专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2018156851A1 VASCULAR PROSTHESIS WITH MOVEABLE FENESTRATION 审中-公开
公开(公告)号：WO2018156851A1
公开(公告)日：2018-08-30
申请号：PCT/US2018/019353
申请日：2018-02-23
申请人： BOLTON MEDICAL, INC.
发明人： ARBEFEUILLE, Samuel
IPC分类号： A61F2/07
CPC分类号： A61F2/07 , A61F2/89 , A61F2002/061 , A61F2002/072 , A61F2002/075 , A61F2220/005 , A61F2220/0075 , A61F2230/0054 , A61F2250/006
摘要： Vascular prosthesis includes a luminal graft component defining a graft fenestration, at least one support disk fenestration, and a moveable disk defining a moveable disk opening, wherein the graft fenestration, the support disk fenestration and the moveable disk opening are all aligned, and the moveable disk is sandwiched between the support disk and the luminal graft component or between two of the support disks. The moveable disk is moveable between the support disk and the luminal graft component. The support disk is fixed to the luminal graft component. The vascular prosthesis is implanted by a method that includes directing the vascular prosthesis to an aneurysm site of a patient, and then implanting a branch prosthesis through the graft fenestration and into an arterial branch, whereby the moveable disk opening moves within the support disk fenestration to properly align the branch prosthesis with the arterial branch.

2. 发明申请

WO2018031632A1 GRAFT PROSTHESIS COUPLER, MODULAR SYSTEM, AND METHODS OF USE 审中-公开
标题翻译：移植假体连接器，模块化系统和使用方法
公开(公告)号：WO2018031632A1
公开(公告)日：2018-02-15
申请号：PCT/US2017/046062
申请日：2017-08-09
申请人： BOLTON MEDICAL, INC.
发明人： ARBEFEUILLE, Samuel , GARCIA, Eduardo, Alejandro , LOSTETTER, Timothy
IPC分类号： A61F2/06 , A61F2/07 , A61F2/848
CPC分类号： A61F2/064 , A61F2/07 , A61F2/848 , A61F2/852 , A61F2002/061 , A61F2002/067 , A61F2002/8483 , A61F2220/0075 , A61F2230/0008 , A61F2250/0039
摘要： A graft prosthesis coupler includes a plurality of luminal grafts, each of which defines a first end, and a second end and a major longitudinal axis, the major longitudinal axes being substantially parallel to each other. The graft prosthesis coupler also includes a circumferential graft that has first and second ends and extends about the plurality of luminal grafts, and a first end wall that lies in a surface defined by the first ends of the luminal grafts and the first end of the circumferential graft. In another embodiment, a graft prosthesis coupler includes a plurality of luminal grafts attached to each other. A modular graft system includes the graft prosthesis coupler and branch graft prostheses. The graft prosthesis coupler can be implanted in a patient at a site of an aneurysm to facilitate implanting the branch graft prostheses into branch vessels at the site of the aneurysm.
摘要翻译：移植物假体连接器包括多个腔移植物，每个腔移植物限定第一端，以及第二端和主纵向轴，主纵向轴基本上彼此平行。移植物假体连接器还包括周向移植物，其具有第一端和第二端并围绕多个腔移植物延伸，以及第一端壁，其位于由腔移植物的第一端限定的表面中，并且周向的第一端接枝。在另一个实施例中，移植物假体联接器包括彼此连接的多个腔移植物。模块化移植物系统包括移植物假体连接器和分支移植物假体。可将移植物假体联接器植入动脉瘤部位的患者体内，以便于将分支移植物假体植入动脉瘤部位的分支血管中。

