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1. 发明申请

WO2003029209A3 CHEMICAL COMPOUNDS 审中-公开
公开(公告)号：WO2003029209A3
公开(公告)日：2003-04-10
申请号：PCT/US2002/031293
申请日：2002-10-01
申请人： SMITHKLINE BEECHAM CORPORATION , ADAMS, Jerry, Leroy , KASPAREC, Jiri , SILVA, Domingos , YUAN, Catherine, C., K.
发明人： ADAMS, Jerry, Leroy , KASPAREC, Jiri , SILVA, Domingos , YUAN, Catherine, C., K.
IPC分类号： C07D487/04
摘要： Pyrazolo-pyrimidine derivatives are described herein. The described invention also includes methods of making such derivatives as well as methods of using the same in the treatment of diseases.

2. 发明申请

WO2003029209A2 CHEMICAL COMPOUNDS 审中-公开
标题翻译：化学化合物
公开(公告)号：WO2003029209A2
公开(公告)日：2003-04-10
申请号：PCT/US2002/031293
申请日：2002-10-01
申请人： SMITHKLINE BEECHAM CORPORATION , ADAMS, Jerry, Leroy , KASPAREC, Jiri , SILVA, Domingos , YUAN, Catherine, C., K.
发明人： ADAMS, Jerry, Leroy , KASPAREC, Jiri , SILVA, Domingos , YUAN, Catherine, C., K.
IPC分类号： C07D
CPC分类号： C07D487/04
摘要： Pyrazolo-pyrimidine derivatives are described herein. The described invention also includes methods of making such derivatives as well as methods of using the same in the treatment of diseases.
摘要翻译：吡唑并嘧啶衍生物在本文中描述。所述发明还包括制备这些衍生物的方法以及使用该衍生物的方法来治疗疾病。

3. 发明申请

WO1992010498A1 NOVEL CSAIDS 审中-公开
标题翻译：新的CSAIDS
公开(公告)号：WO1992010498A1
公开(公告)日：1992-06-25
申请号：PCT/US1991009417
申请日：1991-12-12
申请人： SMITHKLINE BEECHAM CORPORATION , ADAMS, Jerry, Leroy , DULIK, Deanne, Marie , GALLAGHER, Timothy, F. , NEWTON, John
发明人： SMITHKLINE BEECHAM CORPORATION
IPC分类号： C07D487/00
CPC分类号： C07D487/04
摘要： The novel compounds of formulas (I) and (II), bicyclo 5,6-Dihydro-7H-pyrrolo-[1,2-a]-imidazol-7-ol and 7-one substituted ring systems, have been found to be useful inhibitors of the 5-lipoxygenase and cyclooxygenase enzymes, and cytokine suppressive agents, respectively, and therefore useful in the treatment and prophylaxis of disease states mediated thereby.
摘要翻译：式（I）和（II）的新化合物，双环5,6-二氢-7H-吡咯并[1,2-a] - 咪唑-7-醇和7-取代的环体系已经被发现是 5-脂氧合酶和环加氧酶的有用抑制剂和细胞因子抑制剂，因此可用于治疗和预防由此介导的疾病状态。

4. 发明申请

WO2009137391A2 BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS 审中-公开
标题翻译：苯磺酰胺噻唑和恶唑化合物
公开(公告)号：WO2009137391A2
公开(公告)日：2009-11-12
申请号：PCT/US2009/042682
申请日：2009-05-04
申请人： SMITHKLINE BEECHAM CORPORATION , ADAMS, Jerry, Leroy , DICKERSON, Scott, Howard , JOHNSON, Neil, W. , KUNTZ, Kevin , PETROV, Kimberly , RALPH, Jeffrey, M. , RHEAULT, Tara Renae , SCHAAF, Gregory , STELLWAGEN, John , TIAN, Xinrong , UEHLING, David Edward , WATERSON, Alex Gregory , WILSON, Brian
发明人： ADAMS, Jerry, Leroy , DICKERSON, Scott, Howard , JOHNSON, Neil, W. , KUNTZ, Kevin , PETROV, Kimberly , RALPH, Jeffrey, M. , RHEAULT, Tara Renae , SCHAAF, Gregory , STELLWAGEN, John , TIAN, Xinrong , UEHLING, David Edward , WATERSON, Alex Gregory , WILSON, Brian
IPC分类号： A61K31/506 , C07D417/04 , C07D417/14 , A61K31/5377 , A61K31/541 , A61P35/00
CPC分类号： C07D417/14 , A61K31/427 , C07D413/04 , C07D413/14 , C07D417/04
摘要： The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
摘要翻译：本发明提供了噻唑磺酰胺和恶唑磺酰胺化合物，含有该化合物的组合物，以及其制备方法和它们作为药物用途的方法。

