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1. 发明申请

WO2016179137A1 COMPOSITIONS AND METHODS FOR DELIVERY OF POLYUNSATURATED FATTY ACID DERIVATIVES AND ANALOGS 审中-公开
标题翻译：用于输送聚氨酯脂肪酸衍生物和模拟物的组合物和方法
公开(公告)号：WO2016179137A1
公开(公告)日：2016-11-10
申请号：PCT/US2016/030503
申请日：2016-05-03
申请人： CYTOMETIX, INC.
发明人： BROSTROM, Lane , BORDAS-MURPHY, Henry , FALCK, John, R.
IPC分类号： A61K9/48 , A61K31/135 , A61K31/16 , A61K31/164 , A61K31/197 , A61K31/202 , A61K31/381 , A61K31/4468
CPC分类号： A61K9/4825 , A61K9/4858 , A61K9/4891 , A61K31/135 , A61K31/16 , A61K31/164 , A61K31/197 , A61K31/202 , A61K31/381 , A61K31/4468 , A61K2300/00
摘要： The present invention provides a system enabling the oral delivery of therapeutics derived from polyunsaturated fatty acids (PUFAs), their metabolites and derivatives, including, eicosanoids, prostaglandins, prostacyclins, leukotrienes, resolvins, endocannabinoids, thromboxanes, epoxyeicosa-trienoic acids (EETs), hydroxyeicostetraenoic acids (HETEs), and CMX-020. The delivery system includes a vehicle comprising a purified docosahexaenoic acid (DHA) in triglyceride or ester form; a purified eicosapentaenoic acid (EPA) in triglyceride or ester form; a combination of DHA, EPA in either triglyceride or ester forms; or a modified DHA, EPA, or omega-3 fatty acid analog; and optionally, an antioxidant, a surfactant, a solubilizer, a stabilizer, a lubricant, or a pH/tonicity adjustment agent.
摘要翻译：本发明提供一种能够口服递送衍生自多不饱和脂肪酸（PUFA），其代谢物和衍生物，包括类二十烷酸，羟基四环四烯酸（HETE）和CMX-020。递送系统包括载体，其包含甘油三酸酯或酯形式的纯化二十二碳六烯酸（DHA）; 甘油三酯或酯形式的纯化二十碳五烯酸（EPA）; 甘油三酸酯或酯形式的DHA，EPA的组合; 或修饰的DHA，EPA或ω-3脂肪酸类似物; 和任选的抗氧化剂，表面活性剂，增溶剂，稳定剂，润滑剂或pH /张力调节剂。

2. 发明申请

WO2013119948A1 RNA-MEDIATED GENE ASSEMBLY FROM DNA OLIGONUCLEOTIDES 审中-公开
标题翻译：来自DNA寡核苷酸的RNA介导的基因组装
公开(公告)号：WO2013119948A1
公开(公告)日：2013-08-15
申请号：PCT/US2013/025343
申请日：2013-02-08
申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION , WU, Cheng-Hsien , SMITH, Lloyd
发明人： WU, Cheng-Hsien , SMITH, Lloyd
IPC分类号： C12N15/10 , C12P19/34 , C12N15/66 , C40B40/08 , C40B50/06
CPC分类号： C12P19/34 , C12N15/10 , C12N15/1031 , C12N15/66 , C40B40/08 , C40B50/06
摘要： The present invention is directed to methods and materials for RNA- mediated gene assembly from oligonucleotide sequences. In some embodiments, the oligonucleotides used for gene assembly are provided in an array format. An RNA polymerase promoter is appended to surface-bound oligonucleotides and a plurality of RNA copies of each oligonucleotide are then produced with an RNA polymerase. These RNA molecules self-assemble into a desired full-length RNA transcript by hybridization and ligation. The resulting RNA transcript may then be converted into double strand DNA useful in a variety of applications including protein expression.
摘要翻译：本发明涉及由寡核苷酸序列组成的RNA介导的基因的方法和材料。在一些实施方案中，用于基因组装的寡核苷酸以阵列格式提供。将RNA聚合酶启动子附加到表面结合的寡核苷酸上，然后用RNA聚合酶产生每个寡核苷酸的多个RNA拷贝。这些RNA分子通过杂交和连接自组装成所需的全长RNA转录物。然后将得到的RNA转录物转化为可用于各种应用的双链DNA，包括蛋白质表达。

