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1. 发明申请

WO2016146833A1 BIOMARKERS FOR NAD(+)-DIPHTHAMIDE ADP RIBOSYLTRANSFERASE RESISTANCE 审中-公开
标题翻译：生物标记NAD（+） - 二苯胺ADP抗氧化剂耐药性
公开(公告)号：WO2016146833A1
公开(公告)日：2016-09-22
申请号：PCT/EP2016/056028
申请日：2016-03-18
申请人： F. HOFFMANN-LA ROCHE AG , HOFFMANN-LA ROCHE INC.
发明人： BRINKMANN, Ulrich , DENGL, Stefan , NIEDERFELLNER, Gerhard , DA SILVA MATEUS SEIDL, Ana Rita , STAHL, Sebastian
IPC分类号： G01N33/68
CPC分类号： G01N33/68 , G01N2333/91142 , G01N2440/14 , G01N2800/52
摘要： Phosphorylation of the serine residue at position 615 of eukaryotic elongation factor 2 (eEF2) protein is associated with resistance to NAD(+)-diphthamide ADP-ribosyltransferase enzymes such as Pseudomonas exotoxin, diphtheria toxin and cholix toxin, which are used in targeted immunotherapies. Methods of determining resistance and related treatments are provided.
摘要翻译：真核延伸因子2（eEF2）蛋白的615位丝氨酸残基的磷酸化与NAD（+） - 二硫代酰胺ADP-核糖基转移酶（如假单胞菌外毒素，白喉毒素和胆固醇毒素）的抗性相关，用于靶向免疫疗法。提供了确定抵抗力和相关治疗方法。

2. 发明申请

WO2007132167A2 NOVEL MARKERS FOR PRENATAL DIAGNOSIS AND MONITORING 审中-公开
标题翻译：用于临床诊断和监测的新标志
公开(公告)号：WO2007132167A2
公开(公告)日：2007-11-22
申请号：PCT/GB2007/001627
申请日：2007-05-03
申请人： THE CHINESE UNIVERSITY OF HONG KONG , LO, Yuk Ming Dennis , CHIU, Rossa Wai Kwun , CHIM, Stephen Siu Chung , DING, Chunming , JIN, Shengnan , LEE, Tracy Yuen Han , LUN, Fiona Miu Fun
发明人： LO, Yuk Ming Dennis , CHIU, Rossa Wai Kwun , CHIM, Stephen Siu Chung , DING, Chunming , JIN, Shengnan , LEE, Tracy Yuen Han , LUN, Fiona Miu Fun
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6827 , C12Q2600/154 , C12Q2600/156 , C12Q2523/125
摘要： This application provides the use of novel fetal markers for prenatal diagnosis and monitoring of certain pregnancy-related conditions. More specifically, the invention resides in the discovery that certain CpG islands located on fetal chromosome 21 demonstrate a methylation profile that is distinct from that of the corresponding CpG islands located on maternal chromosome 21. This application also provides kits for diagnosing or monitoring of the relevant conditions.
摘要翻译：该应用提供了新颖的胎儿标记物用于产前诊断和监测某些妊娠相关病症的用途。更具体地，本发明在于发现位于胎儿染色体21上的某些CpG岛表现出与位于母体染色体21上的相应CpG岛不同的甲基化谱。该应用还提供用于诊断或监测相关条件。

3. 发明申请

WO2003094086A3 ANALYSIS OF GENE EXPRESSION DATA FOR MULTI-CLASS PREDICTION 审中-公开
公开(公告)号：WO2003094086A3
公开(公告)日：2003-11-13
申请号：PCT/GB2003/001258
申请日：2003-03-24
申请人： BIOTECH RESEARCH VENTURES PTE LIMITED , DENISON, Christopher , TAN, Patrick, Boon, Ooi , OOI, Chia, Huey
发明人： TAN, Patrick, Boon, Ooi , OOI, Chia, Huey
IPC分类号： G06F19/00
摘要： The invention provides a method for identifying, from a pool of parameters whose values are known for a plurality of samples ("training samples") which are classified into multiple classes, a subset of parameters whose values in a sample of unknown class are likely to be predictive of the class of that sample. The invention also provides related uses, computer programs, apparatuses and systems. The invention is particularly applicable to the classification of biological samples on the basis of gene expression data. The classifier is preferably a maximum likelihood classifier.

