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1. 发明申请

WO2016019075A1 SYSTEM AND METHOD FOR OPTOGENETIC THERAPY 审中-公开
标题翻译：用于OPTOGENETIC治疗的系统和方法
公开(公告)号：WO2016019075A1
公开(公告)日：2016-02-04
申请号：PCT/US2015/042758
申请日：2015-07-29
申请人： CIRCUIT THERAPEUTICS, INC.
发明人： TOWNE, Christopher L. , KAPLITT, Michael , DELP, Scott , DEISSEROTH, Karl , ANGELEY, David , ANDERSEN, Dan , LUNDMARK, David C.
IPC分类号： A61N5/06
CPC分类号： A61K48/0075 , A61B18/18 , A61K38/177 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061 , A61N5/0601 , A61N5/0613 , A61N5/062 , A61N5/0622 , A61N2005/0626 , A61N2005/0651 , A61N2005/0662
摘要： One embodiment is directed to a system for controllably managing pain in the afferent nervous system of a patient having a targeted tissue structure that has been genetically modified to have light sensitive protein, comprising a light delivery element configured to direct radiation to at least a portion of a targeted tissue structure; a light source configured to provide light to the light delivery element; and a controller operatively coupled to light source; wherein the targeted tissue structure comprises a sensory neuron of the patient; and wherein the controller is configured to be automatically operated to illuminate the targeted tissue structure with radiation such that a membrane potential of cells comprising the targeted tissue structure is modulated at least in part due to exposure of the light sensitive protein to the radiation.
摘要翻译：一个实施例涉及一种用于可控地管理患有已经被遗传修饰以具有光敏蛋白质的靶组织结构的患者的传入神经系统中的疼痛的系统，该系统包括光传输元件，其配置成将辐射引导至至少一部分靶组织结构; 光源，被配置为向所述光输送元件提供光; 以及可操作地耦合到光源的控制器; 其中所述靶组织结构包括患者的感觉神经元; 并且其中所述控制器被配置为自动操作以用辐射照射所述目标组织结构，使得包含所述靶组织结构的细胞的膜电位至少部分地由于所述光敏蛋白质暴露于所述辐射而被调制。

2. 发明申请

WO2015073991A1 SYSTEM AND METHOD FOR DRUG DELIVERY WITH A SAFETY SYRINGE 审中-公开
标题翻译：用安全性注射剂输送药物的系统和方法
公开(公告)号：WO2015073991A1
公开(公告)日：2015-05-21
申请号：PCT/US2014/065998
申请日：2014-11-17
申请人： CREDENCE MEDSYSTEMS INC.
发明人： SHLUZAS, Alan, E. , DIAZ, Stephen, H. , SHANLEY, John, F. , TILLACK, Jeff , THAYER, Dan
IPC分类号： A61M5/32
CPC分类号： A61M5/3221 , A61M5/2466 , A61M5/31513 , A61M5/322 , A61M5/3234 , A61M2005/2474 , A61M2005/3231 , A61M2005/3241
摘要： One embodiment is directed to a system for injecting, comprising a syringe body defining an interior medicine chamber; a stopper member configured to be inserted into the interior medicine chamber to contain medicine within the medicine chamber; a plunger member configured to be manually manipulated to insert the stopper member relative to the syringe body; a needle having proximal and distal ends, the proximal end comprising an anchoring geometry configured to be at least partially penetrated into the stopper member such that upon retraction of the stopper member, the needle is pulled proximally along with the stopper to be at least partially contained within the interior medicine chamber; and an energy-storing member operatively coupled between the stopper member and the syringe body, the energy-storing member configured to facilitate retraction of the stopper member relative to the syringe body.
摘要翻译：一个实施例涉及一种用于注射的系统，包括限定内部药物腔室的注射器主体; 止动部件，其构造成插入到所述内部药剂室中，以在所述药剂室内容纳药物; 柱塞构件，其构造成手动操作以相对于所述注射器主体插入所述止动构件; 具有近端和远端的针，所述近端包括锚定几何形状，所述锚定几何形状被构造成至少部分地插入所述止动构件中，使得在所述止动构件缩回时，所述针沿着所述止动件向近侧被拉至至少部分地包含内部药房内; 以及能量存储构件，其可操作地联接在所述止动构件和所述注射器主体之间，所述能量存储构件构造成便于所述止动构件相对于所述注射器本体的缩回。