3. 发明申请

WO2014035989A1 FLAGELLIN FUSION PROTEINS AND METHODS OF USE 审中-公开
标题翻译： FLAGELLIN融合蛋白及其使用方法
公开(公告)号：WO2014035989A1
公开(公告)日：2014-03-06
申请号：PCT/US2013/056838
申请日：2013-08-27
申请人： VAXINNATE CORPORATION
发明人： SONG, Langzhou , LIU, Ge , UMLAUF, Scott , KAVITA, Uma , LI, Hong , LIU, Xiangyu , WEAVER, Bruce , TUSSEY, Lynda
IPC分类号： A61K39/145 , A61K39/39 , C07K14/11 , C07K14/255
CPC分类号： A61K39/145 , A61K38/164 , A61K39/12 , A61K39/39 , A61K2039/6068 , A61K2039/70 , C07K14/005 , C07K14/195 , C07K14/255 , C07K2319/00 , C07K2319/40 , C07K2319/74 , C12N7/00 , C12N2760/16134 , C12N2760/16222 , C12N2760/16234
摘要： Compositions that include a fusion protein comprising flagellin and at least one antigen that has an isoelectric point greater than about 7.0 and that is fused to at least one domain 3 of the flagellin activate Toll-like Receptor 5. Methods of stimulating an immune response, in particular, a protective immune response include administering a composition that includes an antigen fused to a loop of domain 3 of flagellin.
摘要翻译：包含包含鞭毛蛋白和至少一种具有大于约7.0的等电点并且与鞭毛蛋白的至少一个结构域3融合的至少一种抗原的融合蛋白的组合物激活Toll样受体5.刺激免疫应答的方法特别地，保护性免疫应答包括施用包含融合到鞭毛蛋白结构域3的环的抗原的组合物。

4. 发明申请

WO2010105195A2 SYSTEM AND METHOD FOR DEPLOYING AN ENDOLUMINAL PROSTHESIS AT A SURGICAL SITE 审中-公开
标题翻译：用于在外科手术部位进行内分泌支原体的系统和方法
公开(公告)号：WO2010105195A2
公开(公告)日：2010-09-16
申请号：PCT/US2010/027191
申请日：2010-03-12
申请人： BOLTON MEDICAL, INC. , ARBEFEUILLE, Samuel , CHRISTIAN, Fletcher , MANGUNO, Joseph, A., Jr. , CANNING, John, C.
发明人： ARBEFEUILLE, Samuel , CHRISTIAN, Fletcher , MANGUNO, Joseph, A., Jr. , CANNING, John, C.
IPC分类号： A61F2/84
CPC分类号： A61F2/95 , A61F2/07 , A61F2/966 , A61F2002/9505 , A61F2002/9511 , A61F2002/9665 , A61F2250/0039
摘要： A system for implanting a prosthesis includes a control lumen and a nose cone affixed at a distal end of the control lumen. At least one supporting wire is affixed at one end, is substantially parallel to a major axis of the control lumen and is free at an opposite end, wherein the free end of at least one of the supporting wires is arcuate. Alternatively, a system for implanting a prosthesis includes at least one suture extending from a nose cone affixed to a distal end of a control lumen, The suture extends from the nose cone to a proximal end to a stent graft extending about the control lumen and from the stent graft to a fixed location on the control lumen. The suture is releasable from the stent graft by remote activation, whereby the suture separates from the nose cone to thereby deploy the stent graft.
摘要翻译：用于植入假体的系统包括固定在控制腔的远端的控制腔和鼻锥。至少一个支撑线固定在一端，基本上平行于控制腔的长轴并且在相对端处是自由的，其中至少一个支撑线的自由端是弓形的。或者，用于植入假体的系统包括从固定到控制腔的远端的鼻锥延伸的至少一根缝合线。缝合线从鼻锥延伸到近端，其延伸围绕控制腔和从支架移植到控制腔上的固定位置。缝合线通过远程激活从支架移植物释放，由此缝合线与鼻锥分离，从而展开支架移植物。

