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1. 发明申请

WO2019068018A3 RECOMBINANT COLLAGEN AND ELASTIN MOLECULES AND USES THEREOF 审中-公开
公开(公告)号：WO2019068018A3
公开(公告)日：2019-04-04
申请号：PCT/US2018/053601
申请日：2018-09-28
申请人： GELTOR, INC.
发明人： OUZOUNOV, Nikolay , LORESTANI, Alexander , BHATIA, Monica
IPC分类号： A61K38/39
摘要： This disclosure provides non-naturally occurring collagen and elastin molecules. The non-naturally occurring collagens and elastins include truncated collagens, truncated elastins, as well as fusion proteins thereof. The non-naturally occurring collagen and elastin are useful in foods, cosmetics and many other products and uses.

2. 发明申请

WO2007084786A1 PYRIMIDINE DERIVATIVES USED AS PI-3 KINASE INHIBITORS 审中-公开
标题翻译：用作PI-3激酶抑制剂的吡嗪衍生物
公开(公告)号：WO2007084786A1
公开(公告)日：2007-07-26
申请号：PCT/US2007/001708
申请日：2007-01-22
申请人： NOVARTIS AG , BURGER, Matthew , NI, Zhi-jie , PECCHI, Sabina , ATALLAH, Gordana , BARTULLIS, Sarah , FRAZIER, Kelly , SMITH, Aaron , VERHAGEN, Joelle , ZHANG, Yanchen , WAGMAN, Allan , NG, Simon , PFISTER, Keith , POON, Daniel , LOUIE, Alicia
发明人： BURGER, Matthew , NI, Zhi-jie , PECCHI, Sabina , ATALLAH, Gordana , BARTULLIS, Sarah , FRAZIER, Kelly , SMITH, Aaron , VERHAGEN, Joelle , ZHANG, Yanchen , WAGMAN, Allan , NG, Simon , PFISTER, Keith , POON, Daniel , LOUIE, Alicia , PICK, Teresa , BARSANTI, Paul , IWANOWICZ, Edwin , FANTL, Wendy , HENDRYCKSON, Tom , KNAPP, Mark , MERITT, Hanne , VOLIVA, Charles , WIESMANN, Marion , XIN, Xiahua
IPC分类号： C07D401/04 , C07D401/14 , C07D405/12 , C07D405/14 , C07D417/12 , A61K31/506 , A61P35/00
CPC分类号： C07D401/04 , C07D401/14 , C07D405/12 , C07D405/14 , C07D417/12
摘要： Phosphatidylinositol (PI) 3-kinase inhibitor compounds (I), their pharmaceutically acceptable salts, and prodrugs thereof ; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.
摘要翻译：磷脂酰肌醇（PI）3-激酶抑制剂化合物（I），其药学上可接受的盐和前药; 单独或与至少一种另外的治疗剂组合的新化合物与药学上可接受的载体的组合物; 以及单独或与至少一种另外的治疗剂组合的新化合物在预防或治疗以生长因子，蛋白质丝氨酸/苏氨酸激酶和磷脂激酶异常活性为特征的增殖性疾病中的用途。

3. 发明申请

WO2019126778A1 NEPETALACTOL OXIDOREDUCTASES, NEPETALACTOL SYNTHASES, AND MICROBES CAPABLE OF PRODUCING NEPETALACTONE 审中-公开
公开(公告)号：WO2019126778A1
公开(公告)日：2019-06-27
申请号：PCT/US2018/067333
申请日：2018-12-21
申请人： ZYMERGEN INC.
发明人： WAWRZYN, Grayson , ROCHE, Christine , WESTFALL, Patrick , LAU, Warren , GANESAN, Savita , MCSORLEY, Fern , SERBER, Zach
IPC分类号： C07D311/94
CPC分类号： C07D311/94 , C12N1/20 , C12N9/0006 , C12N9/001 , C12N15/52 , C12P5/007 , C12P17/06 , C12Y101/01 , C12Y101/01324 , C12Y103/01
摘要： The present disclosure provides isolated nepetalactone oxidoreductase polypeptides (NORs), nepetalactol synthases (NEPSs), and related polynucleotides, engineered host cells, and cultures, as well as methods for producing NORs and NEPSs, and for using them to produce nepetalactol, nepetalactone, and dihydronepetalactone. The present disclosure also provides methods for engineering cells (e.g., microbial cells) to produce nepetalactone from a fermentation substrate such as glucose, as well as engineered cells having this capability and related cultures and methods for producing nepetalactone.

