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1. 发明申请

WO2010132758A2 OSPC-BASED DIAGNOSTIC TEST FOR LYME DISEASE 审中-公开
标题翻译：基于OSPC的LYME疾病诊断测试
公开(公告)号：WO2010132758A2
公开(公告)日：2010-11-18
申请号：PCT/US2010/034885
申请日：2010-05-14
申请人： GOMES-SOLECKI, Maria, J. , DATTWYLER, Raymond, J.
发明人： GOMES-SOLECKI, Maria, J. , DATTWYLER, Raymond, J.
IPC分类号： G01N33/68 , C07K14/195 , G01N33/569 , A61K39/02 , A61P31/04
CPC分类号： A61K39/0225 , G01N2333/20 , Y02A50/401
摘要： The present invention relates, e.g. , to a composition comprising OspC polypeptides from Lyme Disease-causing Borrelia species, wherein the composition comprises one or more isolated polypeptides from OspC families as follows: (a) at least one of each of K, B, and J; or (b) at least one of each of K and E; or (c) at least one of each of K and F. These polypeptides bind specifically to antibodies induced by a causative agent of Lyme disease (a pathogenic Borrelia ), e.g. in a sample from a subject having Lyme disease, and exhibit a high degree of cross-reactivity with OscC polypeptides from other families. Therefore, the noted combinations of polypeptides can be used to diagnose infection from broad cross-section of Borrelia . Also disclosed are diagnostic reagents and kits comprising compositions of the invention, methods for diagnosing infection by Borrelia , and vaccines against Borrelia infection.
摘要翻译：本发明涉及例如包含来自莱姆病引起的疏螺旋体物种的OspC多肽的组合物，其中所述组合物包含来自OspC家族的一种或多种分离的多肽，如下：（a）K，B和焦耳; 或（b）K和E中的至少一个; 或（c）K和F中的至少一个。这些多肽特异性结合由莱姆病（致病性疏螺旋体）病原体引起的抗体。在来自具有莱姆病的受试者的样品中，并且与来自其他家族的OscC多肽表现出高度的交叉反应性。因此，所指出的多肽的组合可以用于诊断来自疏螺旋体的宽横截面的感染。还公开了包含本发明组合物的诊断试剂和试剂盒，用于诊断Borrelia感染的方法和针对Borrelia感染的疫苗。

2. 发明申请

WO2009100137A3 MAGNETIC CELLS FOR LOCALIZING DELIVERY AND TISSUE REPAIR 审中-公开
公开(公告)号：WO2009100137A3
公开(公告)日：2009-08-13
申请号：PCT/US2009/033086
申请日：2009-02-04
申请人： UNIVERSITY OF MIAMI , GOLDBERG, Jeffrey L. , HALPERN, Alan
发明人： GOLDBERG, Jeffrey L. , HALPERN, Alan
IPC分类号： A61K9/00 , A61K33/26 , A61P27/02 , A61K35/44 , A61K9/14
摘要： Normal or genetically modified cell(s) having magnetic nanoparticle(s) bound (affixed) to their surfaces and methods of delivery to target tissues, e.g. for treatment of disease and/or injury.

3. 发明申请

WO2009061382A2 CARDIAC STEM CELL AND MYOCYTE SECRETED PARACRINE FACTORS AND USES THEREOF 审中-公开
标题翻译： CARDIAC干细胞和MYOCYTE分泌参数因子及其用途
公开(公告)号：WO2009061382A2
公开(公告)日：2009-05-14
申请号：PCT/US2008/012415
申请日：2008-11-03
申请人： MARBAN, Eduardo, T. , VAN EYK, Jennifer , STASNA, Miroslava
发明人： MARBAN, Eduardo, T. , VAN EYK, Jennifer , STASNA, Miroslava
IPC分类号： C12N15/10
CPC分类号： G01N33/6893 , G01N33/6869 , G01N33/6887 , G01N33/74 , G01N33/92 , G01N2800/32 , G01N2800/52

4. 发明申请

WO2008002572A2 METHOD FOR MEASURING MATURE BRAIN DERIVED NEUROTROPHIC FACTOR 审中-公开
标题翻译：测定成熟脑源性神经营养因子的方法
公开(公告)号：WO2008002572A2
公开(公告)日：2008-01-03
申请号：PCT/US2007/014828
申请日：2007-06-27
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF HEALTH AND HUMAN SERVICES , LU, Bai , NAGAPPAN, Guhan , ZAITSEV, Eugene
发明人： LU, Bai , NAGAPPAN, Guhan , ZAITSEV, Eugene
CPC分类号： C07K16/22
摘要： A method of obtaining antibody specific for mature brain-derived neurotrophic factor (mBDNF), and uses thereof.
摘要翻译：获得成熟脑源性神经营养因子（mBDNF）特异性抗体的方法及其用途。

