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1. 发明申请

WO2006039079A2 TOPICAL ENDOPARASITICIDE AND ECTOPARASITICIDE FORMULATIONS 审中-公开
标题翻译：局部内皮抑素和ECTOPARASITICIDE配方
公开(公告)号：WO2006039079A2
公开(公告)日：2006-04-13
申请号：PCT/US2005/031983
申请日：2005-09-07
申请人： THE HARTZ MOUNTAIN CORPORATION , COTTRELL, Ian, William , AHN, Albert , FISHER, Richard
发明人： COTTRELL, Ian, William , AHN, Albert , FISHER, Richard
IPC分类号： A01N43/40 , A01N43/08 , A01N37/34
CPC分类号： A01N43/90 , A01N51/00 , A01N47/40 , A01N43/40 , A01N55/00 , A01N53/00 , A01N2300/00
摘要： A topical formulation having significant parasiticidal activity effective against endoparasites and/or ectoparasites such as heartworms, mites, fleas, ticks, flies is provided, which can be safe to use and avoids the many common deleterious side effects of conventional topical formulations. The topical formulations comprise a combination of a macrocyclic lactone, a neo-nicotinoid and optionally, an insect growth regulator. The topical formulation can be packaged together or packaged so that the macrocyclic lactone and the neo-nicotinoid are stored separately prior to administering the topical insecticide formulation to the animal.
摘要翻译：提供了具有有效抵抗内寄生虫和/或外寄生虫如心丝虫，螨虫，跳蚤，蜱，蝇的杀寄生虫活性的局部制剂，其可以安全使用并避免常规局部制剂的许多常见的有害副作用。局部制剂包含大环内酯，新烟碱类和任选的昆虫生长调节剂的组合。局部制剂可以包装在一起或包装，以便在向动物施用局部杀虫剂制剂之前分开储存大环内酯和新烟碱类。

2. 发明申请

WO2007143298A3 HIGH CONCENTRATION TOPICAL INSECTICIDES CONTAINING PYRETHROIDS 审中-公开
标题翻译：高浓度含有杀虫剂的局部杀虫剂
公开(公告)号：WO2007143298A3
公开(公告)日：2009-04-30
申请号：PCT/US2007067699
申请日：2007-04-27
申请人： SUMMIT VETPHARM LLC , COTTRELL IAN W , AHN ALBERT , DORNEVAL LINDA
发明人： COTTRELL IAN W , AHN ALBERT , DORNEVAL LINDA
IPC分类号： A01N25/22 , A01N43/08 , A01N43/40 , A01N53/08
CPC分类号： A01N53/00 , A01N51/00 , A01N43/40 , A01N2300/00
摘要： A topical insecticide preparation is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. The topical insecticide contains a combination of a first pyrethroid insecticide effective for killing fleas, a second pyrethroid insecticide effective for killing ticks, and an insect growth regulator (IGR). The topical insecticide preparation can be packaged together or packaged so that the first and second pyrethroid insecticides are stored separately prior to administration of the insecticide preparation to the animal. The combination of the first and second pyrethroid insecticides with an insect growth regulator results in an insecticide preparation formulated to have enhanced insecticidal activity against fleas and ticks compared to the effectiveness of the first and second insecticides used alone. Further, the combination of the first and second pyrethroid insecticides with an insect growth regulator produces an insecticide preparation having enhanced insecticidal activity against fleas and ticks while advantageously minimizing the total amount of insecticide needed for its effectiveness.
摘要翻译：提供可安全使用并避免常规局部用杀虫剂的许多常见有害副作用的局部用杀虫剂制剂。局部杀虫剂含有杀死跳蚤有效的第一种拟除虫菊酯杀虫剂，杀死蜱有效的第二种拟除虫菊酯杀虫剂和昆虫生长调节剂（IGR）。局部用杀虫剂制剂可以包装在一起或包装，使得在将杀虫剂制剂给予动物之前将第一和第二拟除虫菊酯杀虫剂分开储存。第一和第二种拟除虫菊酯杀虫剂与昆虫生长调节剂的组合导致配制的杀虫剂制剂与单独使用第一和第二杀虫剂的效果相比，具有增强的抗跳蚤和蜱虫杀虫活性。此外，第一和第二种拟除虫菊酯杀虫剂与昆虫生长调节剂的组合产生对蚤和蜱具有增强的杀虫活性的杀虫剂制剂，同时有利地使其有效性所需的杀虫剂总量最小化。

