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1. 发明申请

WO2017009454A1 NOVEL IMAGING COMPOUNDS 审中-公开
标题翻译：新型成像化合物
公开(公告)号：WO2017009454A1
公开(公告)日：2017-01-19
申请号：PCT/EP2016/066901
申请日：2016-07-15
申请人： AC IMMUNE S.A. , PIRAMAL IMAGING SA
发明人： KROTH, Heiko , NAMPALLY, Sreenivasachary , MOLETTE, Jérôme , GABELLIERI, Emanuele , SCHIEFERSTEIN, Hanno , MÜLLER, Andre , SCHMITT-WILLICH, Heribert , BERNDT, Mathias
IPC分类号： C07D471/04 , A61K31/437 , A61P25/28
CPC分类号： C07D471/14 , A61K51/0455 , C07B59/002
摘要： The present invention relates to novel compounds that can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging.
摘要翻译：本发明涉及可用于选择性Tau检测与Tau聚集体如阿尔茨海默氏病和其他tau蛋白病相关的疾病和异常的新型化合物，其使用正电子发射断层扫描（PET）成像。

2. 发明申请

WO2014150877A2 ANTI-TAU ANTIBODIES AND METHODS OF USE 审中-公开
标题翻译：抗TAU抗体和使用方法
公开(公告)号：WO2014150877A2
公开(公告)日：2014-09-25
申请号：PCT/US2014/024440
申请日：2014-03-12
申请人： AC IMMUNE S.A. , GENENTECH, INC.
发明人： AYALON, Gai , DI CARA, Danielle Marie , HOTZEL, Isidro , PFEIFER, Andrea , MUHS, Andreas , PIHLGREN, Maria , ADOLFSSON, Oskar
IPC分类号： C07K16/24
CPC分类号： C07K16/18 , A61K47/6843 , C07K16/44 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/92
摘要： The present invention relates to anti-Tau antibodies, such as antibodies that bind to a phosphorylated epitope on human Tau protein with high specificity and/or affinity, and methods of using the same.
摘要翻译：本发明涉及抗Tau抗体，例如以高特异性和/或亲和力与人Tau蛋白上的磷酸化表位结合的抗体，以及使用其的方法。

3. 发明申请

WO2012055933A1 LIPOSOME-BASED CONSTRUCT COMPRISING A PEPTIDE MODIFIED THROUGH HYDROPHOBIC MOIETIES 审中-公开
标题翻译：基于脂蛋白的构建包含通过疏水性动物修饰的肽
公开(公告)号：WO2012055933A1
公开(公告)日：2012-05-03
申请号：PCT/EP2011/068797
申请日：2011-10-26
申请人： AC IMMUNE S.A. , REIS, Pedro , HICKMAN, David , PIHLGREN BOSCH, Maria , MUHS, Andreas , PFEIFER, Andrea
发明人： REIS, Pedro , HICKMAN, David , PIHLGREN BOSCH, Maria , MUHS, Andreas , PFEIFER, Andrea
IPC分类号： A61K9/127 , A61K9/00 , A61K38/00 , A61K39/00 , A61K47/48
CPC分类号： A61K9/1278 , A61K9/0019 , A61K9/127 , A61K9/1271 , A61K39/0007 , A61K39/385 , A61K39/39 , A61K47/542 , A61K47/62 , A61K47/6911 , A61K2039/55555 , A61K2039/55561 , A61K2039/55572 , C07K16/18 , G01N33/6896 , Y02A50/41
摘要： The present invention relates to method for preparing liposome-based constructs comprising a peptide, particularly an antigenic peptide, of interest modified through hydrophobic moieties reconstituted in liposomes and to the antigenic constructs obtained with said method. The invention further relates to the use of said constructs for the therapeutic and diagnostic use in the treatment of diseases and disorders, which are caused by or associated with proteopathy such as Alzheimer's Disease.
摘要翻译：本发明涉及制备基于脂质体的构建体的方法，其包含通过在脂质体中重构的疏水部分修饰的目标改性的肽，特别是抗原肽，以及用所述方法获得的抗原构建体。本发明还涉及所述构建体在治疗和诊断中用于治疗疾病和病症的用途，所述疾病和病症由诸如阿尔茨海默氏病等蛋白病引起或与之相关。

