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1. 发明申请

WO2023043740A1 SWELLABLE POLYMERIC MATERIALS AND USEFUL ARTICLES INCORPORATING SAME 审中-公开
公开(公告)号：WO2023043740A1
公开(公告)日：2023-03-23
申请号：PCT/US2022/043373
申请日：2022-09-13
申请人： SOANE MATERIALS LLC
发明人： SOANE, David S. , GREENE, Allison Hope , HIGGINS, Sydney Greenough
IPC分类号： A61L15/60 , A61L15/28 , A61L15/48 , A61L15/62 , C08L5/04
摘要： The present invention provides absorbent materials comprising a hydrogel- forming swellable polymer and a plasticizer, wherein the absorbent material demonstrates an advantageous performance characteristic such as advantageous fluid absorption capacity, fluid absorption rate, and rewetting, wherein the advantageous performance characteristic is within at least about 80% of a similar characteristic exhibited by a crosslinked polyacrylate superabsorbent polymer, or wherein the cumulative performance of the advantageous performance characteristics is comparable or superior to performance exhibited by the crosslinked polyacrylate superabsorbent polymer. The present invention also relates to articles of manufacture comprising such absorbent materials, and methods of manufacture.

2. 发明申请

WO2022261103A1 ARTICLES OF MANUFACTURE COMPRISING NANOCELLULOSE ELEMENTS 审中-公开
公开(公告)号：WO2022261103A1
公开(公告)日：2022-12-15
申请号：PCT/US2022/032512
申请日：2022-06-07
申请人： SOANE MATERIALS LLC
发明人： SOANE, David, S. , GREENE, Allison, Hope , COLMENARES, Juan, Sebastian
IPC分类号： D01F9/17 , D01F9/16 , D01F9/12 , D01C1/00
摘要： The present invention provides formulations comprising a suspension of nanocellulose (NC) elements and a drying/dispersal additive selected from the group consisting of temperature-responsive polymers, small molecule additives in volatile systems, and blocking agents and methods of preparing such formulations, and further provides NC-containing materials, composite materials and useful articles of manufacture made therefrom.

3. 发明申请

WO2021150859A1 SYSTEMS AND METHODS FOR PROCESSING GASES 审中-公开
公开(公告)号：WO2021150859A1
公开(公告)日：2021-07-29
申请号：PCT/US2021/014563
申请日：2021-01-22
申请人： TRANSFORM MATERIALS LLC
发明人： SOANE, David, S. , ASHCRAFT, James, Nathan , HUMMELT, Jason, Samuel , SODERHOLM, Mark, Ellis , LEEDS, Mathew , SANTANA, Alexander, Olson , O'REILLY, Matthew, Elijah , OCAMPO, Charles, E.
IPC分类号： B01J19/12 , C07C11/24 , C10H15/06 , C07C21/06 , C10G15/12 , C10G47/22
摘要： The invention includes a gas processing system for transforming a hydrocarbon-containing inflow gas into outflow gas products, where the system includes a gas delivery subsystem, a plasma reaction chamber, and a microwave subsystem, with the gas delivery subsystem in fluid communication with the plasma reaction chamber, so that the gas delivery subsystem directs the hydrocarbon-containing inflow gas into the plasma reaction chamber, and the microwave subsystem directs microwave energy into the plasma reaction chamber to energize the hydrocarbon-containing inflow gas, thereby forming a plasma in the plasma reaction chamber, which plasma effects the transformation of a hydrocarbon in the hydrocarbon-containing inflow gas into the outflow gas products, which comprise acetylene and hydrogen. The invention also includes methods for the use of this gas processing system.

4. 发明申请

WO2020112855A1 EXCIPIENT COMPOUNDS FOR PROTEIN PROCESSING 审中-公开
公开(公告)号：WO2020112855A1
公开(公告)日：2020-06-04
申请号：PCT/US2019/063374
申请日：2019-11-26
申请人： REFORM BIOLOGICS, LLC
发明人： SOANE, David, S. , WUTHRICH, Philip , MAHONEY, Robert, P. , MOODY, Mark , GREENE, Daniel, G. , SCHAUER, Neil , NAIK, Subhashchandra
IPC分类号： A61K47/22 , A61K39/395 , A61K47/12 , A61K47/18 , A61K47/20 , A61K47/24 , A61K47/42 , C07K16/00
摘要： Disclosed herein are methods for improving a parameter of a protein-related process comprising providing a viscosity-reducing excipient compound selected from the group consisting of hindered amines, aromatics and anionic aromatics, functionalized amino acids, oligopeptides, short-chain organic acids, low molecular weight aliphatic polyacids, diones and sulfones, zwitterionic excipients, and crowding agents with hydrogen bonding elements, and adding a viscosity-reducing amount of the viscosity-reducing excipient compound to a carrier solution for the protein-related process, wherein the carrier solution contains a protein of interest, and carrier solutions comprising a liquid medium in which is dissolved a protein of interest, and a viscosity-reducing excipient, wherein the viscosity of the carrier solution has a lower viscosity that that of a control solution that is substantially similar to the carrier solution except for the presence of the viscosity-reducing excipient.

