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1. 发明申请

WO1985003436A1 DIFFUSION COATED MULTIPLE-UNITS DOSAGE FORM 审中-公开
标题翻译：扩散包衣多单位剂型
公开(公告)号：WO1985003436A1
公开(公告)日：1985-08-15
申请号：PCT/DK1985000005
申请日：1985-02-08
申请人： A/S ALFRED BENZON , KJORNAES, Kim , CHRISTENSEN, Finn, Norring , JENSEN, Jens, Rasmus
发明人： A/S ALFRED BENZON
IPC分类号： A61K09/14
CPC分类号： A61K9/5073 , A61K9/2081
摘要： In an oral pharmaceutical controlled release multiple-units formulation, individual units containing an active substance are coated with a substantially water-insoluble, but water-diffusible controlled release coating which includes 1) an inner film layer which causes adhesion between the units at elevated temperatures, comprising a water-dispersible film-forming agent, and 2) an outer film layer comprising a water-based film-forming agent which prevents adhesion between the units at elevated temperatures and imparts flowability to the units. The inner film layer may additionally comprise a substance which is capable of forming a continuous phase. By subjecting the thus coated units to heating to accelerate the formation of a continuous phase of the film-forming agent of the inner layer and optionally also of the additional substance, a coating is formed which substantially does not change its diffusion characteristics in the course of time.

2. 发明申请

WO1986006743A1 BACTERIAL ENZYMES 审中-公开
标题翻译：细菌酶
公开(公告)号：WO1986006743A1
公开(公告)日：1986-11-20
申请号：PCT/DK1986000051
申请日：1986-05-09
申请人： A/S ALFRED BENZON , MOLIN, Soren , GIVSKOV, Michael , RIISE, Erik
发明人： A/S ALFRED BENZON
IPC分类号： C12N15/00
CPC分类号： C12N15/70 , C07K2319/02 , C07K2319/036 , C12N1/08 , C12N9/18 , C12N9/20 , C12N9/22 , C12N15/69 , C12N15/74
摘要： Extracellular Serratia spp. enzymes have been found to be excreted by another gram-negative organism harbouring a plasmid carrying DNA from Serratia spp. encoding the enzymes. This organism, e.g. E. coli, is therefore employed to produce the enzymes, specific examples of Serratia spp. enzymes produced are a nuclease, a lipase and a phospholipase. The nuclease may be employed to remove nucleic acids from a biological material.

3. 发明申请

WO1985003437A1 DIFFUSION COATED MULTIPLE-UNITS DOSAGE FORM 审中-公开
标题翻译：扩散涂层的多单元剂量形式
公开(公告)号：WO1985003437A1
公开(公告)日：1985-08-15
申请号：PCT/DK1985000006
申请日：1985-02-08
申请人： A/S ALFRED BENZON , KJORNAES, Kim , LINNEMANN, Jorgen
发明人： A/S ALFRED BENZON
IPC分类号： A61K09/14
CPC分类号： A61K9/5073 , A61K9/2081
摘要： In an oral pharmaceutical ocntrolled release multiple-units formulation, individual units containing an active substance are coated with a substantially water-insoluble, but water-diffusible controlled release coating which includes 1) an inner film layer comprising a homogeneous combination of a water-dispersible film-forming agent and a polymeric substance which imparts compressibility to the coating, and 2) optionally an outer film layer comprising a film-forming agent which prevents adhesion between the units at elevated temperatures and imparts flowability to the units. The coating possesses a sufficient plastic deformability to result in no significant changes in the release characteristics of compressed coated units relative to non-compressed coated units.
摘要翻译：在用于口服给药的多释放控释药物制剂中，含有活性物质的单个单位用基本上不溶于水但水可扩散的控释包衣进行包衣，包含1）a 内膜层，其包含水分散性成膜剂和赋予涂层可压缩性的聚合物质的均匀组合，和2）任选的包含成膜剂的外膜层，其防止单元之间的粘附在高温下，给他们流动的力量。涂层具有足够的塑性变形性，以避免压缩涂层单元的释放特性与未压缩涂层单元相比发生显着变化。