4. 发明申请

WO2009004038A2 THERAPEUTIC COMPOUND 审中-公开
标题翻译：治疗化合物
公开(公告)号：WO2009004038A2
公开(公告)日：2009-01-08
申请号：PCT/EP2008/058527
申请日：2008-07-02
申请人： AC Immune S.A. , PROTEOSYS AG , PFEIFER, Andrea , SCHRATTENHOLZ, André , MUHS, Andreas
发明人： PFEIFER, Andrea , SCHRATTENHOLZ, André , MUHS, Andreas
IPC分类号： A61K31/551 , A61K31/553 , A61K31/554 , A61P25/28
CPC分类号： C07D471/04
摘要： The present invention relates to a compound that is capable of inhibiting the formation of β-amyloid plaques, of reducing and/or retarding the increase the β-amyloid plaque load in the brain of an animal, particularly a mammal, but especially a human. In particular, the invention relates to compounds of formula (I) and to metabolites thereof.
摘要翻译：本发明涉及能够抑制β-淀粉样蛋白斑形成，减少和/或延缓动物，特别是哺乳动物，特别是人的脑中β-淀粉样斑块负荷增加的化合物。特别地，本发明涉及式（I）的化合物及其代谢物。

5. 发明申请

WO2008156622A8 HUMANIZED ANTIBODIES TO AMYLOID BETA 审中-公开
公开(公告)号：WO2008156622A8
公开(公告)日：2008-12-24
申请号：PCT/US2008/007318
申请日：2008-06-12
申请人： AC IMMUNE S.A. , GENENTECH, INC. , PFEIFER, Andrea , PIHLGREN, Maria , MUHS, Andreas , WATTS, Ryan
发明人： PFEIFER, Andrea , PIHLGREN, Maria , MUHS, Andreas , WATTS, Ryan
IPC分类号： A61K39/395 , A61P25/28 , C07K16/18
摘要： The present application is related to chimeric and humanized antibody and to methods and compositions for the therapeutic and diagnostic use in the treatment of amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease.

6. 发明申请

WO2008011348A2 HUMANIZED ANTIBODY 审中-公开
标题翻译：人类抗体
公开(公告)号：WO2008011348A2
公开(公告)日：2008-01-24
申请号：PCT/US2007/073504
申请日：2007-07-13
申请人： AC IMMUNE S.A. , GENENTECH, INC. , PFEIFER, Andrea , PIHLGREN, Maria , MUHS, Andreas , WATTS, Ryan
发明人： PFEIFER, Andrea , PIHLGREN, Maria , MUHS, Andreas , WATTS, Ryan
IPC分类号： C07K16/00
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , G01N33/6896
摘要： The present invention is related to chimeric and humanized antibody and to methods and compositions for the therapeutic and diagnostic use in the treatment of amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease.
摘要翻译：本发明涉及嵌合和人源化抗体以及用于治疗和诊断用途的方法和组合物，用于治疗淀粉样变性，一类与阿尔茨海默病等淀粉样蛋白相关的病症和异常。

7. 发明申请

WO2007068411A2 THERAPEUTIC VACCINE 审中-公开
标题翻译：治疗疫苗
公开(公告)号：WO2007068411A2
公开(公告)日：2007-06-21
申请号：PCT/EP2006/011861
申请日：2006-12-08
申请人： AC IMMUNE S.A. , PFEIFER, Andrea , NICOLAU, Claude
发明人： PFEIFER, Andrea , NICOLAU, Claude
IPC分类号： A61K39/00 , A61P25/28 , C07K16/18
CPC分类号： A61K39/0008 , C07K16/18 , Y10S424/812
摘要： The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis. In particular, the present invention provides novel methods and compositions for eliciting a highly specific and highly effective immune response in an organism, but particularly within an animal, particularly a mammal or a human, which is capable of preventing or alleviating amyloidosis, or the symptoms associated with amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD), including diseases or conditions characterized by a loss of cognitive memory capacity such as, for example, mild cognitive impairment (MCI).
摘要翻译：本发明涉及用于治疗和诊断用途的方法和组合物，所述方法和组合物用于治疗由淀粉样蛋白或淀粉样样蛋白（包括淀粉样变性）引起或与之相关的疾病和病症。特别地，本发明提供了新颖的方法和组合物，用于在生物体内，特别是能够预防或缓解淀粉样变性的动物，特别是哺乳动物或人类中引发高度特异性和高度有效的免疫应答，或症状与淀粉样变性有关的一组疾病和病症，包括继发淀粉样变性和年龄相关性淀粉样变性，包括但不限于神经系统疾病如阿尔茨海默氏病（AD），包括特征在于认知丧失的疾病或病症记忆能力，例如轻度认知障碍（MCI）。

