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1. 发明申请

WO2018198139A1 ORGANIC FLEXIBLE FERROELECTRIC POLYMER NANOCOMPOSITES 审中-公开
公开(公告)号：WO2018198139A1
公开(公告)日：2018-11-01
申请号：PCT/IN2018/050271
申请日：2018-05-01
申请人： COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH
发明人： SHANMUGANATHAN, Kadhiravan , FARSA, Ram
IPC分类号： G11C11/22
摘要： The present invention discloses organic flexible ferroelectric polymer nanocomposites. The present invention discloses a composite of fluorinated polymers or their copolymers with halogenated cellulosic materials and a facile process for the conversion of non-electroactive alpha phase of fluorinated polymer to electroactive beta phase of fluorinated polymer. Further, it discloses a device comprising the composite with enhanced dielectric properties.

2. 发明申请

WO2013024373A1 PHARMACEUTICAL COMPOSITION COMPRISING CEFUROXIME 审中-公开
标题翻译：包含CEFUROXIME的药物组合物
公开(公告)号：WO2013024373A1
公开(公告)日：2013-02-21
申请号：PCT/IB2012/053283
申请日：2012-06-28
申请人： DHANUKA LABORATORIES LTD. , DHANUKA, Manish , DHOKA, Vishal, Ashoka , SRIVASTAVA, Ravi, Pratap , DHOKA, Ashoka
发明人： DHANUKA, Manish , DHOKA, Vishal, Ashoka , SRIVASTAVA, Ravi, Pratap , DHOKA, Ashoka
IPC分类号： A61K31/545 , A61K47/18 , A61K47/20 , A61K47/26 , A61K9/00
CPC分类号： A61K31/546 , A61K9/10 , A61K9/5015 , A61K47/26
摘要： The present invention discloses a composition of taste masked oral suspension which comprises of bitter taste Cefuroxime axetil, having integral coating of lipid and sweetener system. The sweetener system which is used in composition is disclosed in the invention. The said composition delivers substantial amount of drug immediately at the gastric p H with improved palatability.
摘要翻译：本发明公开了一种具有苦味口服悬浮液的组合物，其含有苦味头孢呋辛酯，具有脂质和甜味剂体系的整体包衣。本发明公开了组合物中使用的甜味剂体系。所述组合物在胃p H处立即提供大量的药物，具有改善的适口性。

3. 发明申请

WO2012176145A1 INSECTICIDAL COMPOSITIONS ISOLATED FROM NOTHAPODITES FOETIDA AND PROCESS FOR THE EXTRACTION THEREOF 审中-公开
标题翻译：从锇酸盐分离的杀虫剂组合物及其提取方法
公开(公告)号：WO2012176145A1
公开(公告)日：2012-12-27
申请号：PCT/IB2012/053135
申请日：2012-06-21
申请人： COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH , JOSHI, Swati, Pramod , PEREIRA, John , PATANJALI, Phool, Kumar , KUNTE, Sunita, Sharad , SONAWANE, Kiran, Babasaheb , MUMMIGATTI, Suresh, Gurappa , SANNA, Sumithra, Devi , HULLUKERE, Krishnaiah, Eraiah , CHAUDHARY, Seema
发明人： JOSHI, Swati, Pramod , PEREIRA, John , PATANJALI, Phool, Kumar , KUNTE, Sunita, Sharad , SONAWANE, Kiran, Babasaheb , MUMMIGATTI, Suresh, Gurappa , SANNA, Sumithra, Devi , HULLUKERE, Krishnaiah, Eraiah , CHAUDHARY, Seema
IPC分类号： C07D471/14 , C07C69/616 , C07H1/08 , A01N43/90 , A01P7/00
CPC分类号： A01N43/90 , A01N37/10 , A01N65/00 , A01N65/08 , C07C69/80 , C07D471/14 , C07H15/26
摘要： The present invention relates to an insecticidal enriched extract (biopesticide) isolated from the stem of Nothapodites foetida (Wight) Sleumer (formerly Mappiafoetida (Miers) useful for the insect free storage and transport of grains and seed. The insecticidal activity of the enriched extract (biopesticide) of the invention is ascribed to compound/s other than camptothecin. The invention further relates to the process for preparation thereof, containing Compounds of general formula 1 and formula 2 (General formula 1) wherein R1=CH 3 , CH 2 OAC and wherein R2= COOH, or (I) and R3=H. OH. (Formula 2)
摘要翻译：本发明涉及从用于无昆虫储存和运输谷物和种子的Nothapodites foetida（Wight）Sleumer（以前称为Mappiafoetida（Miers））的茎分离的杀虫剂富集的提取物（biopesticide），富集的提取物的杀虫活性本发明还涉及其制备方法，该方法含有通式1和式2化合物（通式1），其中R 1 = CH 3，CH 2 OAC，其中R 2为烷基， = COOH，或（I），R 3 = H。OH。（式2）

