专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2008036375A2 USE OF IMPEDANCE-BASED CYTOLOGICAL PROFILING TO CLASSIFY CELLULAR RESPONSE PROFILES UPON EXPOSURE TO BIOLOGICALLY ACTIVE AGENTS 审中-公开
标题翻译：基于阻抗的细胞学分型技术在接触生物活性剂时对细胞反应特征进行分类
公开(公告)号：WO2008036375A2
公开(公告)日：2008-03-27
申请号：PCT/US2007/020418
申请日：2007-09-20
申请人： ACEA BIOSCIENCES CORPORATION , WANG, Xiaobo , ABASSI, Yama, A. , ZHANG, Wenfu , XU, Xiao
发明人： WANG, Xiaobo , ABASSI, Yama, A. , ZHANG, Wenfu , XU, Xiao
IPC分类号： G06F19/00
CPC分类号： G01N33/54373 , G01N33/5005 , G01N33/5438 , G06F19/24
摘要： The present invention provides methods of multi-dimensional profiling of biologically active agents and determining their effects on biological systems. The methods of the present invention include real-time impedance monitoring of cellular responses to biologically active agents and categorization of cellular kinetic profiles into mechanism specific cellular response profile groups. The grouping of similar cellular response profiles allows the correlation between agent and mechanism, thus allowing for the identification of potential therapeutic applications of agents or further study of cellular responses or mechanisms.
摘要翻译：本发明提供了多维分析生物活性剂并确定其对生物系统的影响的方法。本发明的方法包括对生物活性剂的细胞响应的实时阻抗监测以及将细胞动力学曲线分类成机制特异性细胞响应曲线组。类似的细胞反应谱的分组允许药剂和机制之间的相关性，从而允许鉴定药剂的潜在治疗应用或进一步研究细胞应答或机制。

2. 发明申请

WO2006058185A2 DEVICE AND METHOD FOR ELECTROPORATION-BASED DELIVERY OF MOECULES INTO CELLS AND DYNAMIC MONITORING OF CELL RESPONSES 审中-公开
标题翻译：用于基于电导输送到细胞中的装置和方法以及细胞响应的动态监测
公开(公告)号：WO2006058185A2
公开(公告)日：2006-06-01
申请号：PCT/US2005/042684
申请日：2005-11-23
申请人： ABASSI, Yama A. , WANG, Xiaobo , ATIENZA, Josephine , XU, Xiao , XU, Junquan
发明人： ABASSI, Yama A. , WANG, Xiaobo , ATIENZA, Josephine , XU, Xiao , XU, Junquan
IPC分类号： G11C11/00
CPC分类号： G01N33/5008 , C12M35/02 , C12N15/87 , G01N15/12 , G01N33/48728
摘要： The present invention includes devices and methods for transfecting a cell or cell population and dynamic monitoring of cellular events. A variety of microelectronic devices are provide that incorporate functions such as electroporation, modulation of a transmembrane potential and dynamic monitoring of cellular functions and mechanisms.
摘要翻译：本发明包括用于转染细胞或细胞群的装置和方法以及细胞事件的动态监测。提供了多种微电子器件，其包括诸如电穿孔，跨膜电位的调节和细胞功能和机制的动态监测的功能。