5. 发明申请

WO2020041597A1 SYSTEMS AND METHODS FOR PROCESSING GASES 审中-公开
公开(公告)号：WO2020041597A1
公开(公告)日：2020-02-27
申请号：PCT/US2019/047718
申请日：2019-08-22
申请人： TRANSFORM MATERIALS LLC
发明人： SOANE, David, S. , ASHCRAFT, James, Nathan , HUMMELT, Jason, Samuel , SODERHOLM, Mark, Ellis , LEEDS, Mathew , SANTANA, Alexander, Olson , O'REILLY, Matthew, Elijah
IPC分类号： C07C2/74 , C07C2/00 , C07C7/09 , C07C7/11 , C07C7/144
摘要： The invention includes a gas processing system for transforming a hydrocarbon- containing inflow gas into outflow gas products, where the system includes a gas delivery subsystem, a plasma reaction chamber, and a microwave subsystem, with the gas delivery subsystem in fluid communication with the plasma reaction chamber, so that the gas delivery subsystem directs the hydrocarbon-containing inflow gas into the plasma reaction chamber, and the microwave subsystem directs microwave energy into the plasma reaction chamber to energize the hydrocarbon-containing inflow gas, thereby forming a plasma in the plasma reaction chamber, which plasma effects the transformation of a hydrocarbon in the hydrocarbon-containing inflow gas into the outflow gas products, which comprise acetylene and hydrogen. The invention also includes methods for the use of the gas processing system.

6. 发明申请

WO2018013673A1 STABILIZING EXCIPIENTS FOR THERAPEUTIC PROTEIN FORMULATIONS 审中-公开
标题翻译：稳定治疗性蛋白质制剂的优点
公开(公告)号：WO2018013673A1
公开(公告)日：2018-01-18
申请号：PCT/US2017/041691
申请日：2017-07-12
申请人： REFORM BIOLOGICS, LLC
发明人： SOANE, David, S. , MAHONEY, Robert, P. , WUTHRICH, Philip , GREENE, Daniel, G.
IPC分类号： A61K47/48 , C12N9/36 , A61K47/22
摘要： The invention encompasses therapeutic formulations comprising a protein active ingredient and a stabilizing excipient, methods of improving stability in a therapeutic formulation comprising a protein active ingredient by adding a stability -improving amount of a stabilizing excipient to the therapeutic formulation, and methods of reducing adverse infusion-related effects in a patient, comprising administering to a patient in need thereof a therapeutic formulation comprising a protein active ingredient and a stabilizing excipient.
摘要翻译：本发明包括包含蛋白质活性成分和稳定赋形剂的治疗制剂，通过向治疗剂中添加稳定性改善量的稳定赋形剂来改善包含蛋白质活性成分的治疗制剂中的稳定性的方法制剂和减少患者不良输注相关效应的方法，其包括向有需要的患者施用包含蛋白质活性成分和稳定赋形剂的治疗制剂。

7. 发明申请

WO2017019471A1 CONTINUOUS ADIABATIC INVERSE EMULSION POLYMERIZATION PROCESS 审中-公开
标题翻译：连续自发反相乳液聚合方法
公开(公告)号：WO2017019471A1
公开(公告)日：2017-02-02
申请号：PCT/US2016/043460
申请日：2016-07-22
申请人： TECHNOLOGY INVESTMENT & DEVELOPMENT, LLC
发明人： KANE, James , DURHAM, James, F.
IPC分类号： B01F17/34 , C08F2/32 , B01F17/00
CPC分类号： C08F2/32 , C08F2/01 , C08F6/20 , C08F220/56 , C08F220/34 , C08F2220/585 , C08F220/06
摘要： The present invention provides methods and systems for continuous polymerization of ethylenically unsaturated monomers in a water-in-oil inverse emulsion under adiabatic conditions without the need for external cooling during the polymerization. The method comprises neutralizing a monomer composition comprising at least one acidic vinyl monomer with a base in an aqueous medium comprising water and water ice to form an aqueous monomer solution therefrom; homogenizing and degassing to form an inverse monomer emulsion; initiating polymerization; passing the inverse emulsion through a tube reactor without cooling, and flash evaporating a portion of the water from inverse emulsion to cool and concentrate the resulting polymer-containing inverse emulsion. During neutralization, the aqueous medium comprises an amount of water ice sufficient to maintain a temperature of 30°C or less, and the polymerization is initiated by adding a free-radical polymerization initiator to the emulsion prior to passing the emulsion through the tube reactor.
摘要翻译：本发明提供了在绝热条件下在油包水反相乳液中连续聚合烯属不饱和单体的方法和系统，而不需要在聚合过程中进行外部冷却。该方法包括在包含水和水冰的水性介质中中和包含至少一种酸性乙烯基单体的单体组合物与碱形成其中的单体水溶液; 匀化和脱气形成反相单体乳液; 引发聚合; 使反相乳液通过管式反应器而不冷却，并从反相乳液中闪蒸一部分水以冷却并浓缩得到的含聚合物的反相乳液。在中和过程中，水介质包含一定量的足以保持30℃或更低温度的水冰，并且在将乳液通过管式反应器之前，通过向乳液中加入自由基聚合引发剂来开始聚合。

