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1. 发明申请

WO2005060540A2 NORETHINDRONE SUSTAINED RELEASE FORMULATIONS AND METHODS ASSOCIATED THEREWITH 审中-公开
标题翻译： NORELHINDRONE可持续发布的配方和方法相关
公开(公告)号：WO2005060540A2
公开(公告)日：2005-07-07
申请号：PCT/US2004/040073
申请日：2004-11-30
申请人： WATSON PHARMACEUTICALS, INCORPORATED , QUAN,Danyi , RUIZ, Ana , ANIGBOGU, Angela
发明人： QUAN,Danyi , RUIZ, Ana , ANIGBOGU, Angela
IPC分类号： A61F13/00 , A61K9/70 , A61K31/56 , A61K31/565 , A61K31/567
CPC分类号： A61K9/7061 , A61K31/56 , A61K31/565 , A61K31/567
摘要： Sustained delivery formulations of norethindrone are disclosed and described. In one aspect, the formulation may be a transdermal formulation that includes both norethindrone and norethindrone acetate. In another aspect, the formulation may further include a penetration enhancer. Coadministration of norethindrone and norethindrone acetate has been found to provide a number of advantages, such as achievement of peak norethindrone serum levels substantially within 24 hours after initiation of administration.
摘要翻译：公开和描述炔诺酮的持续递送制剂。一方面，制剂可以是包括炔诺酮和醋酸炔诺酮二者的透皮制剂。在另一方面，制剂还可包含渗透增强剂。已经发现炔诺酮和醋酸炔诺酮的共同施用提供了许多优点，例如在开始给药后24小时内达到顶点炔诺酮血清水平。

2. 发明申请

WO2005024384A3 DEVICES AND METHODS FOR SEPARATING PHOSPHOLIPIDS FROM BIOLOGICAL SAMPLES 审中-公开
公开(公告)号：WO2005024384A3
公开(公告)日：2005-03-17
申请号：PCT/US2004/029207
申请日：2004-09-07
申请人： TANDEM LABS , BENNETT, Patrick, Kevin , VAN HORNE, Kenneth, Charles
发明人： BENNETT, Patrick, Kevin , VAN HORNE, Kenneth, Charles
IPC分类号： G01N33/92 , G01N1/18 , C12M1/34
摘要： Device and methods for the removal of phospholipids from biological samples are disclosed and described. Removal of phospholipids may be desirable for the analysis of the phospholipids themselves, or to prevent the phospholipids from conflicting with and effectively masking other analytes in the sample for which identification or quantification is sought.

3. 发明申请

WO2004102154A2 SYSTEMS AND METHODS FOR MEASURING FLUID PROPERTIES 审中-公开
标题翻译：用于测量流体特性的系统和方法
公开(公告)号：WO2004102154A2
公开(公告)日：2004-11-25
申请号：PCT/US2004/014247
申请日：2004-05-06
申请人： THROMBODYNE, INC. , ZHENG, Yu , SUKAVANESHVAR, Sivaprasad , THEKKEDATH, Ramachandran
发明人： ZHENG, Yu , SUKAVANESHVAR, Sivaprasad , THEKKEDATH, Ramachandran
IPC分类号： G01N
CPC分类号： G01N15/0205 , B01F7/00491 , B01F7/26 , B01F7/28 , B01F11/0071 , B01F15/00915 , G01N11/14 , G01N33/4905 , G01N33/86 , G01N2015/0092 , Y10T436/117497
摘要： A method for measuring properties of a fluid including placing a quantity of fluid in a container; inducing flow in the fluid wherein the flow is substantially streamlined in at least a measuring region of the container, and wherein the fluid is recirculated through the measuring region; creating a mixing region separate from the measuring region sufficient to substantially mix the fluid; and measuring a property of the fluid in the streamlined region. The invention is of particular interest in the assessment of blood platelet function. The method provides specific localized regions of thorough mixing that enable reproducible platelet aggregation, and also provides specific localized regions of streamlined flow that enable certain modalities of assessing aggregation. Both of these regions of flow are induced such that damage to platelet aggregates and other blood components is minimized.
摘要翻译：一种用于测量流体性质的方法，包括将一定量的流体放置在容器中; 在流体中引起流动，其中流体在容器的至少一个测量区域中基本上流线型化，并且其中流体通过测量区域再循环; 产生与足以使流体基本混合的测量区域分开的混合区域; 并测量流线型区域中的流体的性质。本发明特别关注血小板功能的评估。该方法提供了完全混合的特定局部区域，使得可重现的血小板聚集，并且还提供流线型流的特定局部区域，其使得能够进行某些评估聚集的方式。诱导这两个流动区域使得血小板聚集体和其他血液成分的损伤最小化。