3. 发明申请

WO2006031291A2 A NOVEL CLASS OF THERAPEUTIC PROTEIN BASED MOLECULES 审中-公开
标题翻译：一类新的基于蛋白质的蛋白质分子
公开(公告)号：WO2006031291A2
公开(公告)日：2006-03-23
申请号：PCT/US2005/025831
申请日：2005-07-21
申请人： FANG, Fang , MALAKHOV, Michael
发明人： FANG, Fang , MALAKHOV, Michael
IPC分类号： C12N9/36 , C07H21/04 , C12N1/21 , C12N15/75
CPC分类号： C12N9/2402 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/01 , C07K2319/33 , C12N2760/16111 , C12Y302/01018
摘要： The present invention provides new compositions and methods for preventing and treating pathogen infection. In particular, the present invention provides compounds having an anchoring domain that anchors the compound to the surface of a target cell, and a therapeutic domain that can act extracellularly to prevent infection of a target cell by a pathogen, such as a virus. The present invention also comprises therapeutic compositions having sialidase activity, including protein-based compounds having sialidase catalytic domains. Compounds of the invention can be used for treating or preventing pathogen infection, and for treating and reducing allergic and inflammatory responses. The invention also provides compositions and methods for enhancing transduction of target cells by recombinant viruses. Such compositions and methods can be used in gene therapy.
摘要翻译：本发明提供了用于预防和治疗病原体感染的新的组合物和方法。特别地，本发明提供了具有将化合物锚定在靶细胞表面的锚定结构域的化合物，以及可以在细胞外作用以防止病原体如病毒感染靶细胞的治疗结构域。本发明还包括具有唾液酸酶活性的治疗组合物，包括具有唾液酸酶催化结构域的蛋白质类化合物。本发明的化合物可用于治疗或预防病原体感染，以及用于治疗和减少变态反应和炎症反应。本发明还提供了通过重组病毒增强靶细胞转导的组合物和方法。这些组合物和方法可用于基因治疗。

4. 发明申请

WO2008085984A1 COMPOUNDS WITH (SUBSTITUTED PHENYL)-PROPENAL MOIETY, THEIR DERIVATIVES, BIOLOGICAL ACTIVITY, AND USES THEREOF 审中-公开
标题翻译：（取代苯基） - 丙酸酯的化合物，其衍生物，生物活性及其用途
公开(公告)号：WO2008085984A1
公开(公告)日：2008-07-17
申请号：PCT/US2008/000285
申请日：2008-01-08
申请人： ANDROSCIENCE CORPORATION , SHIH, Charles C.y. , SHI, Qian , WANG, Hui-kang , SU, Ching-yuan
发明人： SHIH, Charles C.y. , SHI, Qian , WANG, Hui-kang , SU, Ching-yuan
IPC分类号： C07C49/15
CPC分类号： C07C49/255 , C07C45/00 , C07C45/30 , C07C45/673 , C07C45/68 , C07C45/73 , C07C45/74 , C07C47/277 , C07C49/248 , C07C49/753 , C07C69/007 , C07C69/738 , C07C69/96 , C07C225/16 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C49/12
摘要： The present invention includes compounds, pharmaceuticals and cosmetics having at least one (substituted phenyl)-propenal moiety. The compounds and compositions of the present invention are useful in the treatment or prevention of many medical conditions such as androgen associated conditions. The present invention also includes methods of treating a medical condition including an androgen associated condition, using at least one of the disclosed compounds.
摘要翻译：本发明包括具有至少一个（取代的苯基） - 丙烯酸部分的化合物，药物和化妆品。本发明的化合物和组合物可用于治疗或预防许多医学病症如雄激素相关病症。本发明还包括使用所公开的化合物中的至少一种来治疗包括雄激素相关病症的医学病症的方法。

5. 发明申请

WO2006088904A3 FECAL SAMPLE TEST DEVICE AND METHODS OF USE 审中-公开
公开(公告)号：WO2006088904A3
公开(公告)日：2006-08-24
申请号：PCT/US2006/005237
申请日：2006-02-15
申请人： GAO, Ping
发明人： GAO, Ping
IPC分类号： G01N15/06 , G01N21/00 , G01N21/03 , G01N33/53 , G01N33/543 , G01N33/566 , B01L3/00 , C12Q1/00 , C12M1/34 , C12M1/36
摘要： The present invention includes devices and methods for the detection of an analyte in a fecal sample. The fecal sample test device includes a sample collection structure and sample collection housing, a detection housing, a fecal suspension solution or fecal dilution solution, a detection housing capable of attachment to the collection housing and an analyte detecting means. When attached, the collection housing permits a portion of liquid extracted sample to fluidly flow into the detection housing where the analyte detection means detects the presence or quantity of an analyte suspected of being present in the fecal sample.

