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1. 发明申请

WO2010138782A1 IN VITRO PRODUCTION OF OLIGODENDROCYTES FROM HUMAN UMBILICAL CORD STEM CELLS 审中-公开
标题翻译：从人类脐带干细胞中制备寡糖的体外生产
公开(公告)号：WO2010138782A1
公开(公告)日：2010-12-02
申请号：PCT/US2010/036505
申请日：2010-05-28
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH , HICKMAN, James, J. , DAVIS, Hedvika
发明人： HICKMAN, James, J. , DAVIS, Hedvika
IPC分类号： A01N63/00 , C12N5/071
CPC分类号： C12N5/0622 , C12N2500/90 , C12N2501/01 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2501/70 , C12N2501/81 , C12N2501/91 , C12N2506/025 , C12N2506/1369 , C12N2506/1392
摘要： The invention provides a method of producing oligodendrocytes by in vitro differentiation of human multi-potent progenitor cells (MLPCs). The method comprises culturing culturing isolated MLPCs on a first surface in a serum-free defined culture medium; replacing the culture medium with serum-free culture medium supplemented with bFGF, EGF and PDGF-AA for approximately 24 hours; changing the cultured MLPCs into the supplemented serum-free culture medium further supplemented with differentiation factors norepinephrine, forskolin. and K252a; establishing a 3D environment by covering the culture with a second surface opposite and spaced apart from the first surface, so as to contain the MLPCs therebetween; and continuing to culture until a majority of the MLPCs have differentiated into oligodendrocytes. Additionally included is a method of treatment for a subject afflicted by a disease characterized by central or peripheral nervous system demyelination, the method comprising transplanting into the subject oligodendrocytes produced according to the method disclosed.
摘要翻译：本发明提供了通过体外分化人多能祖细胞（MLPC）产生少突胶质细胞的方法。该方法包括在无血清定义培养基的第一表面培养培养分离的MLPC; 用补充有bFGF，EGF和PDGF-AA的无血清培养基代替培养基约24小时; 将培养的MLPC变成补充的无血清培养基，进一步补充分化因子去甲肾上腺素，毛喉素。和K252a; 通过用与第一表面相对且间隔开的第二表面覆盖培养来建立3D环境，以便在其间容纳MLPC; 并继续培养，直到大多数MLPC已经分化为少突胶质细胞。另外包括治疗由以中枢神经系统或周围神经系统脱髓鞘为特征的疾病所折磨的受试者的方法，该方法包括将根据所公开的方法产生的少突胶质细胞移植到受试者中。

2. 发明申请

WO2006096156A1 MOVING MIRROR OPTICAL SCANNER AND ASSOCIATED METHODS 审中-公开
标题翻译：移动镜面光学扫描仪及相关方法
公开(公告)号：WO2006096156A1
公开(公告)日：2006-09-14
申请号：PCT/US2005/006698
申请日：2005-03-04
申请人： PANGOLIN LASER SYSTEMS, INC. , BENNER, William, R. , BACS, Aron
发明人： BENNER, William, R. , BACS, Aron
IPC分类号： G02B26/08
CPC分类号： G02B26/101 , G02B26/105
摘要： An apparatus and method for an optical scanner comprises a mirror (Fig. 5, 3), a coil (Fig. 6, 10), a magnetic circuit (Fig. 6, 6), and a support connected to the mirror. The mirror has a reflective surface and a periphery. A coil of electrically conductive material consists of a plurality of windings around the periphery of the mirror. The magnetic circuit comprises a magnet having opposite poles generating a magnetic flux therebetween. A support is connected to the mirror, the support rotatably supporting the mirror in the magnetic flux with the magnetic flux intersecting the coil.
摘要翻译：一种用于光学扫描器的装置和方法，包括一个反射镜（图5,3），一个线圈（图6,10），一个磁路（图6,6）和一个连接到镜子的支架。镜子有一个反光表面和一个周边。导电材料的线圈由围绕镜子周边的多个绕组组成。磁路包括具有相反磁极的磁体，它们之间产生磁通量。支撑件连接到反射镜，支撑件可旋转地支撑在磁通中的反射镜，磁通量与线圈相交。

