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1. 发明申请

WO2004057579A2 ENHANCED DATA STORAGE AND RETRIEVAL DEVICES AND SYSTEMS AND METHODS FOR UTILIZING SAME 审中-公开
标题翻译：增强的数据存储和检索设备以及利用该设备的系统和方法
公开(公告)号：WO2004057579A2
公开(公告)日：2004-07-08
申请号：PCT/US2003/037253
申请日：2003-11-20
申请人： BERKSHIRE LABORATORIES, INC. , BROOKS, Juliana, H., J. , MORTENSON, Mark, G.
发明人： BROOKS, Juliana, H., J. , MORTENSON, Mark, G.
IPC分类号： G11B
CPC分类号： G11B11/10508 , G11B5/02 , G11B5/0275 , G11B11/10515 , G11B11/10532 , G11B11/10547 , G11B11/10584
摘要： The present invention relates generally to the storage and/or retrieval of information on magnetic storage media by using one or more novel approaches alone or in combination. These novel approaches are capable of using at least one code which may comprise more than two values (i.e., more than a "0" and a "1"). A series of approaches applies generally to existing electric and/or magnetic storage/retrieval systems (e.g., magnetic, magneto-optic, etc.) as well as other novel electrical/magnetic systems. Each series of approaches is capable of storing information in one or more codes, wherein such approaches permit, if desired, the use of at least one higher order code which is different from the traditional binary code of "0's" and "l's" currently utilized for the storage of digital information. Said at least one higher order code may comprise three or more optical and/or magnetic values or bits that are used to represent, for example, ASCII or Unicode characters that are currently represented predominately by the traditional binary code. This higher order code may also be an analog or analog-like code.
摘要翻译：本发明总体上涉及通过单独或组合使用一种或多种新方法在磁存储介质上存储和/或检索信息。这些新颖的方法能够使用至少一个可包含多于两个值（即，多于“0”和“1”）的代码。一系列方法通常适用于现有的电和/或磁存储/检索系统（例如，磁，磁光等）以及其他新颖的电/磁系统。每一系列方法都能够将信息存储在一个或多个代码中，其中如果需要，这些方法允许使用至少一个不同于传统二进制代码“0”的至少一个更高阶代码。和“1”。目前用于存储数字信息。所述至少一个较高阶代码可以包括三个或更多个光学值和/或磁值或位，其用于表示例如主要由传统二进制代码主要表示的ASCII或Unicode字符。这个更高阶的代码也可以是模拟或类似模拟的代码。

2. 发明申请

WO2003089692A3 METHODS FOR CONTROLLING CRYSTAL GROWTH, CRYSTALLIZATION, STRUCTURES AND PHASES IN MATERIALS AND SYSTEMS 审中-公开
公开(公告)号：WO2003089692A3
公开(公告)日：2003-10-30
申请号：PCT/US2003/008904
申请日：2003-03-21
申请人： BERKSHIRE LABORATORIES, INC. , BLUM, Bentley, J. , BROOKS, Juliana, H., J. , MORTENSON, Mark, G.
发明人： BLUM, Bentley, J. , BROOKS, Juliana, H., J. , MORTENSON, Mark, G.
IPC分类号： B01D9/00
摘要： This invention relates to novel methods for affecting, controlling and/or directing various crystal formation, structure formation or phase formation/phase change reaction pathways or systems by exposing one or more components in a holoreaction system to at least one spectral energy pattern. In a first aspect of the invention, at least one spectral energy pattern can be applied to a crystallization reaction system. In a second aspect of the invention, at lest one spectral energy conditioning pattern can be applied to a conditioning reaction system. The spectral energy conditioning pattern can, for example, be applied at a separate location from the reaction vessel (e.g., in a conditioning reaction vessel) or can be applied in (or to) the reaction vessel, but prior to other (or all) crystallization reaction system participants being introduced into the reaction vessel.

