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1. 发明申请

WO2009111709A3 BALLOON CATHETER DEVICES WITH SOLVENT-SWELLABLE POLYMER 审中-公开
公开(公告)号：WO2009111709A3
公开(公告)日：2009-09-11
申请号：PCT/US2009/036349
申请日：2009-03-06
申请人： BOSTON SCIENTIFIC SCIMED, INC. , CHEN, John
发明人： CHEN, John
IPC分类号： A61L29/04 , A61L29/08 , A61L29/16
摘要： Methods for making a balloon catheter device comprising a solvent-swellable polymer are provided. The method includes providing a balloon, wherein a wall of the balloon or a coating over the balloon comprises a polymer, wherein the polymer is swellable in an organic solvent. In certain embodiments of the invention, the polymer on the balloon is exposed to a mixture of said solvent and a therapeutic agent; and the solvent is thereafter removing, leaving the therapeutic agent in the polymer.

2. 发明申请

WO2005080626A1 A METHOD FOR COATING A MEDICAL DEVICE USING A MATRIX ASSISTED PULSED-LASER EVAPORATION TECHNIQUE AND ASSOCIATED SYSTEM AND MEDICAL DEVICE 审中-公开
标题翻译：使用矩阵辅助脉冲激光蒸发技术和相关系统和医疗装置涂敷医疗装置的方法
公开(公告)号：WO2005080626A1
公开(公告)日：2005-09-01
申请号：PCT/US2005/004596
申请日：2005-02-14
申请人： BOSTON SCIENTIFIC SCIMED, INC. , WORSHAM, Rob
发明人： WORSHAM, Rob
IPC分类号： C23C14/28
CPC分类号： C23C14/28 , B05D1/60 , C23C14/12
摘要： A method is provided for coating at least a portion of at least one medical device. The method includes arranging the at least one medical device in a vapor cone and directing an energy beam at a frozen target. The frozen target includes an agent and the energy beam vaporizes the agent into the vapor cone. A device is provided for coating at least one medical device. The device includes a target assembly, an energy beam directed at the target assembly, and an arrangement adapted to hold the at least one medical device in a vapor cone. The vapor cone originates at a target point that an energy beam beam contacts a frozen target in the target assembly. A medical device is provided having a coating applied by a method. The method includes arranging the medical device in a vapor cone and directing an energy beam at a frozen target. The frozen target includes an agent and the energy beam vaporizes the agent into the vapor cone.
摘要翻译：提供了一种用于涂覆至少一个医疗装置的至少一部分的方法。所述方法包括将所述至少一个医疗装置布置在蒸气锥体中并且将能量束引导到冷冻目标。冷冻的目标物包括试剂，能量束将试剂汽化成蒸气锥体。提供了用于涂覆至少一个医疗装置的装置。该装置包括目标组件，指向目标组件的能量束，以及适于将至少一个医疗装置保持在蒸气锥体中的装置。蒸气锥体起始于能量束束接触目标组件中的冻结目标的目标点。提供了具有通过一种方法施加的涂层的医疗装置。该方法包括将医疗装置布置在蒸汽锥体中并将能量束引导到冻结的目标。冷冻的目标物包括试剂，能量束将试剂汽化成蒸气锥体。

