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1. 发明申请

WO2022212914A1 METHODS OF TREATING VIRAL DISEASES 审中-公开
公开(公告)号：WO2022212914A1
公开(公告)日：2022-10-06
申请号：PCT/US2022/023162
申请日：2022-04-01
申请人： AMPIO PHARMACEUTICALS, INC.
发明人： BAR-OR, David , THOMAS, Gregory
IPC分类号： A61K38/12 , C07D403/06 , C07D409/14 , A61P31/14 , A61P31/12
摘要： The present disclosure provides methods of treating a TLR7- and/or TLR-mediated disease and also methods of treating disease in a multi-modal treatment regimen. The methods comprise administering an effective amount of a pharmaceutical composition prepared by removing albumin from a solution of a human serum albumin composition and/or comprising a diketopiperazine with amino acid side chains of aspartic acid and alanine (DA-DKP), such as a low molecular weight fraction of human serum albumin.

2. 发明申请

WO2013055749A1 IMPLANTABLE MEDICAL DEVICES WITH INCREASED IMMUNE TOLERANCE, AND METHODS FOR MAKING AND IMPLANTING 审中-公开
标题翻译：具有增加的免疫耐受性的可植入医疗装置，以及制造和植入方法
公开(公告)号：WO2013055749A1
公开(公告)日：2013-04-18
申请号：PCT/US2012/059483
申请日：2012-10-10
申请人： AMPIO PHARMACEUTICALS, INC.
发明人： BAR-OR, David
IPC分类号： A61F13/00
CPC分类号： A61L27/28 , A61K31/495 , A61K31/496 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/204 , A61L2300/41 , A61L2300/606 , F04C2270/0421
摘要： The present invention relates to the contacting of one or more surfaces of an implantable medical device with one or more diketopiperazines (DKPs).
摘要翻译：本发明涉及可植入医疗装置的一个或多个表面与一种或多种二酮哌嗪（DKP）的接触。

3. 发明申请

WO2021195265A1 METHODS FOR TREATING DISEASES ASSOCIATED WITH RESPIRATORY VIRUSES 审中-公开
公开(公告)号：WO2021195265A1
公开(公告)日：2021-09-30
申请号：PCT/US2021/023960
申请日：2021-03-24
申请人： AMPIO PHARMACEUTICALS, INC.
发明人： BAR-OR, David , CHEREVKA, Holli
IPC分类号： A61K39/12 , A61K39/155 , C07K14/005 , A61K31/20 , A61K31/405 , A61K31/495 , A61K38/385 , A61K9/0078 , A61P11/00 , A61P31/14
摘要： The present disclosure provides a method of treating a disease associated with a respiratory virus. The method comprises administering an effective amount of a pharmaceutical composition prepared by removing albumin from a solution of a human serum albumin composition and/or comprising a diketopiperazine with amino acid side chains of aspartic acid and alanine (DA-DKP), such as a low molecular weight fraction of human serum albumin. The present disclosure also provides a pharmaceutical product as well as a kit comprising DA-DKP.

4. 发明申请

WO2014145729A3 COMPOSITIONS FOR THE MOBILIZATION, HOMING, EXPANSION AND DIFFERENTIATION OF STEM CELLS AND METHODS OF USING THE SAME 审中-公开
标题翻译：干细胞的移动，诱导，扩增和分化的组合物及其使用方法
公开(公告)号：WO2014145729A3
公开(公告)日：2014-12-24
申请号：PCT/US2014030538
申请日：2014-03-17
申请人： AMPIO PHARMACEUTICALS INC
发明人： BAR-OR DAVID , THOMAS GREG
IPC分类号： A61K31/496 , A01N25/00 , A61K38/12
CPC分类号： A61K31/495 , A61K31/20 , A61K31/405 , A61K35/28 , A61K35/32 , C12N5/0663 , C12N2501/999 , A61K2300/00
摘要： The invention provides compositions that increase the mobilization, homing, expansion, and/or differentiation of stem cells and methods of using the same for the treatment of mammals.
摘要翻译：本发明提供增加干细胞的动员，归巢，扩增和/或分化的组合物及其用于治疗哺乳动物的方法。