3. 发明申请

WO2007127959A3 HIGH CONCENTRATION TOPICAL INSECTICIDE CONTAINING INSECT GROWTH REGULATOR 审中-公开
标题翻译：高浓度化学杀菌剂含有生长调节剂
公开(公告)号：WO2007127959A3
公开(公告)日：2008-11-06
申请号：PCT/US2007067703
申请日：2007-04-27
申请人： SUMMIT VETPHARM LLC , COTTRELL IAN W , AHN ALBERT , DORNEVAL LINDA
发明人： COTTRELL IAN W , AHN ALBERT , DORNEVAL LINDA
IPC分类号： A01N25/00 , A01N43/40
CPC分类号： A01N33/12 , A01N43/40 , A01N51/00 , A01N25/02 , A01N2300/00
摘要： A topical insecticide is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. The insecticide contains an insecticide and an insect growth regulator effective for killing fleas, flea larvae and flea eggs. The insecticide is formulated by dissolving an insecticidal (tetrahydro-3-furanyl) methylamine derivative and an insect growth regulator (IGR) in a solvent containing N-octyl pyrrolidone and/or N-methyl pyrrolidone to increase the solvency of the IGR component, thereby providing an insecticide having high insecticidal activity.
摘要翻译：提供一种局部用杀虫剂，其可以安全使用，并避免常规外用杀虫剂常见的有害副作用。杀虫剂含有杀虫剂和昆虫生长调节剂，可有效杀死跳蚤，跳蚤幼虫和跳蚤卵。通过将杀虫剂（四氢-3-呋喃基）甲胺衍生物和昆虫生长调节剂（IGR）溶解在含有N-辛基吡咯烷酮和/或N-甲基吡咯烷酮的溶剂中以提高IGR成分的溶解能力来配制杀虫剂，从而提供具有高杀虫活性的杀虫剂。

4. 发明申请

WO2007127966A2 HIGH CONCENTRATION DINOTEFURAN FORMULATIONS 审中-公开
标题翻译：高浓度DINOTEFURA配方
公开(公告)号：WO2007127966A2
公开(公告)日：2007-11-08
申请号：PCT/US2007/067711
申请日：2007-04-27
申请人： SUMMIT VETPHARM, LLC , COTTRELL, Ian, W. , AHN, Albert , DORNEVAL, Linda
发明人： COTTRELL, Ian, W. , AHN, Albert , DORNEVAL, Linda
IPC分类号： A01K29/00
CPC分类号： A01N51/00 , A01N25/02 , A01N43/36 , A01N2300/00
摘要： A topical insecticide is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. In one preferred embodiment of the invention, the active ingredient of the insecticide formulation is an amine derivative, having a nitro-methylene group, a nitroamino group or a cyanoamino group, which can be formulated to have low toxicity and excellent insecticidal activity. One particularly suitable insecticide is 1-{(tetrahydro-3-furanyl)methyl}-2-nitro-3-methylguanidine (dinotefuran), an aldulticide that will kill adult fleas dissolved in ethyl lactate.
摘要翻译：提供一种局部用杀虫剂，其可以安全使用，并避免常规外用杀虫剂常见的有害副作用。在本发明的一个优选实施方案中，杀虫剂制剂的活性成分是具有硝基亚甲基，硝基氨基或氰基氨基的胺衍生物，其可配制成具有低毒性和优异的杀虫活性。一种特别合适的杀虫剂是1-{（四氢-3-呋喃基）甲基} -2-硝基-3-甲基胍（dinotefuran），其将杀死溶解在乳酸乙酯中的成年蚤。

5. 发明申请

WO2007011602A3 HIGH CONCENTRATION MULTIACTION TOPICAL INSECTICIDES CONTAINING PYRETHROIDS 审中-公开
公开(公告)号：WO2007011602A3
公开(公告)日：2007-01-25
申请号：PCT/US2006/027023
申请日：2006-07-11
申请人： SUMMIT VETPHARM, LLC , COTTRELL, Ian, William , AHN, Albert , FISHER, Richard , MONRO, Christine , JOSEPH, Pierre
发明人： COTTRELL, Ian, William , AHN, Albert , FISHER, Richard , MONRO, Christine , JOSEPH, Pierre
IPC分类号： A01N43/08 , A01N43/40 , A01N53/08 , A01N57/10 , A01N37/00 , A01N37/02 , A01N37/06
摘要： A topical insecticide preparation is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. The topical insecticide contains a combination of a first pyrethroid insecticide effective for killing fleas, a second pyrethroid insecticide effective for killing ticks, and an insect growth regulator (IGR). The topical insecticide preparation can be packaged together or packaged so that the first and second pyrethroid insecticides are stored separately prior to administration of the insecticide preparation to the animal. The combination of the first and second pyrethroid insecticides with an insect growth regulator results in an insecticide preparation formulated to have enhanced insecticidal activity against fleas and ticks compared to the effectiveness of the first and second insecticides used alone. Further, the combination of the first and second pyrethroid insecticides with an insect growth regulator produces an insecticide preparation having enhanced insecticidal activity against fleas and ticks while advantageously minimizing the total amount of insecticide needed for its effectiveness.

