
申请人： H R D CORPORATION , HASSAN, Abbas , HASSAN, Aziz , VISWANATHAN, Krishnan , BORSINGER, Gregory, G. , ANTHONY, Rayford, G.
发明人： HASSAN, Abbas , HASSAN, Aziz , VISWANATHAN, Krishnan , BORSINGER, Gregory, G. , ANTHONY, Rayford, G.
IPC分类号： C10G1/04 , C10G31/00 , C07C7/00 , C10C3/00
摘要： Herein disclosed is a method of removing at least one component from a feed by subjecting the feed to high shear in the presence of carbon dioxide to produce a high shear-treated product and separating the at least one component from the high shear-treated product to produce a component-reduced product. Also disclosed is a method of removing asphaltenes from asphaltenic oil by subjecting the asphaltenic oil to a shear rate of at least 10,000s -1 in the presence of carbon dioxide to produce a high shear-treated product and separating asphaltenes from the high shear-treated product to produce an asphaltene-reduced product oil. Systems are also provided for carrying out the methods.

3. 发明申请

WO2010096645A3 APPARATUS AND METHOD FOR GAS SEPARATION 审中-公开
标题翻译：气体分离装置和方法
公开(公告)号：WO2010096645A3
公开(公告)日：2010-12-16
申请号：PCT/US2010024721
申请日：2010-02-19
申请人： H R D CORP , HASSAN ABBAS , ANTHONY RAYFORD G , HASSAN AZIZ
发明人： HASSAN ABBAS , ANTHONY RAYFORD G , HASSAN AZIZ
IPC分类号： B01D45/14 , B01D53/24 , B04B5/08
CPC分类号： B01D53/24 , B01D45/14 , B01D53/22 , B01D59/20 , B01D63/06 , B01D2256/24 , B01D2257/102 , B01D2257/504 , B01D2313/18 , B04B5/08 , B04B7/08 , Y02C10/10
摘要： Herein disclosed is an apparatus comprising (1) a porous rotor symmetrically positioned about an axis of rotation and surrounding an interior space; (2) an outer casing, wherein the outer casing and the rotor are separated by an annular space; (3) a motor configured for rotating the rotor about the axis of rotation; (4) a feed inlet positioned along the axis of rotation and fluidly connected with the interior space; and (5) a first outlet, wherein the first outlet is fluidly connected with the interior space. Herein disclosed is a system, comprising at least one disclosed apparatus. Herein disclosed is also a method of separating a feed gas into a first fraction and a second fraction, wherein the first fraction has an average molecular weight lower than the average molecular weight of the second fraction.
摘要翻译：本文公开了一种装置，包括：（1）围绕旋转轴对称地定位并围绕内部空间的多孔转子; （2）外壳，其中所述外壳和所述转子由环形空间分开; （3）构造成使转子围绕旋转轴线旋转的马达; （4）沿着旋转轴定位并与内部空间流体连接的进料口; 和（5）第一出口，其中第一出口与内部空间流体连接。本文公开了一种包括至少一个公开的装置的系统。本文公开的是将进料气体分离成第一馏分和第二馏分的方法，其中第一馏分的平均分子量低于第二馏分的平均分子量。

4. 发明申请

WO2010096410A3 SYSTEM AND METHOD FOR GAS REACTION 审中-公开
标题翻译：用于气体反应的系统和方法
公开(公告)号：WO2010096410A3
公开(公告)日：2010-12-02
申请号：PCT/US2010024361
申请日：2010-02-17
申请人： H R D CORP , HASSAN ABBAS , ANTHONY RAYFORD G , HASSAN AZIZ
发明人： HASSAN ABBAS , ANTHONY RAYFORD G , HASSAN AZIZ
IPC分类号： B01J8/10 , B01J15/00 , B01J19/18 , B01J35/10
CPC分类号： B01J12/007 , B01J8/10 , B01J2208/028 , B01J2219/00189
摘要： Herein disclosed is an apparatus, which comprises (1) a first cylindrical, porous, catalytic rotor symmetrically positioned about an axis of rotation and surrounding a first interior space; wherein the first porous catalytic rotor comprises a first catalyst; (2) an outer casing, wherein the outer casing and the rotor are separated by an annular space; (3) a motor configured for rotating the rotor about the axis of rotation; (4) a feed inlet line; and (5) a first outlet line, wherein the first outlet line is fluidly connected with the annular space. Herein disclosed is also a method comprising: (1) passing a feed gas comprising at least one gaseous reactant through a porous, catalytic rotor, wherein the porous, catalytic rotor is permeable to the at least one gaseous reactant and is made from or contains a catalyst effective for catalyzing a first reaction; and (2) extracting a first desired product.
摘要翻译：本文公开了一种装置，其包括（1）围绕旋转轴线对称地定位并围绕第一内部空间的第一圆柱形多孔催化转子; 其中所述第一多孔催化转子包含第一催化剂; （2）外壳，其中外壳和转子由环形空间隔开; （3）构造成用于使转子绕旋转轴线旋转的电机; （4）进料入口管线; 和（5）第一出口管线，其中第一出口管线与环形空间流体连通。本文公开的方法还包括：（1）使包含至少一种气态反应物的进料气通过多孔催化转子，其中所述多孔催化转子对于所述至少一种气态反应物是可渗透的并且由或由有效催化第一反应的催化剂; 和（2）提取第一所需产品。