3. 发明申请

WO2010068304A1 FORMULATIONS AND METHODS FOR MAINTAINING NORMAL HORMONE LEVELS 审中-公开
标题翻译：维持正常人血浆水平的制剂和方法
公开(公告)号：WO2010068304A1
公开(公告)日：2010-06-17
申请号：PCT/US2009/033223
申请日：2009-02-05
申请人： FREELIFE INTERNATIONAL, INC. , AMAGASE, Harunobo
发明人： AMAGASE, Harunobo
IPC分类号： A23L1/29 , A23L2/00 , A23L2/08
CPC分类号： A23L33/105 , A23L33/30
摘要： The invention provides methods for maintaining normal levels of catecholamines, glucocorticoids, adrenal steroids, and their related hormones in a human subject by administering Lycium plants or Lycium plant extract preparations, preferably goji juice. The invention also provides a food or dietary supplement formulation, which contains Lycium plants or Lycium plant extract preparations.
摘要翻译：本发明提供了通过施用枸杞植物或枸杞植物提取物制剂（优选枸杞汁）在人类受试者中维持儿茶酚胺，糖皮质激素，肾上腺类固醇及其相关激素的正常水平的方法。本发明还提供了含有枸杞植物或枸杞植物提取物制剂的食品或膳食补充剂制剂。

4. 发明申请

WO2009052160A1 METHOD FOR ADMINISTERING ANTICOAGULATION THERAPY 审中-公开
标题翻译：用于治疗抗凝治疗的方法
公开(公告)号：WO2009052160A1
公开(公告)日：2009-04-23
申请号：PCT/US2008/079966
申请日：2008-10-15
申请人： MARSHFIELD CLINIC , CALDWELL, Michael, D. , BERG, Richard, L. , BURMESTER, James, K.
发明人： CALDWELL, Michael, D. , BERG, Richard, L. , BURMESTER, James, K.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172
摘要： The present invention provides a method for use in treating a patient with an anticoagulant to optimize drug therapy and/or to prevent an adverse drug response. More particularly, the present invention relates to a method and system for use in treating a patient with Coumadin® or a substance containing warfarin. Methods of the present invention utilize variables that include the patient's CYP4F2 genotype.
摘要翻译：本发明提供了一种用于治疗患有抗凝血剂的患者以优化药物治疗和/或预防药物不良反应的方法。更具体地说，本发明涉及用于治疗患有Coumadin或含有华法林的物质的患者的方法和系统。本发明的方法利用包括患者CYP4F2基因型的变量。

5. 发明申请

WO2003074998A1 FLUID PRESENCE AND QUALITATIVE MEASUREMENTS BY TRANSIENT IMMITIVITY RESPONSE 审中-公开
标题翻译：流体流动性和质量测量由瞬态活动性反应
公开(公告)号：WO2003074998A1
公开(公告)日：2003-09-12
申请号：PCT/US2002/036921
申请日：2002-11-18
申请人： SAMPSON, Allen, R. , DAVIS, Robert, E.
发明人： SAMPSON, Allen, R. , DAVIS, Robert, E.
IPC分类号： G01N27/02
CPC分类号： G01N27/221 , G01N27/228
摘要： An apparatus and method for obtaining a measurement of various qualities of an electrochemical cell (12). The apparatus includes first (9) and second (10) electrodes and an excitation source (8) for providing a time varying excitation voltage to the first electrode (9). The excitation voltage (8) is switched between two voltage levels with the first and second voltages alternately applied to the first electrode for predetermined times. An external capacitance (Cout) is connected between the second electrode (10) and ground. The apparatus is capable of determining the time related rates at which electrical charge is transferred from the first electrode (9) to charge the external capacitance (Cout). These rates, here termed Transient Immitivity Response (TIR), may be provided as a digital or analog output (11).
摘要翻译：一种用于获得电化学电池（12）的各种质量的测量的装置和方法。该装置包括第一电极（9）和第二电极（10）和用于向第一电极（9）提供时变激励电压的激励源（8）。激励电压（8）在两个电压电平之间切换，其中第一和第二电压交替施加到第一电极预定次数。外部电容（Cout）连接在第二电极（10）和地之间。该装置能够确定从第一电极（9）传送电荷以对外部电容（Cout）充电的时间相关速率。这些速率，这里称为瞬态映射反应（TIR），可以作为数字或模拟输出（11）提供。