6. 发明申请

WO2006036625A2 ENCAPSULATED PHARMACEUTICAL AGENTS 审中-公开
标题翻译：封装的药物剂
公开(公告)号：WO2006036625A2
公开(公告)日：2006-04-06
申请号：PCT/US2005/033402
申请日：2005-09-16
申请人： THE HARTZ MOUNTAIN CORPORATION , COTTRELL, Ian, William , AHN, Albert , FISHER, Richard
发明人： COTTRELL, Ian, William , AHN, Albert , FISHER, Richard
IPC分类号： A61K31/7048 , A61K31/4965 , C07D239/42
CPC分类号： A01N43/60 , A01N43/90 , A61K9/0053 , A61K9/5047 , A61K31/4965 , A61K31/7048 , A01N25/22 , A01N25/26 , A01N43/54 , A01N2300/00
摘要： The present invention provides stable lipid-based pharmaceutical formulations containing ivermectin, praziquantel and pyrantel pamoate, and methods for preparing the formulations. Further provided is a method of treating helminthiasis of mammals, which comprises administering a pharmaceutical composition that is highly effective against helminths, particularly tapeworm, hookworm, roundworm and heartworm of domestic animals and farm animals.
摘要翻译：本发明提供了含有依维菌素，吡喹酮和吡喃酚双羟萘酸盐的稳定的基于脂质的药物制剂，以及制备该制剂的方法。进一步提供了一种治疗哺乳动物蠕虫病的方法，该方法包括施用对家畜和农场动物的蠕虫，特别是绦虫，钩虫，蛔虫和心丝虫非常有效的药物组合物。

7. 发明申请

WO2006036624A2 LIPID STABILIZED FORMULATIONS 审中-公开
标题翻译：脂质稳定剂
公开(公告)号：WO2006036624A2
公开(公告)日：2006-04-06
申请号：PCT/US2005033401
申请日：2005-09-16
申请人： HARTZ MOUNTAIN CORP , COTTRELL IAN WILLIAM , AHN ALBERT , FISHER RICHARD
发明人： COTTRELL IAN WILLIAM , AHN ALBERT , FISHER RICHARD
IPC分类号： A61K31/517 , A61K9/00 , A61K31/7048
CPC分类号： A61K45/06 , A61K9/0056 , A61K9/1617 , A61K31/517 , A61K31/7048 , A61K2300/00
摘要： The present invention provides a lipid based system for isolating components in a pharmaceutical formulation. Also provided are methods for preparing stable pharmaceutical formulations containing at least two active ingredients. Further provided are methods of treating helminthiasis in mammals, which comprises administering a pharmaceutical composition that is highly effective against helminths, particularly tapeworn, hookworm, roundworm and heartworm of domestic animals and farm animals.
摘要翻译：本发明提供了用于分离药物制剂中的组分的基于脂质的系统。还提供了用于制备含有至少两种活性成分的稳定药物制剂的方法。进一步提供了治疗哺乳动物蠕虫病的方法，其包括施用对家畜和农场动物的蠕虫，特别是带卷虫，钩虫，蛔虫和心丝虫非常有效的药物组合物。

