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1. 发明申请

WO2017031399A1 COMPOSITIONS AND MULTIPLEXED SYSTEMS FOR COUPLED CELL-FREE TRANSCRIPTION-TRANSLATION AND PROTEIN SYNTHESIS AND METHODS FOR USING THEM 审中-公开
标题翻译：用于联合细胞免疫转录和蛋白质合成的组合物和多重系统及其使用方法
公开(公告)号：WO2017031399A1
公开(公告)日：2017-02-23
申请号：PCT/US2016/047704
申请日：2016-08-19
申请人： GENOMATICA, INC.
发明人： CULLER, Stephanie , CHEN, Ihsiung Brandon , PHARKYA, Priti , VAN DIEN, Steve , BARTON, Nelson
IPC分类号： A61K35/12 , A61K48/00 , C12N5/00 , C12N5/02 , C12N15/09 , C12N5/10
CPC分类号： A61K35/66 , Y02A50/409 , Y02A50/469 , A61K35/12
摘要： In alternative embodiments, provided herein are transcription/ translation (TX-TL) systems and methods of using them for use as rapid prototyping platforms for the synthesis, modification and identification of natural products (NPs), and natural product analogs (NPAs) and secondary metabolites, from biosynthetic gene cluster pipelines. In alternative embodiments, exemplary TX-TL systems as provided herein are used for the combinatorial biosynthesis of natural products (NPs), natural product analogs (NPAs) and secondary metabolites. In alternative embodiments, exemplary TX-TL systems as provided herein are used for the rapid prototyping of complex biosynthetic pathways as a way to rapidly assess combinatorial and biosynthetic designs before moving to cellular hosts. In alternative embodiments, these exemplary TX-TL systems are multiplexed for high-throughput (HT) automation and for prototyping engineered platforms for the synthesis or modification of natural products (NPs), and natural product analogs (NPAs) and secondary metabolites analogs.
摘要翻译：在替代实施方案中，本文提供的是转录/翻译（TX-TL）系统和使用它们作为用于合成，修饰和鉴定天然产物（NP）和天然产物类似物（NPA）和次要的快速原型平台的方法。代谢物，来自生物合成基因簇管线。在替代实施方案中，本文提供的示例性TX-TL系统用于天然产物（NP），天然产物类似物（NPA）和次级代谢物的组合生物合成。在替代实施例中，本文提供的示例性TX-TL系统用于复杂生物合成途径的快速原型化，作为在移动到蜂窝主机之前快速评估组合和生物合成设计的方式。在替代实施例中，这些示例性TX-TL系统被复用用于高通量（HT）自动化和用于天然产物（NP）和天然产物类似物（NPAs）和次级代谢物类似物的合成或修饰的原型设计平台。

2. 发明申请

WO2016172226A1 COMPOSITIONS FOR DETECTING CIRCULATING INTEGRIN BETA-3 BIOMARKER AND METHODS FOR DETECTING CANCERS AND ASSESSING TUMOR PRESENCE OR PROGRESSION, CANCER DRUG RESISTANCE AND TUMOR STEMNESS 审中-公开
标题翻译：用于检测循环积分蛋白β-3生物标记物的组合物和用于检测癌症并评估肿瘤存在或进展，癌症药物耐药性和肿瘤干细胞的方法
公开(公告)号：WO2016172226A1
公开(公告)日：2016-10-27
申请号：PCT/US2016/028461
申请日：2016-04-20
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： CHERESH, David A. , SEGUIN, Laetitia , FUJITA, Yu , WEIS, Sarah
IPC分类号： A61P35/04 , G01N33/53 , G01N33/574 , G01N33/50 , G01N33/48 , C07K16/28 , C12Q1/68
CPC分类号： G01N33/57492 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , G01N33/5011 , G01N2333/70557 , G01N2500/10 , G01N2800/52
摘要： Provided are compositions and methods comprising use of beta-3 integrin for detecting circulating tumor cells (CTCs), tumor stem cells, extracellular vesicles (EVs), including exosomes and microvesicles, that are released by CTCs or cancer cells, and the tumor from which the CTCs or EVs derive, to make a patient prognosis, and to assess tumor progression, and drug resistance, e.g., for breast, colon, lung and pancreatic cancers. In alternative embodiments, a patient fluid sample, e.g., blood, is taken and used to detect cancer stem cells, EVs- and/or CTCs-comprising beta-3 integrin and/or alphavbeta3 integrin. Provided are compositions and methods using biomarker beta-3 integrin for anti-cancer drug design; and compositions and methods that include conjugation of an imaging or therapeutic agent to an antibody targeting integrin β3 for detection and/or targeted destruction of integrin beta-3 expressing cancer stem cells and/or CTCs.
摘要翻译：提供的组合物和方法包括使用β-3整联蛋白来检测由CTC或癌细胞释放的循环肿瘤细胞（CTC），肿瘤干细胞，细胞外囊泡（EV），包括外来体和微泡，以及其中 CTC或EV得出，以作出患者预后，并评估肿瘤进展和耐药性，例如对于乳腺癌，结肠癌，肺癌和胰腺癌。在替代实施例中，采集患者流体样本，例如血液，并用于检测癌干细胞，包含β-3整联蛋白和/或alphavbeta3整联蛋白的EVs和/或CTC。提供使用生物标志物β-3整合素用于抗癌药物设计的组合物和方法; 以及包括成像或治疗剂与靶向整联蛋白β3的抗体缀合以用于检测和/或靶向破坏整合素β-3表达癌干细胞和/或CTC的组合物和方法。