4. 发明申请

WO2012143877A2 AN EXPRESSION CONSTRUCT AND PROCESS FOR ENHANCING THE CARBON, NITROGEN, BIOMASS AND YIELD OF PLANTS 审中-公开
标题翻译：一种提高植物碳，氮，生物量和产量的表达构建方法
公开(公告)号：WO2012143877A2
公开(公告)日：2012-10-26
申请号：PCT/IB2012/051965
申请日：2012-04-19
申请人： COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH , KAACHRA, Anish , VATS, Surender, Kumar , AHUJA, Paramvir, Singh , KUMAR, Sanjay
发明人： KAACHRA, Anish , VATS, Surender, Kumar , AHUJA, Paramvir, Singh , KUMAR, Sanjay
IPC分类号： C12N15/82
CPC分类号： C12N15/8243 , C12N15/8261 , Y02A40/146 , Y02P60/247
摘要： The assimilated C and N largely influence plant growth and crop yields. Previous attempts to alter the carbon and nitrogen status of the plants attempted with one or two genes The present invention involves simultaneous co-overexpression of three genes wherein one gene (PEPCase) efficiently capture CO2 whereas the other two encode for enzymes (Asp AT and GS) involved in nitrogen assimilation. The combined effect is the enhancement of carbon and nitrogen status of the plant and the productivity.
摘要翻译：同化的C和N主要影响植物生长和作物产量。先前尝试改变用一种或两种基因尝试的植物的碳和氮状态本发明涉及三种基因的同时共表达，其中一种基因（PEPCase）有效地捕获CO 2，而另两种基因编码酶（Asp AT和GS ）参与氮同化。综合效应是提高了植物的碳氮状况和生产力。

5. 发明申请

WO2012131505A1 PROCESS FOR THE MODIFICATION OF CURCUMA AROMATICA ESSENTIAL OIL 审中-公开
标题翻译：修饰油性芳香油基油的方法
公开(公告)号：WO2012131505A1
公开(公告)日：2012-10-04
申请号：PCT/IB2012/050962
申请日：2012-03-01
申请人： COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH , AGNIHOTRI, Vijai, Kant , SINGH, Bikram , BABU, Garikapati, Dyva, Kiran , CHAND, Gopi , SINGH, Rakesh, Deosharan , AHUJA, Paramvir, Singh
发明人： AGNIHOTRI, Vijai, Kant , SINGH, Bikram , BABU, Garikapati, Dyva, Kiran , CHAND, Gopi , SINGH, Rakesh, Deosharan , AHUJA, Paramvir, Singh
IPC分类号： A23L1/015 , C11B9/02
CPC分类号： C11B9/0046 , A23L27/12 , C11B9/022
摘要： Curcuma aromatica essential oil is blue-black dark liquid with camphoraceous, woody, amber and spicy characteristic odour and is less valued in market, however the prepared value added products have very good shining color with the improved fragrance. The present invention relates to an efficient process for the modification of Curcuma aromatica essential oil to develop value added fragranced products, the process comprising the steps of mixing of essential oil with one solvent or a combination of more than one solvents, cooling the mixture over ice bath or at lower temperature at rotation of 1000 rpm or at simple magnetic stirrer at high speed, addition of reducing agent at different proportion at a certain time period for desired product, after completion of the reaction, addition of ice water to the reaction mixture to terminate the reaction, extracting the mixture using solvent for three to five times, washing the extractive with dilute acidic water and then with water, washed product was dried at lower temperature to obtain modified essential oils in order to develop fragranced products with recovery of 60 to 95% and use of the modified essential oil in the range between 0.05 to 100% in perfumery or allied industries.
摘要翻译：姜黄香精油是蓝黑色深色液体，具有樟脑，木质，琥珀和辛辣的特征气味，市场价值较低，但配制的增值产品具有非常好的发光颜色，具有改善的香味。本发明涉及一种改善姜黄香精油以开发增值香料的有效方法，该方法包括以下步骤：将精油与一种溶剂或多种溶剂的组合混合，在冰上冷却混合物浴或在1000rpm的旋转下或在简单的磁力搅拌器下以较高的速度在较低的温度下，在所需产物的一定时间内以不同比例加入还原剂，反应完成后，向反应混合物中加入冰水终止反应，用溶剂萃取混合物三至五次，用稀酸水洗涤萃取液，然后用水洗涤，将产物在较低温度下干燥，得到改性精油，以开发回收率为60〜 95％，在香料或相关行业使用0.05至100％之间的改性精油。

