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1. 发明申请

WO2007045644A1 VENTED DRUG RESERVOIR UNIT 审中-公开
标题翻译：透明药物储存单位
公开(公告)号：WO2007045644A1
公开(公告)日：2007-04-26
申请号：PCT/EP2006/067483
申请日：2006-10-17
申请人： NOVO NORDISK A/S , KALLESØE NIELSEN, Karsten , AAGAARD, Lars
发明人： KALLESØE NIELSEN, Karsten , AAGAARD, Lars
IPC分类号： A61M5/142
CPC分类号： A61M5/14248 , A61M2005/14252 , A61M2205/583 , Y10T137/0324
摘要： A reservoir unit (200) is provided comprising a housing (201) in which a reservoir (250) with a transparent portion (251) is arranged, the housing comprising a window (203) allowing a portion of the reservoir to be inspected. The reservoir unit is adapted to be moved from a first "cold" condition to a second "warm" condition with no visible water condensing on the interior surface of the window portion. Further, a vent (210, 211) is adapted to provide pressure equalization between the interior of the housing and the exterior. In this way it is possible to perform visual inspection of the reservoir at all times without being confused by dew or condensed water drops, e.g. when a prefilled reservoir unit containing a drug which requires storage at a given low temperature, as is the case for insulin-containing drugs, is taken out in ambient temperature.
摘要翻译：提供了一种储存器单元（200），其包括壳体（201），其中布置有具有透明部分（251）的储存器（250），所述壳体包括允许检查储存器的一部分的窗口（203）。储存器单元适于从第一“冷”状态移动到第二“暖”状态，在窗口部分的内表面上没有可见的水凝结。此外，排气口（210,211）适于在壳体的内部和外部之间提供压力平衡。以这种方式，可以始终对储存器进行目视检查，而不会被露水或冷凝水滴混淆，例如，当在环境温度下取出包含需要在给定低温下储存的药物的预填充贮存器单元（如含胰岛素的药物的情况）时。

2. 发明申请

WO02092825B1 RETROVIRAL VECTORS FOR GENE THERAPY 审中-公开
标题翻译：用于基因治疗的退行性载体
公开(公告)号：WO02092825B1
公开(公告)日：2003-08-07
申请号：PCT/DK0200331
申请日：2002-05-17
申请人： UNIV AARHUS , MIKKELSEN JACOB GIEHM , RASMUSSEN SOEREN VESTERGAARD , DUCH MOGENS , PEDERSEN FINN SKOU , AAGAARD LARS
发明人： MIKKELSEN JACOB GIEHM , RASMUSSEN SOEREN VESTERGAARD , DUCH MOGENS , PEDERSEN FINN SKOU , AAGAARD LARS
IPC分类号： C12N15/09 , A61K35/76 , A61K39/00 , A61K39/12 , A61K48/00 , A61P43/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12N15/867 , C12Q1/06
CPC分类号： C12N15/86 , A61K39/00 , A61K48/00 , C12N2740/13043
摘要： The present invention relates to improved vectors useful in gene therapy which improvement particularly resides in improved safety of such vectors. The improvement is achieved by incorporating sequences into the gene therapy vector which promote dimer formation of transcripts derived from said vector. Such sequences are in a preferred embodiment self-complementary palindromic or nonpalindromic sequences.
摘要翻译：本发明涉及用于基因治疗的改良载体，其改进特别在于提高这些载体的安全性。通过将序列并入促进从所述载体衍生的转录物的二聚体形成的基因治疗载体中来实现改善。这样的序列在优选的实施方案中是自身互补的回文或非正义链序列。

3. 发明申请

WO2008119648A1 ELECTRONIC DEVICE ASSEMBLY WITH SAFETY ELECTRIC CONNECTOR 审中-公开
标题翻译：电子装置与安全电连接器组装
公开(公告)号：WO2008119648A1
公开(公告)日：2008-10-09
申请号：PCT/EP2008/053107
申请日：2008-03-14
申请人： NOVO NORDISK A/S , NØRGAARD, Jesper, Bach , AAGAARD, Lars , MUNK, Jens, Aage
发明人： NØRGAARD, Jesper, Bach , AAGAARD, Lars , MUNK, Jens, Aage
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , A61B2562/222 , A61B2562/225 , Y10T29/49826
摘要： The application provides an assembly comprising a housing (20) having an electrical housing connector (50) and a strip port (40) for a BGM sensor arranged in the vicinity of the electrical connector. The assembly further comprises an external electrical connector (60) adapted for releasable connection to the housing connector, wherein the external electrical connector comprises a portion (62) adapted to block the port opening when the external electrical connector is connected to the housing connector, thereby preventing insertion of a strip in the port when the two connectors are connected to each other. In this way it is prevented in a simple and cost-effective manner that a patient via an inserted strip is subjected to a too high voltage or current supplied to the circuitry of the electronic device.
摘要翻译：该应用提供了一种组件，其包括具有电气外壳连接器（50）的壳体（20）和布置在电连接器附近的用于BGM传感器的带状端口（40）。组件还包括适于可释放地连接到壳体连接器的外部电连接器（60），其中外部电连接器包括适于在外部电连接器连接到壳体连接器时阻挡端口开口的部分（62），由此当两个连接器彼此连接时，防止条带插入端口中。以这种方式，以简单和成本有效的方式防止患者经由插入的条带受到提供给电子设备的电路的太高的电压或电流。

