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1. 发明申请

WO2010107533A1 BIODELIVERY SYSTEMS 审中-公开
标题翻译：生物系统
公开(公告)号：WO2010107533A1
公开(公告)日：2010-09-23
申请号：PCT/US2010/023973
申请日：2010-02-12
申请人： GENERAL ELECTRIC COMPANY , WHITEKETTLE, Wilson, Kurt , TAFEL, Gloria, Jean , MURPHY, Kimberly , ZHAO, Qing
发明人： WHITEKETTLE, Wilson, Kurt , TAFEL, Gloria, Jean , MURPHY, Kimberly , ZHAO, Qing
IPC分类号： A01N47/44 , A01N47/48 , C02F1/50
CPC分类号： C02F1/50 , A01N25/28 , A01N25/34 , A01N33/12 , A01N35/08 , A01N43/80 , A01N59/26 , A01N37/34
摘要： A biodelivery system has been found which increases the efficiency and effectiveness of introducing anti microbial compounds into complex biofilm matrices through the use of liposome carriers, thereby removing the biofouling in industrial water bearing s\ stems, including piping, heat exchanges, condensers, filtration s> stems and fluid storage tanks According to one embodiment of the invention, antimicrobial compound containing liposomes are added to water systems prone to biofouling and biofilm formation The liposomes, being similar in composition to microbial membranes or cells, are readily incorporated into the existing biofilm Once the antimicrobial compound containing liposomes become entrained with the biofilm matrix, the decomposition or disintegration of the liposome proceeds Thereafter the biocidal core is released to react directly with the biofilm encased microorganisms. Upon the death of the organisms, the matrix decomposes and thereby results m reduced fouling of the water bearing system, resulting in increased heat transfer, increased flux, less deposit of colloidal and particulate solids and dissolved organics on the surface of the microfiltration membrane, thereby reducing the frequency and duration of the membrane cleaning and ultimate replacement
摘要翻译：已经发现生物输送系统通过使用脂质体载体而增加了将抗微生物化合物引入复杂生物膜基质的效率和有效性，从而消除了工业含水的生物污垢，包括管道，热交换器，冷凝器，过滤器 >茎和液体储存罐根据本发明的一个实施方案，将含抗微生物化合物的脂质体加入易于生物结垢和生物膜形成的水体系中。组成与微生物膜或细胞相似的脂质体容易并入现有的生物膜中含有脂质体的抗微生物化合物变得与生物膜基质夹带，脂质体的分解或分解进行。然后将杀生物核心释放直接与生物膜包裹的微生物反应。在生物体死亡时，基质分解，从而导致含水系统的结垢减少，导致增加的热传递，增加的通量，较少的胶体和颗粒固体的沉积以及溶解的有机物沉积在微滤膜的表面上，由此降低膜清洗的频率和持续时间并最终更换

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