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1. 发明申请

WO2023055799A2 METHOD TO CONDUCT POLYMERASE CHAIN REACTION AMPLIFICATION OF BIOLOGICAL SAMPLE WITHOUT NUCLEIC ACIDS ISOLATION 审中-公开
公开(公告)号：WO2023055799A2
公开(公告)日：2023-04-06
申请号：PCT/US2022/045036
申请日：2022-09-28
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
发明人： SUGAYA, Kiminobu , MANJUSHA, Vaidya
IPC分类号： C12Q1/686 , C12M1/36 , C12P19/34 , C12Q1/6806
摘要： Disclosed is a method to amplified nucleic acids by polymerase chain reaction (PCR) without isolation or purification from the biological samples. All the reactions associated with reverse transcriptase qPCR or real-time qPCR are completed on a filter paper chamber using a handheld Real-time PCR device. The process requires a very small amount of sample since there is no loss of materials associated with isolation and purification steps. The amplification process is faster than a normal tube-based PCR reaction because the thin chamber makes heating and cooling process fast. This technique is applicable in the rapid detection of pathogenic viruses from body fluids, such as COVID-19 detection in saliva. The technology is valuable for quantitative detection of nucleic acids that are established markers of diseases. Novel use of a piece of filter paper to perform sample collection, storage, and conduct direct PCR amplification without any extraction of the sample will allow us to test infections and the diseases anywhere by anybody without the requirement of technical knowledge or skills.

2. 发明申请

WO2023039467A1 MEDICAL CLAMP HAVING A BLADE 审中-公开
公开(公告)号：WO2023039467A1
公开(公告)日：2023-03-16
申请号：PCT/US2022/076104
申请日：2022-09-08
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. , ORLANDO HEALTH INC. , SWANA, Hubert , HANNA, Riham, M. , GOMEZ, Evan, C.
发明人： HARTMANN, Thomas , SONG, Sang-Eun
IPC分类号： A61B17/28 , A61B17/326 , A61B17/122
摘要： A medical instrument may include a first elongated arm and a second elongated arm, the first elongated arm and the second elongated arm being coupled at a pivot joint. Thus, pivoting of the first elongated arm relative to the second elongated arm about the pivot joint causes a distal end of the first elongated arm to move relative to a distal end of the second elongated arm. A blade may be fixed to the distal end of at least one of the first elongated arm and the second elongated arm such that the blade moves when the respective elongated arm pivots.

3. 发明申请

WO2023019124A1 METHOD TO PRESERVE NUCLEIC ACIDS IN WATER SAMPLES 审中-公开
公开(公告)号：WO2023019124A1
公开(公告)日：2023-02-16
申请号：PCT/US2022/074690
申请日：2022-08-09
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
发明人： MOORE, Sean
IPC分类号： A01N1/02 , C12N15/10 , C12Q1/68
摘要： Numerous fields of basic research, medicine, and technology require an understanding of the biological composition and diversity in water samples. A common approach to acquiring such information is to collect samples 'in the field' and to subsequently extract nucleic acids in a laboratory for sequence analyses. A challenge to this pipeline is the preservation of the abundance and quality of the nucleic acids present in and around the organisms because, once a sample is harvested, it is no longer connected to the environment that established it. Many organisms, particularly microbes, rapidly adapt to such environmental changes and the relative abundance and quality of nucleic acids within them can change in a manner of minutes. A common methodology intended to address this problem is to filter the water to collect microorganisms on site and then to store the filters in a frozen state until they are processed. This technique creates several problems: the filter systems are expensive, require a vacuum, and are cumbersome to operate; the microbes change their metabolisms as they are filtered; freezing the samples requires substantial infrastructure at the collection site and during transport; and freezing and thawing many organisms causes their cells to break open, which releases their nucleic acids. The disclosed invention circumvents these problems by allowing microorganisms and their nucleic acids to be rapidly preserved on site using simple collection vessels, without the need for refrigeration or freezing. The methodology allows for the subsequent recovery and processing of nucleic acids for downstream molecular analyses. Although the current embodiment was developed for sea water collection, it can be also be applied to other aqueous samples