5. 发明申请

WO2007092033A2 RAPID IDENTIFICATION OF THE VARIETIES AND GENOTYPES OF CRYPTOCOCCUS NEOFORMANS SPECIES COMPLEX USING A HIGH-THROUGHPUT FLOW CYTOMETER 审中-公开
标题翻译：快速识别CRYPTOCOCCUS NEOFORMANS物种的变异和遗传多样性使用高通量流量计
公开(公告)号：WO2007092033A2
公开(公告)日：2007-08-16
申请号：PCT/US2006/018979
申请日：2006-05-17
申请人： UNIVERSITY OF MIAMI , DIAZ, Mara R. , FELL, Jack W.
发明人： DIAZ, Mara R. , FELL, Jack W.
CPC分类号： C12Q1/6895
摘要： Nucleic acid probes and molecular method to identify the varieties and genotypic groups within C. neoformans species complex. The method employs a flow cytometer with a dual laser system that allows the simultaneous detection of different target sequences in a multiplex and high-throughput format. The assay uses a liquid suspension hybridization format with specific oligonucleotide probes that are covalently bound to the surface of fluorescent color-coded microspheres. Biotinylated target amplicons, which hybridized to their complementary probe sequences, are quantified by the addition of the conjugate, streptavidin-R-phycoerythrin. The assay is specific and sensitive, and allows discrimination of 1bp mismatch with no apparent cross-reactivity and is capable of detecting 101 to 103 genome copies. The assay can be used directly with yeast cells or isolated DNA, can be undertaken in less than one hour following PCR amplification and permits identification of species in a multiplex format. In addition, to multiplex capability, the assay allows simultaneous detection of target sequences in a single reaction.
摘要翻译：核酸探针和分子方法鉴定新型隐球菌物种复合物中的品种和基因型组。该方法采用具有双激光系统的流式细胞仪，其允许以多路和高通量格式同时检测不同的靶序列。该测定法使用液体悬浮杂交形式与特定的寡核苷酸探针共价结合荧光色编码微球体的表面。通过加入缀合物链亲和素-R-藻红蛋白来定量与其互补探针序列杂交的生物素化靶扩增子。该测定是特异性和灵敏的，并且允许区分1bp错配，没有明显的交叉反应性，并且能够检测101至103个基因组拷贝。该测定可以直接用于酵母细胞或分离的DNA，可以在PCR扩增后不到一小时内进行，并允许以多重格式鉴定物种。此外，为了复用能力，该测定允许在单次反应中同时检测靶序列。

6. 发明申请

WO2005077006A2 METHODS AND COMPOSITIONS FOR DETECTING AND TREATING RETINAL DISEASES 审中-公开
标题翻译：检测和治疗感染性疾病的方法和组合物
公开(公告)号：WO2005077006A2
公开(公告)日：2005-08-25
申请号：PCT/US2005/003880
申请日：2005-02-09
申请人： UNIVERSITY OF MIAMI , INANA, George , MCLAREN, Margaret
发明人： INANA, George , MCLAREN, Margaret
IPC分类号： A61K31/557 , A61K48/00 , C12N9/64
CPC分类号： A61K48/005 , A01K2217/05 , A01K2267/03 , A61K31/557 , A61K31/7088 , C12N9/6491 , C12Q1/6883 , C12Q2600/156
摘要： The invention discloses multiple genes related to age-related macular degeneration (AMD) and/or phagocytosis by RPE cells of the eye, and methods and compositions for detecting and treating AMD and other retinal degenerative conditions based on these phagocytosis-related and/or AMD-related genes. Also provided are animal models useful for testing therapeutic compounds and treatment protocols for AMD, and gene arrays including polymorphic variants of phagocytosis-related and/or AMD-related genes, useful for genetic screening of nucleic acid samples from subjects to obtain profiles of polymorphic variant sequences in a plurality of genes associated with AMD.
摘要翻译：本发明公开了与眼睛的RPE细胞的年龄相关性黄斑变性（AMD）和/或吞噬作用相关的多个基因，以及用于基于这些吞噬相关和/或AMD检测和治疗AMD和其他视网膜退行性病症的方法和组合物相关基因。还提供了可用于测试AMD的治疗化合物和治疗方案的动物模型，以及包括吞噬相关和/或AMD相关基因的多态性变体的基因阵列，其用于从受试者的核酸样品的遗传筛选以获得多态变体与AMD相关的多个基因中的序列。