5. 发明申请

WO2007018941A2 COMPOUNDS 审中-公开
标题翻译：化合物
公开(公告)号：WO2007018941A2
公开(公告)日：2007-02-15
申请号：PCT/US2006/027138
申请日：2006-07-13
申请人： SMITHKLINE BEECHAM CORPORATION , ADAMS, Jerry, Leroy , DREWRY, David, Harold , LINN, James, Andrew
发明人： ADAMS, Jerry, Leroy , DREWRY, David, Harold , LINN, James, Andrew
IPC分类号： C07D413/14 , C07D409/14
CPC分类号： C07D409/04 , C07D409/14 , C07D417/14
摘要： A compound of formula (I): compositions and medicaments containing the same as well as processes for the preparation and use of such compounds, compositions and medicaments, particularly in diseases associated with inappropriate Aurora activity.
摘要翻译：式（I）的化合物：包含其的组合物和药物以及用于制备和使用这些化合物，组合物和药物的方法，特别是在与不适当的Aurora活性相关的疾病中。

6. 发明申请

WO2004021979A2 NOVEL COMPOUNDS 审中-公开
标题翻译：新型化合物
公开(公告)号：WO2004021979A2
公开(公告)日：2004-03-18
申请号：PCT/US2003/026508
申请日：2003-08-26
申请人： SMITHKLINE BEECHAM CORPORATION , ADAMS, Jerry, Leroy , BOEHM, Jeffrey, C. , WAN, Zehong
发明人： ADAMS, Jerry, Leroy , BOEHM, Jeffrey, C. , WAN, Zehong
IPC分类号： A61K
CPC分类号： C07D487/04 , C07D473/34
摘要： Novel substituted pyrrolo[2.3-d]pyrimidin-4-yl compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.
摘要翻译：新型取代的吡咯并[2,3-d]嘧啶-4-基化合物和用作CSBP / p38激酶抑制剂治疗的组合物。

7. 发明申请

WO1998006715A1 NOVEL PIPERAZINE CONTAINING COMPOUNDS 审中-公开
标题翻译：新型PIPERAZINE含有化合物
公开(公告)号：WO1998006715A1
公开(公告)日：1998-02-19
申请号：PCT/US1997013873
申请日：1997-08-07
申请人： SMITHKLINE BEECHAM CORPORATION , SMITHKLINE BEECHAM PLC , ADAMS, Jerry, Leroy , BOEHM, Jeffrey, Charles , CHAN, George, Wai-Kin , RAHMAN, Shirley, K.
发明人： SMITHKLINE BEECHAM CORPORATION , SMITHKLINE BEECHAM PLC
IPC分类号： C07D403/06
CPC分类号： C07D401/12 , C07D209/42
摘要： Novel 3-Carboxyindole piperazine amide containing compounds, and compositions for use in therapy as anti-inflammatory agents, and inhibitors of cytokine p38/MAP kinase mediated diseases.
摘要翻译：含有新型3-羧基吲哚哌嗪酰胺的化合物和用作治疗作为抗炎剂的组合物，以及细胞因子p38 / MAP激酶介导的疾病的抑制剂。