4. 发明申请

WO2022169476A1 APPARATUS AND METHOD TO FACILITATE COMMUNICATION BETWEEN HORSE AND RIDER 审中-公开
公开(公告)号：WO2022169476A1
公开(公告)日：2022-08-11
申请号：PCT/US2021/035339
申请日：2021-06-02
申请人： LAUGHING HORSE INNOVATIONS, LLC
发明人： GUENTHAL, Marcus , ZUNIGA, Alejandro, Francisco Valdivia
IPC分类号： B68B3/04 , B68B1/00 , B68B1/04 , B68B3/06 , B68B3/14 , B68B5/06
摘要： An apparatus and method are provided to facilitate horse riding. The apparatus includes a line that defines an opening sized to receive a head of the horse. The apparatus also includes one or more tips operatively connected to the line and oriented inward from the line into the opening. Upon positioning the head of the horse through the opening the one or more tips are positioned to engage a body of the horse. The method includes providing the apparatus and passing, the opening defined by the line, over the head of the horse. The method also includes passing, the rein, through openings defined by rings that are operatively connected to the line. The method also includes actuating the line to engage the horse to facilitate movement of the horse.

5. 发明申请

WO2021226042A1 BIOMARKERS FOR ASSESSING LIVER DISEASE 审中-公开
公开(公告)号：WO2021226042A1
公开(公告)日：2021-11-11
申请号：PCT/US2021/030599
申请日：2021-05-04
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
发明人： KHODAYARI, Nazli , BRANTLY, Mark, Louis , CLARK, Virginia
IPC分类号： A61K9/127 , C12Q1/68 , G01N33/50 , G01N33/53 , G01N33/68
摘要： Disclosed herein is a method for detecting liver disease in a patient. Also, disclosed are methods of isolating EVs derived from hepatocytes. Methods of assessing effectiveness of liver therapies are also disclosed. Methods involve isolating or otherwise obtaining EVs derived from hepatocytes and analyzing the content of the EVs.

6. 发明申请

WO2021222779A1 DISPENSABLE NANOPARTICLE BASED COMPOSITION FOR DISINFECTION 审中-公开
公开(公告)号：WO2021222779A1
公开(公告)日：2021-11-04
申请号：PCT/US2021/030221
申请日：2021-04-30
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. , KISMET TECHNOLOGIES LLC
发明人： SEAL, Sudipta , NEAL, Craig , DRAKE, Christina Hartsell
IPC分类号： A01N25/00 , A01N59/16 , A61L2/16 , A61L2/26
摘要： Disclosed herein are rapid and residual disinfectant compositions that include a metal-associated cerium oxide nanoparticles. Also disclosed are methods of making disinfectant compositions. Films comprising the disclosed compositions are also disclosed as well as methods of disinfecting a surface.