3. 发明申请

WO2006052961A3 AUDIENCE SCANNING LIGHT PROJECTOR AND ASSOCIATED METHODS 审中-公开
公开(公告)号：WO2006052961A3
公开(公告)日：2006-05-18
申请号：PCT/US2005/040418
申请日：2005-11-07
申请人： BENNER, William, R., Jr.
IPC分类号： G09G5/00 , H04N7/18 , H04N5/225 , G03B17/00 , G03B21/00
摘要： A scanning laser system has a scan position controller to control an X-Y beam translator and a beam power controller to control a light source. A processor has accessible a table having a matrix of elements representing regions having spatial coordinates in at least two dimensions. A plurality of regions is required to define a space approximately sized as a human head. Each element contains a beam power variable indicative of radiation exposure at a corresponding region. Software resident in the processor has code for receiving a value of beam power incident on each region being scanned, for incrementing a stored beam power variable for each region if the beam power value is above a predetermined threshold, and for outputting to at least one of the scan position and the beam power controller a signal indicative of each region at which the beam power variable is above a predetermined value.

4. 发明申请

WO2010117438A2 COMPOUNDS THAT SUPPRESS CANCER CELLS AND EXHIBIT ANTITUMOR ACTIVITY 审中-公开
标题翻译：抑制癌细胞和展示抗肿瘤活性的化合物
公开(公告)号：WO2010117438A2
公开(公告)日：2010-10-14
申请号：PCT/US2010/001021
申请日：2010-04-05
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. , UNIVERSITY OF TORONTO MISSISSAUGA , TURKSON, James , GUNNING, Patrick
发明人： TURKSON, James , GUNNING, Patrick
IPC分类号： C07D211/14
CPC分类号： A61K31/451 , A61K31/196 , C07C311/19 , C07C2601/14 , C07D211/26
摘要： The present invention provides compounds S3I-201.1066 (Formula 1) and S3I-201.2096 (Formula 2) as selective Stat3 binding agents that block Stat3 association with cognate receptor pTyr motifs, Stat3 phosphorylation and nuclear translocation, Stat3 transcriptional function, and consequently induced Stat3-specific antitumor cell effects in vitr o and antitumor response in vivo .
摘要翻译：本发明提供了作为选择性Stat3结合剂的化合物S3I-201.1066（式1）和S3I-201.2096（式2），其阻断Stat3与同源受体pTyr基序，Stat3磷酸化和核易位Stat3转录功能的关联，并因此诱导Stat3- 体外特异性抗肿瘤细胞效应和体内抗肿瘤反应。

5. 发明申请

WO2008070697A4 STAT3 INHIBITOR HAVING ANTI-CANCER ACTIVITY AND ASSOCIATED METHODS 审中-公开
公开(公告)号：WO2008070697A4
公开(公告)日：2008-06-12
申请号：PCT/US2007/086453
申请日：2007-12-05
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. , TURKSON, James , HAMILTON, Andrew, D. , JOVE, Richard , SEBTI, Said, M.
发明人： TURKSON, James , HAMILTON, Andrew, D. , JOVE, Richard , SEBTI, Said, M.
IPC分类号： A61K31/535 , C07D211/00
摘要： A small-molecule Stat3 dimerization inhibitor, S3I-M2001. is described and the dynamics of intracellular processing of activated Stat3 within the context of the biochemical and biological effects of the Stat3 chemical probe inhibitor are elucidated. S3I-M2001 is a newly-identified oxazole-based peptidomimetic of the Stat3 Src Homology (SH) 2 domain-binding phosphotyrosine peptide that selectively disrupts active Stat3:Stat3 dimers. Stat3-dependent malignant transformation, survival, and migration and invasion of mouse and human cancer cells harboring persistently-activated Stat3 were inhibited by S3I-M2001. S3I-M2001 inhibited Stat3-dependent transcriptional regulation of tumor survival genes, such as Bcl-xL. The disclosed compound is useful as a new potential treatment for certain cancers.