5. 发明申请

WO2006078657A2 COMPOSITIONS OF PATHOGEN-ASSOCIATED MOLECULAR PATTERNS AND METHODS OF USE 审中-公开
标题翻译：病原相关分子模式的组合物及其使用方法
公开(公告)号：WO2006078657A2
公开(公告)日：2006-07-27
申请号：PCT/US2006/001623
申请日：2006-01-19
申请人： VAXINNATE CORPORATION , POWELL, Thomas, J. , NAKAAR, Valerian , SONG, Langzhou , HULEATT, James, W. , MCDONALD, William, F. , HEWITT, Duane, D.
发明人： POWELL, Thomas, J. , NAKAAR, Valerian , SONG, Langzhou , HULEATT, James, W. , MCDONALD, William, F. , HEWITT, Duane, D.
CPC分类号： A61K39/12 , A61K38/162 , A61K38/164 , A61K39/0258 , A61K39/0275 , A61K2039/6068 , C07K14/005 , C07K14/245 , C07K14/255 , C07K2319/00 , C12N7/00 , C12N2770/24022 , C12N2770/24122 , C12N2770/24134 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： Compositions comprise at least a portion of an antigen and at least a portion of a flagellin that lacks a hinge region. Compositions, fusion proteins and polypeptides comprise at least a portion of at least one pathogen-associated molecular pattern and at least a portion of at least one viral protein. The viral protein of the compositions, fusion proteins and polypeptides of the invention are flaviviral proteins, including a West Nile flaviviral protein, a Dengue flaviviral protein, a Langat flaviviral protein, a Kunjin flaviviral protein, a Murray Valley encephalitis flaviviral protein, a Japanese encephalitis flaviviral protein, a Tick- borne encephalitis flaviviral protein, a Yellow fever flaviviral protein and a hepatitis C flaviviral protein. The compositions, fusion proteins and polypeptides are used to stimulate an immune response in a subject.
摘要翻译：组合物包含至少一部分抗原和至少一部分缺乏铰链区的鞭毛蛋白。组合物，融合蛋白质和多肽包含至少一种与病原体相关的分子模式和至少一部分至少一种病毒蛋白的至少一部分。本发明的组合物，融合蛋白和多肽的病毒蛋白是黄病毒蛋白，包括西尼罗河黄病毒蛋白，登革热黄病毒蛋白，兰加特黄病毒蛋白，昆金黄病毒蛋白，墨累谷脑炎黄病毒蛋白，日本脑炎黄病毒蛋白，蜱传脑炎黄病毒蛋白，黄热病黄病毒蛋白和丙型肝炎黄病毒蛋白。组合物，融合蛋白和多肽用于刺激受试者的免疫应答。

6. 发明申请

WO2018156853A1 DELIVERY SYSTEM FOR RADIALLY CONSTRICTING A STENT GRAFT AND METHOD OF USE 审中-公开
公开(公告)号：WO2018156853A1
公开(公告)日：2018-08-30
申请号：PCT/US2018/019355
申请日：2018-02-23
申请人： BOLTON MEDICAL, INC.
发明人： GARCIA, Eduardo, Alejandro
IPC分类号： A61F2/966 , A61F2/07
摘要： A stent graft delivery system includes a handle, a guidewire catheter extending distally from the handle, at least one tube, and at least one wire extending through the at least one tube, wherein each wire of the stent graft delivery system is configured as a loop at the distal end of the tube. The stent graft delivery system can be employed to implant stent grafts in a patient to thereby treat, for example, an aortic aneurysm spanning a region of an aorta that includes at least one arterial branch.

7. 发明申请

WO2018156849A1 VASCULAR PROSTHESIS WITH FENESTRATION RING AND METHODS OF USE 审中-公开
公开(公告)号：WO2018156849A1
公开(公告)日：2018-08-30
申请号：PCT/US2018/019351
申请日：2018-02-23
申请人： BOLTON MEDICAL, INC.
发明人： LOSTETTER, Timothy
IPC分类号： A61F2/07
摘要： The vascular prosthesis includes a luminal graft component having at least one fenestration. At least one fenestration ring borders the at least one fenestration and is fixed to the luminal graft component. The fenestration ring includes a main component with two opposing ends and a connecting component. The diameter of the fenestration ring can expand upon insertion of a branch prosthesis through the fenestration ring during implantation at a surgical site. The vascular prosthesis can be implanted in a patient to thereby treat, for example, an arterial aneurysm, spanning a region of an aneurysm that includes at least one arterial branch.

