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1. 发明申请

WO2011150493A1 MITOCHONDRIAL PENETRATING PEPTIDES AS CARRIERS FOR ANTIMICROBIALS 审中-公开
标题翻译：作为抗微生物载体的麻醉刺激肽
公开(公告)号：WO2011150493A1
公开(公告)日：2011-12-08
申请号：PCT/CA2011/000609
申请日：2011-05-27
申请人： THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO , KELLEY, Shana , PEREIRA, Mark
发明人： KELLEY, Shana , PEREIRA, Mark
IPC分类号： C07K7/06 , A61K47/48 , A61P31/00 , A61P31/04 , A61P31/12 , C07K5/10 , A61K31/519
CPC分类号： C07K7/06 , A61K47/64 , A61K47/645
摘要： There is described herein compounds comprising a mitochondrial penetrating peptide (MPP) conjugated to an antimicrobial, and their method of use.
摘要翻译：在本文中描述了包含与抗微生物结合的线粒体穿透肽（MPP）的化合物及其使用方法。

2. 发明申请

WO2011085499A1 ANTIMICROBIAL TISSUE PAPER AND PROCESS TO MANUFACTURE SAME 审中-公开
标题翻译：抗菌组织纸及其制造方法
公开(公告)号：WO2011085499A1
公开(公告)日：2011-07-21
申请号：PCT/CA2011/050021
申请日：2011-01-18
申请人： CASCADES CANADA INC. , CHAREST, Marie-Hélène , SAMUEL, Jean-François , ALLARD, Pascal , ARSENAULT, Régis , BEAULNE, Charles , BOUCHARD, Jean-Marc , GRATON, Benoît , SANAPO, Gabriel
发明人： CHAREST, Marie-Hélène , SAMUEL, Jean-François , ALLARD, Pascal , ARSENAULT, Régis , BEAULNE, Charles , BOUCHARD, Jean-Marc , GRATON, Benoît , SANAPO, Gabriel
IPC分类号： D21H21/36 , A01N25/34 , A01N33/12 , A01P1/00
CPC分类号： A01N25/34 , A01N33/12 , A61L15/28 , A61L15/44 , A61L15/46 , A61L2300/204 , A61L2300/208 , A61L2300/404 , A61L2300/406 , A61L2300/408 , A61L2300/802 , D21H17/44 , D21H21/24 , D21H21/36 , D21H27/002 , A01N25/10 , A01N47/44 , C08L1/02
摘要： An antimicrobial paper includes a paper web having a grammage between 10 and 60 grams per square meter, a cationizing agent in a concentration ranging between 0.05 wt% and 5 wt%, an antimicrobial agent in a concentration ranging between 0.01 wt% and 3 wt%, the antimicrobial agent and the cationizing agent being added on the paper web having a consistency above 15 wt%, the antimicrobial paper having an antimicrobial agent release of above about 0.01 wt% when wetted.
摘要翻译：抗微生物纸包括具有10至60克/平方米的克重的纸幅，浓度范围为0.05重量％至5重量％的阳离子化剂，浓度范围为0.01重量％至3重量％的抗微生物剂，，抗微生物剂和阳离子化剂加入到具有15重量％以上的浓度的纸幅上时，抗微生物纸在润湿时具有高于约0.01重量％的抗菌剂释放。

3. 发明申请

WO2011075837A1 COATINGS CONTAINING NANOCRYSTALLINE CELLULOSE, PROCESSES FOR PREPARATION AND USE THEREOF 审中-公开
标题翻译：包含纳米晶体纤维素的涂料，其制备和使用方法
公开(公告)号：WO2011075837A1
公开(公告)日：2011-06-30
申请号：PCT/CA2010/002034
申请日：2010-12-20
申请人： FPINNOVATIONS , LANDRY, Véronic , BLANCHET, Pierre
发明人： LANDRY, Véronic , BLANCHET, Pierre
IPC分类号： C09D101/02 , C09D151/02 , C09D201/00
CPC分类号： C09D151/02 , C08F251/02 , C09D143/04 , C08F220/28
摘要： This invention relates to coatings for wood and improvement in the surface properties of cured coatings of the invention. The invention further relates to a method for improving at least one property such as mechanical, optical or a combination thereof and to a process for preparing a nanocrystalline cellulose-containing hydrodispersible, hydrosoluble and hydrophobic wood coating.
摘要翻译：本发明涉及用于木材的涂层和改进本发明的固化涂层的表面性能。本发明还涉及一种用于改进至少一种性质如机械，光学或其组合的方法，以及制备含纳米晶体纤维素的可分散水解，水溶性和疏水性木材涂层的方法。