3. 发明申请

WO2012135743A2 NOVEL GOLD-PLATINUM BASED BI-METALLIC NANOCRYSTAL SUSPENSIONS, ELECTROCHEMICAL MANUFACTURING PROCESSES THEREFOR AND USES FOR THE SAME 审中-公开
标题翻译：新型金 - 铂基二金属纳米悬浮液，其电化学制造方法及其用途
公开(公告)号：WO2012135743A2
公开(公告)日：2012-10-04
申请号：PCT/US2012/031654
申请日：2012-03-30
申请人： GR INTELLECTUAL RESERVE, LLC , DORFMAN, Adam, R. , BRYCE, David, A. , GRACE, Maxwell, A. , PIERCE, D., Kyle , MERZLIAKOV, Mikhail , MORTENSON, Mark, G.
发明人： DORFMAN, Adam, R. , BRYCE, David, A. , GRACE, Maxwell, A. , PIERCE, D., Kyle , MERZLIAKOV, Mikhail , MORTENSON, Mark, G.
IPC分类号： A61K9/14
CPC分类号： A61K33/24 , A61K9/10 , A61K9/14 , A61K9/1611 , B82Y5/00 , C22C1/0466 , C22C5/02 , C22C5/04 , C22C30/00
摘要： The present invention relates to novel gold-platinum based bi-metallic nanocrystal suspensions that have nanocrystal surfaces that are substantially free from organic or other impurities or films associated with typical chemical reductants/stabilizers and/or raw materials used in nanoparticle formation processes. Specifically, the surfaces are "clean" relative to the surfaces of metal-based nanoparticles made using chemical reduction (and other) processes that require organic (or other) reductants and/or surfactants to grow (and/or suspend) metal nanoparticles from metal ions in a solution. The invention includes novel electrochemical manufacturing apparatuses and techniques for making the bi-metallic nanocrystal suspensions. The techniques do not require the use or presence of chlorine ions/atoms and/or chlorides or chlorine-based materials for the manufacturing process/final suspension. The invention further includes pharmaceutical compositions thereof and the use of the bi-metallic nanocrystals or suspensions or colloids thereof for the treatment or prevention of diseases or conditions for which metal-based therapy is already known, including, for example, for cancerous diseases or conditions.
摘要翻译：本发明涉及具有纳米晶体表面的新型金 - 铂基双金属纳米晶体悬浮液，其基本上不含与用于纳米颗粒形成过程中的典型化学还原剂/稳定剂和/或原料相关的有机或其它杂质或膜。具体地说，相对于使用需要有机（或其它）还原剂和/或表面活性剂从金属生长（和/或悬浮）金属纳米粒子的化学还原（和其它）方法制备的金属基纳米颗粒的表面，表面“干净” 离子在溶液中。本发明包括用于制备双金属纳米晶体悬浮液的新型电化学制造装置和技术。这些技术不需要使用或存在氯离子/原子和/或氯化物或氯基材料用于制造过程/最终悬浮液。本发明还包括其药物组合物，以及双金属纳米晶体或其悬浮液或胶体在治疗或预防已知金属基治疗的疾病或病症中的用途，包括例如癌性疾病或病症。

4. 发明申请

WO2003089692A2 METHODS FOR CONTROLLING CRYSTAL GROWTH, CRYSTALLIZATION, STRUCTURES AND PHASES IN MATERIALS AND SYSTEMS 审中-公开
标题翻译：控制材料和系统中晶体生长，结晶，结构和相位的方法
公开(公告)号：WO2003089692A2
公开(公告)日：2003-10-30
申请号：PCT/US2003/008904
申请日：2003-03-21
申请人： BERKSHIRE LABORATORIES, INC. , BLUM, Bentley, J. , BROOKS, Juliana, H., J. , MORTENSON, Mark, G.
发明人： BLUM, Bentley, J. , BROOKS, Juliana, H., J. , MORTENSON, Mark, G.
IPC分类号： C30B
CPC分类号： C01B3/0031 , B01D9/005 , B01D9/0063 , B01J19/121 , B01J19/122 , B01J19/127 , C01B3/0026 , C01B5/00 , C01B13/0214 , C01D3/04 , C01D3/10 , C12N13/00 , Y02E60/327
摘要： This invention relates to novel methods for affecting, controlling and/or directing various crystal formation, structure formation or phase formation/phase change reaction pathways or systems by exposing one or more components in a holoreaction system to at least one spectral energy pattern. In a first aspect of the invention, at least one spectral energy pattern can be applied to a crystallization reaction system. In a second aspect of the invention, at lest one spectral energy conditioning pattern can be applied to a conditioning reaction system. The spectral energy conditioning pattern can, for example, be applied at a separate location from the reaction vessel (e.g., in a conditioning reaction vessel) or can be applied in (or to) the reaction vessel, but prior to other (or all) crystallization reaction system participants being introduced into the reaction vessel.
摘要翻译：本发明涉及通过将一个或多个组合在一个或多个组合中暴露于至少一个光谱能量图案来影响，控制和/或指导各种晶体形成，结构形成或相形成/相变反应途径或系统的新方法。在本发明的第一方面中，至少一种光谱能量图案可以应用于结晶反应系统。在本发明的第二方面，至少一个光谱能量调节模式可以应用于调理反应系统。例如，光谱能量调节图案可以在与反应容器（例如在调理反应容器中）分开的位置处施加，或者可以应用于反应容器（或反应容器中），但在其它（或全部）之前）结晶反应系统参与者被引入反应容器。