3. 发明申请

WO2014144293A2 DEVELOPMENT AND USE OF MICROBES FOR IMPURITY REDUCTION IN BIOMASS HYDROLYSATES AND FERMENTATION BROTHS 审中-公开
标题翻译：生物质水解物和发酵液中减少微生物的微生物开发利用
公开(公告)号：WO2014144293A2
公开(公告)日：2014-09-18
申请号：PCT/US2014/028638
申请日：2014-03-14
申请人： GENOMATICA, INC.
发明人： LIEVENSE, Jefferson, Clay , VAN DIJKEN, Johannes, Pieter
IPC分类号： A61F13/471
CPC分类号： C12N1/20 , C12N1/16 , C12N1/18 , C12P7/02 , C12P7/16 , C12P7/18 , C12P7/40 , C12P7/44 , C12P13/001 , C12P13/005 , C12P17/10 , C12P21/00 , C12P39/00 , Y02E50/10
摘要： In alternative embodiments, the invention provides co-culture methods for improving the yield, economy or efficiency of a biosynthesis of a compound by a. microbial organism. In alternative embodiments, the invention provides co-culture methods for improving the yield, economy or efficiency of a biosynthesis of: an alcohol; a diol; a triol; a monohydric, a dihydric or a trihydric alcohol; a lower monohydric, a dihydric or a trihydric alcohol; a butanediol; a germinal or a vicinal diol; or a 1,4-Butanediol (BDO). In alternative embodiments, a co-culture of the invention uses a nutrient source comprising a biomass or a feedstock.
摘要翻译：在替代实施方案中，本发明提供了共培养方法，用于提高化合物的生物合成的产率，经济性或效率。微生物。在替代实施方案中，本发明提供用于提高生物合成的产率，经济性或效率的共培养方法：醇; 二醇三醇一元醇，二元醇或三元醇; 低级一元，二元醇或三元醇; 丁二醇生发或邻位二醇; 或1,4-丁二醇（BDO）。在替代实施方案中，本发明的共培养物使用包含生物质或原料的营养源。

4. 发明申请

WO2014047463A3 LIBRARIES OF COMPOUNDS HAVING DESIRED PROPERTIES AND METHODS FOR MAKING AND USING THEM 审中-公开
公开(公告)号：WO2014047463A3
公开(公告)日：2014-03-27
申请号：PCT/US2013/060970
申请日：2013-09-20
申请人： BIOBLOCKS, INC.
发明人： PALLAI, Peter, V. , WADE, Warren
IPC分类号： C07D405/04 , C07D491/18 , C07D403/04 , C07D401/04 , C07D417/04 , C07D491/052 , C07D417/06 , C40B60/12 , C40B20/00 , C40B60/14 , C40B80/00 , G06F3/048 , G06F19/10 , G06F17/50
摘要： In alternative embodiments the invention provides libraries of compounds, or drugs or drug candidates, manufactured and selected for having a desired property such as a biological or a chemical activity, and methods for making and using them. In one embodiment, the invention provides methods for identifying desirable compounds from very large compound sets using a compound fragment as the query. In alternative embodiments, the invention provides methods of making compounds, and libraries of compounds, using a "feasible reaction" growth scheme.