8. 发明申请

WO2020163730A3 METHOD OF SAFE ADMINISTRATION OF PHOSPHORYLATED TAU PEPTIDE VACCINE 审中-公开
公开(公告)号：WO2020163730A3
公开(公告)日：2020-08-13
申请号：PCT/US2020/017235
申请日：2020-02-07
申请人： AC IMMUNE S.A. , JANSSEN PHARMACEUTICALS, INC.
发明人： PFEIFER, Andrea , MUHS, Andreas , PIHLGREN BOSCH, Maria , VUKICEVIC VERHILLE, Marija , PIOT, Nicolas , GHIMIRE, Saroj Raj , RAMSBURG, Elizabeth Anne , DE MARCO, Donata , SADAKA, Charlotte
IPC分类号： A61K39/00 , A61P25/28
摘要： Methods for inducing anti-phosphorylated Tau antibodies without inducing a severe adverse event in humans are described. The methods include administering to the subject an effective amount of liposomes including a toll-like receptor 4 agonist and a Tau phosphopeptide presented on the surface of the liposome.

9. 发明申请

WO2020163730A2 METHOD OF SAFE ADMINISTRATION OF PHOSPHORYLATED TAU PEPTIDE VACCINE 审中-公开
公开(公告)号：WO2020163730A2
公开(公告)日：2020-08-13
申请号：PCT/US2020/017235
申请日：2020-02-07
申请人： AC IMMUNE S.A. , JANSSEN PHARMACEUTICALS, INC.
发明人： PFEIFER, Andrea , MUHS, Andreas , PIHLGREN BOSCH, Maria , VUKICEVIC VERHILLE, Marija , PIOT, Nicolas , GHIMIRE, Saroj Raj , RAMSBURG, Elizabeth Anne , DE MARCO, Donata , SADAKA, Charlotte
IPC分类号： A61K39/00 , A61P25/28
摘要： Methods for inducing anti-phosphorylated Tau antibodies without inducing a severe adverse event in humans are described. The methods include administering to the subject an effective amount of liposomes including a toll-like receptor 4 agonist and a Tau phosphopeptide presented on the surface of the liposome.

10. 发明申请

WO2012016173A2 SAFE AND FUNCTIONAL HUMANIZED ANTIBODIES 审中-公开
标题翻译：安全和功能性人类抗体
公开(公告)号：WO2012016173A2
公开(公告)日：2012-02-02
申请号：PCT/US2011/045948
申请日：2011-07-29
申请人： AC IMMUNE S.A. , GENENTECH, INC. , PFEIFER, Andrea , MUHS, Andreas , ADOLFSSON, Oskar , WATTS, Ryan
发明人： PFEIFER, Andrea , MUHS, Andreas , ADOLFSSON, Oskar , WATTS, Ryan
IPC分类号： G01N33/53
CPC分类号： C07K16/18 , C07K14/4711 , C07K2317/24 , G01N33/5055 , G01N33/5058 , G01N2333/4709 , G01N2500/10 , G01N2800/2821
摘要： The present invention is related to safe and functional antibodies for the therapeutic and diagnostic use in the treatment of an amyloidosis, a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease.
摘要翻译：本发明涉及用于治疗淀粉样变性的治疗和诊断用途的安全和功能性抗体，与淀粉样蛋白相关的一组疾病和异常，例如阿尔茨海默氏病。

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