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1. 发明申请

WO2006077655A1 物質の減圧下における乾燥または濃縮方法审中-公开
标题翻译：在减压下干燥或浓缩物质的方法
公开(公告)号：WO2006077655A1
公开(公告)日：2006-07-27
申请号：PCT/JP2005/001173
申请日：2005-01-21
申请人：八木俊一
发明人：八木俊一
IPC分类号： F26B3/347 , F26B5/06
CPC分类号： F26B5/048
摘要： [PROBLEMS] In the mass production of dry substance or concentrate, to ensure the recurrence of uniform drying or uniform concentrating of a substance to be dried or to be concentrated. [MEANS FOR SOLVING PROBLEMS] There is provided a method of drying or concentrating a substance through microwave heating of the substance under reduced pressure to thereby effect water removal, wherein in the heating step, not only is vapor discharge carried out by means of a vacuum pump of given air volume displacement but also heating is conducted with the use of microwave of given output to thereby form a pressure curve, and wherein on a pressure curve obtained by initiating pressure measurement at the time of first minimum pressure value upon progression of pressure reduction, which pressure curve shows pressure increase from the first minimum pressure value in accordance with progression of heating of the heating object, a pressure difference value is designated in the stage of, with the maximum pressure value brought about by pressure increase as a basis, pressure decrease from the maximum pressure value and when the pressure decreases to the pressure difference value, the heating is discontinued or terminated.
摘要翻译： [问题]在大量生产干物质或浓缩物时，确保均匀干燥或均匀浓缩待干燥物质或浓缩的物质的复发。 [解决问题的手段]提供了一种通过在减压下微波加热物质来干燥或浓缩物质从而实现除水的方法，其中在加热步骤中，不仅通过真空进行蒸气放电使用给定输出的微波进行给定空气体积位移的泵，同时进行加热，从而形成压力曲线，并且其中在通过在减压进行时在第一最小压力值时启动压力测量而获得的压力曲线，该压力曲线表示根据加热对象的加热进行从第一最小压力值的压力增加，在以压力增加带来的最大压力值作为基础的压力级中指定压差值，作为基准，压力从最大压力值减小，当压力降低到压差值时，加热 g停产或终止。

2. 发明申请

WO2011001976A1 スレオ－３－（３，４－ジヒドロキシフェニル）－Ｌ－セリンの製造法审中-公开
标题翻译：生产3-（3,4-二羟基苯基）-L-丝氨酸的方法
公开(公告)号：WO2011001976A1
公开(公告)日：2011-01-06
申请号：PCT/JP2010/061052
申请日：2010-06-29
申请人：大日本住友製薬株式会社 , 八木俊一 , 小山功二 , 伊藤昌典
发明人：八木　俊一 , 小山　功二 , 伊藤　昌典
IPC分类号： C07C227/18 , C07C227/30 , C07C229/36
CPC分类号： C07D209/48 , C07C227/18 , C07C227/30 , C07C229/36
摘要：　下記式（１）で表されるスレオ－Ｎ－フタロイル－３－（３，４－ジヒドロキシフェニル）－Ｌ－セリンをメチルアミンと反応させる工程を含む、ドロキシドパまたはその薬学上許容されうる塩の製造法であって、末梢性起立性低血圧症の治療剤、あるいはパーキンソン病治療剤として有用であるスレオ－３－（３，４－ジヒドロキシフェニル）－Ｌ－セリン（一般名：ドロキシドパ）の煩雑な操作を必要としない生産効率の良い製造方法を提供する。
摘要翻译：本发明公开了一种用于使由式（1）表示的N-邻苯二甲酰基-3-（3,4-二羟基苯基）-L-丝氨酸与甲胺反应的步骤的方法，其中，可用于作为外周直立性低血压的补救剂或帕金森氏病的补救剂的3-（3,4-二羟基苯基）-L-丝氨酸（通用名：Droxidopa），而不需要麻烦的操作。