5. 发明申请

WO2014145729A2 COMPOSITIONS FOR THE MOBILIZATION, HOMING, EXPANSION AND DIFFERENTIATION OF STEM CELLS AND METHODS OF USING THE SAME 审中-公开
标题翻译：用于移植，归巢，扩增和分化干细胞的组合物及使用该组合物的方法
公开(公告)号：WO2014145729A2
公开(公告)日：2014-09-18
申请号：PCT/US2014/030538
申请日：2014-03-17
申请人： AMPIO PHARMACEUTICALS, INC.
发明人： BAR-OR, David , THOMAS, Greg
IPC分类号： B32B15/01
CPC分类号： A61K31/495 , A61K31/20 , A61K31/405 , A61K35/28 , A61K35/32 , C12N5/0663 , C12N2501/999 , A61K2300/00
摘要： The invention provides compositions that increase the mobilization, homing, expansion, and/or differentiation of stem cells and methods of using the same for the treatment of mammals.
摘要翻译：本发明提供了增加干细胞的动员，归巢，扩增和/或分化的组合物和使用该组合物治疗哺乳动物的方法。

6. 发明申请

WO2013055734A1 TREATMENT OF DEGENERATIVE JOINT DISEASE 审中-公开
标题翻译：治疗联合疾病
公开(公告)号：WO2013055734A1
公开(公告)日：2013-04-18
申请号：PCT/US2012/059455
申请日：2012-10-10
申请人： AMPIO PHARMACEUTICALS, INC.
发明人： BAR-OR, David , WINKLER, James, V.
IPC分类号： A61K38/00 , A61P19/02 , A61K31/4965
CPC分类号： A61K38/12 , A61K9/0019 , A61K31/167 , A61K31/405 , A61K31/495 , A61K31/573 , A61K45/06
摘要： The invention provides a method of treating a degenerative joint disease. The method comprises administering an effective amount of a pharmaceutical composition comprising a diketopiperazine with amino acid side chains of aspartic acid and alanine (DA-DKP). The invention also provides a pharmaceutical product as well as a kit comprising DA-DKP.
摘要翻译：本发明提供一种治疗退行性关节疾病的方法。该方法包括施用有效量的包含二酮哌嗪与天冬氨酸和丙氨酸（DA-DKP）的氨基酸侧链的药物组合物。本发明还提供药物产品以及包含DA-DKP的试剂盒。

7. 发明申请

WO2018022695A1 TREATMENT OF DISEASES MEDIATED BY VASCULAR HYPERPERMEABILITY 审中-公开
标题翻译：血管超敏性介导的疾病治疗
公开(公告)号：WO2018022695A1
公开(公告)日：2018-02-01
申请号：PCT/US2017/043856
申请日：2017-07-26
申请人： AMPIO PHARMACEUTICALS, INC.
发明人： BAR-OR, David , THOMAS, Gregory
IPC分类号： C07K14/76 , C07K14/765 , A61K38/38
CPC分类号： A61K38/385 , A61K31/4439 , A61K35/16 , A61K45/06 , A61K2236/30 , A61P27/02 , C07K14/76 , C07K14/765 , A61K2300/00
摘要： The invention provides a method of inhibiting vascular hyperpermeability in an animal in need thereof. The method comprises administering an effective amount of a pharmaceutical composition prepared by removing albumin from a human serum albumin composition and one or more p38 MAPK inhibitors to the animal.
摘要翻译：本发明提供了抑制有需要的动物血管渗透性过高的方法。该方法包括给予动物有效量的通过从人血清白蛋白组合物和一种或多种p38MAPK抑制剂中除去白蛋白而制备的药物组合物。