8. 发明申请

WO2004023872A3 HIGH CONCENTRATION TOPICAL INSECTICIDE 审中-公开
标题翻译：高浓度局部杀虫剂
公开(公告)号：WO2004023872A3
公开(公告)日：2004-07-22
申请号：PCT/US0328943
申请日：2003-09-11
申请人： HARTZ MOUNTAIN CORP , COTTRELL IAN WILLIAM , LYTWYN MICHAEL WILLIAM , MONRO CHRISTINE MARIE , AHN ALBERT , JOSEPH PIERRE ROSEMOND
发明人： COTTRELL IAN WILLIAM , LYTWYN MICHAEL WILLIAM , MONRO CHRISTINE MARIE , AHN ALBERT , JOSEPH PIERRE ROSEMOND
IPC分类号： C07D307/14 , A01N25/02 , A01N51/00 , A01K29/00 , A01N25/00
CPC分类号： A01N51/00 , A01N37/36 , A01N25/32 , A01N25/02 , A01N31/04 , A01N31/02 , A01N2300/00
摘要： A topical insecticide is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. In one preferred embodiment of the invention, the active ingredient of the insecticide formulation is an amine derivative, having a nitro-methylene group, a nitroamino group or a cyanoamino group, which can be formulated to have low toxicity and excellent insecticidal activity. One particularly suitable insecticide is 1-{(tetrahydro-3-furanyl)methyl}-2-nitro-3-methylguanidine (dinotefuran), an aldulticide that will kill adult fleas, dissolved in phenyl methanol or ethanol and ethyl lactate.
摘要翻译：提供可安全使用并避免常规局部用杀虫剂的许多常见有害副作用的局部用杀虫剂。在本发明的一个优选实施方案中，杀虫剂制剂的活性成分是具有硝基 - 亚甲基，硝基氨基或氰基氨基的胺衍生物，其可以配制成具有低毒性和优异的杀虫活性。一种特别合适的杀虫剂是1 - {（四氢-3-呋喃基）甲基} -2-硝基-3-甲基胍（dinotefuran），一种能杀死成虫的溶芽剂，溶于苯甲醇或乙醇和乳酸乙酯。

9. 发明申请

WO2007127966A3 HIGH CONCENTRATION DINOTEFURAN FORMULATIONS 审中-公开
标题翻译：高浓度DINOTEFURA配方
公开(公告)号：WO2007127966A3
公开(公告)日：2008-11-13
申请号：PCT/US2007067711
申请日：2007-04-27
申请人： SUMMIT VETPHARM LLC , COTTRELL IAN W , AHN ALBERT , DORNEVAL LINDA
发明人： COTTRELL IAN W , AHN ALBERT , DORNEVAL LINDA
IPC分类号： A01N25/00 , A01N43/40
CPC分类号： A01N51/00 , A01N25/02 , A01N43/36 , A01N2300/00
摘要： A topical insecticide is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. In one preferred embodiment of the invention, the active ingredient of the insecticide formulation is an amine derivative, having a nitro-methylene group, a nitroamino group or a cyanoamino group, which can be formulated to have low toxicity and excellent insecticidal activity. One particularly suitable insecticide is 1-{(tetrahydro-3-furanyl)methyl}-2-nitro-3-methylguanidine (dinotefuran), an aldulticide that will kill adult fleas dissolved in ethyl lactate.
摘要翻译：提供了一种局部用杀虫剂，其可以安全使用并避免常规外用杀虫剂的许多常见的有害副作用。在本发明的一个优选实施方案中，杀虫剂制剂的活性成分是具有硝基亚甲基，硝基氨基或氰基氨基的胺衍生物，其可配制成具有低毒性和优异的杀虫活性。一种特别合适的杀虫剂是1-{（四氢-3-呋喃基）甲基} -2-硝基-3-甲基胍（dinotefuran），其将杀死溶解在乳酸乙酯中的成年蚤。

10. 发明申请

WO2006036625A3 ENCAPSULATED PHARMACEUTICAL AGENTS 审中-公开
标题翻译：封装药剂
公开(公告)号：WO2006036625A3
公开(公告)日：2006-06-22
申请号：PCT/US2005033402
申请日：2005-09-16
申请人： HARTZ MOUNTAIN CORP , COTTRELL IAN WILLIAM , AHN ALBERT , FISHER RICHARD
发明人： COTTRELL IAN WILLIAM , AHN ALBERT , FISHER RICHARD
IPC分类号： A61K9/00 , A61K31/502
CPC分类号： A01N43/60 , A01N43/90 , A61K9/0053 , A61K9/5047 , A61K31/4965 , A61K31/7048 , A01N25/22 , A01N25/26 , A01N43/54 , A01N2300/00
摘要： The present invention provides stable lipid-based pharmaceutical formulations containing ivermectin, praziquantel and pyrantel pamoate, and methods for preparing the formulations. Further provided is a method of treating helminthiasis of mammals, which comprises administering a pharmaceutical composition that is highly effective against helminths, particularly tapeworm, hookworm, roundworm and heartworm of domestic animals and farm animals.
摘要翻译：本发明提供了含有伊维菌素，吡喹酮和扑热息痛的稳定的基于脂质的药物制剂，以及制备制剂的方法。进一步提供一种治疗哺乳动物蠕虫病的方法，其包括对家畜和农场动物的蠕虫，特别是绦虫，钩虫，蛔虫和心虫病具有高度有效的药物组合物。

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