4. 发明申请

WO1984001171A1 PLASMIDS WITH CONDITIONAL UNCONTROLLED REPLICATION BEHAVIOUR 审中-公开
标题翻译：具有条件不连续复制行为的PLASMIDS
公开(公告)号：WO1984001171A1
公开(公告)日：1984-03-29
申请号：PCT/DK1983000084
申请日：1983-09-09
申请人： A/S ALFRED BENZON , MOLIN, Soren , LARSEN, Jens, Erik, Love , LIGHT, Janice, Ann
发明人： A/S ALFRED BENZON
IPC分类号： C12N15/00
CPC分类号： C12N15/68 , C12N15/69
摘要： Plasmids useful as cloning vectors which carry a regulatable promoter which has been inserted in such a way that transcription from the promoter regulates replication so that increased transcription leads to a substantially increased or uncontrolled plasmid copy number when host microorganisms containing the plasmid are cultivated under conditions securing such increased transcription. The regulatable promoter is preferably lambda PR, the activity of which is controlled by a temperature-sensitive lambda cl repressor. To obtain gene products of the plasmids, host microorganisms to which such plasmids have been transformed are cultivated at about 30 C to secure a constant, low plasmid copy number during the seeding and multiplication stages of the microorganism, after which the temperature is shifted to about 36-42 C to obtain an uncontrolled plasmid copy number and an amplified amount of gene product. The gene product is then harvested from the culture.
摘要翻译：可用作携带可调节启动子的克隆载体的质粒，其以从启动子转录调节复制的方式插入，使得当含有质粒的宿主微生物的培养时，增加的转录导致显着增加或不受控制的质粒拷贝数，这种增加的转录。可调节的启动子优选为λPR，其活性由温度敏感的λ1c阻遏物控制。为了获得质粒的基因产物，在大约30℃培养这些质粒转化的宿主微生物，以在微生物的播种和繁殖阶段期间确保恒定的低质粒拷贝数，之后温度为转移到约36-42℃以获得不受控制的质粒拷贝数和扩增量的基因产物。然后从培养物中收获基因产物。

5. 发明申请

WO1986007608A1 STABILIZATION OF UNSTABLY INHERITED REPLICONS 审中-公开
标题翻译：不稳定的不利因素的稳定
公开(公告)号：WO1986007608A1
公开(公告)日：1986-12-31
申请号：PCT/DK1986000070
申请日：1986-06-18
申请人： A/S ALFRED BENZON , MOLIN, Soren , GERDES, Kenn, Axo , RASMUSSEN, Poul, Baad , ANDERSSON, Poul, Kirketerp
发明人： A/S ALFRED BENZON
IPC分类号： C12N15/00
CPC分类号： C12N15/68 , C12N15/67 , Y10S435/874 , Y10S435/88
摘要： The stable maintenance of a replicon in a population of growing cells is ensured by providing the replicon with a sequence which encodes a product capable of killing the cell harbouring the replicon or the progeny of the cell (or encodes a precursor for the product) and a sequence encoding an antagonist for the killing product (or a precursor for the antagonist). The antagonist is one which suppresses the killing product (or a precursor for the killing product) in cells harbouring the replicon, whereas the antagonist activity decays when the replicon is lost from the cell so that the antagonist (or its precursor) is no longer continuously expressed. This means that the killing product (or its precursor) present in the now replicon-free cell is no longer suppressed by the antagonist, resulting in cell death. Cells containing the thus stabilized replicon may be grown on a large scale without any significant loss of the replicon from the cell population even when no selection pressure is applied. Cells containing the thus stabilized replicon may be grown on a large scale without any significant loss of the replicon from the cell population even when no selection pressure is applied.