7. 发明申请

WO2021221784A2 CIRCULAR BIFUNCTIONAL APTAMERS AND TRIFUNCTIONAL APTAMERS TARGETING TAU 审中-公开
公开(公告)号：WO2021221784A2
公开(公告)日：2021-11-04
申请号：PCT/US2021/020322
申请日：2021-03-01
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED , GRYPHON BIO THERAPEUTICS, INC.
发明人： WANG, Kevin K-Wang , LI, Xiaowei , TAN, Weihong , WANG, Bang , HASKINS, William
IPC分类号： C12N15/11 , C12N15/115 , C12N2310/16 , C12N2310/3513 , C12N2310/3517 , C12N2310/3519 , C12N2310/51 , C12N2310/532
摘要： The lack of blood-brain barrier (BBB) penetrating ability has hindered the delivery of many therapeutic agents for tauopathy therapeutic treatment. A circular bifunctional aptamer reported here has been able to enhance the in vivo BBB penetration for improved therapy. The circular aptamer includes one transferrin receptor (TfR) aptamer to facilitate TfR-aptamer recognition-induced transcytosis across BBB endothelial cells, and one Tau protein aptamer selected to inhibit Tau phosphorylation and other tauopathy-related pathological events in the brain. This bispecific construct exhibits strong specificity towards Tau and enhanced plasma stability in comparison to linear Tau aptamer. In vivo administration of circular Tau-TfR aptamer results in a rapid uptake into relevant brain regions after crossing the BBB, such as hippocampus and cortex. A Y-shaped trispecific aptamer including one aptamer for L1CAM, one aptamer for Tau and one aptamer for TfR reported here has enhanced BBB and neuron cell membrane permeation. Bispecific and trispecific Tau aptamer coupled to a signaling moiety (such as dodecane tetraacetic acid (DOTA) or DOTA complexed to Gd+3) for neuroimaging, and bispecific or trispecific Tau aptamer coupled to protein aggregate binding moiety (such as methylene blue) for enhanced ability to disrupt tau aggregation are also contemplated in this invention.

8. 发明申请

WO2021127649A1 RENAL REPLACEMENT THERAPY MACHINE 审中-公开
公开(公告)号：WO2021127649A1
公开(公告)日：2021-06-24
申请号：PCT/US2020/066453
申请日：2020-12-21
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
发明人： HATAMIZADEH, Parta
IPC分类号： A61M1/14
摘要： A renal replacement apparatus (100), having a hemofilter (108); an extracorporeal blood circuit (102) configured to communicate blood from a patient (104), through the hemofilter, and back to the patient; and a flow measuring device (150) configured to measure at least one blood flow property as the blood is leaving the hemofilter and before the blood returns to the patient at a flow measuring device location (152), wherein the flow measuring device comprises at least one of a viscometer and a rheometer. Alternately, or in addition, the renal replacement apparatus may include thermomodulator system (222) including at least one thermomodulator configured to selectively heat and cool the blood in the extracorporeal blood circuit. The renal replacement apparatus (100) may have a controller (160). The controller may use artificial intelligence. Other embodiments are described herein.

9. 发明申请

WO2021022248A2 METHOD AND APPARATUS FOR ENHANCING OPERATION OF LEG PROSTHESIS 审中-公开
公开(公告)号：WO2021022248A2
公开(公告)日：2021-02-04
申请号：PCT/US2020/044726
申请日：2020-08-03
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
发明人： CHOI, Hwan , CARBONELL, Gabriel Rios
IPC分类号： A61F2/60 , A61F2/66 , A61H1/02 , A61F2/08
摘要： A method and apparatus for enhancing the operation of leg prothesis is provided. The apparatus includes a cable configured to be attached to the leg prosthesis worn by a subject to move through a plurality of gait phases. The apparatus also includes a module configured to be mounted to the leg prosthesis. The module includes a tension spring configured to engage the cable to maintain tension in the cable. The module also includes a locking mechanism configured to lock a position of the tension spring and maintain a length of the cable defined between the module and the leg prosthesis during at least one first gait phase of the plurality of gait phases. The locking mechanism is further configured to unlock the position of the tension spring to permit variation of the length of the cable during at least one second gait phase of the plurality of gait phases.

10. 发明申请

WO2020247911A1 DENTAL IMPLANT ABUTMENT 审中-公开
公开(公告)号：WO2020247911A1
公开(公告)日：2020-12-10
申请号：PCT/US2020/036602
申请日：2020-06-08
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
发明人： ESTELLE, Abigail , SCHARE, Howard , SALMAN, Salam, Omar , FERNANDES, Rui, P.
IPC分类号： A61C8/00
摘要： Disclosed herein unique dental implant abutment comprising one or more through channels. The dental abutments typically include a body portion; a plurality of cooperative apertures disposed within the body portion; a shank portion functionally coupled with the body portion; and a threaded portion functionally coupled with the shank portion. Also disclosed are methods of using dental implant abutments for various dental related surgeries.

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