4. 发明申请

WO2004053459A2 COMPOUNDS AND MEHTODS OF USE THEREOF FOR ASSAYING LYSOPHOSPHOLIPASE D ACTIVITY 审中-公开
标题翻译：用于测定赖氨酸磷脂酶活性的化合物及其用途
公开(公告)号：WO2004053459A2
公开(公告)日：2004-06-24
申请号：PCT/US2003/039279
申请日：2003-12-10
申请人： ECHELON BIOSCIENCES INCORPORATED , FERGUSON, Colin , PRESTWICH, Glenn
发明人： FERGUSON, Colin , PRESTWICH, Glenn
IPC分类号： G01N
CPC分类号： G01N33/689 , C07F9/65522 , C07F9/6596 , C12Q1/34 , G01N33/542 , G01N33/57407 , G01N2333/918
摘要： Fluorogenic lysophosphatidic acid derivatives which can be used as substrates in a continuous, fluorogenic assay that can be performed in microtiter plates. The assays permit measuring LysoPLD activity levels in normal events such as pregnancy or disease states such as cancer. In addition, the present invention can be adopted to high throughout screening(HTS) for identification of potential inhibitors of lysoPLD activity.
摘要翻译：荧光生成的溶血磷脂酸衍生物，可在连续荧光测定中用作底物，可在微量滴定板中进行。该测定允许在正常事件如妊娠或疾病状态如癌症中测量LysoPLD活性水平。此外，本发明可以用于高度整体筛选（HTS），用于鉴定潜在的溶菌酶活性抑制剂。

5. 发明申请

WO2004041187A2 COMPOSITIONS AND METHODS FOR TRANSDERMAL OXYBUTYNIN THERAPY 审中-公开
标题翻译：用于超氧氧自由基治疗的组合物和方法
公开(公告)号：WO2004041187A2
公开(公告)日：2004-05-21
申请号：PCT/US2003/034653
申请日：2003-10-31
申请人： WATSON PHARMACEUTICALS, INC. , SANDERS, Steven, W. , EBERT, Charles, D.
发明人： SANDERS, Steven, W. , EBERT, Charles, D.
IPC分类号： A61K
CPC分类号： A61K9/7061 , A61K9/0014 , A61K9/0024 , A61K9/1647 , A61K31/216 , A61K47/10 , A61K47/14 , A61K47/38 , A61K2300/00
摘要： The present invention provides compositions and methods for administering oxybutynin while minimizing the incidence and or severity of adverse drug experiences associated with oxybutynin therapy. In one aspect, these compositions and methods provide a lower plasma concentration of oxybutynin metabolites, such as N-desethyloxybutynin, which is presumed to be contributing at least in part to some of the adverse drug experiences, while maintaining sufficient oxybutynin plasma concentration to benefit a subject with oxybutynin therapy. The invention also provides isomers of oxybutynin and its metabolites that meet these characteristics of minimized incidence and/or severity of adverse drug experiences, and maintenance of beneficial and effective therapy for overactive bladder.
摘要翻译：本发明提供了用于奥昔布宁的组合物和方法，同时最小化与奥昔布宁治疗相关的不良药物经历的发生率和/或严重程度。在一个方面，这些组合物和方法提供了较低的奥昔布宁代谢物的血浆浓度，例如N-去乙氧基丁啶，其被推定为至少部分地促成一些不良药物经历，同时保持足够的奥昔布宁血浆浓度以有益于奥昔布宁治疗。本发明还提供了符合以下特征的奥昔布宁及其代谢物的异构体，这些特征使不良药物经历的发生率和/或严重程度最小化，以及维持膀胱活动过度活动的有益和有效治疗。