5. 发明申请

WO2010090811A1 PROCESS FOR HYDRODESULFURIZATION, HYDRODENITROGENATION, HYDROFINISHING, OR AMINE PRODUCTION 审中-公开
标题翻译：水解，氢化，氢化或胺生产工艺
公开(公告)号：WO2010090811A1
公开(公告)日：2010-08-12
申请号：PCT/US2010/021324
申请日：2010-01-18
申请人： H R D CORPORATION , HASSAN, Abbas , ANTHONY, Rayford, G. , BORSINGER, Gregory, G. , HASSAN, Aziz , BAGHERZADEH, Ebrahim
发明人： HASSAN, Abbas , ANTHONY, Rayford, G. , BORSINGER, Gregory, G. , HASSAN, Aziz , BAGHERZADEH, Ebrahim
IPC分类号： C10G47/00 , B01J23/40 , B01J23/74
CPC分类号： B01J23/85 , B01J23/24 , B01J23/28 , B01J23/30 , B01J23/40 , B01J23/70 , B01J23/72 , B01J23/74 , C10G49/002 , C10G49/04 , C10G49/06 , C10G49/12 , C10G2300/1025 , C10G2300/1033 , C10G2300/104 , C10G2300/1044 , C10G2300/1051 , C10G2300/1055 , C10G2300/202 , C10G2300/207 , C10G2300/40
摘要： Herein disclosed is a method for hydrodesulfurization, hydrodenitrogenation, hydrofinishing, amine production or a combination thereof. The method comprises forming a dispersion comprising hydrogen-containing gas bubbles dispersed in a liquid feedstock, wherein the bubbles have a mean diameter of less than about 5 μm and wherein the feedstock comprises a mixture of petroleum-derived hydrocarbons and a naturally derived renewable oil. The feedstock comprises hydrocarbons selected from the group consisting of liquid natural gas, crude oil, crude oil fractions, gasoline, diesel, naphtha, kerosene, jet fuel, fuel oils, and combinations thereof. The method further comprises contacting the dispersion with a catalyst that is active for hydrodesulfurization, hydrodenitrogenation, hydrofinishing, amine production, or a combination thereof. The catalyst comprises homogeneous catalysts and heterogeneous catalysts. The catalyst may be utilized in fixed-bed or slurry applications.
摘要翻译：本文公开了加氢脱硫，加氢脱氮，加氢精制，胺生产或其组合的方法。该方法包括形成包含分散在液体原料中的含氢气泡的分散体，其中气泡具有小于约5μm的平均直径，并且其中原料包含石油衍生烃和天然衍生的可再生油的混合物。原料包括选自液体天然气，原油，原油馏分，汽油，柴油，石脑油，煤油，喷气燃料，燃料油及其组合的烃。该方法还包括使分散体与催化剂接触，所述催化剂对于加氢脱硫，加氢脱氮，加氢精制，胺生产或其组合是有活性的。该催化剂包含均相催化剂和非均相催化剂。催化剂可用于固定床或浆料应用。