3. 发明申请

WO2014153546A1 SYSTEM AND METHOD FOR ADAPTABLE SAFETY SYRINGE 审中-公开
标题翻译：适用于安全性的SYRINGE系统和方法
公开(公告)号：WO2014153546A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/031508
申请日：2014-03-21
申请人： REPRISE TECHNOLOGIES, LLC.
发明人： SHLUZAS, Alan E. , DIAZ, Stephen H. , SHANLEY, John F.
IPC分类号： A61M5/50
CPC分类号： A61M5/322 , A61M5/3134 , A61M5/344 , A61M5/347 , A61M39/10 , A61M2005/3224 , A61M2005/323 , A61M2039/1077
摘要： One embodiment is directed to a method of conducting an injection, comprising: providing an assembly of a syringe plunger movably coupled to a syringe body which may contain fluid for infusion, the syringe body having a distal end that is removably coupled to a Luer adaptor, the Luer adaptor defining a needle lumen through which a needle may be coupled, the Luer adaptor comprising a distal surface configured to be removably coupled to a Luer fitting of another device; deciding upon infusion via needle injection or Luer coupling; and selectably configuring the assembly for needle injection or Luer coupling by removing the Luer adaptor to further expose the needle for needle injection, or by leaving the Luer adaptor in place and coupling it to the Luer fitting of the other device.
摘要翻译：一个实施例涉及一种进行注射的方法，包括：提供可移动地联接到注射器主体的注射器柱塞的组件，所述注射器柱塞可以包含用于输注的流体，所述注射器主体具有可拆卸地联接到Luer适配器的远端，所述Luer适配器限定针腔，所述针可以穿过所述针腔，所述Luer适配器包括构造成可移除地联接到另一装置的Luer配件的远侧表面; 通过针注射或鲁尔耦合决定输液; 并且通过拆下Luer适配器可选择地配置针头注射或Luer联接装置，以进一步暴露注射针头，或者将Luer适配器放在适当位置并将其连接到另一个装置的Luer配件上。

4. 发明申请

WO2014113506A1 ULTRA-HIGH RESOLUTION SCANNING FIBER DISPLAY 审中-公开
标题翻译：超高分辨率扫描光纤显示器
公开(公告)号：WO2014113506A1
公开(公告)日：2014-07-24
申请号：PCT/US2014/011736
申请日：2014-01-15
申请人： MAGIC LEAP, INC.
发明人： SCHOWENGERDT, Brian T. , WATSON, Matthew D.
IPC分类号： G02B6/02
CPC分类号： G02B6/06 , G02B6/02042 , G02B6/028 , G02B6/08 , G02B6/32 , G02B26/08 , G02B26/10 , G02B27/0101 , G02B2027/0123 , G02B2027/0147 , G02F1/335
摘要： One embodiment is directed to a compact system for scanning electromagnetic imaging radiation, comprising a first waveguide and a second waveguide, each of which is operatively coupled to at least one electromagnetic radiation source and configured such that output from the first and second waveguides is luminance modulated and scanned along one or more axes to form at least a portion of an image.
摘要翻译：一个实施例涉及用于扫描电磁成像辐射的紧凑系统，其包括第一波导和第二波导，每个波导和第二波导可操作地耦合到至少一个电磁辐射源，并且被配置为使得来自第一和第二波导的输出被亮度调制并沿一个或多个轴扫描以形成图像的至少一部分。