5. 发明申请

WO2011006007A1 NOVEL GOLD-BASED NANOCRYSTALS FOR MEDICAL TREATMENTS AND ELECTROCHEMICAL MANUFACTURING PROCESSES THEREFOR 审中-公开
标题翻译：用于医疗治疗的新型金基纳米晶体及其电化学制造工艺
公开(公告)号：WO2011006007A1
公开(公告)日：2011-01-13
申请号：PCT/US2010/041427
申请日：2010-07-08
申请人： GR INTELLECTUAL RESERVE, LLC , MORTENSON, Mark , PIERCE, D., Kyle , BRYCE, David , DORFMAN, Adam , WILCOX, Reed , LOCKETT, Anthony , MERZLIAKOV, Mikhail
发明人： MORTENSON, Mark , PIERCE, D., Kyle , BRYCE, David , DORFMAN, Adam , WILCOX, Reed , LOCKETT, Anthony , MERZLIAKOV, Mikhail
IPC分类号： A01N55/02 , A61K31/28 , C30B1/00
CPC分类号： A61K33/24 , A61K9/0095 , A61K9/08 , A61K9/10 , A61K9/14 , A61K47/02 , B22F1/0022 , B22F9/00 , B22F2001/0037 , B82Y30/00 , C30B7/12 , C30B29/02 , C30B29/60 , Y02A50/401 , Y02A50/411
摘要： The present invention relates to novel gold nanocrystals and nanocrystal shape distributions that have surfaces that are substantially free from organic impurities or films. Specifically, the surfaces are "clean" relative to the surfaces of gold nanoparticles made using chemical reduction processes that require organic reductants and/or surfactants to grow gold nanoparticles from gold ions in solution. The invention includes novel electrochemical manufacturing apparatuses and techniques for making the gold-based nanocrystals. The invention further includes pharmaceutical compositions thereof and the use of the gold nanocrystals or suspensions or colloids thereof for the treatment or prevention of diseases or conditions for which gold therapy is already known and more generally for conditions resulting from pathological cellular activation, such as inflammatory (including chronic inflammatory) conditions, autoimmune conditions, hypersensitivity reactions and/or cancerous diseases or conditions In one embodiment, the condition is mediated by MIF (macrophage migration inhibiting factor).
摘要翻译：本发明涉及具有基本上不含有机杂质或膜的表面的新的金纳米晶体和纳米晶体形状分布。具体地说，相对于使用需要有机还原剂和/或表面活性剂的化学还原法制备的金纳米颗粒的表面，表面是“干净的”，以从溶液中的金离子生长金纳米颗粒。本发明包括用于制造金基纳米晶体的新型电化学制造装置和技术。本发明还包括其药物组合物和金纳米晶体或其悬浮液或胶体用于治疗或预防已知金疗法的疾病或病症，更通常地用于病理性细胞活化所引起的病症，例如炎性（包括慢性炎症）病症，自身免疫病症，超敏反应和/或癌性疾病或病症在一个实施方案中，该病症由MIF（巨噬细胞迁移抑制因子）介导。