4. 发明申请

WO2011066659A1 METHOD OF REGULATING PPAR, OBESITY RELATED PATHWAYS AND THEIR ASSOCIATED METABOLIC IMPACT 审中-公开
标题翻译：调节PPAR，肥胖相关途径及其相关代谢影响的方法
公开(公告)号：WO2011066659A1
公开(公告)日：2011-06-09
申请号：PCT/CA2010/001928
申请日：2010-12-03
申请人： TECHNOLOGIE BIOLACTIS INC. 15468 , SIMARD, Eric , TROTTIER, Eric , BEAULIEU, Josée , LAPOINTE, Jean-François , LEMIEUX, Pierre
发明人： SIMARD, Eric , TROTTIER, Eric , BEAULIEU, Josée , LAPOINTE, Jean-François , LEMIEUX, Pierre
IPC分类号： A61K38/01 , A61K35/74 , A61P3/06 , A61P3/10
CPC分类号： A61K35/20 , A61K38/018
摘要： It is disclosed a method of modulating a peroxisome proliferator activated receptor (PPAR) activity in a patient comprising administering to said subject an effective amount of a malleable protein matrix (MPM), uses thereof and pharmaceutical compositions comprising MPM for treating obesity related disorders and their associated metabolic impact by modulating PPAR activity.
摘要翻译：公开了一种调节患者过氧化物酶体增殖物激活受体（PPAR）活性的方法，包括向所述受试者施用有效量的可延展蛋白质基质（MPM），其用途和包含MPM的药物组合物，用于治疗肥胖相关病症及其通过调节PPAR活性引起的相关代谢影响。

5. 发明申请

WO2011057382A1 SPIROCYCLIC PIPERIDINE DERIVATIVES USEFUL AS RENIN INHIBITORS 审中-公开
标题翻译：作为RININ抑制剂有用的螺环哌啶衍生物
公开(公告)号：WO2011057382A1
公开(公告)日：2011-05-19
申请号：PCT/CA2010/001632
申请日：2010-10-12
申请人： MERCK FROSST CANADA LTD. , CHEN, Austin , ASPIOTIS, Renee , MCKAY, Daniel , HAN, Yongxin , FOURNIER, Pierre-André
发明人： CHEN, Austin , ASPIOTIS, Renee , MCKAY, Daniel , HAN, Yongxin , FOURNIER, Pierre-André
IPC分类号： C07D491/107 , A61P25/22 , A61P27/02 , A61P5/42 , A61P9/00 , C07D491/20 , A61K31/438 , A61P13/12
CPC分类号： C07D491/107 , C07D491/20
摘要： Renin inhibitors which are spirocyclic piperidine derivatives, of formula (I) and pharmaceutical compositions thereof useful in the treatment of cardiovascular diseases and renal insufficiency. or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt of the stereoisomer thereof, wherein: n, for each instance in which it occurs, is independently 0, 1, or 2; W is a five- or six-membered saturated or unsaturated heterocyclic or carbocyclic monocyclic ring, A is (i) a five- or six-membered saturated or unsaturated heterocyclic or carbocyclic monocyclic ring or (ii) a first five- or six-membered saturated or unsaturated heterocyclic or carbocyclic ring which is fused to a second five- or six-membered saturated or unsaturated heterocyclic or carbocyclic ring, V is -(C=O)-, -CH 2 - or =CH-; U is a bond or -CH2-, or, when V iS =CH-, U is-CH=; X is =CH-, =CF-, =C(OR 3 )-, or -(C=O)-; and Y is =CH-, =CF-, =N-, or, for the case when X is -(C=O)-, Y is -N(R 3 )-.
摘要翻译：作为式（I）的螺环哌啶衍生物的肾素抑制剂及其用于治疗心血管疾病和肾功能不全的药物组合物。或其立体异构体，或其药学上可接受的盐或其立体异构体的药学上可接受的盐，其中：对于其发生的每一种情况，n独立地为0,1或2; W是五或六元饱和或不饱和的杂环或碳环单环，A是（i）五或六元饱和或不饱和的杂环或碳环单环或（ii）第一个五元或六元饱和或不饱和的杂环或碳环与第二个五元或六元饱和或不饱和的杂环或碳环稠合，V是 - （C = O） - ， - CH 2 - 或= CH-; U是键或-CH 2 - ，或当V iS = CH-时，U是-CH =; X = CH-，= CF-，= C（OR 3） - 或 - （C = O） - ; 并且Y是= CH-，= CF-，= N-，或者对于X是 - （C = O） - 的情况，Y是-N（R 3） - 。