5. 发明申请

WO2014022509A1 ACCESS CLOSURE CONFIGURATION 审中-公开
标题翻译：访问关闭配置
公开(公告)号：WO2014022509A1
公开(公告)日：2014-02-06
申请号：PCT/US2013/052926
申请日：2013-07-31
申请人： ARSTASIS, INC.
发明人： MODESITT, D., Bruce , PARASCHAC, Joseph, F. , ELLINGWOOD, Brian, A.
IPC分类号： A61B17/34
CPC分类号： A61B17/3417 , A61M25/008 , A61M25/0082 , A61M25/04 , A61M25/065 , A61M2025/0095
摘要： One embodiment is directed to a device for forming a tract, comprising an anchor assembly wherein at least a distal tip of the flexible distal portion is configured to be placed within a lumen of a blood vessel through a first passage created across the wall with a sharpened member at a first angle relative to a lumen longitudinal axis defined by the lumen of the blood vessel in the region adjacent the first passage; and wherein upon applying a force to the anchor assembly to position an adjacent portion of the blood vessel wall into a desired contact configuration relative to the anchor assembly, the needle is operatively coupled to the anchor assembly such that it may be advanced across the wall of the blood vessel and into contact with a saddle-shaped needle receiving structure, thereby creating an expandable tract between overlapping tissue portions of the vessel wall.
摘要翻译：一个实施例涉及用于形成管道的装置，其包括锚固组件，其中柔性远侧部分的至少远侧末端被配置为通过跨越壁产生的第一通道而放置在血管的内腔中，该第一通道具有锐化构件相对于在与第一通道相邻的区域中由血管的腔限定的管腔纵向轴线成一定角度; 并且其中当向所述锚固组件施加力以将所述血管壁的相邻部分相对于所述锚固组件定位成期望的接触构造时，所述针可操作地联接到所述锚固组件，使得所述针可以前进穿过所述锚固组件的壁血管并与鞍形针接收结构接触，从而在血管壁的重叠组织部分之间产生可扩张的管道。

6. 发明申请

WO2013077895A1 THREE DIMENSIONAL VIRTUAL AND AUGMENTED REALITY DISPLAY SYSTEM 审中-公开
标题翻译：三维虚拟和增强现实显示系统
公开(公告)号：WO2013077895A1
公开(公告)日：2013-05-30
申请号：PCT/US2012/000560
申请日：2012-11-23
申请人： MAGIC LEAP, INC.
发明人： MACNAMARA, John, Graham
IPC分类号： G06T15/00
CPC分类号： G02B27/2228 , G02B5/1828 , G02B5/1876 , G02B27/0101 , G02B27/22 , G02B27/2264 , G02B27/2278 , G02B2027/0134 , G03B21/00 , G03B35/18
摘要： A system may comprise a selectively transparent projection device for projecting an image toward an eye of a viewer from a projection device position in space relative to the eye of the viewer, the projection device being capable of assuming a substantially transparent state when no image is projected; an occlusion mask device coupled to the projection device and configured to selectively block light traveling toward the eye from one or more positions opposite of the projection device from the eye of the viewer in an occluding pattern correlated with the image projected by the projection device; and a zone plate diffraction patterning device interposed between the eye of the viewer and the projection device and configured to cause light from the projection device to pass through a diffraction pattern having a selectable geometry as it travels to the eye.
摘要翻译：系统可以包括选择性地透明的投影装置，用于相对于观看者的眼睛从空间中的投影装置位置向观看者的眼睛投影图像，投影装置能够在没有投影图像时呈现基本上透明的状态 ; 闭合掩模装置，其耦合到所述投影装置，并且被配置为以与由所述投影装置投影的图像相关的遮挡图案，从与所述投影装置相对的一个或多个位置与所述观看者的眼睛有选择地阻挡朝向所述眼睛行进的光; 以及插入在观察者的眼睛和投影装置之间并且被配置为使得来自投影装置的光在其行进到眼睛时通过具有可选几何形状的衍射图案的区域板衍射图案形成装置。