5. 发明申请

WO2014005094A1 COMPOSITIONS AND METHODS FOR IDENTIFYING AND COMPARING MEMBERS OF MICROBIAL COMMUNITIES BY COMPUTATIONAL ANALYSIS OF AMPLICON SEQUENCES 审中-公开
标题翻译：通过AMPLICON序列的计算分析来鉴定和比较微生物群落成员的组合物和方法
公开(公告)号：WO2014005094A1
公开(公告)日：2014-01-03
申请号：PCT/US2013/048719
申请日：2013-06-28
申请人： TAXON BIOSCIENCES, INC.
发明人： KUNIN, Victor , ASHBY, Matthew , SCHERER, Stewart , PATIN, Nasstasia
IPC分类号： C12Q1/04 , C12Q1/68 , C12N1/20 , G06F17/00
CPC分类号： C12Q1/689 , C12Q1/04 , C12Q1/6809 , G06F19/18 , G06F19/26 , C12Q2535/122 , C12Q2537/165
摘要： In alternative embodiments, the invention provides computational algorithms, computer programs, software and other methods, systems and products of manufacture (e.g., computers, devices or apparatus) for identifying members of microbial communities, their abundance and distribution from amplicon sequence data, and comparing microbial communities and consortia. In alternative embodiments, the invention provides computer- implemented methods comprising a subset of, substantially all, or all of the steps as set forth in the flow chart of Figure 1, Figure 3 or Figure 4. In alternative embodiments, the invention provides methods for identification of consortia, optionally followed by construction of artificial microbial consortia from pure strains or enrichment cultures.
摘要翻译：在替代实施例中，本发明提供用于识别微生物群落成员的计算算法，计算机程序，软件和其他方法，系统和产品（例如计算机，设备或设备），其丰度和从扩增子序列数据的分布，以及比较微生物群落和财团。在替代实施例中，本发明提供计算机实现的方法，其包括图1，图3或图4的流程图中阐述的步骤的子集，基本上全部或全部。在替代实施例中，本发明提供了用于识别联合体，随后可以从纯菌株或富集培养物中构建人造微生物菌群。

6. 发明申请

WO2013192545A1 COMPOSITIONS AND METHODS FOR MEDIATING PLANT STOMATAL DEVELOPMENT IN RESPONSE TO CARBON DIOXIDE AND APPLICATIONS FOR ENGINEERING DROUGHT TOLERANCE IN PLANTS 审中-公开
标题翻译：二氧化碳回收植物体发育的组合物和方法及植物耐旱性工程应用
公开(公告)号：WO2013192545A1
公开(公告)日：2013-12-27
申请号：PCT/US2013/047102
申请日：2013-06-21
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： SCHROEDER, Julian, I. , ENGINEER, Cawas
IPC分类号： C12N15/82 , C12N5/04 , C12N5/14 , C12N15/63 , C12N9/14 , C12N15/29 , C07K14/415 , C07H21/02 , C07H21/04 , A01H1/00 , A01H5/00
CPC分类号： C12N15/8269 , C12N15/8218 , C12N15/8261 , C12N15/8271 , C12N15/8273 , Y02A40/146
摘要： In alternative embodiments, the invention provides compositions and methods for manipulating the exchange of water and/or carbon dioxide (CO2) through plant stomata by controlling the expression of a novel apoplastic subtilisin-like serine endopeptidase-like protein. In alternative embodiments, the invention provides plants having increased water use efficiency, and drought-resistant plants; and methods for engineering of water transpiration and water use efficiency in plants, and engineering plants with increased water use efficiency and drought-resistant plants.
摘要翻译：在替代实施方案中，本发明提供了通过控制新型外胚层枯草杆菌蛋白酶样丝氨酸内肽酶样蛋白的表达来操纵通过植物气孔的水和/或二氧化碳（CO 2）的交换的组合物和方法。在替代实施方案中，本发明提供了具有增加的水利用效率的植物和耐旱植物; 以及植物水分蒸发和水分利用效率工程方法，以及水分利用效率提高和抗旱植物的工程设备。