4. 发明申请

WO2007031532A1 RESERVOIR DEVICE WITH INSPECTION AID FOR DETECTION OF DRUG CONDITION 审中-公开
标题翻译：具有用于检测药物条件的检查辅助设备
公开(公告)号：WO2007031532A1
公开(公告)日：2007-03-22
申请号：PCT/EP2006/066306
申请日：2006-09-13
申请人： NOVO NORDISK A/S , HANSEN, Steffen , JEPPESEN, Per , AAGAARD, Lars , BUNDGAARD-NIELSEN, Kirsten , HANSEN, Anita, Joan
发明人： HANSEN, Steffen , JEPPESEN, Per , AAGAARD, Lars , BUNDGAARD-NIELSEN, Kirsten , HANSEN, Anita, Joan
IPC分类号： A61M5/00 , A61J1/00
CPC分类号： A61M5/14248 , A61M2205/583
摘要： The invention provides a reservoir unit with a reservoir arranged within a housing. The reservoir defines an interior adapted to contain a translucent fluid drug, and comprises a first transparent area. A second area is associated with the reservoir and arranged substantially opposite the first area, the second area comprising a visually non-uniform portion. The housing comprises an inspection portion allowing a user to inspect a portion of the reservoir through the first area with the second area serving as a background, the second area thereby serving as an aid for evaluating a condition of a drug contained in the reservoir, e.g. fibrillated insulin.
摘要翻译：本发明提供了一种储存器单元，其具有布置在壳体内的储存器。储存器限定适于容纳半透明流体药物的内部，并且包括第一透明区域。第二区域与储存器相关联并且基本上与第一区域相对布置，第二区域包括视觉上不均匀的部分。壳体包括检查部分，允许使用者通过第一区域检查储存器的一部分，其中第二区域用作背景，因此第二区域用作辅助以评估包含在储存器中的药物的状况，例如。原纤化胰岛素

5. 发明申请

WO2002092825A3 RETROVIRAL VECTORS FOR GENE THERAPY 审中-公开
公开(公告)号：WO2002092825A3
公开(公告)日：2002-11-21
申请号：PCT/DK2002/000331
申请日：2002-05-17
申请人： AARHUS UNIVERSITET , MIKKELSEN, Jacob, Giehm , RASMUSSEN, Soeren, Vestergaard , DUCH, Mogens , PEDERSEN, Finn, Skou , AAGAARD, Lars
发明人： MIKKELSEN, Jacob, Giehm , RASMUSSEN, Soeren, Vestergaard , DUCH, Mogens , PEDERSEN, Finn, Skou , AAGAARD, Lars
IPC分类号： C12N15/867
摘要： The present invention relates to improved vectors useful in gene therapy which improvement particularly resides in improved safety of such vectors. The improvement is achieved by incorporating sequences into the gene therapy vector which promote dimer formation of transcripts derived from said vector. Such sequences are in a preferred embodiment self-complementary palindromic or nonpalindromic sequences.

6. 发明申请

WO02092825A2 IMPROVED VECTORS FOR GENE THERAPY 审中-公开
标题翻译：改进的基因治疗药物
公开(公告)号：WO02092825A2
公开(公告)日：2002-11-21
申请号：PCT/DK0200331
申请日：2002-05-17
申请人： UNIV AARHUS , MIKKELSEN JACOB GIEHM , RASMUSSEN SOEREN VESTERGAARD , DUCH MOGENS , PEDERSEN FINN SKOU , AAGAARD LARS
发明人： MIKKELSEN JACOB GIEHM , RASMUSSEN SOEREN VESTERGAARD , DUCH MOGENS , PEDERSEN FINN SKOU , AAGAARD LARS
IPC分类号： C12N15/09 , A61K35/76 , A61K39/00 , A61K39/12 , A61K48/00 , A61P43/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12N15/867 , C12Q1/06 , C12N15/86
CPC分类号： C12N15/86 , A61K39/00 , A61K48/00 , C12N2740/13043
摘要： The present invention relates to improved vectors useful in gene therapy which improvement particularly resides in improved safety of such vectors. The improvement is achieved by incorporating sequences into the gene therapy vector which promote dimer formation of transcripts derived from said vector. Such sequences are in a preferred embodiment self-complementary palindromic or nonpalindromic sequences.
摘要翻译：本发明涉及用于基因治疗的改良载体，其改进特别在于提高这些载体的安全性。通过将序列并入促进从所述载体衍生的转录物的二聚体形成的基因治疗载体中来实现改善。这样的序列在优选的实施方案中是自身互补的回文或非正义链序列。

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