6. 发明申请

WO2003008026A2 APPARATUS AND METHOD FOR SELF-INDUCED COUGH-CARDIOPULMONARY RESUSCITATION 审中-公开
标题翻译：用于自我诱导的心脏重建障碍的装置和方法
公开(公告)号：WO2003008026A2
公开(公告)日：2003-01-30
申请号：PCT/US2002/022564
申请日：2002-07-16
申请人： PNEUMOFLEX SYSTEMS, L.L.C. , ADDINGTON, W., Robert , STEPHENS, Robert, E. , MILLER, Stuart, P.
发明人： ADDINGTON, W., Robert , STEPHENS, Robert, E. , MILLER, Stuart, P.
IPC分类号： A61M11/00
CPC分类号： A61M15/009 , A61M2205/3553 , A61M2205/3592 , A61M2209/06
摘要： A apparatus and method for self-treatment of cardiac arrhythmia by a patient, comprising a container sized to be portable by the patient and having therein a chamber containing a medicament composition comprising a pharmaceutically acceptable carrier mixed with a chemoirritant, preferably L-tartaric acid; a nebulizing valve connected to the chamber so as to provide an outlet therefor; a source of motivating force connected with the chamber so as to motivate the composition through the opening in the nebulizing valve to thereby cause nebulization of the composition; a wireless transmitter responsive to activation of the nebulizer for sending a wireless signal requesting medical assistance; and a power source operatively connected for providing power; wherein the chemoirritant is mixed in the composition in an amount sufficient for causing the patient to produce an involuntary cough effective to maintain at least partial blood circulation.
摘要翻译：一种用于由患者自我治疗心律失常的装置（30,40），包括容器（44），容器（44）的尺寸适于由患者便携，并且其中包含含有药物组合物的腔室，所述药物组合物包含与化学刺激剂混合的药学上可接受的载体，优选L-酒石酸; 连接到所述室的雾化阀，从而提供出口; 与室连通的激励源，以通过雾化阀中的开口激励组合物，从而使组合物雾化; 响应于激活雾化器以发送请求医疗援助的无线信号的无线发射机; 以及可操作地连接以提供电力的电源; 其中所述化学刺激剂以足以引起患者产生有效维持至少部分血液循环的非自愿咳嗽的量在所述组合物中混合。

7. 发明申请

WO2010138679A1 METHOD OF SCREENING DRUGS FOR REVERSAL OF AMYLOID BETA NEUROTOXICITY 审中-公开
标题翻译：筛选用于逆转AMYLOID BET神经毒性的药物的方法
公开(公告)号：WO2010138679A1
公开(公告)日：2010-12-02
申请号：PCT/US2010/036336
申请日：2010-05-27
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. , HICKMAN, James, J. , VARGHESE, Kucku , MOLNAR, Peter
发明人： HICKMAN, James, J. , VARGHESE, Kucku , MOLNAR, Peter
IPC分类号： C12Q1/68
CPC分类号： C07K14/4711
摘要： A method of screening a compound for effectiveness in treating amyloid beta neurotoxicity comprises culturing mammalian neurons in serum-free defined medium until the neurons are electrically functional, exposing the electrically stable neurons to amyloid beta, monitoring the exposed neurons for impairment of electrical functionality, and treating the exposed neurons with the candidate drug while monitoring their electrical activity for reversal of impairment. The invention also includes a method of identifying a mammalian neuron having a biological marker conferring predisposition to development of Alzheimer's disease, the method comprising culturing the mammalian neuron in serum-free medium until the neuron is electrically functional, exposing the electrically stable neuron to amyloid beta while monitoring for impairment of electrical functionality as an indicator of presence of said biological marker, and verifying presence of the biological marker by treating the impaired neuron with an anti-amyloidogenic compound while monitoring for return of neuron functionality.
摘要翻译：筛选化合物以治疗淀粉样蛋白β神经毒性的有效性的方法包括在无血清定义的培养基中培养哺乳动物神经元，直到神经元具有电功能，将电稳定的神经元暴露于淀粉样蛋白β，监测暴露的神经元损害电功能，以及用候选药物治疗暴露的神经元，同时监测其电活动以逆转损伤。本发明还包括鉴定具有赋予阿尔茨海默病发展倾向的生物学标记的哺乳动物神经元的方法，所述方法包括在无血清培养基中培养哺乳动物神经元，直到神经元具有电功能，将电稳定的神经元暴露于淀粉样蛋白β 同时监测电功能损伤作为所述生物标志物存在的指标，以及通过用抗淀粉样变性化合物治疗受损神经元同时监测神经元功能的返回来验证生物标志物的存在。