6. 发明申请

WO2003101461A1 NORETHINDRONE SUSTAINED RELEASE FORMULATIONS AND METHODS ASSOCIATED THEREWITH 审中-公开
标题翻译： NORELHINDRONE可持续发布的配方和方法相关
公开(公告)号：WO2003101461A1
公开(公告)日：2003-12-11
申请号：PCT/US2003/016933
申请日：2003-05-30
申请人： WATSON PHARMACEUTICALS, INC. , ANIGBOGU, Angela , QUAN, Danyi , RUIZ, Anna
发明人： ANIGBOGU, Angela , QUAN, Danyi , RUIZ, Anna
IPC分类号： A61K31/56
CPC分类号： A61K9/7061 , A61K31/56 , A61K31/565 , A61K31/567
摘要： Sustained delivery formulations of norethindrone are disclosed and described. In one aspect, the formulation may be a transdermal formulation that includes both norethindrone and norethindrone acetate. In another aspect, the formulation may further include a penetration enhancer. Coadministration of norethindrone and norethindrone acetate has been found to provide a number of advantages, such as achievement of peak norethindrone serum levels substantially within 24 hours after initiation of administration.
摘要翻译：公开和描述炔诺酮的持续递送制剂。一方面，制剂可以是包括炔诺酮和醋酸炔诺酮两者的透皮制剂。在另一方面，制剂还可包含渗透增强剂。已经发现炔诺酮和醋酸炔诺酮的共同施用提供了许多优点，例如在开始给药后24小时内达到顶点炔诺酮血清水平。

7. 发明申请

WO2003061610A1 ANTIMICROBIAL AND SPORICIDAL COMPOSITION 审中-公开
标题翻译：抗微生物和杀菌组合物
公开(公告)号：WO2003061610A1
公开(公告)日：2003-07-31
申请号：PCT/US2003/001598
申请日：2003-01-17
申请人： WALKER, Edward, B.
发明人： WALKER, Edward, B.
IPC分类号： A61K7/00
CPC分类号： A61K8/347 , A01N33/12 , A61K8/416 , A61K8/44 , A61K2800/51 , A61K2800/522 , A61Q17/00 , A01N37/24
摘要： Germicidal compositions with enhanced activity towards killing microbiolical spores and vetgetative cells comprising certain quaternary ammonium compounds (QACs), phenolic compounds, monohydric alcohols, hydrogen peroxide, iodeine, triclocarban, triclosan or combinations thereof with one or more spore coat opening agents. The invention also provides for the application of the germicidal compositions to animate and inanimate surfaces to help kill germs and protect against the risk of infection from bacteria, molds, yeasts, fungi, viruses, and microbiological spores.
摘要翻译：包含某些季铵化合物（QAC），酚类化合物，一元醇，过氧化氢，碘代，三氯沙坦，三氯生或其与一种或多种孢子涂层开放剂的组合的杀死微生物孢子和微生物细胞的活性增强的杀菌组合物。本发明还提供杀菌组合物在动画和无生命表面上的应用，以帮助杀死细菌并防止细菌，霉菌，酵母，真菌，病毒和微生物孢子感染的风险。