6. 发明申请

WO2010039970A2 APPLYING SHEAR STRESS FOR DISEASE TREATMENT 审中-公开
标题翻译：应用剪应力治疗疾病
公开(公告)号：WO2010039970A2
公开(公告)日：2010-04-08
申请号：PCT/US2009059247
申请日：2009-10-01
申请人： H R D CORP , HASSAN ABBAS , ANTHONY RAYFORD G , BORSINGER GREGORY G , HASSAN AZIZ
发明人： HASSAN ABBAS , ANTHONY RAYFORD G , BORSINGER GREGORY G , HASSAN AZIZ
IPC分类号： A61M5/14 , A61M37/00
CPC分类号： A61M5/142 , A61M1/36 , A61M2206/16
摘要： Herein disclosed is a system for applying shear stress ex-situ to a fluid. In some embodiments, the system comprises a shear device; and at least one device configured for intravenous administration of the fluid to a patient, the devices defining a fluid passage configured to be sterilized and maintained sterile during use, the fluid comprising at least one therapeutic fluid, blood, or a combination thereof. The shear device of the system is in fluid communication with the at least one device configured for intravenous administration of the fluid to a patient. Herein also disclosed is a method of preparing a fluid for intravenous administration to a patient.
摘要翻译：这里公开的是一种用于对流体非原位施加剪应力的系统。在一些实施例中，该系统包括剪切装置; 以及至少一个被配置用于向患者静脉内施用流体的装置，所述装置限定流体通道，所述流体通道被构造成在使用期间被灭菌并保持无菌，所述流体包括至少一种治疗流体，血液或其组合。系统的剪切装置与配置用于将流体静脉内施用于患者的至少一个装置流体连通。本文还公开了制备用于向患者静脉内施用的流体的方法。

7. 发明申请

WO2009002730A3 HIGH SHEAR PROCESS FOR THE PRODUCTION OF BUTADIENE SULFONE 审中-公开
标题翻译：用于生产丁二烯磺酸盐的高剪切工艺
公开(公告)号：WO2009002730A3
公开(公告)日：2009-09-11
申请号：PCT/US2008066884
申请日：2008-06-13
申请人： H R D CORP , HASSAN ABBAS , BAGHERZADEH EBRAHIM , ANTHONY RAYFORD G , BORSINGER GREGORY , HASSAN AZIZ
发明人： HASSAN ABBAS , BAGHERZADEH EBRAHIM , ANTHONY RAYFORD G , BORSINGER GREGORY , HASSAN AZIZ
IPC分类号： C07D333/48 , C08F34/04
CPC分类号： C07D333/48 , B01F7/00766 , B01F13/1013 , B01F13/1016 , B01J19/0066 , B01J19/1806 , B01J2219/00006 , B01J2219/00177 , B01J2219/00189
摘要： Use of a high shear mechanical device incorporated into a process for the production of sulfolene as a reactor device is capable of decreasing mass transfer limitations, thereby enhancing the sulfolene production process. A system for the production of sulfolene from butadiene and sulfur dioxide, the system comprising a reactor and an external high shear mixer the outlet of which is fluidly connected to the inlet of the reactor; the high shear mixer capable of providing a dispersion of sulfur dioxide gas bubbles within a liquid, the bubbles having an average bubble diameter of less than about 100µm.
摘要翻译：使用结合到生产环丁烯作为反应器装置的方法中的高剪切机械装置能够降低传质限制，从而增强了环丁烯的生产过程。用于从丁二烯和二氧化硫生产环丁烯砜的系统，该系统包括反应器和外部高剪切混合器，其出口流体连接到反应器的入口; 能够在液体内提供二氧化硫气泡分散的高剪切混合器，气泡的平均气泡直径小于约100μm。

8. 发明申请

WO2009003028A3 METHOD OF MAKING CHLOROHYDRINS 审中-公开
标题翻译：制备氯仿的方法
公开(公告)号：WO2009003028A3
公开(公告)日：2009-02-26
申请号：PCT/US2008068168
申请日：2008-06-25
申请人： H R D CORP , HASSAN ABBAS , BAGHERZADEH EBRAHIM , ANTHONY RAYFORD G , BORSINGER GREGORY , HASSAN AZIZ
发明人： HASSAN ABBAS , BAGHERZADEH EBRAHIM , ANTHONY RAYFORD G , BORSINGER GREGORY , HASSAN AZIZ
IPC分类号： C07C31/34 , B01F1/00 , B01F7/26 , C07C29/64
CPC分类号： C07C29/66 , B01F7/00766 , B01F13/1013 , B01F13/1016 , C07C31/42
摘要： Methods and systems for the preparation of chlorohydrins are described herein. The methods and systems incorporate the novel use of a high shear device to promote dispersion and solubility of olefins into the chlorinating phase. The high shear device may allow for lower reaction temperatures and pressures and may also reduce chlorination time.
摘要翻译：本文描述了用于制备氯代醇的方法和系统。该方法和系统结合了高剪切装置的新用途，以促进烯烃在氯化相中的分散和溶解。高剪切装置可以允许较低的反应温度和压力，并且还可以减少氯化时间。