3. 发明申请

WO2009137384A2 MEDICAL DEVICES HAVING A BIORESORBABLE COATING LAYER WITH A PRE-DETERMINED PATTERN FOR FRAGMENTATION 审中-公开
标题翻译：具有预先确定的图案的可生物降解涂层的医疗装置
公开(公告)号：WO2009137384A2
公开(公告)日：2009-11-12
申请号：PCT/US2009/042666
申请日：2009-05-04
申请人： BOSTON SCIENTIFIC SCIMED, INC. , EDELMAN, Peter , ALI, Afsar
发明人： EDELMAN, Peter , ALI, Afsar
IPC分类号： A61L31/10 , A61L31/14 , A61L31/16
CPC分类号： A61L31/148 , A61L31/10 , A61L31/16 , A61L2300/00
摘要： Intravascular medical devices comprising a coating layer disposed on a substrate associated with the medical device, wherein the coating layer has a pre-determined fragmentation pattern. At least a portion of the coating layer comprises a plurality of discontinuous bioresorbable members, wherein the discontinuous bioresorbable members have a size less than the luminal diameter of an arteriole. The coating layer may be formed by excavating portions of a coating layer (e.g., by laser ablation) to create gaps which define the discontinuous bioresorbable members. In certain embodiments, the coating layer is formed of a heat-bondable material. In such embodiments, the discontinuous bioresorbable members may be adhered to the substrate via heat bonds. Also disclosed are methods of forming a coating layer on medical devices and methods of treating intravascular sites.
摘要翻译：包括设置在与医疗装置相关联的衬底上的涂层的血管内医疗装置，其中所述涂层具有预定的碎裂模式。所述涂层的至少一部分包括多个不连续的生物可再吸收构件，其中所述不连续的生物可再吸收构件的尺寸小于小动脉的管腔直径。可以通过挖掘涂层的部分（例如通过激光烧蚀）来形成涂层以产生限定不连续生物可再吸收构件的间隙。在某些实施方案中，涂层由可热粘合的材料形成。在这样的实施例中，不连续的生物可再吸收构件可以通过热键粘附到基底上。还公开了在医疗装置上形成涂层的方法和治疗血管内部位的方法。

4. 发明申请

WO2009132176A2 MEDICAL DEVICES HAVING INORGANIC PARTICLE LAYERS 审中-公开
标题翻译：具有无机颗粒层的医疗器械
公开(公告)号：WO2009132176A2
公开(公告)日：2009-10-29
申请号：PCT/US2009/041520
申请日：2009-04-23
申请人： BOSTON SCIENTIFIC SCIMED, INC. , KUEHLING, Michael , SEIDEL, Dominique , SCHEUERMANN, Torsten , WEBER, Jan
发明人： KUEHLING, Michael , SEIDEL, Dominique , SCHEUERMANN, Torsten , WEBER, Jan
IPC分类号： A61L31/08 , A61L31/16
CPC分类号： A61L31/16 , A61L31/08 , A61L2300/61 , A61L2300/62 , A61L2420/02
摘要： An expandable medical device having a particle layer disposed over a reservoir containing a therapeutic agent. The particle layer has a first porosity when the medical device is in the unexpanded configuration and a second porosity when the medical device is in the expanded configuration. The particle layer comprises a plurality of micron-sized or nano-sized particles. In certain embodiments, the particles are not connected to each other, and as such, the different porosities are provided by changes in the spacing between the particles as the medical device is expanded/unexpanded. Also disclosed are medical devices having a particle layer, wherein the particle layer comprises a plurality of encapsulated particles, and methods of coating medical devices with particles.
摘要翻译：一种可膨胀医疗装置，其具有设置在含有治疗剂的贮器上方的颗粒层。当医疗装置处于未膨胀构型时，颗粒层具有第一孔隙度，并且当医疗装置处于膨胀构型时具有第二孔隙率。颗粒层包含多个微米级或纳米尺寸的颗粒。在某些实施方案中，颗粒彼此不连接，因此，当医疗装置膨胀/未膨胀时，由颗粒之间的间隔的变化提供不同的孔隙度。还公开了具有颗粒层的医疗装置，其中所述颗粒层包含多个包封的颗粒，以及用颗粒涂覆医疗装置的方法。

