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1. 发明申请

WO2023027996A1 COMPOSITION AND METHODS FOR PREVENTING, ALLEVIATING OR TREATING CANCER 审中-公开
公开(公告)号：WO2023027996A1
公开(公告)日：2023-03-02
申请号：PCT/US2022/041059
申请日：2022-08-22
申请人： CKP THERAPEUTICS, INC.
发明人： PARK, Ki , KIM, Seokmo
IPC分类号： A61K31/5415 , A61K31/337 , A61K31/282
摘要： A compound represented by Formula 1 according to the present disclosure, when used in combination with an anticancer drug, may significantly improve the anticancer effect of the anticancer drug, and may induce the same anticancer effect even when the anticancer drug is used in a significantly smaller amount than the conventionally used amount, thereby reducing the side effects caused by administration of the anticancer drug. Furthermore, the compound represented by Formula 1 makes it possible to effectively prevent, alleviate or treat either anticancer-resistant cancer or cancer which recurs or metastasizes after anticancer drug treatment.

2. 发明申请

WO2023027995A1 COMPOSITION AND METHODS FOR PREVENTING, ALLEVIATING OR TREATING CANCER 审中-公开
公开(公告)号：WO2023027995A1
公开(公告)日：2023-03-02
申请号：PCT/US2022/041058
申请日：2022-08-22
申请人： CKP THERAPEUTICS, INC.
发明人： PARK, Ki , KIM, Seokmo
IPC分类号： C07D471/02 , A61K31/33 , C07D471/04 , A61K31/395
摘要： A compound represented by Formula 1 according to the present disclosure, when used in combination with an anticancer drug, may significantly improve the anticancer effect of the anticancer drug, and may induce the same anticancer effect even when the anticancer drug is used in a significantly smaller amount than the conventionally used amount, thereby reducing the side effects caused by administration of the anticancer drug. Furthermore, the compound represented by Formula 1 makes it possible to effectively prevent, alleviate or treat either anticancer-resistant cancer or cancer which recurs or metastasizes after anticancer drug treatment.

3. 发明申请

WO2021163671A1 ONE TIME USE FLUID METERING DEVICE 审中-公开
公开(公告)号：WO2021163671A1
公开(公告)日：2021-08-19
申请号：PCT/US2021/018130
申请日：2021-02-15
申请人： RXACTUATOR, INC.
发明人： BANISTER, Mark
IPC分类号： A61M5/142
摘要： A wearable fluid metering device for delivering medication subcutaneously, intramuscularly or intravenously to a patient, includes a polymer actuator pump. The polymer actuator pump is flexible so it will conform to shape and yet can be used to rapidly displace a volume within a confined area. The actuator is much faster than prior art polymer actuator designs and can be actuated in multiple ways including introduction and hydration of the polymer matrix by a solution or the actuator can be actuated via pH change while it is in solution. The pH change can be made via electrical current such as that used in electro chemistry or the pH change can be made via a chemical change introduced to the actuator hydrating solution.

4. 发明申请

WO2020198736A4 COLLAPSIBLE, DISPOSABLE MEDICATION INHALATION SPACER AND METHOD 审中-公开
公开(公告)号：WO2020198736A4
公开(公告)日：2020-10-01
申请号：PCT/US2020/025714
申请日：2020-03-30
申请人： THAYER MEDICAL CORPORATION
发明人： HYDE, Joel , STRICKLAND, James , JOHNSON, Jennifer
IPC分类号： A61M15/00
摘要： A medication inhalation apparatus preferably formed of a single, unitary sheet of stock, includes an outer housing, movable between collapsed and expanded states, encompassing a first volume. An inner housing within the outer housing encompasses an inner or second volume. An inhaler opening to the first volume is within a wall of the outer housing at a first location. A mouth opening to the inner volume is within a wall of the outer housing and the inner housing at a second location. A one-way inhalation valve connecting the first volume and the inner volume is within a wall of the inner housing. A one-way exhalation valve connecting the inner volume and the exterior of the outer housing is within a wall of the outer housing and inner housing at a third location. The valve preferably includes an elongated spring body formed of a semi-pliant material with a strength and rigidity providing limited flexibility. A first separation is perpendicular to the elongate axis of the spring body, and extends from a first edge of the spring body across at least a portion of a width of the spring body. A second separation perpendicular to the elongate axis of the spring body extends from a second edge of the spring body across at least a portion of the width of the spring body.