8. 发明申请

WO2010033685A1 INHIBITORS OF STAT3 审中-公开
标题翻译： STAT3抑制剂
公开(公告)号：WO2010033685A1
公开(公告)日：2010-03-25
申请号：PCT/US2009/057291
申请日：2009-09-17
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. , TURKSON, James , HAMILTON, Andrew, D.
发明人： TURKSON, James , HAMILTON, Andrew, D.
IPC分类号： C07D215/00
CPC分类号： C07D263/34 , C07D277/56 , C07F9/12 , C07F9/653 , C07F9/6539
摘要： Disclosed herein are compounds derived from a chemical structure according to the formula (I) wherein X comprises oxygen or sulfur, R 1 comprises a phenyl or naphthyl group, R 2 comprises an amide group and R 3 comprises a phosphate group. The disclosed compounds demonstrate inhibitory activity against STAT3, a protein found in certain tumor tissues and which promotes cellular overproliferation and resistance to apoptosis. The invention includes compositions containing the disclosed compounds, as well as methods of treatment therewith.
摘要翻译：本文公开的是衍生自根据式（I）的化学结构的化合物，其中X包含氧或硫，R 1包括苯基或萘基，R 2包含酰胺基，R 3包含磷酸酯基。所公开的化合物显示对STAT3的抑制活性，STAT3是某些肿瘤组织中发现的蛋白质，其促进细胞过度增殖和对细胞凋亡的抗性。本发明包括含有所公开化合物的组合物，以及其处理方法。

9. 发明申请

WO2009073184A8 COMPOSITIONS FOR INDUCING LABOR AND ASSOCIATED METHODS 审中-公开
公开(公告)号：WO2009073184A8
公开(公告)日：2009-06-11
申请号：PCT/US2008/013317
申请日：2008-12-03
申请人： FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , OLCESE, James
发明人： OLCESE, James
IPC分类号： A01N43/42 , A61K31/44
摘要： The invention discloses a pharmaceutical composition containing oxytocin and melatonin in amounts therapeutically effective for inducing labor in a pregnant human patient. Preferably, the oxytocin content is reduced to mitigate unwanted side effects and the melatonin content synergistically enhances the oxytocin's labor-inducing effectiveness. Also disclosed is a pharmaceutical composition for treatment of a pregnant human patient experiencing pre-term labor characterized by early expression of melatonin receptors in myometrial cells, the composition containing one or more agents which interfere with melatonin binding to said receptors. Additionally, the invention includes a method of treatment effective in inducing labor in a pregnant human patient, the method comprising coadministering melatonin and oxytocin to the patient and a method of treating pre-term labor in a pregnant human patient manifesting early expression of melatonin receptors in her myometrial tissues, the method comprising administering to the patient an agent effective in blocking melatonin binding to the receptors.

10. 发明申请

WO2008121953A3 INTERFERON PRODUCED IN PLASTIDS 审中-公开
公开(公告)号：WO2008121953A3
公开(公告)日：2008-10-09
申请号：PCT/US2008/058879
申请日：2008-03-31
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. , DANIELL, Henry
发明人： DANIELL, Henry
IPC分类号： C12N15/82 , C12Q1/68
摘要： Disclosed herein is an expression cassette containing a polynucleotide encoding an IFNa2b polypeptide and having two overlapping primers at a 5' end encoding a polyhistidine tag and a thrombin cleavage site fused to the polypeptide, the expression cassette carried by a vector competent for integrating the expression cassette in a plastid genome. Also disclosed is a transgenic plastid, preferably a chloroplast, containing a genome transformed by integration of an expression cassette having a non-plant gene encoding an IFNa2b polypeptide and having regions that encode a polyhistidine tag and a thrombin cleavage site fused with the IFNa2b polypeptide.

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