5. 发明申请

WO2009111716A1 BALLOON CATHETER DEVICES WITH SHEATH COVERING 审中-公开
标题翻译：带有护罩的气囊导管装置
公开(公告)号：WO2009111716A1
公开(公告)日：2009-09-11
申请号：PCT/US2009/036359
申请日：2009-03-06
申请人： BOSTON SCIENTIFIC SCIMED, INC. , CHEN, John , RIZQ, Raed , HARRISON, Kent , HORN, Daniel , KOCUR, Gordon , EIDENSCHINK, Tracee , ARCAND, Ben , SUTERMEISTER, Derek , RASSAT, Jay , MCGUINESS, Colm , NAIMARK, Wendy , CHENG, Ruth
发明人： CHEN, John , RIZQ, Raed , HARRISON, Kent , HORN, Daniel , KOCUR, Gordon , EIDENSCHINK, Tracee , ARCAND, Ben , SUTERMEISTER, Derek , RASSAT, Jay , MCGUINESS, Colm , NAIMARK, Wendy , CHENG, Ruth
IPC分类号： A61M25/10 , A61L29/00 , A61M25/00
CPC分类号： A61M25/1029 , A61L29/085 , A61L29/16 , A61L2300/416 , A61M25/0045 , A61M25/10 , A61M2025/0056 , A61M2025/1031 , A61M2025/105 , B29L2009/005 , C08L53/02
摘要： Catheter devices (200) having an expandable balloon (204) for delivering a therapeutic agent to a body site. In one aspect, one or more sheaths are disposed around the balloon with the therapeutic agent being disposed within the sheath (206), being disposed over the sheath, being contained in the space between the sheath and the balloon, or being otherwise associated with the sheath. In another aspect, the balloon includes a micro-electromechanical system (MEMS) for drug delivery.
摘要翻译：具有用于将治疗剂递送到身体部位的可膨胀气囊（204）的导管装置（200）。在一个方面，一个或多个护套设置在球囊周围，治疗剂设置在护套（206）内，设置在护套上方，被包含在护套和气囊之间的空间中，或以其它方式与鞘。另一方面，气囊包括用于药物递送的微机电系统（MEMS）。

6. 发明申请

WO2009111608A1 TRIGGERED DRUG RELEASE 审中-公开
公开(公告)号：WO2009111608A1
公开(公告)日：2009-09-11
申请号：PCT/US2009/036121
申请日：2009-03-05
申请人： BOSTON SCIENTIFIC SCIMED, INC. , KANGAS, Steve , ATANASOSKA, Liliana
发明人： KANGAS, Steve , ATANASOSKA, Liliana
IPC分类号： A61M25/10
CPC分类号： A61M25/10 , A61L29/085 , A61L29/14 , A61L29/145 , A61L29/16 , A61L2300/602
摘要： Methods and devices for triggering drug release from the outer expandable portion of a balloon catheter are provided. Drug is released from a drug coated balloon catheter via a triggering condition. The triggering condition can be a change in solubility or volume or hydrolysis.
摘要翻译：提供了用于从气囊导管的外部可扩张部分触发药物释放的方法和装置。通过触发条件从药物包被的气囊导管释放药物。触发条件可以是溶解度或体积或水解的变化。