5. 发明申请

WO2020036998A1 USE OF METAL-CORE PRINTED CIRCUIT BOARD (PCB) FOR GENERATION OF ULTRA-NARROW, HIGH-CURRENT PULSE DRIVER 审中-公开
公开(公告)号：WO2020036998A1
公开(公告)日：2020-02-20
申请号：PCT/US2019/046410
申请日：2019-08-13
申请人： LASERTEL, INC.
发明人： RUBEN, Eric, Paul , MAILLARD, Jean Michel , THIAGARAJAN, Prabhu
IPC分类号： H01S5/042 , H01S5/06 , H01S5/20 , H01S5/183
摘要： A metal-core printed circuit board (MCPCB) and method of generating an ultra-narrow, high-current pulse driver with a MCPCB is provided. The MCPCB includes a rigid, metal heat sink layer and at least one electrically conductive top layer. At least one electrically insulating dielectric layer is positioned between the conductive top layer and rigid, metal heat sink layer, wherein the dielectric layer has a thickness of less than 0.007 inches.

6. 发明申请

WO2019241074A1 METHOD AND APPARATUS FOR INCREASING ABSORPTION OF MEDICATIONS AND COSMECEUTICALS THROUGH THE SKIN OF THE USER 审中-公开
公开(公告)号：WO2019241074A1
公开(公告)日：2019-12-19
申请号：PCT/US2019/036123
申请日：2019-06-07
申请人： FIRST STEP HOLDINGS, LLC
发明人： SHEFTEL, Scott, N. , SKIBA, Jeffry, B.
IPC分类号： A61N1/32 , A61K9/00 , A61N1/04 , A61N1/20 , A61N1/30
摘要： The present invention provides a device for increasing absorption of substances through the skin of an animal or human, comprising: a fabric or substrate; metal particles disposed on or exposed through at least a portion of a surface of the fabric or substrate, as a plurality of lines or dots in a specific pattern that positions the metal particles in discrete electrically isolated locations separated by a distance, wherein the fabric or substrate is configured such that said metal particles contact a skin surface of the human or animal, wherein the plurality of spaced lines are substantially evenly spaced from one other; and a layer adapted to hold a substance; wherein said fabric or substrate forms a plurality of half-cells of an air-metal battery, for ion exchange with the skin of the human or animal whereupon a substance located between the device and the skin is driven in by iontophoresis.

7. 发明申请

WO2019036141A1 INFUSION SITE PROTECTOR 审中-公开
公开(公告)号：WO2019036141A1
公开(公告)日：2019-02-21
申请号：PCT/US2018/042549
申请日：2018-07-17
申请人： CAYWOOD, Lindi J.
发明人： CAYWOOD, Lindi J.
IPC分类号： A61M25/02 , A61M5/14 , A61M5/142 , A61M25/01
摘要： Disclosed are devices and methods for providing comfort to an infusion patient as well as increased patient compliance due to increased comfort. The device includes a protective cover having a main body having an inner surface, an outer surface and a circumferential flange. The main body has a raised outer surface overlying a hollow cavity. The flange has one or more grooves adapted to provide clearance for one or more infusion set tubes to pass between the patient's skin and the cover.

