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1. 发明申请

WO2019018402A3 ANTIGEN BINDING REGIONS AGAINST FIBRONECTIN TYPE III DOMAINS AND METHODS OF USING THE SAME 审中-公开
公开(公告)号：WO2019018402A3
公开(公告)日：2019-01-24
申请号：PCT/US2018/042495
申请日：2018-07-17
申请人： JANSSEN BIOTECH, INC.
发明人： HUANG, Chichi , LEE, John , MOONEY, Jill , NASO, Michael
IPC分类号： A61K39/00 , C07K16/28
摘要： Fibronectin type III (FN3) domain antibodies, polynucleotides capable of encoding the FN3 domain antibodies or antigen-binding fragments, cells expressing FN3 domain antibodies or antigen-binding fragments, as well as associated vectors and detectably labeled FN3 domain antibodies or antigen-binding fragments may be used to engineer FN3 domain-targeting chimeric antigen receptors (CARs). Methods of making the FN3 domain antibodies, CARs, and engineered immune cells, and methods of using the engineered immune cells are applicable to treat diseases including cancer.

2. 发明申请

WO2008039716A2 METHOD FOR DETECTING IL-16 ACTIVITY AND MODULATION OF IL-16 ACTIVITY BASED ON PHOSPHORYLATED STAT-6 PROXY LEVELS 审中-公开
标题翻译：用于检测IL-16活性的方法和基于磷酸化STAT-6代谢水平的IL-16活性的调节
公开(公告)号：WO2008039716A2
公开(公告)日：2008-04-03
申请号：PCT/US2007/079300
申请日：2007-09-24
申请人： CENTOCOR, INC. , GLASS, William, G. , LIU, Changbao
发明人： GLASS, William, G. , LIU, Changbao
IPC分类号： G01N33/53
CPC分类号： G01N33/5044 , C12Q1/42 , C12Q1/485 , G01N33/6869 , G01N2500/00
摘要： Methods for detecting IL-16 biological activity, detecting modulation of IL-16 biological activity, and diagnosing the presence of, or susceptibility to, an IL-16- related disorder in a subject involve measuring and comparing the levels of a phosphorylated STAT- 6 proxy produced by eukaryotic cells expressing CD4 or CD9, peripheral blood mononuclear cells, HuT-78 cells, or THP-I cells.
摘要翻译：用于检测IL-16生物活性，检测IL-16生物活性的调节以及诊断受试者中IL-16相关病症的存在或易感性的方法包括测量和比较磷酸化STAT-6 由表达CD4或CD9的真核细胞产生的代谢物，外周血单核细胞，HuT-78细胞或THP-1细胞。

3. 发明申请

WO2008028044A2 MARKERS AND METHODS FOR ASSESSING AND TREATING ULCERATIVE COLITIS AND RELATED DISORDERS USING 66 GENE PANEL 审中-公开
标题翻译：使用66基因组评估和治疗精神病患者和相关疾病的标记和方法
公开(公告)号：WO2008028044A2
公开(公告)日：2008-03-06
申请号：PCT/US2007/077247
申请日：2007-08-30
申请人： CENTOCOR, INC. , LI, Xilin , SONG, Xiao-yu
发明人： LI, Xilin , SONG, Xiao-yu
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158
摘要： A method for prognostic or diagnostic assessment of a gastrointestinal-related disorder, such as ulcerative colitis, in a subject correlates the presence, absence, and/or magnitude of a gene in a sample with a reference standard to determine the presence and/or severity of the disorder, and/or the response to treatment for the disorder. The method enables identification of the effectiveness of candidate therapies.
摘要翻译：对受试者胃肠相关疾病如溃疡性结肠炎的预后或诊断性评价的方法将样品中的基因的存在，不存在和/或大小与参考标准相关联，以确定存在和/或严重程度的疾病，和/或对于该疾病的治疗的反应。该方法能够识别候选治疗的有效性。