7. 发明申请

WO2013020090A2 STREPTOCOCCAL GLcNAc-LACKING GLYCOPOLYPEPTIDES, CELL WALL CARBOHYDRATES, STREPTOCOCCUS VACCINES, AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：链球菌葡萄糖缺陷型糖蛋白多肽，细胞壁碳水化合物，链球菌疫苗及其制备和使用方法
公开(公告)号：WO2013020090A2
公开(公告)日：2013-02-07
申请号：PCT/US2012/049604
申请日：2012-08-03
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , NIZET, Victor , SORGE, Nina, Van
发明人： NIZET, Victor , SORGE, Nina, Van
IPC分类号： A61K39/09 , A61K39/40 , C07K14/315 , C07K16/12 , C12N15/31 , C12N15/63
CPC分类号： A61K39/092 , A61K2039/522 , A61K2039/552 , C07K14/315 , C07K16/1275 , C07K16/44 , C08B37/0006 , C12N1/20 , C12N1/36 , G01N33/5308 , G01N33/56938 , G01N33/56944 , G01N2400/02 , G01N2500/00
摘要： In alternative embodiments, the invention provides vaccines, pharmaceutical compounds and formulations for diagnosing, preventing, treating or ameliorating Group A Streptococcus (GAS), Group C Streptococcus (GCS), or Group A Streptococcus (GGS), infections, or other pathogenic Streptococcus infections, in alternative embodiments, the invention provides compositions such as diagnostic tests, assays, immunoassays and test strips, and methods, for detecting or diagnosing the presence of a Streptococcal infection, e.g., Group A Streptococcus (GAS), Group C Streptococcus (GCS), or Group A Streptococcus (GGS), infections, or other pathogenic Streptococcus infections.
摘要翻译：在可选的实施方案中，本发明提供了用于诊断，预防，治疗或改善A群链球菌（GAS），C群链球菌属（Streptococcus）（GCS）或A群链球菌（GGS），感染或其他致病性链球菌感染，在替代实施方案中，本发明提供了组合物，例如诊断测试，测定，免疫测定和测试条，和用于检测或诊断链球菌感染例如A群链球菌（GAS），C群链球菌（GCS）或A群链球菌（GGS）（GGS）的存在的方法），感染或其他致病性链球菌感染。

8. 发明申请

WO2012129057A2 SSH-2 (SLINGSHOT-2) INHIBITORS AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译： SSH-2（SLINGSHOT-2）抑制剂及其制备和使用方法
公开(公告)号：WO2012129057A2
公开(公告)日：2012-09-27
申请号：PCT/US2012/029267
申请日：2012-03-15
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , HAGA, Jason, H. , CHIEN, Shu , MUI, Matt , LEVESQUE, Marshall, J. , PHAM, Philip, D.
发明人： HAGA, Jason, H. , CHIEN, Shu , MUI, Matt , LEVESQUE, Marshall, J. , PHAM, Philip, D.
IPC分类号： A61K31/343 , A61K31/435 , A61K31/36 , A61K31/502 , A61K31/519 , A61K9/20 , A61K9/16
CPC分类号： C07D487/04 , A61K9/1271 , A61K31/192 , A61K31/365 , A61K31/4025 , A61K31/422 , A61K31/451 , A61K31/497 , A61K31/502 , A61K31/506 , A61K31/519 , C07C311/17 , C07D211/96 , C07D237/32 , C07D307/90 , C07D417/06
摘要： In alternative embodiments, the invention provides compositions that inhibit the polypeptide SSH-2, or SlingSHot-2, a phosphatase enzyme that regulates actin filaments, and methods for making and using them, including methods comprising administering compositions of the invention to regulate or modify actin filament polymerization by inhibiting SSH-2, where in one embodiment compositions of the invention slow or inhibit F-actin depolymerization and severing. In alternative embodiments, compositions and methods of the invention are used to slow or inhibit cell motility and/or internal remodeling. In alternative embodiments, compositions and methods of the invention are used to slow or inhibit, or reverse, or ameliorate the progression of a cancer or a metastasis or other uncontrolled or unregulated cell growth, and/or Alzheimer's disease.
摘要翻译：在替代实施方案中，本发明提供抑制多肽SSH-2或SlingSHot-2，调节肌动蛋白丝的磷酸酶的组合物，以及制备和使用它们的方法，包括施用本发明的组合物以调节或修饰肌动蛋白通过抑制SSH-2进行长丝聚合，其中在一个实施方案中本发明组合物缓慢或抑制F-肌动蛋白解聚和切断。在替代实施方案中，本发明的组合物和方法用于减缓或抑制细胞运动性和/或内部重塑。在替代实施方案中，本发明的组合物和方法用于减缓或抑制或逆转或改善癌症或转移或其他不受控制或未调节的细胞生长和/或阿尔茨海默病的进展。