7. 发明申请

WO2005046731A1 INTERFERENCE WITH C-MAF FUNCTION IN MULTIPLE MYELOMA 审中-公开
标题翻译：与多个MYELOMA中的C-MAF功能的干扰
公开(公告)号：WO2005046731A1
公开(公告)日：2005-05-26
申请号：PCT/US2003/033162
申请日：2003-10-17
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF HEALTH AND HUMAN SERVICES , STAUDT, Louis, M., M.D., Ph.D. , HURT, Elaine , KUEHL, Michael
发明人： STAUDT, Louis, M., M.D., Ph.D. , HURT, Elaine , KUEHL, Michael
IPC分类号： A61K48/00
CPC分类号： C12N15/1135 , C07K14/82 , C12N2310/14 , C12Q1/6883 , G01N33/5011 , G01N33/57407
摘要： The present invention relates to a method for inhibiting the proliferation, survival and/or migration of a multiple myeloma cell that expresses (overexpresses) c-maf, comprising contacting the multiple myeloma cell with an effective amount of an inhibitor of expression and/or activity of c-maf, integrin 7 and/or cyclin D2. Also disclosed are methods for detecting multiple myeloma in a subject, and for treating multiple myeloma in a subject who has multiple myeloma cells that express c-maf. Also disclosed is a method for identifying an agent that inhibits the proliferation of multiple myeloma cells that express c-maf, and/or inhibits the adhesion of the multiple myeloma cells to bone marrow stromal cells.
摘要翻译：本发明涉及抑制表达（过表达）c-maf的多发性骨髓瘤细胞的增殖，存活和/或迁移的方法，包括使多发性骨髓瘤细胞与有效量的表达和/或活性抑制剂接触的c-maf，整合素7和/或细胞周期蛋白D2。还公开了用于检测受试者中多发性骨髓瘤的方法，以及用于治疗具有表达c-maf的多发性骨髓瘤细胞的受试者中的多发性骨髓瘤的方法。还公开了用于鉴定抑制表达c-maf的多发性骨髓瘤细胞的增殖，和/或抑制多发性骨髓瘤细胞对骨髓基质细胞的粘附的药剂的方法。

8. 发明申请

WO2004020406A2 VARIANTS OF VIBRIO CHOLERAE O1 BIOTYPE E1 TOR WITH ATTRIBUTES OF CLASSICAL BIOTYPE 审中-公开
标题翻译： VIBRIO CHOLERAE O1 BIOTYPE E1 TOR具有经典生物特性的变种
公开(公告)号：WO2004020406A2
公开(公告)日：2004-03-11
申请号：PCT/US2003/026968
申请日：2003-08-29
申请人： INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH , NAIR, G., Balakrish , FARUQUE, S., M. , SACK, David, A.
发明人： NAIR, G., Balakrish , FARUQUE, S., M. , SACK, David, A.
IPC分类号： C07D
CPC分类号： C12N1/20 , A61K39/107 , A61K2039/522 , Y02A50/472
摘要： The invention relates to novel types of Vibrio cholerae that are useful for vaccines and immunological compositions.
摘要翻译：本发明涉及可用于疫苗和免疫组合物的新型霍乱弧菌。

9. 发明申请

WO2003092789A3 INTENSITY MODULATED RADIOTHERAPY INVERSE PLANNING ALGORITHM 审中-公开
公开(公告)号：WO2003092789A3
公开(公告)日：2003-11-13
申请号：PCT/US2003/013338
申请日：2003-04-29
申请人： UNIVERSITY OF MIAMI , LUO, Chunsong
发明人： LUO, Chunsong
IPC分类号： A61N5/00
摘要： A computerized intensity modulated radiotherapy (IMRT) dosage optimization comprises: dividing the volume into dose voxels (102) to be irradiated with weighted pencil beams from gantry angles; selecting dose voxels (104) from the planning target volume (PTV), organs at risk (OAR) and normal tissue in the PTV neighborhood; choosing a dose matrix (106) for the voxels; constructing beam weight vectors (108); calculating a transfer matrix (110); inverting the matrix (112); populating the beam weight vector with the product of the inverted transfer matrix and the dose matrix (114); iteratively modifying dose values (118); and repeating the matrix multiplication (114) until negative beam weights are eliminated (116).

10. 发明申请

WO2002100334A3 USE OF RADIOPHARMACEUTICAL COMPLEXES IN ACHIEVING TRANSPLANTATION TOLERANCE 审中-公开
公开(公告)号：WO2002100334A3
公开(公告)日：2002-12-19
申请号：PCT/US2002/018165
申请日：2002-06-11
申请人： UNIVERSITY OF MIAMI
发明人： INVERARDI, Luca , RICORDI, Camillo , PAGANELLI, Giovanni , SERAFINI, Aldo
IPC分类号： A61K51/00
摘要： Non-lethal methods of conditioning a recipient prior to bone marrow transplantation to achieve highly enhanced, stable, long-term hematopoietic chimerism in presence of transient immunosuppression are described. In particular, the administration of non-lethal doses of bone-seeking radiopharmaceuticals such as 153 Samarium Lexidronam, a radioactive compound linked to a tetraphosphonate group, to target bone marrow cells, are disclosed herein.

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