6. 发明申请

WO2022040380A1 EFFERVESCENT FORMULATION CONTAINING APOAEQUORIN 审中-公开
公开(公告)号：WO2022040380A1
公开(公告)日：2022-02-24
申请号：PCT/US2021/046614
申请日：2021-08-19
申请人： QUINCY BIOSCIENCE, LLC
发明人： UNDERWOOD, Mark, Y.
IPC分类号： A61K9/00
摘要： This invention relates generally to compositions useful for the maintenance of calcium homeostasis. In particular, this invention is directed to apoaequorin-containing effervescent compositions useful in preventing and/or alleviating diseases or symptoms associated with calcium imbalance. Certain embodiments of the invention further contain active ingredients including at least one stimulant (e.g., caffeine) and/or vitamin D.

7. 发明申请

WO2015061397A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT 审中-公开
标题翻译：克拉莫衍生物和相关成像和处理方法
公开(公告)号：WO2015061397A1
公开(公告)日：2015-04-30
申请号：PCT/US2014/061694
申请日：2014-10-22
申请人： THE GENERAL HOSTPITAL CORPORATION , ELMALEH, David, R. , SHOUP, Timothy
发明人： ELMALEH, David, R. , SHOUP, Timothy
IPC分类号： A61K31/353 , A61K51/00 , C07D311/24
CPC分类号： A61K51/0421 , A61K9/0019 , A61K9/0053 , A61K9/0073 , A61K9/0075 , A61K9/4808 , A61K31/192 , A61K31/352 , A61K31/353 , C07D311/24
摘要： Novel cromolyn analogs useful as imaging agents for detecting atherosclerotic plaques and for treating atherosclerosis and Alzheimer's Disease, and methods of making the cromolyn analogs, are disclosed. The cromolyn analogs have the general formula; wherein X is OH, C 1 -C 6 alkoxyl; Y and Z are independently selected from a C 1 -C 6 alky], C 1 -C 6 alkoxyl, halogen, mi-substituted or C 1 -C 6 substituted amine, 18 F, 19 F, or H; and n is 1, 2, or 3; and wherein for structure (I), if n are both 1 and Y and Z are both H and X is OH.
摘要翻译：公开了用作检测动脉粥样硬化斑块和治疗动脉粥样硬化和阿尔茨海默氏病的显像剂的新型色甘酸类似物，以及制备色甘酸类似物的方法。色甘酸类似物具有通式：其中X是OH，C 1 -C 6烷氧基; Y和Z独立地选自C 1 -C 6烷基，C 1 -C 6烷氧基，卤素，取代或C 1 -C 6取代的胺，18 F，19 F或H; n为1,2或3; 并且其中对于结构（I），如果n均为1且Y和Z均为H且X为OH。

8. 发明申请

WO2014107502A2 METHODS AND COMPOSITIONS FOR REPLICATION OF THREOSE NUCLEIC ACIDS 审中-公开
标题翻译：用于复制有害核酸的方法和组合物
公开(公告)号：WO2014107502A2
公开(公告)日：2014-07-10
申请号：PCT/US2014/010062
申请日：2014-01-02
申请人： ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY , CHAPUT, John , YU, Hanyang , ZHANG, Su , DUNN, Matthew, R.
发明人： CHAPUT, John , YU, Hanyang , ZHANG, Su , DUNN, Matthew, R.
CPC分类号： C12P19/34 , C12N15/1058 , C12N15/1093 , C12N15/63
摘要： Methods and compositions for replication of threose nucleic acids (TNAs) are described. The described methods include a method for transcribing a DNA template into a TNA, and a method for reverse transcribing a threose nucleic acid into a cDNA.
摘要翻译：描述了用于复制苏氨酸核酸（TNA）的方法和组合物。所述方法包括将DNA模板转录成TNA的方法，以及将苏糖核酸逆转录为cDNA的方法。