7. 发明申请

WO2009135008A2 DRUG-LOADED MEDICAL DEVICES AND METHODS FOR MANUFACTURING DRUG-LOADED MEDICAL DEVICES 审中-公开
标题翻译：药物装载医疗装置及其制造装载药物的方法
公开(公告)号：WO2009135008A2
公开(公告)日：2009-11-05
申请号：PCT/US2009/042319
申请日：2009-04-30
申请人： BOSTON SCIENTIFIC SCIMED, INC. , KUEHLING, Michael , XU, Yixin
发明人： KUEHLING, Michael , XU, Yixin
IPC分类号： A61L31/14 , A61L31/16
CPC分类号： A61L31/10 , A61L31/146 , A61L31/16 , A61L2300/606
摘要： Drug-loaded medical devices such as stents and methods for manufacturing them are provided. In certain embodiments, the therapeutic agent is loaded only in or on areas of the medical device that do not undergo substantial deformation during expansion. The medical device may be provided with reservoirs in or on the first portions of the medical device that do not undergo substantial deformation during expansion, and the therapeutic agent may be loaded in these reservoirs. The reservoirs may be covered with a porous coating which may be a non- polymeric coating. In other embodiments, a non-polymeric coating is provided in a discontinuous manner in or on the medical device. A method includes the steps of providing a transfer member that includes a translucent substrate and a layer of transfer material such as a film or foil; attaching reservoirs to the transfer material; positioning the transfer member with the reservoirs adjacent a medical device, such as a stent, with the reservoirs facing the medical device; and directing a laser beam at the transfer member such that the laser beam passes through the translucent substrate to vaporize a portion of the transfer material, creating a pocket of trapped gas between the translucent substrate and reservoir, thereby forcing the reservoir from the transfer member to the medical device. The reservoirs may be formed of a non-polymeric material.
摘要翻译：提供诸如支架的药物装载的医疗装置及其制造方法。在某些实施方案中，治疗剂仅在扩张期间不经历基本变形的医疗装置的区域中或其上加载。医疗装置可以在医疗装置的第一部分中或其上设置有在膨胀期间不经历实质变形的第一部分上的储存器，并且治疗剂可以装载在这些储存器中。储存器可以用可以是非聚合物涂层的多孔涂层覆盖。在其它实施方案中，在医疗装置中或其上以不连续的方式提供非聚合物涂层。一种方法包括提供包括透光性基板和转印材料层例如膜或箔的转印部件的步骤; 将储存器附接到转印材料上; 将所述转移构件与所述储存器邻近医疗装置（例如支架）定位，所述储存器面向所述医疗装置; 并且将激光束引导在转印部件处，使得激光束通过透光性基板以蒸发转印材料的一部分，从而在透光性基板和储存器之间形成捕获气体的袋状物，从而迫使储存器从转印部件医疗器械。储存器可以由非聚合材料形成。

8. 发明申请

WO2009111712A1 BALLOON CATHETER DEVICES WITH FOLDED BALLOONS 审中-公开
标题翻译：具有折叠气球的气缸导管装置
公开(公告)号：WO2009111712A1
公开(公告)日：2009-09-11
申请号：PCT/US2009/036354
申请日：2009-03-06
申请人： BOSTON SCIENTIFIC SCIMED, INC. , KNAPP, David , MICKLEY, Timothy , CHEN, John , SUTERMEISTER, Derek , FREYMAN, Toby , KOCUR, Gordon , HORN, Daniel , ANDERSON, Jim , ARCAND, Ben , RASSAT, Jay , RIZQ, Raed , NAZAROVA, Irina , QUILLIN, Dan , WEBER, Jan , SCHEUERMANN, Torsten
发明人： KNAPP, David , MICKLEY, Timothy , CHEN, John , SUTERMEISTER, Derek , FREYMAN, Toby , KOCUR, Gordon , HORN, Daniel , ANDERSON, Jim , ARCAND, Ben , RASSAT, Jay , RIZQ, Raed , NAZAROVA, Irina , QUILLIN, Dan , WEBER, Jan , SCHEUERMANN, Torsten
IPC分类号： A61M25/10 , A61L29/00
CPC分类号： A61M25/1029 , A61L29/085 , A61L29/16 , A61L2300/416 , A61M25/0045 , A61M25/10 , A61M2025/0056 , A61M2025/1031 , A61M2025/105 , B29L2009/005 , C08L53/02
摘要： Catheter devices (10) having an expandable balloon (14) for delivering a therapeutic agent to a body site. The balloon has one or more folds (16) which serve as a reservoir for containing the therapeutic agent. The fold may have any of various configurations to hold the therapeutic agent. In some cases, the balloon comprises one or more lobes that forms the fold(s). The therapeutic agent may be provided in various ways. For example, the therapeutic agent may be contained in packets that rupture upon expansion of the balloon, or as a plurality of discrete bulk masses, or sealed within compartments.
摘要翻译：具有用于将治疗剂递送到身体部位的可膨胀气囊（14）的导管装置（10）。气囊具有一个或多个褶皱（16），其用作容纳治疗剂的储存器。折叠可以具有保持治疗剂的各种构造中的任何一种。在一些情况下，气囊包括形成褶皱的一个或多个凸起。治疗剂可以以各种方式提供。例如，治疗剂可以包含在囊膨胀时破裂的包装中，或者作为多个离散的体积块，或者密封在隔室内。