6. 发明申请

WO2006033696A2 HIGH DENSITY ION TRANSPORT MEASUREMENT BIOCHIP DEVICES AND METHODS 审中-公开
标题翻译：高密度离子运输测量生物芯片装置和方法
公开(公告)号：WO2006033696A2
公开(公告)日：2006-03-30
申请号：PCT/US2005/023993
申请日：2005-07-05
申请人： GUIA, Antonio , WALKER, George , HUANG, Mingxian , MENIKH, Abdelleh , WU, Lei , KHACHONESIN, Sithiphong , YUAN, Julian , XU, Jia
发明人： GUIA, Antonio , WALKER, George , HUANG, Mingxian , MENIKH, Abdelleh , WU, Lei , KHACHONESIN, Sithiphong , YUAN, Julian , XU, Jia
IPC分类号： C12Q1/00
CPC分类号： G01N33/54366 , G01N33/48728
摘要： The present invention includes biochips for the measurement of cellular ion channels and methods of use and manufacture. The biochips of the present invention have enhanced sealing capabilities provided in part by chemically modifying the surface of the biochip surface or substrate or by exposure to an ionized gas. The present invention also includes novel cartridges for biochips.
摘要翻译：本发明包括用于测量细胞离子通道的生物芯片以及使用和制造方法。本发明的生物芯片具有部分通过化学改性生物芯片表面或基底的表面或通过暴露于电离气体而提供的增强的密封能力。本发明还包括用于生物芯片的新型药筒。

7. 发明申请

WO2006036952A2 DYNAMIC MONITORING OF CELL ADHESION AND SPREADING USING THE RT-CES SYSTEM 审中-公开
标题翻译：细胞粘附的动态监测和使用RT-CES系统的扩散
公开(公告)号：WO2006036952A2
公开(公告)日：2006-04-06
申请号：PCT/US2005/034561
申请日：2005-09-27
申请人： ABASSI, Yama, A. , ATIENZA, Josephine , XU, Xiao , WANG, Xiaobo
发明人： ABASSI, Yama, A. , ATIENZA, Josephine , XU, Xiao , WANG, Xiaobo
IPC分类号： G11C11/00 , C12M1/34 , H01M4/50
CPC分类号： G01N29/036 , G01N2291/0257
摘要： The present invention includes devices and methods for dynamically monitoring cell adhesion and cell spreading. Cells are added to a microelectronic cell sensor array operably connected to an impedance analyzer. The device also includes a coating including biological molecule or organic compound capable of interacting with the cell. Cell adhesion and cell mobility is determined by detecting changes in impedance and comparing impedance or cell index values between samples.
摘要翻译：本发明包括用于动态监测细胞粘附和细胞扩散的装置和方法。将细胞添加到可操作地连接到阻抗分析器的微电子单元传感器阵列。该装置还包括包含能够与细胞相互作用的生物分子或有机化合物的涂层。通过检测阻抗变化并比较样品之间的阻抗或细胞指数值来确定细胞粘附和细胞迁移率。