6. 发明申请

WO2012104793A1 AN ANTIBACTERIAL AND ANTIVIRAL COMPOUND 审中-公开
标题翻译：抗生素和抗病毒化合物
公开(公告)号：WO2012104793A1
公开(公告)日：2012-08-09
申请号：PCT/IB2012/050463
申请日：2012-02-01
申请人： INDIAN COUNCIL OF MEDICAL RESEARCH , KUMAR, Vanaja , DOBLE, Mukesh , RAMASAMY, Balagurunathan , GANESAN, Suresh , MANIKKAM, Radhakrishnan , HANNA, Luke, Elizabeth , SWAMINATHAN, Sowmya , NAGAMIAH, Selvakumar
发明人： KUMAR, Vanaja , DOBLE, Mukesh , RAMASAMY, Balagurunathan , GANESAN, Suresh , MANIKKAM, Radhakrishnan , HANNA, Luke, Elizabeth , SWAMINATHAN, Sowmya , NAGAMIAH, Selvakumar
IPC分类号： C07C233/09 , A61K31/16 , A61P31/04 , A61P31/06 , A61P31/18 , C12P13/02
CPC分类号： A61K31/16 , C07C233/09 , C12P13/02 , C12R1/04
摘要： The invention provides a compound represented by Formula (I) 5-(4-bromobutyl)- N -(but-3-enyl)dodec-11-enamide or a derivative thereof. Said compound is effective against bacterial and viral pathogens.
摘要翻译：本发明提供由式（I）5-（4-溴丁基）-N-（丁-3-烯基）十二碳-7-烯酰胺或其衍生物表示的化合物。所述化合物对细菌和病毒病原体有效。

7. 发明申请

WO2012131630A1 CATALYST FREE SYNTHESIS OF VERTICALLY ALIGNED CNTs ON SiNW ARRAYS 审中-公开
标题翻译：催化剂在SiNW阵列上的垂直对准CNT的合成
公开(公告)号：WO2012131630A1
公开(公告)日：2012-10-04
申请号：PCT/IB2012/051546
申请日：2012-03-30
申请人： COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH , SHELKE, Manjusha, Vilas
发明人： SHELKE, Manjusha, Vilas
IPC分类号： H01L51/05
CPC分类号： H01L21/02603 , B82Y10/00 , B82Y30/00 , B82Y40/00 , C01B32/16 , C01B2202/06 , C01B2202/36 , C30B25/00 , C30B29/06 , C30B29/60 , C30B29/602 , H01L21/02527 , H01L21/02532 , H01L21/0262 , H01L29/0676 , H01L51/0048 , H01L51/0587
摘要： The present invention discloses novel one dimensional, direct nano-heterojunctions of vertically aligned silicon nanowires (Si NW)- carbon nano tube (CNT) arrays with ultra-low turn-on field useful in single electronic devices. The invention further discloses catalyst free chemical vapor deposition (CVD) route for synthesis of one dimensional, direct nano-heterojunctions of vertically aligned Si NW-CNT arrays.
摘要翻译：本发明公开了用于单电子器件的具有超低导通场的垂直取向硅纳米线（Si NW） - 碳纳米管（CNT）阵列的新颖的一维直接纳米异质结。本发明还公开了用于合成垂直排列的Si NW-CNT阵列的一维直接纳米异质结的无催化剂化学气相沉积（CVD）途径。