4. 发明申请

WO2008137383A9 MARKERS AND METHODS FOR ASSESSING AND TREATING ULCERATIVE COLITIS AND RELATED DISORDERS USING A 19 GENE PANEL 审中-公开
公开(公告)号：WO2008137383A9
公开(公告)日：2008-11-13
申请号：PCT/US2008/061760
申请日：2008-04-28
申请人： CENTOCOR, INC. , BARIBAUD, Frederic , LI, Xilin , MA, Keying , SONG, Xiao-yu
发明人： BARIBAUD, Frederic , LI, Xilin , MA, Keying , SONG, Xiao-yu
IPC分类号： C40B30/04 , C12Q1/68 , C40B30/08

5. 发明申请

WO2008028031A3 MARKERS AND METHODS FOR ASSESSING AND TREATING ULCERATIVE COLITIS AND RELATED DISORDERS USING A 43 GENE PANEL 审中-公开
公开(公告)号：WO2008028031A3
公开(公告)日：2008-03-06
申请号：PCT/US2007/077229
申请日：2007-08-30
申请人： CENTOCOR, INC. , LI, Xilin , SONG, Xiao-yu
发明人： LI, Xilin , SONG, Xiao-yu
IPC分类号： C12Q1/68 , C12M1/34 , A61K49/00 , A61K39/395 , C07H21/04
摘要： A method for prognostic or diagnostic assessment of a gastrointestinal-related disorder, such as ulcerative colitis, in a subject correlates the presence, absence, and/or magnitude of a gene in a sample with a reference standard to determine the presence and/or severity of the disorder, and/or the response to treatment for the disorder. The method enables identification of the effectiveness of candidate therapies.

6. 发明申请

WO2007024743A2 PROTEOLYSIS RESISTANT ANTIBODY PREPARATIONS 审中-公开
标题翻译：抗粘蛋白抗体制剂
公开(公告)号：WO2007024743A2
公开(公告)日：2007-03-01
申请号：PCT/US2006/032458
申请日：2006-08-18
申请人： CENTOCOR, INC. , RAJU, T. Shantha , SCALLON, Bernard
发明人： RAJU, T. Shantha , SCALLON, Bernard
IPC分类号： A61K39/395 , C12P21/06
CPC分类号： C07K16/00 , C07K2317/41 , C07K2317/50
摘要： Antibody preparations with substantially homogeneous and unsialylated glycoforms, such as G0 and G2, are prepared by enzymatic treatment, expression under certain conditions, use of particular host cells, and contact with serum. These antibody preparations resist cleavage by proteases, such as papain, ficin, bromolein, pepsin, a matrix metalloproteinase, such as MMP-7, neutrophil elastase (HNE), stromelysin (MMP-3) and macrophage elastase (MMP-12), and glycosylation modification enzymes. The antibody preparations with substantially homogeneous and unsialylated glycoforms and methods of testing for glycosylation in an antibody are useful in connection with characterization of antibody properties and/or in diseases or conditions characterized by an increase in protease activity.
摘要翻译：通过酶处理，在某些条件下表达，使用特定的宿主细胞和与血清接触来制备具有基本上均相和非唾液酸化的糖形式的抗体制剂，例如G0和G2。这些抗体制剂抵抗蛋白酶如木瓜蛋白酶，蓖麻毒素，溴林灵，胃蛋白酶，基质金属蛋白酶如MMP-7，嗜中性粒细胞弹性蛋白酶（HNE），溶基质溶解素（MMP-3）和巨噬细胞弹性蛋白酶（MMP-12）的切割，以及糖基化修饰酶。具有基本上均相和非唾液酸化的糖型的抗体制剂和在抗体中测试糖基化的方法可用于抗体特性表征和/或以蛋白酶活性增加为特征的疾病或病症中。