9. 发明申请

WO2014066318A1 COMBINATION THERAPIES FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND RELATED DISORDERS 审中-公开
标题翻译：治疗阿尔茨海默病和相关疾病的组合治疗
公开(公告)号：WO2014066318A1
公开(公告)日：2014-05-01
申请号：PCT/US2013/066069
申请日：2013-10-22
申请人： THE GENERAL HOSPITAL CORPORATION , ELMALEH, David, R.
发明人： ELMALEH, David, R.
IPC分类号： A61K31/4162 , A61K31/70 , C07D471/00 , C07D498/00 , C07H5/02 , C07H17/00 , A61P25/28 , A61P25/00
CPC分类号： A61K31/5415 , A61K31/047 , A61K31/075 , A61K31/13 , A61K31/192 , A61K31/194 , A61K31/225 , A61K31/352 , A61K31/353 , A61K31/428 , A61K31/435 , A61K31/438 , A61K31/55 , A61K31/706 , A61K31/713 , A61K38/185 , A61K39/0005 , A61K45/06 , A61K48/00 , A61K51/0453 , C07K16/18 , A61K2300/00
摘要： The present invention relates to combination therapies for treating Alzheimer's disease or an amyloidosis-associated pathological condition comprising co-administering a therapeutically effective amount of a first compound, and a therapeutically effective amount of a second compound. In certain embodiments, the first compound or the second compound inhibits AB peptide polymerization; is an anti-inflammatory; improves cognitive function, mood, or social behavior; is associated with Tau or alpha-synuclein; or regulates amyloid peptide washout.
摘要翻译：本发明涉及用于治疗阿尔茨海默病或淀粉样变性相关病理状况的组合疗法，包括共同施用治疗有效量的第一化合物和治疗有效量的第二化合物。在某些实施方案中，第一化合物或第二化合物抑制AB肽聚合; 是抗炎药; 提高认知功能，情绪或社会行为; 与Tau或α-突触核蛋白相关; 或调节淀粉样蛋白肽冲洗。

10. 发明申请

WO2013166488A1 METHODS FOR GENERATING THE INNER EAR AND OTHER CRANIAL PLACODE-DERIVED TISSUES USING PLURIPOTENT STEM CELLS 审中-公开
标题翻译：使用多发性干细胞产生内耳和其他致突变体衍生的组织的方法
公开(公告)号：WO2013166488A1
公开(公告)日：2013-11-07
申请号：PCT/US2013/039686
申请日：2013-05-06
申请人： INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION , HASHINO, Eri , OXFORD, Gerry , KOEHLER, Karl, R.
发明人： HASHINO, Eri , OXFORD, Gerry , KOEHLER, Karl, R.
IPC分类号： C12N5/0793 , G01N33/50
CPC分类号： C12N5/0627 , C12N5/062 , C12N2501/113 , C12N2501/115 , C12N2501/119 , C12N2501/15 , C12N2501/155 , C12N2501/415 , C12N2501/727 , C12N2506/02 , C12N2506/03 , C12N2533/90 , G01N33/5044 , G01N33/5073
摘要： Disclosed herein are methods and compositions for generating cultures and isolated cell populations containing preplacodal ectoderms cells, otic placode cells, and inner ear sensory hair cells derived from pluripotent cells by modulating TGFβ, BMP, and FGF signaling pathways under defined culture conditions. Also described are methods for obtaining non-otic placodal tissues from pluripotent stem cells. Methods for identifying agents that induce or enhance differentiation and generation of hair cells are also disclosed. Methods for identifying cytoprotective agents for hair cells are also described.
摘要翻译：本文公开了用于通过在限定的培养条件下调节TGFbeta，BMP和FGF信号传导途径产生培养物和分离的细胞群的方法和组合物，所述细胞群含有通过调节TGFbeta，BMP和FGF信号传导途径而衍生自多能细胞的前节细胞外胚层细胞，耳廓细胞和内耳感觉毛细胞。还描述了从多能干细胞获得非耳廓织构组织的方法。还公开了用于鉴定诱导或增强毛细胞分化和产生的药剂的方法。还描述了用于鉴定毛细胞的细胞保护剂的方法。

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