6. 发明申请

WO2010083040A1 CONTINUOUS SEMICONTINUOUS AND BATCH METHODS FOR TREATING LIQUIDS AND MANUFACTURING CERTAIN CONSTITUENTS (E.G., NANOPARTICLES) IN LIQUIDS, APPARATUSES AND NANOPARTICLES AND NANOPARTICLE/LIQUID SOLUTION(S) AND COLLOIDS RESULTING THEREFROM 审中-公开
标题翻译：用于处理液体和制造液体，装置和纳米颗粒中的某些组分（E.G.，NANOPARTICLES）的连续半成品和批量方法以及对其进行结果的纳米/液体溶液（S）和胶体
公开(公告)号：WO2010083040A1
公开(公告)日：2010-07-22
申请号：PCT/US2010/000088
申请日：2010-01-13
申请人： GR INTELLECTUAL RESERVE, LLC , PIERCE, David, K. , MORTENSON, Mark, G. , BRYCE, David, A. , DORFMAN, Adam, R. , MERZLIAKOV, Mikhail , GRACE, Arthur, Maxwell
发明人： PIERCE, David, K. , MORTENSON, Mark, G. , BRYCE, David, A. , DORFMAN, Adam, R. , MERZLIAKOV, Mikhail , GRACE, Arthur, Maxwell
IPC分类号： B22F9/20 , B32B5/16
CPC分类号： B22F9/20 , B01J19/088 , B01J2219/0809 , B01J2219/0841 , B01J2219/0877 , B01J2219/0894 , B22F2999/00 , B82Y40/00 , C25C1/20 , C25C1/22 , B22F2202/06 , B22F2202/13
摘要： This invention relates generally to novel methods and novel devices for the continuous manufacture of nanoparticles, microparticles and nanoparticle/liquid solution(s) (e.g., colloids). The nanoparticles (and/or micron-sized particles) comprise a variety of possible compositions, sizes and shapes. The particles (e.g., nanoparticles) are caused to be present (e.g., created and/or the liquid is predisposed to their presence (e.g., conditioned)) in a liquid (e.g., water) by, for example, preferably utilizing at least one adjustable plasma (e.g., created by at least one AC and/or DC power source), which plasma communicates with at least a portion of a surface of the liquid. At least one subsequent and/or substantially simultaneous adjustable electrochemical processing technique is also preferred. Multiple adjustable plasmas and/or adjustable electrochemical processing techniques are preferred. Processing enhancers can be utilized alone or with a plasma. Semicontinuous and batch processes can also be utilized. The continuous processes cause at least one liquid to flow into, through and out of at least one trough member, such liquid being processed, conditioned and/or effected in said trough member(s). Results include constituents formed in the liquid including ions, micron-sized particles and/or nanoparticles (e.g., metallic-based nanoparticles) of novel size, shape, composition, concentration, zeta potential and certain other novel properties present in a liquid.
摘要翻译：本发明一般涉及用于连续制造纳米颗粒，微粒和纳米颗粒/液体溶液（例如胶体）的新方法和新颖装置。纳米颗粒（和/或微米尺寸的颗粒）包含各种可能的组合物，尺寸和形状。引起颗粒（例如，纳米颗粒）存在（例如，通过例如优选利用至少一种的方式，在液体（例如水）中存在（例如，产生和/或将液体倾向于其存在（例如，调节））可调节的等离子体（例如，由至少一个AC和/或DC电源产生），其等离子体与液体的至少一部分表面连通。至少一个后续和/或基本上同时可调节的电化学处理技术也是优选的。多重可调等离子体和/或可调电化学处理技术是优选的。处理增强剂可以单独使用或与等离子体一起使用。也可以使用半连续和间歇方法。连续过程导致至少一种液体流入，通过和流出至少一个槽构件，这种液体在所述槽构件中被处理，调节和/或实现。结果包括在液体中形成的成分，包括离子，微米尺寸的颗粒和/或纳米颗粒（例如，基于金属的纳米颗粒），其具有新颖的尺寸，形状，组成，浓度，ζ电位和存在于液体中的某些其它新特性。