9. 发明申请

WO2006047490A2 METHOD OF IMPROVING THE QUALITY AND PERFORMANCE OF A COATING ON A COATED MEDICAL DEVICE USING A SOLVENT TO REFLOW THE COATING 审中-公开
标题翻译：使用溶剂来涂覆涂层的涂层医疗装置上的涂层的质量和性能的改进方法
公开(公告)号：WO2006047490A2
公开(公告)日：2006-05-04
申请号：PCT/US2005/038323
申请日：2005-10-25
申请人： BOSTON SCIENTIFIC SCIMED, INC. , STENZEL, Eric, B.
发明人： STENZEL, Eric, B.
IPC分类号： A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16
CPC分类号： A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2420/02
摘要： A method is provided for coating at least a portion of at least one medical device. The method includes arranging a polymer on the portion of the medical device, arranging a bioactive agent on the portion of the medical device, and spraying, subsequent to the arranging of the polymer and the arranging of the bioactive agent, a solvent on the portion of the medical device. The method may further include selecting a composition of the solvent to achieve a desired agent release response profile for the medical device. A medical appliance is provided having a coating applied by a method that includes arranging a polymer on the portion of the medical device, arranging a bioactive agent on the portion of the medical device, and subsequently spraying a solvent on the portion of the medical device. A method is provided for achieving a desired agent release response profile for a medical device by reflowing the coating with a solvent.
摘要翻译：提供了一种用于涂覆至少一个医疗装置的至少一部分的方法。该方法包括在医疗装置的该部分上布置聚合物，将生物活性剂置于医疗装置的该部分上，以及在将聚合物的排列和生物活性剂的排列之后，在医疗器械。该方法还可以包括选择溶剂的组合物以实现医疗装置的期望的药剂释放反应曲线。提供了一种医疗器具，其具有通过包括在医疗装置的该部分上布置聚合物的方法施加的涂层，在医疗装置的该部分上布置生物活性剂，随后在该医疗装置的该部分上喷涂溶剂。提供了一种用于通过用溶剂回流涂层来获得用于医疗装置的期望的药剂释放反应曲线的方法。

10. 发明申请

WO2007046972A1 AEROSOL CONTAINER WITH INTEGRAL MOUNTING CUP AND ANTI-CLOG VALVE 审中-公开
标题翻译：具有整体安装杯和防液阀的气溶胶容器
公开(公告)号：WO2007046972A1
公开(公告)日：2007-04-26
申请号：PCT/US2006/034960
申请日：2006-09-08
申请人： DISPENSING PATENTS INTERNATIONAL, LLC , MESHBERG, Philip
发明人： MESHBERG, Philip
IPC分类号： B65B7/00
CPC分类号： B65D83/38
摘要： An aerosol dispenser is formed from a metal drawn container with an open bottom and a mounting cup structure integrally formed in its top. A bottom piece is attached to the open bottom with a double seam and a dispensing device held in the mounting cup structure. In one embodiment the dispensing device is an anti-clog valve designed to clear all dispensing passages after each operation.
摘要翻译：气溶胶分配器由金属拉制容器形成，开口底部和安装杯结构一体地形成在其顶部。底部件通过双层接缝连接到开放的底部，并且分配装置保持在安装杯结构中。在一个实施例中，分配装置是设计成在每次操作之后清除所有分配通道的防堵塞阀。

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