4. 发明申请

WO2018005856A1 FEED INGREDIENTS COMPRISING LYSED MICROBIAL CELLS 审中-公开
标题翻译：含有裂解微生物细胞的饲料成分
公开(公告)号：WO2018005856A1
公开(公告)日：2018-01-04
申请号：PCT/US2017/040087
申请日：2017-06-29
申请人： TERRAVIA HOLDINGS, INC.
发明人： RAKITSKY, Walter , PIECHOCKI, John , LU, Wenhua
IPC分类号： A23K10/00 , A23K10/16 , A23K10/18 , A23K10/20 , A23K10/22
摘要： The present disclosure relate to feed ingredients and formulated feed, methods for their manufacture, and uses thereof in nutritional applications such as in aquaculture, terrestrial animal feed, and human nutrition. The feed ingredient compositions comprise lysed microbial cells with a small aspect ratio and triglyceride oil.
摘要翻译：本公开涉及饲料成分和配制的饲料，它们的制造方法，以及其在营养应用中的用途，例如在水产养殖，陆生动物饲料和人类营养中的用途。饲料成分组合物包含具有小纵横比的溶解的微生物细胞和甘油三酯油。

5. 发明申请

WO2007120160A2 COMPOSITIONS AND METHODS FOR VIRAL INHIBITION 审中-公开
标题翻译：用于病毒抑制的组合物和方法
公开(公告)号：WO2007120160A2
公开(公告)日：2007-10-25
申请号：PCT/US2006/023555
申请日：2006-06-16
申请人： NOVARTIS AG , BARSANTI, Paul , BRAMMIER, Nathan , CHANG, Bryan , NI, Zhi-jie , WANG, Weibo , WEINER, Amy
发明人： BARSANTI, Paul , BRAMMIER, Nathan , CHANG, Bryan , NI, Zhi-jie , WANG, Weibo , WEINER, Amy
IPC分类号： A61K31/55
CPC分类号： C07D223/12 , C07D211/74 , C07D281/10 , C07D401/12 , C07D405/12 , C07D417/12
摘要： The present invention discloses novel methods and compositions for viral inhibition, particularly inhibition of HCV and SARS. The invention also provides compositions including novel oxoazepanylacetamide derivatives useful for viral inhibition.
摘要翻译：本发明公开了用于病毒抑制，特别是HCV和SARS抑制的新方法和组合物。本发明还提供了包含用于病毒抑制的新的氧氮杂基乙酰胺衍生物的组合物。

6. 发明申请

WO2007053415A2 AGENTS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS 审中-公开
标题翻译：用于治疗心律失常的药物
公开(公告)号：WO2007053415A2
公开(公告)日：2007-05-10
申请号：PCT/US2006/041749
申请日：2006-10-24
申请人： NOVARTIS VACCINES AND DIAGNOSTICS INC. , CROSS, Maurice, Robert , TERRAR, Derek, Anthony
发明人： CROSS, Maurice, Robert , TERRAR, Derek, Anthony
CPC分类号： A61K31/16 , A61K31/19 , A61K31/194 , A61K31/215 , A61K31/4418 , A61K31/496 , A61K31/4985 , A61K31/513 , A61K31/5377
摘要： The present invention provides a method of treating a subject suffering from a cardiac arrhythmia comprising contacting an effective amount of dexrazoxane or a pharmaceutically acceptable salt, analog, tautomer, or stereoisomer thereof with a cell.
摘要翻译：本发明提供治疗患有心律失常的受试者的方法，包括使有效量的右雷佐生或其药学上可接受的盐，类似物，互变异构体或立体异构体与细胞接触。

7. 发明申请

WO2006022718A1 AKT3 COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译： AKT3组合物和使用方法
公开(公告)号：WO2006022718A1
公开(公告)日：2006-03-02
申请号：PCT/US2004/026569
申请日：2004-08-13
申请人： CHIRON CORPORATION , BUSSIERE, Dirksen , FANG, Eric , MURRAY, Jeremy
发明人： BUSSIERE, Dirksen , FANG, Eric , MURRAY, Jeremy
IPC分类号： C12N9/12
CPC分类号： C12N9/1205 , C07K2299/00
摘要： The present invention relates to the compositions, crystals, and the three dimensional structures of Akt3 and its mutants, to methods for forming the crystals, and to methods for using the three dimensional structures to design and identify therapeutic compounds for the treatment of Akt3 mediated diseases.
摘要翻译：本发明涉及Akt3及其突变体的组成，晶体和三维结构，形成晶体的方法，以及使用三维结构设计和鉴定用于治疗Akt3介导的疾病的治疗化合物的方法。