8. 发明申请

WO2012110945A1 CARBAZOLE END CAPPED BIPYRIDINE COMPOUNDS AND PROCESS FOR PREPARATION THEREOF 审中-公开
标题翻译：卡贝隆封端二苯乙烯化合物及其制备方法
公开(公告)号：WO2012110945A1
公开(公告)日：2012-08-23
申请号：PCT/IB2012/050656
申请日：2012-02-14
申请人： COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH , AYYAPPANPILLAI, Ajayaghosh , KIZHUMURI, Divya , SAMPATH, Srinivasan
发明人： AYYAPPANPILLAI, Ajayaghosh , KIZHUMURI, Divya , SAMPATH, Srinivasan
IPC分类号： C07D401/14
CPC分类号： C07D401/14 , C07F3/06 , C09D5/22 , C09K11/06 , C09K2211/1029 , C09K2211/188 , H01L33/502 , H01L51/0071 , H01L51/0092 , H01L51/5012
摘要： The present invention is to provide highly solid state emissive fluorophores of the formula 1 and 2 useful for the solid state lighting. The formula 1 and 2 have good solid state emission in blue and green region respectively. The zinc complexes of formula 1A and 2A have yellow and red emission respectively in solid state. The present invention also provide high solid state emissive assay of formula 1 and 2 to convert UV light into visible light by coating the color tunable materials on the 365- nm emitting solid state LED. The present invention further provides carbazole end- capped bipyridine for screening of metal salts with different counterions in solutions. The discrimination of the various metal salts can be monitored by noting the fluorescence change in solution. The zinc salts with different counterions have different emission color in solution. The present invention also develop a new two photon active fluorescent Zn 2+ specific probe for detecting Zn 2+ in cellular environments. Assay with formula 3 is used as a fluorescent probe for two photon imaging of Zn 2+ ions in HeLa cells. The high two photon absorption cross section and fluorescence quantum yield of formula 3 made it as a useful probe for detecting Zn 2+ in cellular environment by two photon excited fluorescence imaging.
摘要翻译：本发明是提供可用于固态照明的式1和2的高度固体发射荧光团。公式1和2分别在蓝色和绿色区域具有良好的固态发射。式1A和2A的锌络合物在固态下分别具有黄色和红色发射。本发明还提供式1和2的高固态发射测定法，通过在365nm发射固态LED上涂覆颜色可调谐材料将UV光转换成可见光。本发明还提供了用于在溶液中用不同的抗衡离子筛选金属盐的咔唑封端的联吡啶。可以通过注意溶液中的荧光变化来监测各种金属盐的区别。具有不同抗衡离子的锌盐在溶液中具有不同的发射颜色。本发明还开发了用于在细胞环境中检测Zn 2+的新型双光子活性荧光Zn 2+特异性探针。使用式3的测定用作HeLa细胞中Zn 2+离子的双光子成像的荧光探针。式3的高双光子吸收截面和荧光量子产率使其成为通过两个光子激发荧光成像在细胞环境中检测Zn 2+的有用探针。

9. 发明申请

WO2012104766A1 A NOVEL HIGH AFFINITY BIVALENT HELICALLY CONSTRAINED PEPTIDE AGAINST CANCER 审中-公开
标题翻译：一种新的高亲和力双重有力的约束肽
公开(公告)号：WO2012104766A1
公开(公告)日：2012-08-09
申请号：PCT/IB2012/050409
申请日：2012-01-30
申请人： COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH , DHAR, Amlanjyoti , MALLICK, Shampa , AHMED, Israr , KONAR, Aditya , BANDYOPADHYAY, Santu , ROY, Siddhartha
发明人： DHAR, Amlanjyoti , MALLICK, Shampa , AHMED, Israr , KONAR, Aditya , BANDYOPADHYAY, Santu , ROY, Siddhartha
IPC分类号： A61K38/00 , C07K14/00
CPC分类号： A61K38/16 , A61K9/0019 , A61K38/10 , A61K45/06 , C07K14/00 , C07K14/47 , A61K2300/00
摘要： The present invention describes a novel bivalent helically constrained peptide targeted against S100B that is an effective anti-cancer drug against cancers that over-express S100B. This helix mimetic targeted against S100B induces rapid apoptosis in cancer cells that over-express a calcium binding protein S100B through simultaneous inhibition of key growth pathways including activation of p53.
摘要翻译：本发明描述了针对S100B的新型二价螺旋约束肽，其是针对过表达S100B的癌症的有效抗癌药物。靶向S100B的这种螺旋模拟物通过同时抑制关键生长途径（包括p53的激活）诱导过度表达钙结合蛋白S100B的癌细胞中的快速凋亡。