7. 发明申请

WO2012040233A2 SYSTEM FOR PROVIDING SURGICAL ACCESS 审中-公开
标题翻译：提供手术治疗的系统
公开(公告)号：WO2012040233A2
公开(公告)日：2012-03-29
申请号：PCT/US2011/052404
申请日：2011-09-20
申请人： ENTOURAGE MEDICAL TECHNOLOGIES, LLC , SHANLEY, John, F. , DIAZ, Stephen, H. , SHLUZAS, Alan, E. , LITVACK, Frank
发明人： SHANLEY, John, F. , DIAZ, Stephen, H. , SHLUZAS, Alan, E. , LITVACK, Frank
IPC分类号： A61B17/00 , A61B17/04
CPC分类号： A61B17/0625 , A61B17/0057 , A61B17/0469 , A61B17/0482 , A61B17/0487 , A61B17/06 , A61B17/06066 , A61B17/34 , A61B17/3403 , A61B90/06 , A61B90/08 , A61B90/37 , A61B2017/00044 , A61B2017/00243 , A61B2017/00575 , A61B2017/00628 , A61B2017/00663 , A61B2017/0414 , A61B2017/0417 , A61B2017/0443 , A61B2017/047 , A61B2017/0472 , A61B2017/0475 , A61B2017/0496 , A61B2017/06023 , A61B2017/06042 , A61B2017/06076 , A61B2017/06171 , A61B2017/06176 , A61B2017/3405 , A61B2017/3409 , A61B2017/3413 , A61B2090/062 , A61B2090/065 , A61B2090/0807 , A61B2090/0811 , A61B2090/3735
摘要： One embodiment is directed to a system for providing surgical access across a wall of a tissue structure, comprising a delivery member, a first helical member, an anchor member removably coupled to the helical member distal end, and a suture member coupled distally to a portion of the anchor member and extending proximally to a position wherein at least a portion of it may be freely manipulated by an operator; wherein upon rotation of the delivery member in a first direction, the first helical member and coupled anchor member are advanced across at least a portion of the wall of the tissue structure, pulling along the distal portion of the suture member in a deployed suture pattern which remains coupled to the anchor member, the deployed suture pattern being characterized in that it is substantially helical with between about one and three helical loops.
摘要翻译：一个实施例涉及一种用于提供穿过组织结构的壁的手术进入的系统，包括递送构件，第一螺旋构件，可移除地联接到螺旋构件远端的锚定构件，以及沿远端结合到部分并且向近侧延伸到其操作者可以自由地操纵其至少一部分的位置; 其中当沿着第一方向转动所述传送构件时，所述第一螺旋构件和所述联接的锚定构件穿过所述组织结构的所述壁的至少一部分，沿着所述缝合构件的远端部分以部署的缝合线图案保持联接到锚定构件，所展开的缝合线图案的特征在于其在大约一个和三个螺旋环之间是基本螺旋形的。

8. 发明申请

WO2011103370A1 SYSTEM AND METHOD FOR IMAGE-GUIDED ARTHROSCOPY 审中-公开
标题翻译：用于图像引导的ARTHROSCOPY的系统和方法
公开(公告)号：WO2011103370A1
公开(公告)日：2011-08-25
申请号：PCT/US2011/025347
申请日：2011-02-17
申请人： REPRISE TECHNOLOGIES, LLC , LITVACK, Frank , KLAPPER, Robert, C. , SHANLEY, John, F.
发明人： LITVACK, Frank , KLAPPER, Robert, C. , SHANLEY, John, F.
IPC分类号： A61B17/02 , A61B17/34 , A61B1/313 , A61B1/32 , A61B17/32
CPC分类号： A61B17/0218 , A61B1/313 , A61B1/32 , A61B17/025 , A61B17/34 , A61B17/3423 , A61B17/3439 , A61B17/3472 , A61B17/885 , A61B2017/0225 , A61B2017/0268 , A61B2017/320048 , A61B2017/3486
摘要： Configurations are described for conducting minimally invasive medical diagnoses and interventions utilizing elongate instruments and assemblies comprising one or more imaging devices, and one or more remote retraction and distraction devices. Retraction and distraction devices, such as balloons, mechanical retraction members, and/or trocar screw geometries may be utilized to access, investigate, and intervene at the joint capsule, or inside of the joint capsule. Imaging devices, such as optical image capture devices, ultrasound transducers, and optical coherence tomography fibers, may be utilized to assist with navigation of the pertinent tools during diagnostic and interventional steps.
摘要翻译：描述了使用包括一个或多个成像装置的细长仪器和组件以及一个或多个远程收回和牵引装置进行微创医疗诊断和干预的配置。收缩和牵引装置，例如球囊，机械回缩构件和/或套管针螺钉几何形状可用于进入，调查和介入关节囊或关节囊内。可以利用诸如光学图像捕获装置，超声换能器和光学相干断层摄影光纤的成像装置在诊断和介入步骤期间帮助相关工具的导航。