7. 发明申请

WO2009114040A2 ANTI-IL-12/23P40 ANTIBODIES, EPITOPES, FORMULATIONS, COMPOSITIONS, METHODS AND USES 审中-公开
标题翻译：抗IL-12 / 23P40抗体，抗体，制剂，组合物，方法和用途
公开(公告)号：WO2009114040A2
公开(公告)日：2009-09-17
申请号：PCT/US2008/077839
申请日：2008-09-26
申请人： CENTOCOR ORTHO BIOTECH INC. , DAL MONTE, Paul , GILES-KOMAR, Jill , HEAVNER, George , KNIGHT, David , KHOSSRAVI, Mehrnaz , LUO, Jeffrey , SHEALY, David , VOLKIN, David
发明人： DAL MONTE, Paul , GILES-KOMAR, Jill , HEAVNER, George , KNIGHT, David , KHOSSRAVI, Mehrnaz , LUO, Jeffrey , SHEALY, David , VOLKIN, David
IPC分类号： A61K39/395 , A61P43/00
CPC分类号： A61K47/26 , A61K47/183 , A61K2039/505 , C07K16/244 , C07K2317/34 , C07K2317/76
摘要： An anti-IL-12/23p40 antibody that binds to a portion of the IL-12 or IL-23 protein corresponding to the p40 subunit of IL-12 or IL-23, including compositions, formulations, and methods of administration have applications in diagnostic and/or therapeutic uses and devices.
摘要翻译：结合与IL-12或IL-23的p40亚基相对应的IL-12或IL-23蛋白的一部分的抗IL-12 / 23p40抗体，包括组合物，制剂和施用方法，可应用于诊断和/或治疗用途和装置。

8. 发明申请

WO2009111308A3 A METHOD TO ASSESS STABILITY OF PROTEINS 审中-公开
公开(公告)号：WO2009111308A3
公开(公告)日：2009-09-11
申请号：PCT/US2009/035474
申请日：2009-02-27
申请人： CENTOCOR ORTHO BIOTECH, INC. , BRIGHAM-BURKE, Michael , LACY, Eilyn R.
发明人： BRIGHAM-BURKE, Michael , LACY, Eilyn R.
IPC分类号： G01N33/50 , C08H1/00
摘要： A method for determining conformational stability of proteins detects the change in free sulfhydryls accessible to reaction with a fluorescent probe after combined chemical and thermal denaturation. The method is useful in any application where the stability and integrity of a protein preparation is useful information. The method can be used to screen protein variants for desirable stability profile.

9. 发明申请

WO2009055656A2 VECTORS, HOST CELLS, AND METHODS OF PRODUCTION AND USES 审中-公开
标题翻译：矢量，宿主细胞以及生产和使用方法
公开(公告)号：WO2009055656A2
公开(公告)日：2009-04-30
申请号：PCT/US2008/081090
申请日：2008-10-24
申请人： CENTOCOR, INC. , CARTON, Jill , LU, Jin , SCALLON, Bernard, J. , SNYDER, Linda
发明人： CARTON, Jill , LU, Jin , SCALLON, Bernard, J. , SNYDER, Linda
IPC分类号： A61K39/395
CPC分类号： C07K16/00 , C07K2317/14 , C07K2317/56 , C07K2319/036 , C12N15/85 , C12N2800/22
摘要： ABSTRACT Antibody expression vectors and plasmids can incorporate various antibody gene portions for transcription of the antibody DNA and expression of the antibody in an appropriate host cell. The expression vectors and plasmids have restriction enzyme sites that facilitate ligation of antibody-encoding DNA into the vectors. The vectors incorporate enhancer and promoter sequences that can be varied to interact with transcription factors in the host cell and thereby control transcription of the antibody-encoding DNA. A kit can incorporate these vectors and plasmids.
摘要翻译：摘要抗体表达载体和质粒可掺入各种抗体基因部分用于抗体DNA的转录和抗体在合适的宿主细胞中的表达。表达载体和质粒具有有利于将编码抗体的DNA连接到载体中的限制性酶位点。载体包含增强子和启动子序列，其可以改变以与宿主细胞中的转录因子相互作用，从而控制抗体编码DNA的转录。试剂盒可以包含这些载体和质粒。

10. 发明申请

WO2008052165A8 METHOD FOR TREATING PATHOLOGICAL PULMONARY CONDITIONS AND BLEOMYCIN ASSOCIATED PULMONARY FIBROSIS 审中-公开
公开(公告)号：WO2008052165A8
公开(公告)日：2008-05-02
申请号：PCT/US2007/082680
申请日：2007-10-26
申请人： CENTOCOR ORTHO BIOTECH INC. , GLASS, William , MURRAY, Lynne
发明人： GLASS, William , MURRAY, Lynne
IPC分类号： A61K39/395 , A61K38/20
摘要： Methods for treating pathological pulmonary conditions and bleomycin associated pulmonary fibrosis administer IL-16 antagonists, for example, anti-IL-16 antibodies, to subjects.

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