4. 发明申请

WO2003094086A2 ANALYSIS OF GENE EXPRESSION DATA FOR MULTI-CLASS PREDICTION 审中-公开
标题翻译：用于多级预测的基因表达数据分析
公开(公告)号：WO2003094086A2
公开(公告)日：2003-11-13
申请号：PCT/GB2003/001258
申请日：2003-03-24
申请人： BIOTECH RESEARCH VENTURES PTE LIMITED , DENISON, Christopher , TAN, Patrick, Boon, Ooi , OOI, Chia, Huey
发明人： TAN, Patrick, Boon, Ooi , OOI, Chia, Huey
IPC分类号： G06F19/00
CPC分类号： G06K9/6231 , G06F19/20 , G06F19/24 , G06N3/126
摘要： The invention provides a method for identifying, from a pool of parameters whose values are known for a plurality of samples ("training samples") which are classified into multiple classes, a subset of parameters whose values in a sample of unknown class are likely to be predictive of the class of that sample, the method comprising: (a) providing a first generation population of individuals, each individual representing a candidate subset of parameters; (b) for each individual, evaluating its fitness to predict the class of a sample of unknown class by determining its ability to predict the class of a plurality of test samples of known class;(c) generating a second generation population of individuals from selected individuals in the first generation population, wherein said selected individuals are selected according to their fitness as evaluated in step (b); (d) repeating steps (b) and (c) to evaluate the fitness of the individuals of the second generation population and to generate and evaluate further generations until a termination condition is reached; and(e) selecting the fittest individual, as evaluated in step (b) or step (d), from the final generation or from among the fittest individuals of a plurality of generations, wherein the class prediction in step (b) uses a discriminant-based classifier. The invention also provides related uses, computer programs, apparatuses and systems. The invention is particularly applicable to the classification of biological samples on the basis of gene expression data. The classifier is preferably a maximum likelihood classifier.
摘要翻译：本发明提供了一种用于从被分类为多个类的多个样本（“训练样本”）已知值的参数池中识别未知类样本中的值很可能的参数子集的方法预测该样本的类别，该方法包括：（a）提供第一代个体群体，每个个体代表参数的候选子集; （b）对于每个人，通过确定其预测已知类别的多个测试样本的类别的能力来评估其适合度来预测未知类别的样本的类别;（c）从所选择的生成第二代个体群体第一代人群中的个体，其中所述选择的个体根据其在步骤（b）中评估的适合度来选择; （d）重复步骤（b）和（c）以评估第二代人群的个体的适应度，并产生和评估进一步的代数，直到达到终止条件; 以及（e）从步骤（b）或步骤（d）中评估的最适合的个体中选择多代人中最适合的个体之间的适合个体，其中步骤（b）中的类预测使用判别式的分类器。本发明还提供了相关用途，计算机程序，设备和系统。本发明特别适用于基于基因表达数据的生物样品的分类。分类器优选地是最大似然分类器。

5. 发明申请

WO2002088367A1 PRODUCTION OF THE LANTIBIOTIC CINNAMYCIN WITH GENES ISOLATED FROM STREPTOMYCES CINNAMONEUS 审中-公开
标题翻译：生产具有基因分离的生物活性蛋白酶
公开(公告)号：WO2002088367A1
公开(公告)日：2002-11-07
申请号：PCT/GB2002/001983
申请日：2002-04-29
申请人： PLANT BIOSCIENCE LIMITED , WIDDICK, David, Andrew , BIBB, Mervyn, James
发明人： BIBB, Mervyn, James
IPC分类号： C12N15/63
CPC分类号： C12N15/52 , A61K38/00 , C07K1/047 , C07K14/36
摘要： A 17kb nucleic acid fragment, which confers production of the lantibiotic cinnamycin on non-producer Streptomycete strains, has been isolated from Streptomyces cinnamoneus cinnamoneus DSM 40005 and characterised. Also provided are variants of the 17kb fragment including variants in which non-essential genes are deleted and variants in which the propeptide sequence of the cinnamycin structural gene is altered, for example replaced with the propeptide sequence of similar B-type lantibiotics. Also provided are vectors, host cells and methods of lantibiotic production using the nucleic acid of the invention, and libraries of variants.
摘要翻译：已经从肉桂肉桂醛肉豆蔻DSM 40005中分离了一种17kb的核酸片段，该核酸片段赋予非生产性链霉菌菌株上的生物素甘草素肉桂霉素，并进行了表征。还提供了17kb片段的变体，包括其中非必需基因缺失的变体和其中改变肉桂激素结构基因的前肽序列的变体，例如用类似的B型羊毛硫抗生素的前肽序列替代。还提供了使用本发明的核酸的载体，宿主细胞和使用本发明的核酸的羊毛硫抗生素生产方法和变体库。