6. 发明申请

WO2011044697A1 POROUS BONE SCREW 审中-公开
标题翻译：多孔骨螺丝
公开(公告)号：WO2011044697A1
公开(公告)日：2011-04-21
申请号：PCT/CA2010/001645
申请日：2010-10-13
申请人： THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITY , MARTINEAU, Paul, A. , LEFEBVRE, Louis-Philippe , HARVEY, Edward, J.
发明人： MARTINEAU, Paul, A. , LEFEBVRE, Louis-Philippe , HARVEY, Edward, J.
IPC分类号： A61B17/86
CPC分类号： A61B17/866 , A61B17/863 , A61B17/864 , A61B2017/00526 , A61B2017/561 , B22F3/11 , B22F5/06 , B22F5/10 , B22F7/008
摘要： A bone screw is described which includes a one-piece threaded screw body composed at least partially of a rigid foam. The screw body is headless and includes a bore extending therethrough to define a cannula and thereby providing the screw body with an annular shape defining a radial wall thickness. At least a central portion of the screw body is formed of the rigid foam which defines a matrix having a plurality of inter-connected pores therein. The inter-connected pores are disposed throughout the complete radial wall thickness of the screw body from an outer surface of the screw body to an inner surface thereof within the cannula, such as to permit bone in-growth through the complete radial wall thickness of the annular screw body. The inter-connected pores and the cannula thereby respectively allow bone in-growth through the complete radial wall thickness and the full axial length of the screw body.
摘要翻译：描述了一种骨螺钉，其包括至少部分由硬质泡沫构成的单件螺纹螺纹体。螺丝体是无头的并且包括延伸穿过其中以限定插管的孔，从而为螺钉体提供限定径向壁厚度的环形形状。螺杆体的至少中心部分由硬质泡沫形成，该刚性泡沫限定了在其中具有多个相互连通的孔的基体。相互连接的孔被布置在螺钉体的整个完整的径向壁厚度上，从螺钉体的外表面到套管内的内表面，例如允许骨通过完整的径向壁厚度环形螺丝体。相互连接的孔和套管分别允许骨骼通过完整的径向壁厚度和螺钉体的全部轴向长度生长。

7. 发明申请

WO2011042880A1 PROBE AND METHOD FOR OBTAINING RHEOLOGICAL PROPERTY VALUE 审中-公开
标题翻译：用于获取流变性价值的探索和方法
公开(公告)号：WO2011042880A1
公开(公告)日：2011-04-14
申请号：PCT/IB2010/054542
申请日：2010-10-07
申请人： I.B.B. RHEOLOGIE INC. , BEAUPRÉ, Denis , CHAPDELAINE, Jérôme , CHAPDELAINE, Frédéric
发明人： BEAUPRÉ, Denis , CHAPDELAINE, Jérôme , CHAPDELAINE, Frédéric
IPC分类号： G01N11/10 , B28C5/42
CPC分类号： B28C7/024 , G01N11/14 , G01N2011/0046 , G01N2203/0676
摘要： The probe can include a base and a resistance member extending from the base and onto which a resistance pressure is imparted by a rheological substance when the resistance member is submerged and moved therein. Rheological properties can be obtained using values indicative of the resistance pressure both in a low speed range and in a high speed range.
摘要翻译：探针可以包括从底部延伸的基部和阻力构件，当阻力构件浸没并移动到其上时，由流变物质赋予阻力。可以使用表示低速范围和高速范围内的电阻压力的值来获得流变特性。

8. 发明申请

WO2011026223A1 CONTENT DISTRIBUTION OVER A NETWORK 审中-公开
标题翻译：网络内容分发
公开(公告)号：WO2011026223A1
公开(公告)日：2011-03-10
申请号：PCT/CA2010/001348
申请日：2010-08-27
申请人： ECHENBERG, Andrew
发明人： ECHENBERG, Andrew
IPC分类号： H04L12/16
CPC分类号： G06F8/61 , G06F9/445
摘要： There is described a content distribution network comprising at least one server adapted to generate a substantially real-time instance of a root website and generate host site data in a frame of a host website, the frame comprising content of the host website and at least one blank segment; and at least one user machine connected to the network, the user machine having at least one application running on a processor for displaying the frame comprising content of the host website and having the real-time instance of the root website embedded therein via the at least one blank segment, thereby allowing access to the root website while remaining on the host website, wherein embedding the substantially real-time instance of the root website into the frame of the host website is done on one of the at least one server and the user machine.
摘要翻译：描述了一种内容分发网络，其包括至少一个服务器，其适于生成根网站的基本上实时的实例并且在主机网站的帧中生成主机站点数据，该框架包括主机站点的内容和至少一个空白段以及连接到所述网络的至少一个用户机器，所述用户机器具有在处理器上运行的至少一个应用程序，用于显示包括所述主机网站的内容并且具有至少嵌入其中的根网站的实时实例的所述帧一个空白段，从而允许访问根网站，同时保留在主机网站上，其中将根网站的基本上实时实例嵌入到主机网站的帧中，在至少一个服务器和用户之一上完成机。