9. 发明申请

WO2009002900A3 SYSTEM AND PROCESS FOR PRODUCTION OF TOLUENE DIISOCYANATE 审中-公开
标题翻译：二异氰酸二甲酯生产系统和方法
公开(公告)号：WO2009002900A3
公开(公告)日：2009-02-26
申请号：PCT/US2008067835
申请日：2008-06-23
申请人： H R D CORP , HASSAN ABBAS , BAGHERZADEH EBRAHIM , ANTHONY RAYFORD G , BORSINGER GREGORY , HASSAN AZIZ
发明人： HASSAN ABBAS , BAGHERZADEH EBRAHIM , ANTHONY RAYFORD G , BORSINGER GREGORY , HASSAN AZIZ
IPC分类号： C07C263/10 , B01F7/26
CPC分类号： C07C263/10 , B01F7/00766 , B01F13/1013 , B01F13/1016 , C07C265/14
摘要： A method for producing toluene diisocyanate is disclosed which comprises forming a dispersion comprising phosgene gas bubbles dispersed in toluene diamine liquid phase, wherein said gas bubbles have a mean diameter less than 1 micron; and subjecting the dispersion to phosgenation reaction conditions, whereby at least a portion of the toluene diamine is phosgenated to form toluene diisocyanate. A system for carrying out the phosgenation of toluene diamine is also disclosed.
摘要翻译：公开了一种生产甲苯二异氰酸酯的方法，包括形成分散在甲苯二胺液相中的光气气泡的分散体，其中所述气泡的平均直径小于1微米; 并使分散体进行光气化反应条件，由此将至少一部分甲苯二胺光气化以形成甲苯二异氰酸酯。还公开了一种用于进行甲苯二胺光气化的系统。

10. 发明申请

WO2009003024A3 HIGH SHEAR PROCESS FOR ASPIRIN PRODUCTION 审中-公开
标题翻译：用于ASPIRIN生产的高剪切过程
公开(公告)号：WO2009003024A3
公开(公告)日：2009-02-19
申请号：PCT/US2008068164
申请日：2008-06-25
申请人： H R D CORP , HASSAN ABBAS , BAGHERZADEH EBRAHIM , ANTHONY RAYFORD G , BORSINGER GREGORY , HASSAN AZIZ
发明人： HASSAN ABBAS , BAGHERZADEH EBRAHIM , ANTHONY RAYFORD G , BORSINGER GREGORY , HASSAN AZIZ
IPC分类号： B01D3/40 , A61K31/616 , B01F7/26 , C07C53/02
CPC分类号： B01J19/1806 , B01F7/00766 , B01F13/1013 , B01F13/1016 , B01J8/025 , B01J8/20 , B01J19/0066 , B01J2219/00006 , B01J2219/00779 , C07C67/08 , Y02P20/582 , C07C69/157
摘要： Use of a high shear mechanical device in a process for production of acetyl salicylic acid, by contacting acetic anhydride with salicylic acid in a high shear device. The disclosed process makes possible a decrease in mass transfer limitations, thereby enhancing production of acetyl salicylic acid. A system for production of acetyl salicylic acid is also provided in which a reactor is configured to receive the output from a high shear device, which is configured to receive, via one or more inlets, acetic anhydride, and salicylic acid and generate a fine dispersion or emulsion of reactants.
摘要翻译：通过在高剪切装置中使乙酸酐与水杨酸接触，在生产乙酰水杨酸的方法中使用高剪切机械装置。所公开的方法可以减少传质限制，从而增加乙酰水杨酸的产生。还提供了一种用于生产乙酰基水杨酸的体系，其中反应器构造成从高剪切装置接收输出，该高剪切装置构造成经由一个或多个入口接收乙酸酐和水杨酸，并产生细分散体或反应物的乳液。

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