8. 发明申请

WO2018156840A1 CONSTRAINABLE STENT GRAFT, DELIVERY SYSTEM AND METHODS OF USE 审中-公开
公开(公告)号：WO2018156840A1
公开(公告)日：2018-08-30
申请号：PCT/US2018/019342
申请日：2018-02-23
申请人： BOLTON MEDICAL, INC.
发明人： ARBEFEUILLE, Samuel , BAHAR, Nico
IPC分类号： A61F2/07 , A61F2/962 , A61F2/95 , A61F2/966 , A61F2/06
摘要： A stent graft for treating an arterial aneurysm includes a ligature traversing at least a portion of struts of stents, the ligature having ends that, when linked, at least partially constrict a radial dimension of the stents. The ends of the ligature can be linked by a wire in a stent graft delivery system that threads anchor loops longitudinally spanning ends of the ligature to maintain the stent in a radially constricted position during delivery to the aneurysm. The stent graft can be implanted at the aneurysm by retracting the wire from the linked ends of the ligature and from the anchor loops, thereby releasing the associated stent from the radially constricted position.

9. 发明申请

WO2017176674A1 DELIVERY SYSTEMS WITH INTRODUCER AND DISTAL SHEATHS AND METHODS OF USE 审中-公开
标题翻译：带介绍者和远端皮的递送系统及使用方法
公开(公告)号：WO2017176674A1
公开(公告)日：2017-10-12
申请号：PCT/US2017/025844
申请日：2017-04-04
申请人： BOLTON MEDICAL, INC.
发明人： LOSTETTER, Timothy , RUSH, Scott Lyle
IPC分类号： A61F2/966 , A61F2/07
摘要： A delivery system and method of its use delivers a stent graft prosthesis to a surgical site, such as an abdominal, thoracic or thoraco-abdominal aortic aneurysm. The delivery system includes a handle defining a conduit, an introducer sheath extending distally through the handle, a substantially straight inner control tube extending through the conduit of the handle and from the distal end of the introducer sheath, and a distal sheath that extends through and beyond a distal end of the introducer sheath. The distal sheath can have, in one embodiment, a diameter equal to or less than that of the introducer sheath. Retraction of the distal sheath through the introducer sheath and the handle exposes a stent graft prosthesis extending about the inner control tube. Removal of the inner control tube from the introducer sheath allows for implantation of additional components through the introducer sheath.
摘要翻译：输送系统及其使用方法将支架移植物假体递送至手术部位，例如腹部，胸部或胸腹部腹主动脉瘤。输送系统包括限定导管的手柄，穿过手柄向远侧延伸的导引器鞘，延伸穿过手柄的导管并从导引器鞘的远端延伸的基本笔直的内部控制管以及延伸穿过超过导引鞘的远端。在一个实施例中，远侧鞘可具有等于或小于导引器鞘的直径的直径。通过引入器鞘和手柄的远侧鞘的缩回暴露围绕内部控制管延伸的支架植入物假体。

10. 发明申请

WO2013163402A1 METHODS FOR TREATMENT OF 16P11.2 MICRODELETION SYNDROME 审中-公开
标题翻译：用于治疗16P11.2微阵列综合征的方法
公开(公告)号：WO2013163402A1
公开(公告)日：2013-10-31
申请号：PCT/US2013/038179
申请日：2013-04-25
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： BEAR, Mark, F. , TIAN, Di
IPC分类号： A61K31/196 , A61K31/197 , A61K31/382 , A61K31/4015 , A61K31/44 , A61K31/4439 , A61P25/00
CPC分类号： C07D401/06 , A61K31/198 , A61K31/382 , A61K31/4439
摘要： Subjects that have a 16p11.2 microdeletion syndrome are treated by administering compositions that include mGluR inhibitors, including mGluR antagonists that include mGluR negative allosteric modulators. Administration of compositions employed in the methods of the invention can treat psychiatric, including neuropsychiatric disorders, cognitive impairments, attention, obesity, intellectual disability and seizure disorders.
摘要翻译：具有16p11.2微缺失综合征的受试者通过施用包括mGluR抑制剂的组合物来治疗，包括mGluR拮抗剂，其包括mGluR负变构调节剂。用于本发明方法的组合物的施用可以治疗精神病学，包括神经精神障碍，认知障碍，注意力，肥胖症，智力障碍和癫痫发作障碍。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式