8. 发明申请

WO2005120473A2 ADHESIVE PEEL-FORMING FORMULATIONS FOR DERMAL DELIVERY OF DRUGS AND METHODS OF USING THE SAME 审中-公开
标题翻译：用于药物递送的胶粘剂成型制剂及其使用方法
公开(公告)号：WO2005120473A2
公开(公告)日：2005-12-22
申请号：PCT/US2005/020099
申请日：2005-06-07
申请人： ZARS, INC. , ZHANG, Jie , WARNER, Kevin, S. , ASHBURN, Michael, A. , RIGBY, Larry, D. , NIU, Suyi
发明人： ZHANG, Jie , WARNER, Kevin, S. , ASHBURN, Michael, A. , RIGBY, Larry, D. , NIU, Suyi
IPC分类号： A61K9/70
CPC分类号： A61K9/7015 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/445 , A61K31/573 , A61K47/10 , A61K47/32
摘要： The present invention is drawn to adhesive peel-forming formulations for dermal delivery of a drug. The formulation can include a drug, a solvent vehicle, and a peel-forming agent. The solvent vehicle can include a volatile solvent system having one or more volatile solvent, and a non-volatile solvent system having one or more non-volatile solvent, wherein the non-volatile solvent system has a solubility for the drug that is within a window of operable solubility for the drug such that the drug can be delivered at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified peelable layer after at least a portion of the volatile solvent system is evaporated.
摘要翻译：本发明涉及用于药物真皮递送的粘合剂剥离形成制剂。制剂可以包括药物，溶剂载体和剥离形成剂。溶剂载体可以包括具有一种或多种挥发性溶剂的挥发性溶剂体系和具有一种或多种非挥发性溶剂的非挥发性溶剂体系，其中所述非挥发性溶剂体系对于在窗口内的药物具有溶解性对药物具有可操作的溶解性，使得药物可以在持续的时间段内以治疗有效的速率递送。在挥发性溶剂体系蒸发之前，配方可以具有适用于皮肤表面的粘度。当施用于皮肤时，在挥发性溶剂体系的至少一部分蒸发之后，制剂可以形成固化的可剥离层。

9. 发明申请

WO2005081742A2 TESTOSTERONE ORAL DOSAGE FORMULATIONS AND ASSOCIATED METHODS 审中-公开
标题翻译： TESTOSTERONE口服剂量配方及相关方法
公开(公告)号：WO2005081742A2
公开(公告)日：2005-09-09
申请号：PCT/US2005/001047
申请日：2005-01-10
申请人： WATSON LABORATORIES, INC. , EBERT, Charles
发明人： EBERT, Charles
IPC分类号： A61K9/20 , A61K31/568
CPC分类号： A61K9/2031 , A61K31/568
摘要： Solid oral dosage forms of testosterone and methods for the preparation thereof are disclosed and described. The solid oral dosage form may include a therapeutically effective amount of testosterone in a substantially solid polyethylene glycol carrier. Such a form has been found to alleviate many of the undesirable consequences of undergoing testosterone therapy, such as the pain of injections and problems with patient noncompliance.
摘要翻译：公开和描述了固体口服剂型睾酮及其制备方法。固体口服剂型可包括在基本上固体的聚乙二醇载体中治疗有效量的睾丸激素。已经发现这种形式减轻了经历睾丸激素治疗的许多不期望的后果，例如注射疼痛和患者不合规的问题。

10. 发明申请

WO2005011914A2 SUPERABRASIVE WIRE SAW AND ASSOCIATED METHODS OF MANUFACTURE 审中-公开
标题翻译：超级线和相关的制造方法
公开(公告)号：WO2005011914A2
公开(公告)日：2005-02-10
申请号：PCT/US2004/025428
申请日：2004-07-22
申请人： SUNG, Chien-Min
发明人： SUNG, Chien-Min
IPC分类号： B24B
CPC分类号： B23D61/185 , B28D1/124
摘要： A superabrasive wire saw having a plurality of individual coated superabrasive particles (14) attached to a wire (10) with an organic binder (42) is disclosed and described. The superabrasive particle (46) can be coated with a solidified coating (48) of a molten braze alloy that is chemically bonded to the superabrasive particle (46). The organic binder ( 42) can optionally contain filler materials and/or an organometallic coupling agent to improve the retention of coated superabrasive particles (14). The resulting superabrasive wire saws (28) can be produced having diameters of less than 0.5 mm, which significantly reduce kerf loss. Various methods for making and using such a superabrasive wire saw are additionally disclosed and described.
摘要翻译：公开并描述了具有多个附着在有机粘合剂（42）的导线（10）上的单独涂覆的超级磨料颗粒（14）的超级磨料钢丝锯。超研磨颗粒（46）可以涂覆有化学键合到超研磨颗粒（46）的熔融钎焊合金的固化涂层（48）。有机粘合剂（42）可任选地含有填料和/或有机金属偶联剂，以改善涂层超级磨料颗粒（14）的保留性。可以制造出直径小于0.5mm的所得超细金属丝锯（28），从而显着降低切口损失。另外公开和描述了用于制造和使用这种超级磨料线锯的各种方法。

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