9. 发明申请

WO2011020173A1 BICYCLE FRAME SUSPENSION PIVOT 审中-公开
标题翻译：自行车框架悬挂派
公开(公告)号：WO2011020173A1
公开(公告)日：2011-02-24
申请号：PCT/CA2010/001195
申请日：2010-08-04
申请人： ROCKY MOUNTAIN BICYCLES, A DIVISION OF PROCYCLE GROUP INC. , O'CONNER, D'Arcy
发明人： O'CONNER, D'Arcy
IPC分类号： B62K19/18 , B62K19/00
CPC分类号： B62K19/18 , Y10T403/32951
摘要： A pivot joint for a bicycle frame is described, which includes an inner bearing sleeve concentrically disposed within an outer bearing sleeve. The inner bearing sleeve has an outer bearing surface in rotatably sliding contact with an inner bearing surface of the outer bearing sleeve, such that the inner and outer bearing sleeves are rotatable relative to each other about a central pivot axis to permit relative rotation of the frame components joined by the pivot joint. Each of the inner and outer bearing surfaces includes a substantially axially extending region and at least one angled bearing region that defines an angled raceway surface thereon. The angled raceway surfaces are disposed at an angle relative to the central pivot axis and meet in bearing engagement with each other to define a slip plane disposed at the same angle.
摘要翻译：描述了一种用于自行车车架的枢转接头，其包括同心地设置在外轴承套内的内轴承套。内部轴承套筒具有与外部轴承套筒的内部支承表面可旋转地滑动接触的外部支承表面，使得内部和外部轴承套筒可围绕中心枢转轴线相对于彼此旋转，以允许框架的相对旋转通过枢轴接头连接的部件。内轴承表面和外支承表面中的每一个包括基本上轴向延伸的区域和在其上限定成角度的滚道表面的至少一个成角度的轴承区域。倾斜的滚道表面相对于中心枢转轴线成角度设置，并且彼此轴承接合以限定以相同角度设置的滑动平面。

10. 发明申请

WO2011011895A1 WASTE DISPOSAL DEVICE 审中-公开
标题翻译：垃圾处理设备
公开(公告)号：WO2011011895A1
公开(公告)日：2011-02-03
申请号：PCT/CA2010/001208
申请日：2010-07-30
申请人： INTERNATIONAL REFILLS COMPANY LTD. , ANGELCARE DEVELOPMENTS INC. , MORAND, Michel
发明人： MORAND, Michel
IPC分类号： B65B67/12 , B65D43/26 , B65F1/06
CPC分类号： B65F1/062 , B65F1/1607 , B65F1/163 , B65F2210/167 , B65F2240/132
摘要： A waste disposal device comprises a container having a top opening. The container provides access to an inner cavity that receives a bag with opened and closed ends. A pivoting lid closes/opens access to the opening. An actuation mechanism has a user-actuated interface. A linkage connected to the interface opens/closes the lid. A pair of jaws is connected to the linkage. The jaws move between a clamped position, in which the jaws close off a portion of the bag, and an opened position, in which the jaws are separated to allow waste to reach the closed end. The jaws and the lid are actuated concurrently by a single degree of actuation on the interface, allowing the lid to open and close while the jaws move from the clamped to the opened position, and back to the clamped position. A method for disposal of a waste object is also provided.
摘要翻译：废物处理装置包括具有顶部开口的容器。容器提供通向接收具有开口和封闭端的袋的内腔。枢轴盖关闭/打开进入开口的通道。致动机构具有用户致动的接口。连接到接口的连杆打开/关闭盖子。一对夹爪连接到连杆上。夹爪在夹紧位置之间移动，夹紧位置夹在袋子的一部分之间，并且打开位置，其中夹爪被分离以允许废物到达封闭端。夹爪和盖子通过接口上的单一致动同时致动，允许盖子在夹持件从夹紧件移动到打开位置并且回到夹紧位置时打开和关闭。还提供了废物处理方法。

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