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    • 5. 发明申请
    • MENSTRUAL BLOOD-DERIVED STEM CELLS FOR THE TREATMENT OF HUMAN PANCREATIC CARCINOMA
    • 用于治疗人胰腺癌的人造血干细胞
    • WO2015193825A1
    • 2015-12-23
    • PCT/IB2015/054571
    • 2015-06-17
    • CELLS FOR CELLS S.A.
    • ALCAYAGA, FranciscaKHOURY, Maroun
    • A61K35/14A61P35/00
    • A61K35/14A61K2035/124
    • This invention provides a method and compound product created from menstrual blood- derived mesenchymal stem cells (MenSCs) with an anti-tumor effect. In particular, this invention shows the potential anti-tumor effect MenSCs can have on human pancreatic carcinoma, which has been analyzed on the Mia PaCa 2 human pancreatic carcinoma cell line (ATCC # CRL 1420). MenSCs have been proven to have an in vitro anti-tumor effect both in bi-dimensional cultures (monolayer) and in three-dimensional cultures (tumorspheres). Additionally, MenSCs slow down the appearance of pancreatic tumors when they are co-implanted with the pancreatic carcinoma cell line. MenSCs also have an in vivo therapeutic advantage in the treatment of human pancreatic carcinoma via intra-tumor injections.
    • 本发明提供了具有抗肿瘤作用的月经血源性间充质干细胞(MenSCs)产生的方法和化合物。 特别地,本发明显示MenSC可能对人胰腺癌具有潜在的抗肿瘤作用,已经在Mia PaCa 2人胰腺癌细胞系(ATCC#CRL 1420)上进行了分析。 已经证明MenSCs在二维培养(单层)和三维培养(肿瘤球)中具有体外抗肿瘤作用。 此外,当MenSCs共同植入胰腺癌细胞系时,MenSC可以减缓胰腺肿瘤的出现。 MenSCs还具有通过肿瘤内注射治疗人胰腺癌的体内治疗优势。