3. 发明申请

WO2007029340A1 性行為における潤滑性を有する潤滑剤としてのアロエパウダーの利用方法审中-公开
标题翻译：在作为润滑剂的润滑剂中使用二氧化碳粉末的方法
公开(公告)号：WO2007029340A1
公开(公告)日：2007-03-15
申请号：PCT/JP2005/016703
申请日：2005-09-06
申请人：八木晟 , 松尾圭三 , ウォンイントゥン , 八木俊一
发明人：八木俊一
IPC分类号： A61K36/896 , A61P15/00 , A61K9/06 , A61K9/14 , C10M159/02
CPC分类号： A61K36/886 , A61K2300/00
摘要： A method of using an aloe powder as a lubricant in sexual intercourse which has a high viscosity, a high moistness and a high lubricity, can highly sustain the moistness and lubricity over a long period of time, shows a prolonged moistness closely similar to the sliminess of female body fluid, can facilitate smooth sexual intercourse and has favorable effect of repairing damages such as scratch in the female genital organ. An aloe powder, which is rich in high-molecule polysaccharides, contains aloin in an amount lowered to 50 ppm or less and has 300 or less bacterial colonies per gram, is dissolved in water or an aqueous solution to form a moist and lubricant gel. In the case where female genital organ has no or excessively low moistness and thus sexual intercourse can be hardly conducted, the above-described gel is applied to the labia major or the labia minor and/or around them in the female genital organ, or applied to the male genital organ or both of the female genital organ and the male genital organ.
摘要翻译：在具有高粘度，高湿度和高润滑性的性交中使用芦荟粉末作为润滑剂的方法可以在长时间内高度保持湿润和润滑性，显示出与粘性相似的长时间的湿度的女性体液，可以促进性交顺利，并具有修复女性生殖器官损伤如刮伤的良好效果。富含高分子多糖的芦荟粉末含有降低至50ppm以下的芦荟，每克具有300个以下的细菌菌落，溶解于水或水溶液中，形成湿润润滑剂凝胶。在女性生殖器官没有或过低的湿度并因此几乎不能进行性交的情况下，将上述凝胶应用于阴唇专业或小阴唇和/或其周围的女性生殖器官或应用到男性生殖器官或女性生殖器官和男性生殖器官。

4. 发明申请

WO2006077656A1 減圧下における物質の低温乾燥方法とその装置审中-公开
标题翻译：真空下物质低温干燥的方法及其设备
公开(公告)号：WO2006077656A1
公开(公告)日：2006-07-27
申请号：PCT/JP2005/001175
申请日：2005-01-21
申请人：八木俊一
发明人：八木俊一
IPC分类号： F26B3/347 , F26B5/06
CPC分类号： F26B5/04 , F26B21/14
摘要： [PROBLEMS] Liquid nitrogen is introduced into a vacuum tank and allowed to instantly vaporize to saturation, and this vapor is utilized for cooling a substance. Thus, the substance is dried at a low temperature to an extremely low residual liquid content. The drying is completed in a short time. The drying gives the substance no serious damage such as contamination or oxidation. [MEANS FOR SOLVING PROBLEMS] A method of drying a substance at a low temperature under vacuum which comprises a drying step for removing volatile liquids such as water and an alcohol from the substance, the step being conducted in the following manner. At the stage where the amount of the residual liquids has become small and the temperature of the substance has become apt to rise because of a reduced amount of the heat of vaporization in the substance, the pressure is reduced for a given period. Subsequently, liquid nitrogen is introduced into the vacuum tank to allow it to instantly vaporize to recover a given pressure. The low temperature of the liquid nitrogen which has been thus vaporized to saturation in the vacuum tank is utilized to lower the temperature of the substance. The step is conducted one or more times. Thus, liquids such as water and an alcohol are removed at a low temperature.
摘要翻译： [问题]将液氮引入真空罐中并立即蒸发至饱和，并将该蒸气用于冷却物质。因此，物质在低温下干燥至极低的残留液体含量。干燥在短时间内完成。干燥使物质不会受到严重的损害，例如污染或氧化。解决问题的手段一种在真空下低温干燥物质的方法，其包括从物质中除去挥发性液体如水和醇的干燥步骤，该步骤以下列方式进行。在物质的蒸发热量减少的情况下，残留液体的量变小，物质的温度变得容易上升的阶段，压力降低一定时间。随后，将液氮引入真空槽中，使其立即蒸发以回收给定的压力。利用在真空槽中蒸发至饱和的液氮的低温来降低物质的温度。该步骤进行一次或多次。因此，在低温下除去水和醇等液体。

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