7. 发明申请

WO2007079452A2 METHODS AND APPARATUSES FOR MAKING LIQUIDS MORE REACTIVE 审中-公开
标题翻译：制备液体更多反应的方法和装置
公开(公告)号：WO2007079452A2
公开(公告)日：2007-07-12
申请号：PCT/US2007/000168
申请日：2007-01-03
申请人： GR INTELLECTUAL RESERVE, LLC , PIERCE, David, K. , BRYCE, David, A. , MORTENSON, Mark, G.
发明人： PIERCE, David, K. , BRYCE, David, A. , MORTENSON, Mark, G.
IPC分类号： C25B15/00
CPC分类号： B01J19/088 , B01J2219/0809 , B01J2219/0828 , B01J2219/083 , B01J2219/0841 , B01J2219/0877 , B01J2219/0894 , C02F1/4608 , H05H1/48 , H05H2001/481 , H05H2245/1225
摘要： This invention relates generally to novel methods for affecting, controlling, and/or directing various reactions with and in various liquids (such as water) by creating an energy field within and/or juxtaposed to at least one surface of said liquid. An important aspect of the invention involves the creation of a plasma, which plasma is created between at least one electrode located above the surface of the liquid and at least a portion of the surface of the liquid itself, which functions as at least one second electrode. In order to permit at least a portion of the surface of the liquid to function effectively as a second electrode, at least one additional electrically conducting electrode is typically located within (e.g., at least partially submerged within) said liquid. The plasma results in a restructuring of the liquid and/or the presence of at least one active species within said liquid.
摘要翻译：本发明一般涉及通过在所述液体的至少一个表面内和/或并置的能量场来影响，控制和/或指导与各种液体（例如水）的各种反应的新方法。本发明的一个重要方面涉及等离子体的产生，该等离子体产生在位于液体表面之上的至少一个电极与液体本身表面的至少一部分之间的至少一个电极之间，该电极用作至少一个第二电极。为了允许液体的表面的至少一部分有效地作为第二电极起作用，至少一个额外的导电电极通常位于所述液体的内部（例如，至少部分地浸入）内。等离子体导致液体的重组和/或所述液体中至少一种活性物质的存在。

8. 发明申请

WO2014182888A2 METHODS AND TREATMENT FOR CERTAIN DEMYELINATION AND DYSMYELINATION-BASED DISORDERS AND/OR PROMOTING REMYELINATION 审中-公开
标题翻译：某些化学和基于脱乙酰化的疾病和/或促进REMYELINATION的方法和治疗
公开(公告)号：WO2014182888A2
公开(公告)日：2014-11-13
申请号：PCT/US2014/037280
申请日：2014-05-08
申请人： GR INTELLECTUAL RESERVE, LLC , ZHANG, Zhongyan , MORTENSON, Mark G.
发明人： ZHANG, Zhongyan , MORTENSON, Mark G.
IPC分类号： A61K33/24 , A61K9/14
CPC分类号： A61K33/24 , A61K9/10 , A61K9/14 , A61K9/16 , A61K47/02
摘要： The invention relates to methods and compositions for treating demyelination and/or dysmyelination and/or promoting remyelination of neurons and/or preventing the development of myelin-related diseases by administering to a subject in need thereof an effective amount (either therapeutic or prophylactic) of an elemental gold crystal nanosuspension.
摘要翻译：本发明涉及用于治疗脱髓鞘和/或脱髓鞘和/或促进神经元的再髓鞘化和/或预防髓鞘相关疾病的发展的方法和组合物，其通过向有需要的受试者施用有效量（治疗性或预防性）元素金晶纳米悬浮液。