8. 发明申请

WO2017058802A1 TRIGLYCERIDE OILS HAVING ASYMMETRIC TRIGLYCERIDE MOLECULES 审中-公开
标题翻译：具有不对称TRIGLYCERIDE分子的TRIGLYCERIDE油
公开(公告)号：WO2017058802A1
公开(公告)日：2017-04-06
申请号：PCT/US2016/053979
申请日：2016-09-27
申请人： TERRAVIA HOLDINGS, INC.
发明人： RAKITSKY, Walter
IPC分类号： C12P7/64 , C12N9/24 , C11C3/12
CPC分类号： C12P7/6463 , C11B7/0058 , C11B7/0075 , C11C1/045 , C11C3/12 , C11C3/123
摘要： Triglyceride oils having one or more populations of asymmetric triglyceride molecules are provided. Asymmetric triglyceride molecule populations are triglyceride molecules that consist of a C8:0 fatty acid or a C10:0 fatty acid at the sn-1 position and the sn-2 position, and C16:0 or C18:0 at the sn-3 position. Another population of asymmetric triglyceride molecules are triglyceride molecules that consist of a C16:0 fatty acid or a C18:0 fatty acid at the sn-1 position and the sn-2 position, and C8:0 or C10:0 fatty acid at the sn-3 position. Methods of producing triglyceride oils and using the same are provided using sucrose invertase and hydrogenation of the triglyceride oil. Triglyceride molecules are produced by using recombinant DNA techniques to produce oleaginous recombinant cells.
摘要翻译：提供了具有一个或多个不对称甘油三酯分子群体的甘油三酯油。不对称甘油三酯分子群体是在sn-1位置和sn-2位置由C 8：0脂肪酸或C 10：0脂肪酸组成的甘油三酯分子，在sn-3位置由C16：0或C18：0组成。不对称甘油三酯分子的另一群体是甘油三酯分子，其由sn-1位置和sn-2位置处的C16：0脂肪酸或C18：0脂肪酸组成，C8：0或C10：0脂肪酸在 sn-3位置。使用蔗糖转化酶和甘油三酯油的氢化制备甘油三酯油并使用其的方法。通过使用重组DNA技术产生含油重组细胞产生甘油三酯分子。

9. 发明申请

WO2007062076A3 DEXRAZOXANE FORMULATIONS AND METHODS 审中-公开
公开(公告)号：WO2007062076A3
公开(公告)日：2007-05-31
申请号：PCT/US2006/045125
申请日：2006-11-20
申请人： NOVARTIS AG , OKHAMAFE, Augustus , HORA, Mininder , FAKES, David , WEI, Rebecca , DANI, Bhas , HASHASH, Ahmad
发明人： OKHAMAFE, Augustus , HORA, Mininder , FAKES, David , WEI, Rebecca , DANI, Bhas , HASHASH, Ahmad
IPC分类号： A61K31/495 , A61K9/19 , A61P31/00
摘要： Improved formulations of dexrazoxane for making injectable solutions in a clinical setting are provided. In some embodiments, high pH formulations are provided to reduce or eliminate pain upon injection. According to various embodiments, dexrazoxane may be formulated as a lyophilized or non-lyophilized acid salt or as a lyophilized or non-lyophilized free base. In some embodiments, dexrazoxane is provided as a sterile dry milled powder of a free base or an isolated acid salt crystal. Formulations that require significantly reduced clinical preparation time are provided. Single-container presentations of unit doses of dexrazoxane are also provided. The formulations of the present invention may be provided in a vial, infusion bottle or infusion bag. In some embodiments, the container may be directly attachable to a diluent-containing container for easy preparation. In other embodiments, diluent may be added directly to the container. Improved methods of manufacturing dexrazoxane that allow greater processing latitude are also provided.

10. 发明申请

WO2019099561A1 TEXTILE COMPRISING SILANIZED SYMBIOTIC CULTURE OF BACTERIA AND YEAST 审中-公开
公开(公告)号：WO2019099561A1
公开(公告)日：2019-05-23
申请号：PCT/US2018/061111
申请日：2018-11-14
申请人： GELTOR, INC.
发明人： OUZOUNOV, Nikolay , ACHACOSO, Anthony
IPC分类号： D06N3/00
CPC分类号： D06N3/00 , D06N3/0061 , D06N3/0063 , D06N2211/28
摘要： The disclosure provides flexible, hydrophobic textiles, methods of producing the textiles and uses of the textiles. The flexible, hydrophobic textiles feel and behave like leather. The textiles are prepared from a symbiotic culture of bacteria and yeast and are reacted with silica sol.

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