9. 发明申请

WO2018161056A1 SYSTEM FOR OPTOGENETIC THERAPY 审中-公开
公开(公告)号：WO2018161056A1
公开(公告)日：2018-09-07
申请号：PCT/US2018/020799
申请日：2018-03-02
申请人： CIRCUIT THERAPEUTICS, INC.
发明人： ELLINGWOOD, Brian Andrew , BECKEY, Brian , BERRY, Ethan , MODESITT, Bruce , ANDERSEN, Dan , ANGELEY, David , DREWS, Michael , NGUYEN-VU, T.D. Barbara , LEUNG, Laura , POPESCU, Andrei T.
IPC分类号： A61B6/00 , A61M1/30 , A61M5/178 , A61M25/00
摘要： One embodment is directed to a probe for illuminating a target tissue of a patient, comprising: a plurality of optical fibers; a probe body portion having proximal and distal ends, the probe body portion being moveably coupled to the plurality of fibers and configured to at least partially encapsulate the plurality of fibers; a distal end portion coupled to the distal end of the probe body portion, the distal end portion comprising at least one guiding feature configured to redirect a path of at least one of the optical fibers comprising the plurality of optical fibers as such at least portion of one of the optical fibers is extended through and past the distal end portion by moving the plurality of fibers relative to the probe body portion. The probe further may comprise an ejector portion configured to move the plurality of fibers relative to the probe body portion.

10. 发明申请

WO2017066495A1 SURGICAL CLOSURE CONFIGURATIONS 审中-公开
标题翻译：手术关闭配置
公开(公告)号：WO2017066495A1
公开(公告)日：2017-04-20
申请号：PCT/US2016/056923
申请日：2016-10-13
申请人： ENTOURAGE MEDICAL TECHNOLOGIES, INC.
发明人： SHLUZAS, Alan E. , SHANLEY, John F.
IPC分类号： A61B17/04 , A61B17/94 , A61F2/02
CPC分类号： A61B17/04 , A61B17/0469 , A61B17/0482 , A61B17/06 , A61B17/06066 , A61B17/06109 , A61B2017/047 , A61B2017/06076 , A61F2/02 , A61F2/0811 , A61F2002/0829 , A61F2002/0852 , A61F2002/0888
摘要： One embodiment is directed to a system for closing a wound created across a portion of a tissue structure, comprising a suture member having proximal and distal ends; an anchor member coupled to the distal end of the suture member; a tension retainer assembly releasably coupleable to the suture member; and a suture buttress movably intercoupled to the suture member between the anchor member and the tension retainer and configured to minimize direct sliding contact between the suture member and the tissue structure portion around the location of the suture buttress. Other configurations are disclosed for utilizing suture buttress material, also termed tubular braided pledgets, for various suturing, closure, and stabilization configurations.
摘要翻译：一个实施例涉及一种用于闭合在组织结构的一部分上创建的伤口的系统，该系统包括具有近端和远端的缝合线构件; 联接到缝合线构件的远端的锚定构件; 可释放地连接至所述缝合线构件的张力保持器组件; 以及缝合支柱，其可移动地在锚定构件和张力保持器之间与缝合线构件相互连接并且被配置为最小化缝合线构件和围绕缝合线支墩的位置的组织结构部分之间的直接滑动接触。公开了利用缝合支撑材料（也称为管状编织脱脂棉）用于各种缝合，闭合和稳定构型的其他构造。

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