10. 发明申请

WO2009095773A2 NOVEL HETEROCYCLES 审中-公开
标题翻译：新型杂环
公开(公告)号：WO2009095773A2
公开(公告)日：2009-08-06
申请号：PCT/IB2009/000157
申请日：2009-01-30
申请人： ORCHID RESEARCH LABORATORIES LIMITED , ORCHID RESEARCH LABORATORIES LIMITED , SRINIVAS, Visweswara, Akella, Satya, Surya , TADIPARTHI, Ravikumar , SHARMA, Ganapavarapu, Veera, Raghava , SAPPANIMUTHU, Thirunavukkarasu , BHAKIARAJ, Durairaj, Peter , KACHHADIA, Virendra , NARASIMHAN, Kilambi , THARA, Sathya, Narayana , RAJAGOPAL, Sriram , NARAYANAN, Sukunath , PARAMESWARAN, Venkatesan , JANARTHANAM, Venkatesan , NARAYANAM, Maruthikumar , GADDE, Sathyanarayana , RAMACHANDRAN, Uma , BALASUBRAMANIAN, Gopalan , SURENDRAN, Narayanan , NARAYANAN, Shridhar , VISHWAKARMA, Lolaknath, Santosh , SAXENA, Sanjeev
发明人： SRINIVAS, Visweswara, Akella, Satya, Surya , TADIPARTHI, Ravikumar , SHARMA, Ganapavarapu, Veera, Raghava , SAPPANIMUTHU, Thirunavukkarasu , BHAKIARAJ, Durairaj, Peter , KACHHADIA, Virendra , NARASIMHAN, Kilambi , THARA, Sathya, Narayana , RAJAGOPAL, Sriram , NARAYANAN, Sukunath , PARAMESWARAN, Venkatesan , JANARTHANAM, Venkatesan , NARAYANAM, Maruthikumar , GADDE, Sathyanarayana , RAMACHANDRAN, Uma , BALASUBRAMANIAN, Gopalan , SURENDRAN, Narayanan , NARAYANAN, Shridhar , VISHWAKARMA, Lolaknath, Santosh , SAXENA, Sanjeev
IPC分类号： C07D403/04 , C07D401/04 , C07D239/26
CPC分类号： C07D239/42 , A61K31/5377 , C07D265/28 , C07D401/04
摘要： Described are novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof. These compounds are useful in the treatment of immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; atherosclerosis; cancer; cachexia; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; ARDS; psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; asthma; COPD; bone resorption diseases; multiple sclerosis; sepsis; septic shock; toxic shock syndrome and fever. More particularly these compounds are useful as PDE4 inhibitors and are useful for treating PDE4 mediated diseases.
摘要翻译：描述了通式（I）的新型杂环化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物，药学上可接受的盐，药物组合物，代谢物和前药。这些化合物可用于治疗免疫性疾病，炎症，疼痛障碍，类风湿性关节炎; 骨质疏松症; 多发性骨髓瘤 uveititis; 急性和慢性粒细胞白血病; 动脉粥样硬化; 癌症; 恶病质; 缺血诱导的细胞损伤; 胰腺β细胞破坏; 骨关节炎; 类风湿性脊柱炎; 痛风性关节炎炎症性肠病; ARDS; 银屑病; 克罗恩病; 过敏性鼻炎; 溃疡性结肠炎过敏性反应; 接触性皮炎; 肌肉退化; 哮喘; 慢性阻塞性肺病; 骨吸收疾病; 多发性硬化症败血症; 败血性休克中毒性休克综合征和发烧。更特别地，这些化合物可用作PDE4抑制剂，并且可用于治疗PDE4介导的疾病。

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