8. 发明申请

WO1996030337A1 PHOTOLYTICALLY CLEAVABLE ENCODING AND LINKING AGENTS FOR USE IN COMBINATORIAL CHEMISTRY 审中-公开
标题翻译：用于组合化学的光致可清除编码和连接试剂
公开(公告)号：WO1996030337A1
公开(公告)日：1996-10-03
申请号：PCT/US1996004414
申请日：1996-03-29
申请人： SMITHKLINE BEECHAM CORPORATION , GARIGIPATI, Ravi, Shanker , ADAMS, Jerry, Leroy
发明人： SMITHKLINE BEECHAM CORPORATION
IPC分类号： C07C311/16
CPC分类号： C07C311/16 , B01J2219/00572 , C40B70/00
摘要： The present invention is to novel photochemically cleavable aryl sulfonamides of the formula: P-A3-A2-A1-S(O)2NR1R2 wherein: R1 and R2 are independently selected from optionally substituted alkyl, arylalkyl or heteroarylalkyl; A1 is an aryl or heteroaryl moiety; A2 is a linking agent is an aryl, heteroaryl, arylalkyl, heteroaryl alkyl, or an alkyl, wherein the alkyl moiety in the arylalkyl, heteroaryl alkyl, or alkyl group is optionally interrupted one or more times independently by oxygen, NR3, sulfur or an amide group; R3 is alkyl; A3 is an electron rich aryl or heteroaryl moiety having an E1/2 potential of 0.5 to 2.0 and which moiety is capable of forming an exciplex; P is a solid support. Another aspect of the present invention is to the novel use of these photolytically cleavable aryl sulfonamides in combinatorial chemistry synthesis, for use in non-sequential encoding, as a tagging agent. Another aspect of the present inevention is to the novel use of these photolytically cleavable aryl sulfonamides in combinatorial chemistry synthesis, as a linking agent which is bound to a solid support, and upon photolytic cleavage will provide a free amine of the desired final products, i.e. the use of sulfonamides for the solid phase synthesis of amines.
摘要翻译：本发明是新型的具有下式的光化学可裂解的芳基磺酰胺：P-A3-A2-A1-S（O）2NR1R2其中：R1和R2独立地选自任选取代的烷基，芳基烷基或杂芳基烷基; A1是芳基或杂芳基部分; A2是连接剂是芳基，杂芳基，芳基烷基，杂芳基烷基或烷基，其中芳基烷基，杂芳基烷基或烷基中的烷基部分任选地被氧，NR 3，硫或酰胺基; R3是烷基; A3是具有0.5至2.0的E1 / 2电位的电子富集的芳基或杂芳基部分，并且该部分能够形成激元复合体; P是一个坚实的支持。本发明的另一方面是这些光可裂解的芳基磺酰胺在组合化学合成中的新用途，用于非顺序编码作为标记试剂。本发明的另一个方面是这些光可裂解的芳基磺酰胺在组合化学合成中的新用途，作为与固体支持物结合的连接剂，并且在光解裂解时将提供所需最终产物的游离胺，即使用磺酰胺进行固相合成胺。

9. 发明申请

WO1996021654A1 NOVEL COMPOUNDS 审中-公开
标题翻译：新型化合物
公开(公告)号：WO1996021654A1
公开(公告)日：1996-07-18
申请号：PCT/US1996001094
申请日：1996-01-11
申请人： SMITHKLINE BEECHAM CORPORATION , ADAMS, Jerry, Leroy , GARIGIPATI, Ravi, Shanker , LEE, John, Cheung-Lun
发明人： SMITHKLINE BEECHAM CORPORATION
IPC分类号： C07D233/00
CPC分类号： C07D401/04 , C07D405/04 , C07D405/14
摘要： This invention relates to 1-cycloalkyl, 4,5-trisubstituted imidazole compounds, process for the preparation thereof, the use thereof in treating cytokine mediated diseases and pharmaceutical compositions for the use in such therapy.
摘要翻译：本发明涉及1-环烷基，4,5-三取代的咪唑化合物，其制备方法，其用于治疗细胞因子介导的疾病和用于这种治疗的药物组合物。

10. 发明申请

WO1995033713A1 ANTI-INFLAMMATORY COMPOUNDS 审中-公开
标题翻译：抗炎化合物
公开(公告)号：WO1995033713A1
公开(公告)日：1995-12-14
申请号：PCT/US1995007041
申请日：1995-06-02
申请人： SMITHKLINE BEECHAM CORPORATION , ADAMS, Jerry, Leroy , HALL, Ralph, Floyd
发明人： SMITHKLINE BEECHAM CORPORATION
IPC分类号： C07C301/02
CPC分类号： C07C311/09 , C07C317/22 , C07C323/20
摘要： This invention relates to the novel compounds and pharmaceutical compositions of formula (I). This invention also relates to a method of treating or reducing inflammation in a mammal in need thereof, which comprises administering to said mammal an effective amount of a compound or composition of formula (I).
摘要翻译：本发明涉及式（I）的新化合物和药物组合物。本发明还涉及在有需要的哺乳动物中治疗或减轻炎症的方法，其包括给予所述哺乳动物有效量的式（I）化合物或组合物。

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