9. 发明申请

WO2009009143A1 CONTINUOUS METHODS FOR TREATING LIQUIDS AND MANUFACTURING CERTAIN CONSTITUENTS (E.G., NANOPARTICLES) IN LIQUIDS, APPARATUSES AND NANOPARTICLES AND NANOPARTICLE/LIQUID SOLUTION(S) RESULTING THEREFROM 审中-公开
标题翻译：用于处理液体和制造液体中的某些组分（E.G.，NANOPARTICLES）在液体，装置和纳米颗粒和纳米颗粒/液体溶液（S）结果的连续方法
公开(公告)号：WO2009009143A1
公开(公告)日：2009-01-15
申请号：PCT/US2008/008558
申请日：2008-07-11
申请人： GR INTELLECTUAL RESERVE, LLC , PIERCE, David, K. , MORTENSON, Mark, G. , BRYCE, David, A.
发明人： PIERCE, David, K. , MORTENSON, Mark, G. , BRYCE, David, A.
IPC分类号： C01G1/00 , B82B3/00
CPC分类号： A01N59/16 , A01N59/00 , B01J19/088 , B01J2219/0811 , B01J2219/0894 , B22F3/003 , B22F2999/00 , C22B3/02 , C22B3/22 , C22B4/005 , C22B4/08 , H05H1/48 , H05H2001/483 , Y02P10/234 , B22F9/14 , B22F2202/13 , B22F1/0018 , C25C5/02
摘要： Methods and devices for the continuous manufacture of nanopεrticles, microparticles and nanoparticle/liquid solution(s) are disclosed. The nanoparticles (and/or micron-sized particles) comprise a variety of possible compositions, sizes and shapes. The particles (e. g., nanoparticles) are caused to be present (e g, created) in a liquid (e. g., water) by utilizing at least one adjustable plasma (e. g., created by at least one AC and/or DC power source), which plasma communicates with at least a portion of a surface of the liquid. The continuous process causes at least one liquid to flow into, through and out of at least one trough member, such liquid being processed, conditioned and/or effected in said trough member(s).
摘要翻译：公开了用于连续制造纳米颗粒，微粒和纳米颗粒/液体溶液的方法和装置。纳米颗粒（和/或微米尺寸的颗粒）包含各种可能的组合物，尺寸和形状。通过利用至少一个可调等离子体（例如，由至少一个AC和/或DC电源产生），使颗粒（例如，纳米颗粒）存在（例如，产生）在液体（例如，水）中，其中等离子体与液体的至少一部分表面连通。连续过程使至少一种液体流入，通过和流出至少一个槽构件，这种液体在所述槽构件中被处理，调节和/或实现。

10. 发明申请

WO2006074117A2 SILVER/WATER, SILVER GELS AND SILVER-BASED COMPOSITIONS; AND METHODS FOR MAKING AND USING THE SAME 审中-公开
标题翻译：银/水，银胶和银基组合物; 以及制备和使用该方法的方法
公开(公告)号：WO2006074117A2
公开(公告)日：2006-07-13
申请号：PCT/US2005/047699
申请日：2005-12-30
申请人： HOLLADAY, Robert , MOELLER, William , MEHTA, Dilip , BROOKS, Juliana, H., J. , ROY, Rustum , MORTENSON, Mark
发明人： HOLLADAY, Robert , MOELLER, William , MEHTA, Dilip , BROOKS, Juliana, H., J. , ROY, Rustum , MORTENSON, Mark
IPC分类号： G01N33/53
CPC分类号： A61K33/38 , A01N59/16 , A61K31/28 , A61K31/65 , A61K33/24 , A61K33/30 , A61K33/34 , A61K45/06 , Y02A50/411 , A01N25/04 , A01N59/00 , A01N2300/00
摘要： We disclose a colorless composition comprising metal particles (e.g., silver nanoparticles) and water, wherein said particles comprise an interior of elemental metal (e.g., silver) and an exterior of metal oxide (e.g., one or more silver oxide(s)), wherein the metal nanoparticles are present in the water at a level of about 5-40 ppm, and wherein the composition manifests significant antimicrobial properties. Methods of use of the composition are described. The composition can be incorporated into a hydrogel with essentially no loss of antimicrobial properties. Various metal-containing compositions with unexpected biological efficacy are also disclosed.
摘要翻译：我们公开了包含金属颗粒（例如，银纳米颗粒）和水的无色组合物，其中所述颗粒包含元素金属（例如银）和金属氧化物（例如，一种或多种氧化银）的外部，其中所述金属纳米颗粒以约5-40ppm的水平存在于所述水中，并且其中所述组合物显示出显着的抗微生物性质。描述了组合物的使用方法。组合物可以掺入水凝胶中，基本上没有抗微生物性能的损失。还公开了具有出人意料的生物功效的各种含金属组合物。

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