8. 发明申请

WO2016209969A1 USE OF LOW MOLECULAR WEIGHT FRACTIONS OF HUMAN SERUM ALBUMIN IN TREATING DISEASES 审中-公开
标题翻译：人血清白蛋白低分子量分子在治疗疾病中的应用
公开(公告)号：WO2016209969A1
公开(公告)日：2016-12-29
申请号：PCT/US2016/038774
申请日：2016-06-22
申请人： AMPIO PHARMACEUTICALS, INC.
发明人： BAR-OR, David , FREDERICK, Elizabeth , HAUSBURG, Melissa
IPC分类号： A61K38/12
CPC分类号： A61K38/385
摘要： The present invention provides a method of modulating various aspects of the immune system. In particular, the present invention teaches the use of diketopiperazines (DKPs) to modulate various aspects of the immune system such as, for example, inflammation, T-cells and various cytokines.
摘要翻译：本发明提供一种调节免疫系统的各个方面的方法。特别地，本发明教导了使用二酮哌嗪（DKP）来调节免疫系统的各个方面，例如炎症，T细胞和各种细胞因子。

9. 发明申请

WO2014121210A1 METHODS FOR PRODUCING DIKETOPIPERAZINES AND COMPOSITIONS CONTAINING DIKETOPIPERAZINES 审中-公开
标题翻译：生产二酮类药物的方法和含有二酮类药物的组合物
公开(公告)号：WO2014121210A1
公开(公告)日：2014-08-07
申请号：PCT/US2014/014478
申请日：2014-02-03
申请人： AMPIO PHARMACEUTICALS, INC.
发明人： BAR-OR, David
IPC分类号： A61K38/38 , C07D241/52 , C07K14/76
CPC分类号： A61K38/05 , A61K38/385 , C07K14/76 , C12P21/06
摘要： Methods of making increased amounts of diketopiperazines (DKP) such as DA- DKP in pharmaceutical compositions of proteins and peptides are disclosed. The disclosure further provides methods of making a DKP, including (1) contacting albumin with an enzyme (such as a dipeptidyl peptidase IV (DPP-IV)) that cleaves a pair of N- terminal amino acids from the albumin, and (2 heating the albumin under conditions effective to cause the formation of the DKP. Further, treatment of DKP- and albumin- containing streams to produce improved, higher value, DKP compositions and purified albumin compositions for therapeutic uses is also disclosed. In addition to a first therapeutic DKP composition comprising a low albumin content, a second valuable therapeutic composition is also produced characterized by a high albumin concentration.
摘要翻译：公开了在蛋白质和肽的药物组合物中增加量的二酮哌嗪（DKP）如DA-DKP的方法。本公开进一步提供制备DKP的方法，其包括（1）使白蛋白与从白蛋白切割一对N-末端氨基酸的酶（例如二肽基肽酶IV（DPP-IV））接触，和（2加热此外，还公开了有效引起DKP形成的白蛋白，此外，还公开了治疗DKP和含有白蛋白的流以产生改善的，更高价值的DKP组合物和用于治疗用途的纯化白蛋白组合物，除了第一种治疗还含有白蛋白含量低的DKP组合物，第二有价值的治疗组合物的特征在于白蛋白浓度高。

10. 发明申请

WO2014100352A1 METHOD FOR TREATMENT OF DISEASES 审中-公开
标题翻译：治疗疾病的方法
公开(公告)号：WO2014100352A1
公开(公告)日：2014-06-26
申请号：PCT/US2013/076421
申请日：2013-12-19
申请人： AMPIO PHARMACEUTICALS, INC.
发明人： BAR-OR, David
IPC分类号： A61K31/58
CPC分类号： A61K31/58 , A61B5/4839 , A61B5/4872 , A61K9/0053
摘要： The invention provides a method of inhibiting vascular hyperpermeability in an animal in need thereof. The method comprises administering a vascular- hyperpermeability-inhibiting amount of a danazol compound to the animal. The method comprises administering an effective amount of a danazol compound to the animal accounting for the body fat content of the animal. The invention also provides a method of modulating the cytoskeleton of an endothelial cell in an animal.
摘要翻译：本发明提供了抑制有需要的动物血管高渗透性的方法。该方法包括向动物施用抑制血管渗透压的量的达那唑化合物。该方法包括向动物施用有效量的达那唑化合物，其占动物体内脂肪含量。本发明还提供调节动物内皮细胞的细胞骨架的方法。

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