8. 发明申请

WO2006017762A2 DYNAMIC MONITORING OF ACTIVATION OF G-PROTEIN (GPCR) AND RECEPTOR TYROSINE KINASE (RTK) IN LIVING CELLS USING REAL-TIME MICROELECTRONIC CELL SENSING TECHNOLOGY 审中-公开
标题翻译：使用实时微电子细胞感测技术动态监测生活细胞中G蛋白（GPCR）和受体酪氨酸激酶（RTK）的活性
公开(公告)号：WO2006017762A2
公开(公告)日：2006-02-16
申请号：PCT/US2005/027943
申请日：2005-08-04
申请人： ABASSI, Yama, A. , YU, Naichen , ATIENZA, Josephine , XU, Xiao , WANG, Xiaobo
发明人： ABASSI, Yama, A. , YU, Naichen , ATIENZA, Josephine , XU, Xiao , WANG, Xiaobo
IPC分类号： C12M1/34 , H01M4/50
CPC分类号： G01N33/4836
摘要： The present application includes systems and methods for identifying a compound capable of interacting with a G-Protein Coupled Receptor (GPCR) or Receptor Tyrosine Kinase (RTK) including providing a device capable of measuring cell-substrate impedance operably connected to an impedance analyzer, adding test cells expressing a GPCR or a RTK to wells of the device, monitoring the impedances of the wells before and after adding a compound of interest, determining the change in the impedance or cell index of a well, comparing the change in impedance or cell index between the compound and the control, and identifying the compound interacts with the GPCR or RTK if the comparison demonstrates a significant difference between the change in impedance or cell index.
摘要翻译：本申请包括用于鉴定能够与G-蛋白偶联受体（GPCR）或受体酪氨酸激酶（RTK）相互作用的化合物的系统和方法，包括提供能够测量可操作地连接到阻抗分析仪的细胞 - 基底阻抗的装置，测试细胞表达GPCR或RTK到设备的孔中，监测在添加感兴趣的化合物之前和之后孔的阻抗，确定孔的阻抗或细胞指数的变化，比较阻抗或细胞指数的变化在化合物和对照之间，并且如果比较显示阻抗或细胞指数的变化之间的显着差异，则鉴定化合物与GPCR或RTK相互作用。

9. 发明申请

WO2005098396A3 HIGH-DENSITY ION TRANSPORT MEASUREMENT BIOCHIP DEVICES AND METHODS 审中-公开
公开(公告)号：WO2005098396A3
公开(公告)日：2005-10-20
申请号：PCT/US2005/000732
申请日：2005-01-10
申请人： XU, Jia , GUIA, Antonio , WALKER, George , HUANG, Mingxian , WU, Lei , KHACHONESIN, Sithiphong , YUAN, Julian
发明人： XU, Jia , GUIA, Antonio , WALKER, George , HUANG, Mingxian , WU, Lei , KHACHONESIN, Sithiphong , YUAN, Julian
IPC分类号： C12M1/34 , C12M3/00
摘要： The present invention provides novel biochips, biochip-based devices, and device configurations that can be used for ion transport measurement. The chips, devices, and designs of the present invention are particularly suited to high-throughput assays such as compound screening assays using patch clamping techniques. The invention includes high-density biochips made by novel methods and methods of making high density biochips, and also provides novel upper chamber configurations and fluidics designs for upper chambers of ion transport measurement devices that can be used in high throughput patch clamp assays. The present invention also includes methods of using ion transport measuring chips and devices of the present invention.

10. 发明申请

WO2006062647A2 GENE EXPRESSION AND GENETIC CHANGES IMPLICATED IN ALCOHOLISM 审中-公开
标题翻译：基因表达和遗传变异在酒精中的影响
公开(公告)号：WO2006062647A2
公开(公告)日：2006-06-15
申请号：PCT/US2005/040257
申请日：2005-11-08
申请人： NEUROME, INC. , LI, Ting-kai , CARR, Lucinda, G. , ELLISON, Julie, A. , CHANG, Hwai, Wen , LO, David, D.
发明人： LI, Ting-kai , CARR, Lucinda, G. , ELLISON, Julie, A. , CHANG, Hwai, Wen , LO, David, D.
IPC分类号： A61K48/00
CPC分类号： C12Q1/6883 , A61K38/1709 , A61K48/00 , C12Q2600/156 , C12Q2600/158 , G01N33/6893 , G01N33/98 , G01N2800/307
摘要： Polynucleotides, polypeptides, kits and methods are provided related to regulated genes characteristic of alcoholism
摘要翻译：提供了与酒精中毒特征的调节基因相关的多核苷酸，多肽，试剂盒和方法

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式