6. 发明申请

WO1983003762A1 COMPOSITION AND METHOD FOR INVESTIGATING ALIMENTARY FUNCTIONS 审中-公开
标题翻译：用于调查神经功能的组合物和方法
公开(公告)号：WO1983003762A1
公开(公告)日：1983-11-10
申请号：PCT/DK1983000047
申请日：1983-04-22
申请人： A/S ALFRED BENZON , CHRISTENSEN, Finn, Norring , JENSEN, Jens, Rasmus , BECHGAARD, Helle
发明人： A/S ALFRED BENZON
IPC分类号： A61K49/02
CPC分类号： A61K51/1255 , A61K2123/00
摘要： Enterally administrable diagnostic compositions for investigating alimentary functions comprise multiple units of a size of at the most 5 mm, preferably between 0.5 and 1.3 mm, in particular between 0.7 and 1.0 mm, each unit comprising a tracer-binding agent such as an ion exchange resin to which a radioactive tracer substance with a half-like of at the most 5 days, in particular 99mTc, 113mIn, 111In and 129Cs, is associated, the tracer-binding agent being formulated with pharmaceutically acceptable excipients, in particular granulating excipients in such a way that the exposure of the gastrointestinal mucosa to the tracer-binding agent is reduced and that the units do not disintegrate during the passage through the gastrointestinal tract. Preferred units comprise cross-sectionally substantially homogeneous multi-component cores in which the tracer-binding agent is granulated with one or more excipients and which are optionally coated with a diffusion coating permitting the labelling of the units to be performed at the site of use by immersing the units in a solution of tracer substance. Tracer-binding agents are normally present in an amount of about 2-20% by weight, preferably about 5-10% by weight, calculated on the units. Due to low leaching and the non-disintegrating properties, the composition can be used to investigate gastric emptying also of the last 20% of a food bolus, cf. Fig. 2 which illustrates the average gastric emptying pattern for 7 healthy volunteers (A) compared to the emptying from a person with the "Giesskannen" phenomenon (B).

7. 发明申请

WO1984001172A1 STABILIZED PLASMIDS 审中-公开
标题翻译：稳定的PLASMIDS
公开(公告)号：WO1984001172A1
公开(公告)日：1984-03-29
申请号：PCT/DK1983000086
申请日：1983-09-15
申请人： A/S ALFRED BENZON , MOLIN, Soren , GERDES, Kenn, Axo
发明人： A/S ALFRED BENZON
IPC分类号： C12N15/00
CPC分类号： C12N15/69 , C12N15/68
摘要： Plasmids which are in themselves unstably inherited or which have become unstable due to the insertion of a DNA fragment comprising one or more genes not naturally related to the plasmid are stabilized by means of a partitioning function exerted by a par region, especially a plasmid R1 par region, inserted into the plasmid on a DNA fragment which may be the length of the wild-type R1 EcoR1-A fragment, but which is preferably shorter than this fragment, and which may comprise the R1 par region A, the R1 par region B or both these R1 par regions. The stabilization obtained for several different types of plasmid, especially by employing both R1 par regions, approaches the stability level of wild-type plasmids, i.e. they typically have a frequency of loss of less than 5 x 10-6 per cell per generation. Such stabilized plasmids are useful in large-scale production of gene products as no particular bacterial strains or mutants are needed to secure plasmid maintenance, and as it is not necessary to employ a specific composition of the nutrient medium in which the host cells are grown in order to prevent loss of the plasmid from the bacterial population.

8. 发明申请

WO1983000693A1 SUBJECTS RELATING TO HUMAN INTEFERON-'alpha' SUBTYPE PROTEINS AND CORRESPONDING ANTIBODIES 审中-公开
标题翻译：与人类α亚型蛋白质和相关抗体有关的物质
公开(公告)号：WO1983000693A1
公开(公告)日：1983-03-03
申请号：PCT/DK1982000077
申请日：1982-08-13
申请人： A/S ALFRED BENZON , BERG, Kurt, Frimann
发明人： A/S ALFRED BENZON
IPC分类号： C07G07/00
CPC分类号： C07K16/249 , A61K38/00 , C07K14/56
摘要： HuIFN- alpha proteins which under SDS PAGE conditions adapted for separation show 13 sharp stained protein bands at 16,600, 16,980, 17,380, 17,580, 18,410, 18,840, 19,050, 19,500, 20,420, 20,890, 21,380, 21,880, and 22,910 "Daltons", each of the proteins having antiviral interferon activity in various interferon test systems as illustrated in Fig. 2. Rabbit antibodies raised against each of the 12 individual species from 16,980 to 22,910 "Daltons" will react against all of these species. The interferon proteins are produced by subjecting a solution containing human Le form interferon proteins to antibody affinity chromatography.
摘要翻译：在适合分离的SDS PAGE条件下的HuIFN-α蛋白在16,600,16,980,17,380,17,580,18,410,18,840,19,050,19,500,20,420,20,890,21,380,21,880和22,910“道尔顿”上显示13个清晰的染色蛋白条带，每个的如图1所示的各种干扰素测试系统中具有抗病毒干扰素活性的蛋白质。 2.从16,980个到22,910个“道尔顿”的12个个体中的每一个产生的兔抗体将与所有这些物种反应。干扰素蛋白是通过使含有人Le型干扰素蛋白质的溶液进行抗体亲和层析来制备的。

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