9. 发明申请

WO2012125413A2 COMPOSITIONS FOR AMELIORATING SYSTEMIC INFLAMMATION AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译： AMELIORATING系统性炎症的组合物及其制备和使用方法
公开(公告)号：WO2012125413A2
公开(公告)日：2012-09-20
申请号：PCT/US2012/028312
申请日：2012-03-08
申请人： VICUS THERAPEUTICS, LLC , MAKI, John , BASCOMB, Newell , TURNER, Timothy, J.
发明人： MAKI, John , BASCOMB, Newell , TURNER, Timothy, J.
IPC分类号： A61K31/135 , A61K31/535 , A61K31/404 , A61K31/40 , A61K9/20 , A61K9/48 , A61P25/00 , A61P37/00
CPC分类号： A61K31/7072 , A61J1/035 , A61K31/122 , A61K31/135 , A61K31/138 , A61K31/166 , A61K31/167 , A61K31/18 , A61K31/192 , A61K31/196 , A61K31/337 , A61K31/365 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/407 , A61K31/415 , A61K31/427 , A61K31/454 , A61K31/4745 , A61K31/496 , A61K31/513 , A61K31/52 , A61K31/522 , A61K31/535 , A61K31/536 , A61K31/5377 , A61K31/5415 , A61K31/551 , A61K31/616 , A61K31/662 , A61K31/7056 , A61K38/13 , A61K38/212 , A61K39/39533 , A61K45/06 , A61K2300/00
摘要： In alternative embodiments the invention provides compositions, e.g., pharmaceutical compositions and preparations, formulations, kits and other products of manufacture, e.g., exemplary drug combinations packaged together or separately in blister packs, lidded blisters or blister cards, or wrapped in paper, plastic or cellophane wrappers (e.g., a shrink wrap), comprising a combination regimen of at least two active ingredients designed to diminish systemic inflammation by targeting (inhibiting) two different, but convergent, signaling pathways, i.e., the sympathetic nervous system and the lipid- derived autacoid system; and methods for making and using these compositions. In alternative embodiments, the compositions of the invention (e.g., the combination of drugs) are used to ameliorate, diminish, treat, block or prevent an inflammatory response secondary to an infection, e.g., a viral infection and/or a reactivation.
摘要翻译：在可选实施方式中，本发明提供了组合物，例如药物组合物和制剂，制剂，试剂盒和其他制造产品，例如包装在一起或分开包装在泡罩包装，带盖泡罩或泡罩卡中的示例性药物组合，或包裹在纸，塑料或玻璃纸包装物（例如收缩包装物）中，其包含至少两种活性成分的组合方案，其被设计为通过靶向（抑制）两种不同但收敛的信号传导途径，即交感神经系统和脂质衍生的autacoid系统; 以及制备和使用这些组合物的方法。在可选的实施方案中，本发明的组合物（例如药物组合）用于改善，减少，治疗，阻断或预防继发于感染（例如病毒感染和/或再激活）的炎症反应。 p>

10. 发明申请

WO2011112893A2 COMPOSITIONS FOR AMELIORATING CELL PROLIFERATIVE DISORDERS AND METHODS OF MAKING AND USING THEM 审中-公开
标题翻译：用于美容细胞增殖性疾病的组合物及其制备和使用方法
公开(公告)号：WO2011112893A2
公开(公告)日：2011-09-15
申请号：PCT/US2011/028029
申请日：2011-03-11
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , GERWICK, William, H. , TIDGEWELL, Kevin , VALERIOTE, Fred
发明人： GERWICK, William, H. , TIDGEWELL, Kevin , VALERIOTE, Fred
IPC分类号： A61K31/427 , A61K31/426 , A61K9/20 , A61K9/08 , A61P29/00 , A61P25/00
CPC分类号： C07D513/18 , C07D513/08
摘要： In alternative embodiments, the invention provides apratoxin F and apratoxin G compounds, which include apratoxin F and apratoxin G stereoisomers, derivatives and analogs compositions and methods. In alternative embodiments, the invention provides pharmaceutical compositions and formulations comprising apratoxin F (compound 6 of Figure 1) and apratoxin G (compound 7 of Figure 1) and their stereoisomers, derivatives and analogs. In alternative embodiments, pharmaceutical compositions and formulations of the invention are administered in an amount sufficient to treat, prevent and/or ameliorate a disease or condition that can be ameliorated by decreasing or inhibiting cell growth, e.g., pathological, uncontrolled or unwanted cell growth, e.g., a cancer or a metastases, or any disease or condition (e.g., allergy) or infection having a hyperproliferative cell growth component.
摘要翻译：在替代实施方案中，本发明提供了包括apratoxin F和apratoxin G立体异构体，衍生物和类似物组合物和方法的apratoxin F和apratoxin G化合物。在可选的实施方案中，本发明提供了包含apratoxin F（图1的化合物6）和apratoxin G（图1的化合物7）及其立体异构体，衍生物和类似物的药物组合物和制剂。在替代实施方案中，本发明的药物组合物和制剂以足以治疗，预防和/或缓解可通过减少或抑制细胞生长（例如病理性，不受控或不需要的细胞生长）而改善的疾病或病症的量施用，例如癌症或转移瘤或具有过度增殖性细胞生长成分的任何疾病或病症（例如变态反应）或感染。

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