8. 发明申请

WO2014071038A1 LOW INTERFACIAL TENSION SURFACTANTS FOR PETROLEUM APPLICATIONS 审中-公开
标题翻译：用于石油应用的低界面张力表面活性剂
公开(公告)号：WO2014071038A1
公开(公告)日：2014-05-08
申请号：PCT/US2013/067809
申请日：2013-10-31
申请人： SOANE ENERGY, LLC
发明人： SOANE, David, S. , PORTILLA, Rosa, Casado , DISE, John, H. , MAHONEY, Robert, P.
IPC分类号： C07C229/30 , C10G1/04
CPC分类号： C07C233/18 , C07C69/593 , C07C2601/14 , C08G65/22 , C08G65/3324 , C08G2650/06 , C08G2650/50 , C08G2650/58 , C10G33/04 , C10G75/04 , C10G2300/1033
摘要： The invention relates to a class of novel surfactants that have utility in the recovery and/or extraction of oil.
摘要翻译：本发明涉及一类可用于回收和/或提取油的新型表面活性剂。

9. 发明申请

WO2014062660A1 SEED COATING FORMULATION SYSTEMS 审中-公开
标题翻译：种子涂料配方系统
公开(公告)号：WO2014062660A1
公开(公告)日：2014-04-24
申请号：PCT/US2013/065016
申请日：2013-10-15
申请人： CROP ENHANCEMENT, LLC
发明人： JOGIKALMATH, Gangadhar , SCHNEIDER, Andrea , SOANE, David, S.
IPC分类号： B05B17/00 , B05C5/00
CPC分类号： A01C1/06 , A01N25/00 , A01N25/28 , A01N43/70 , A01N43/707 , A01N37/26 , A01N43/40 , A01N43/50 , A01N43/56 , A01N43/653 , A01N43/88 , A01N47/36
摘要： The present invention provides seed coating systems and methods for their use, where a seed coating system comprises encapsulated active ingredient particles that comprise an active ingredient and an encapsulation layer with a preselected release profile, and a polymeric seed coating, wherein the polymeric seed coating releasably affixes the encapsulated active ingredient particle in proximity to a surface of a seed. In embodiments, the seed coating system comprising a plurality of active ingredient layers, and active ingredients is disclosed. Further, its mechanism of affixation to a seed surface is disclosed.
摘要翻译：本发明提供种子包衣系统及其使用方法，其中种子包衣系统包含包含活性成分的包封的活性成分颗粒和具有预选释放特征的包封层和聚合种子包衣，其中可释放的聚合种子包衣将包封的活性成分颗粒粘附在种子表面附近。在实施方案中，公开了包含多个活性成分层和活性成分的种子包衣系统。此外，公开了其粘附到种子表面的机制。

10. 发明申请

WO2014055392A2 METHOD OF PROTECTING CARDIAC FUNCTION 审中-公开
标题翻译：保护心脏功能的方法
公开(公告)号：WO2014055392A2
公开(公告)日：2014-04-10
申请号：PCT/US2013/062553
申请日：2013-09-30
申请人： DECIMMUNE THERAPEUTICS, INC.
发明人： HAAS, Michael, S.
IPC分类号： A61K39/395
CPC分类号： C07K16/18 , A61K38/16 , A61K2039/505 , C07K2317/20 , C07K2317/32 , C07K2317/34 , C07K2317/565 , C07K2317/76
摘要： The invention is a method of protecting cardiac function in a subject in need thereof comprising administering to said subject an effective amount of an inhibitor of the interaction between a pathogenic IgM and the N2 epitope in cardiac tissue.
摘要翻译：本发明是一种在有需要的受试者中保护心脏功能的方法，包括向所述受试者施用有效量的致病性IgM与心脏组织中的N2表位之间相互作用的抑制剂。

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