8. 发明申请

WO2018089797A1 FORMULATIONS FOR THE TREATMENT OF OCULAR SURFACE DISEASES AND RELATED METHODS 审中-公开
标题翻译：治疗眼表疾病的制剂及相关方法
公开(公告)号：WO2018089797A1
公开(公告)日：2018-05-17
申请号：PCT/US2017/061108
申请日：2017-11-10
申请人： WANG, Mingwu , WANG, Cindy, A.
发明人： WANG, Mingwu , WANG, Cindy, A.
IPC分类号： A61K31/138
摘要： Formulations for treating ocular surface diseases, such as dry eye disease, and related methods are disclosed. The formulations include ambroxol or a chemical derivative thereof (for example, ambroxol hydrochloride) dispersed in a carrier and may optionally include a biocompatible polymer to provide extended release properties.
摘要翻译：公开了用于治疗眼表疾病例如干眼病的制剂和相关方法。该制剂包括分散在载体中的氨溴索或其化学衍生物（例如氨溴索盐酸盐），并且可以任选地包括生物相容性聚合物以提供延长的释放性质。

9. 发明申请

WO2017204885A1 SYSTEM AND METHOD FOR OPTICAL AND LASER-BASED COUNTER INTELLIGENCE, SURVEILLANCE, AND RECONNAISSANCE 审中-公开
标题翻译：用于基于光学和激光的计数器智能，监视和再现的系统和方法
公开(公告)号：WO2017204885A1
公开(公告)日：2017-11-30
申请号：PCT/US2017/021925
申请日：2017-03-10
申请人： SELEX GALILEO INC.
发明人： KEEGAN, Matthew , MCELHINNEY, Mark , MAILLARD, Jean Michel
IPC分类号： H04K3/00 , H04N21/437 , G01S7/537
摘要： Systems and methods for preventing image capture and exploitation by optically transmitting a disruptive effect to a digital imaging system. The disruptive effect interferes with the algorithms used to compress and analyze digital images and can be used to disable the imaging equipment or inject foreign code into the imaging system or image processing computer.
摘要翻译：通过向数字成像系统光学传输破坏性效果来防止图像捕获和利用的系统和方法。干扰效应会干扰用于压缩和分析数字图像的算法，并可用于禁用成像设备或将外部代码注入成像系统或图像处理计算机。

10. 发明申请

WO2017147313A1 SOLVENT EXTRACTION AND STRIPPING SYSTEM 审中-公开
标题翻译：溶剂萃取和溶出系统
公开(公告)号：WO2017147313A1
公开(公告)日：2017-08-31
申请号：PCT/US2017/019157
申请日：2017-02-23
申请人： MINEXTECH LLC
发明人： ERNT, William Daniel , GALIK, George M.
IPC分类号： C10G73/10
CPC分类号： C25C1/12 , B01D11/0476 , B01F3/0861 , B01F5/0465 , B01F5/061 , B01F5/0615 , B01F2005/0637 , B01F2215/0075 , C22B3/0005 , C22B3/08 , C22B3/16 , C22B3/22 , C22B15/0071 , C22B15/0086 , Y02P10/234 , Y02P10/236
摘要： An apparatus for separating a mixture of two liquids of different densities which liquids are substantially insoluble in one another includes a hollow permeable body having a recess for receiving a first fluid which can flow from the recess through the permeable body to an exterior of the permeable body. A housing surrounds and is spaced from the exterior of the permeable body. The housing has an inlet for a second fluid and an outlet for a mixture of the first and second fluid. A baffle or baffles are provided in the space between the exterior of the permeable body and the housing, and to define a mixing channel in space between the exterior of the permeable body and the housing so that the second fluid can enter the housing inlet and flow through the mixing channel to the outlet, while picking up fluid on the exterior of the permeable body.
摘要翻译：用于分离不同密度的两种液体的混合物的装置，所述液体彼此基本上不可溶，包括中空的可渗透体，其具有用于接收第一流体的凹部，所述第一流体可从凹部流过可渗透体身体到可渗透体的外部。壳体包围并与可渗透体的外部隔开。壳体具有用于第二流体的入口和用于第一流体和第二流体的混合物的出口。在可渗透体的外部和壳体之间的空间中设置有挡板或挡板，并且在可渗透体的外部和壳体之间的空间中限定混合通道，使得第二流体可以进入壳体入口并流动通过混合通道到达出口，同时在渗透体外部拾取流体。

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