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1. 发明申请

WO2012052060A1 METHOD TO INCREASE THE GROWTH VELOCITY OF HUMAN INFANTS 审中-公开
标题翻译：增加人体生长速度的方法
公开(公告)号：WO2012052060A1
公开(公告)日：2012-04-26
申请号：PCT/EP2010/065916
申请日：2010-10-21
申请人： SWEDISH ORPHAN BIOVITRUM AB (PUBL) , HERNELL, Olle , STRÖMBERG, Patrik , SVENSSON, Lennart , TIMDAHL, Kristina , VAGERÖ, Mårten , ÖHMAN, Maria , OLSSON, Birgitta
发明人： HERNELL, Olle , STRÖMBERG, Patrik , SVENSSON, Lennart , TIMDAHL, Kristina , VAGERÖ, Mårten , ÖHMAN, Maria , OLSSON, Birgitta
IPC分类号： A61K38/43 , A61P1/00
CPC分类号： A61K38/465 , A23L5/00 , A23L33/17 , A23L33/40 , A23V2002/00 , C12Y301/01003 , C12Y301/01013
摘要： The present invention relates to a method to increase the growth velocity of a human infant, said method comprising the enteral administration to said infant of recombinant human bile-salt- stimulated lipase (rhBSSL). Such method has particular utility for underweight or preterm human infants, particular those in medical need of increasing their growth velocity. In other aspects, the invention relates to compositions, including infant feeds, kits, packaged-pharmaceutical-products and pharmaceutical compositions, and also to methods to prepare infant feeds, in each case useful for increasing the growth velocity of a human infant. In another aspect, the present invention relates to methods to: (X) protect the small bowel mucosa of a human infant from damage; to (Y) protect an immature intestinal epithelium of a human infant from the deleterious effects of incompletely digested and/or excess fat and/or lipid; and/or to (Z) limit accumulation of incompletely digested and/or excess fat and/or lipid in the ileum of a human infant; said methods in each case comprising the step of enteral administration of recombinant human bile salt stimulated lipase to said infant. The present invention also relates compositions, including infant feeds, kits, packaged-pharmaceutical-products and pharmaceutical compositions, and also to methods to prepare infant feeds, in each case useful for these protective or accumulation-limiting methods.
摘要翻译：本发明涉及一种增加人类婴儿生长速度的方法，所述方法包括对所述婴儿的重组人胆汁盐刺激的脂肪酶（rhBSSL）进行肠内给药。这种方法对于体重不足或早产儿的婴儿特别有用，特别是医疗需要增加其生长速度的方法。在其它方面，本发明涉及组合物，包括婴儿饲料，试剂盒，包装的药物产品和药物组合物，还涉及制备婴儿饲料的方法，每种情况都可用于增加人类婴儿的生长速度。另一方面，本发明涉及以下方法：（X）保护人类婴儿的小肠粘膜免受损伤; 至（Y）保护人类婴幼儿的未成熟肠上皮细胞不完全消化和/或过量脂肪和/或脂质的有害作用; 和/或（Z）限制人类婴儿回肠中不完全消化和/或多余的脂肪和/或脂质的积累; 所述方法在每种情况下包括向所述婴儿肠内施用重组人胆汁盐刺激的脂肪酶的步骤。本发明还涉及组合物，包括婴儿饲料，试剂盒，包装的药物产品和药物组合物，还涉及制备婴儿饲料的方法，每种情况都可用于这些保护性或积聚限制性方法。

2. 发明申请

WO2012052059A1 METHOD TO INCREASE THE ABSORPTION OF UNSATURATED FATTY ACIDS BY HUMAN INFANTS 审中-公开
标题翻译：增加人体免疫吸收不饱和脂肪酸的方法
公开(公告)号：WO2012052059A1
公开(公告)日：2012-04-26
申请号：PCT/EP2010/065915
申请日：2010-10-21
申请人： SWEDISH ORPHAN BIOVITRUM AB (PUBL) , HERNELL, Olle , OLSSON, Birgitta , STRÖMBERG, Patrik , SVENSSON, Lennart , TIMDAHL, Kristina , VAGERÖ, Mårten , ÖHMAN, Maria
发明人： HERNELL, Olle , OLSSON, Birgitta , STRÖMBERG, Patrik , SVENSSON, Lennart , TIMDAHL, Kristina , VAGERÖ, Mårten , ÖHMAN, Maria
IPC分类号： A61K38/43 , A61P1/00
CPC分类号： A61K38/465 , A23C9/1216 , A23C9/206 , A23L29/06 , A23L33/12 , A23L33/40 , A23V2002/00 , C12Y301/01003 , A23V2200/08 , A23V2250/54 , A23V2300/50
摘要： The present invention relates to a method to increase the absorption by a human infant of at least one unsaturated fatty acid, said method comprising the enteral administration to said infant of recombinant human bile-salt-stimulated lipase (rhBSSL). In another aspect the invention also relates to a method to improve the visual and/or cognitive development of a human infant, said method comprising the enteral administration to said infant of rhBSSL. Such methods have particular utility for preterm human infants, particular those in medical need of increasing their absorption of or availability to such unsaturated fatty acids. In further aspects, the invention relates to kits, packaged- pharmaceutical-products, recombinant human bile-salt-stimulated lipase and pharmaceutical compositions, in each case useful for increasing the absorption by a human infant of at least one unsaturated fatty acid, or for increasing the visual and/or cognitive development of a human infant.
摘要翻译：本发明涉及一种增加人类婴幼儿至少一种不饱和脂肪酸吸收的方法，所述方法包括向所述婴儿重组人胆汁盐刺激的脂肪酶（rhBSSL）进行肠内施用。在另一方面，本发明还涉及一种改善人类婴儿的视觉和/或认知发育的方法，所述方法包括对所述婴儿的rhBSSL的肠内施用。这些方法对于早产儿的婴儿具有特别的用途，特别是在医学上需要增加其对这种不饱和脂肪酸的吸收或可用性的这些方法。在另外的方面，本发明涉及试剂盒，包装的药物产品，重组人胆汁盐刺激的脂肪酶和药物组合物，在每种情况下都可用于增加人类婴幼儿至少一种不饱和脂肪酸的吸收，或用于增加人类婴儿的视觉和/或认知发育。

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