6. 发明申请

WO2010131066A2 MULTI-CHANNEL VALVES AND SPRAY CONTAINERS COMPRISING MULTI-CHANNEL VALVES 审中-公开
标题翻译：包含多通道阀的多通道阀和喷雾容器
公开(公告)号：WO2010131066A2
公开(公告)日：2010-11-18
申请号：PCT/IB2009/005863
申请日：2009-05-15
申请人： STORMES CUUVENE LTD. , DAVIES, Philip, O.
发明人： DAVIES, Philip, O.
IPC分类号： B65D83/14
CPC分类号： B05B11/0059 , B05B11/307 , B05B15/18 , B05B15/30
摘要： Provided are multi-channel valves comprising first and second siphon channels comprising first ends that are operably connected to each other; and (ii) at least one actuator, the actuator capable of movement between at least a first position (where the first siphon channel is occluded) and a second position (where the second siphon channel is occluded). Also provided are spray containers operable in a plurality of positions, the containers comprising multi-channel valves wherein movement of an actuator causes communication between a sprayer head and liquid contents of the container via at least one of two dip tubes to be disrupted, thereby facilitating the drawing of the liquid contents from the lowest point in the container.
摘要翻译：提供了多通道阀，其包括第一和第二虹吸通道，其包括彼此可操作地连接的第一端; 和（ii）至少一个致动器，所述致动器能够在至少第一位置（其中所述第一虹吸通道被阻塞）和第二位置（所述第二虹吸通道被吸入的位置）之间移动。还提供了可在多个位置操作的喷雾容器，所述容器包括多通道阀，其中致动器的运动通过两个浸入管中的至少一个被破坏从而促进喷雾器头与容器的液体内容物之间的连通，液体内容物从容器中最低点抽出。

7. 发明申请

WO2007132166A2 NEW FETAL METHYLATION MARKERS 审中-公开
标题翻译：新型甲基化标记
公开(公告)号：WO2007132166A2
公开(公告)日：2007-11-22
申请号：PCT/GB2007/001625
申请日：2007-05-03
申请人： THE CHINESE UNIVERSITY OF HONG KONG , LO, Yuk Ming, Dennis , CHIU, Rossa Wai Kwun , CHIM, Stephen Siu Chung , DING, Chunming , CHAN, Kwan Chee , WONG, Hing Nam Ivy , YUEN, Ka Chun Ryan
发明人： LO, Yuk Ming, Dennis , CHIU, Rossa Wai Kwun , CHIM, Stephen Siu Chung , DING, Chunming , CHAN, Kwan Chee , WONG, Hing Nam Ivy , YUEN, Ka Chun Ryan
IPC分类号： C12Q1/68
CPC分类号： C12Q1/68 , C12Q1/6876 , C12Q1/6883 , C12Q2600/154 , C12Q2600/156
摘要： This application describes the discovery that, in a pregnant woman, certain genes (such as RASSF1A, APC, CASP8, RARB, SCGB3A1, DAB21P , PTPN6, THY1, TMEFF2 , and PYCARD ) originated from a fetus are highly methylated, whereas the same genes of maternal origin are unmethylated. This discovery allows the easy detection of one or more of these methylated fetal genes in a biological sample from a pregnant woman, serving as a universal indicator of the presence of fetal DNA in the sample. These fetal methylation markers are particularly useful as positive controls for a non-invasive analytical process during which the quality and quantity of fetal DNA are monitored. These newly identified fetal markers can also be measured directly for diagnosis of certain pregnancy-related conditions.
摘要翻译：该应用描述了在孕妇中发现来自胎儿的某些基因（如RASSF1A，APC，CASP8，RARB，SCGB3A1，DAB21P，PTPN6，THY1，TMEFF2和PYCARD）高度甲基化，而相同的基因产妇来源是未甲基化。该发现允许从孕妇的生物样品中容易地检测这些甲基化胎儿基因中的一种或多种，作为样品中胎儿DNA存在的通用指标。这些胎儿甲基化标记物作为非侵入性分析过程的阳性对照特别有用，在此过程中监测胎儿DNA的质量和数量。这些新确定的胎儿标记物也可以直接测量以诊断某些妊娠相关病症。

8. 发明申请

WO2004001424A1 MATERIALS AND METHODS FOR INDUCTIONS OF IMMUNE TOLERANCE 审中-公开
标题翻译：免疫耐受诱导材料与方法
公开(公告)号：WO2004001424A1
公开(公告)日：2003-12-31
申请号：PCT/GB2003/002739
申请日：2003-06-24
申请人： UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN , BARKER, Robert, Norman , MARSHALL, Neil, Andrew , VICKERS, Mark, Adrian
发明人： BARKER, Robert, Norman , MARSHALL, Neil, Andrew , VICKERS, Mark, Adrian
IPC分类号： G01N33/68
CPC分类号： G01N33/56983 , C07K14/005 , C12N2710/16222 , G01N2333/045 , G01N2333/05 , G01N2500/00
摘要： The invention provides methods of inducing immune tolerance to target antigens in individuals seropositive for certain infectious agents by administration of epitopes derived from those infectious agents. Epitopes derived from viruses which carry homologues of interleukin 10 (IL-10) in their genome, such as Epstein Barr virus and cytomegalovirus, are particularly suitable for these purposes. Particularly preferred is the use of the EBV LMP1 protein and epitopes thereof.
摘要翻译：本发明提供了通过施用衍生自这些感染因子的表位来诱导针对某些感染因子血清阳性的个体的靶抗原的免疫耐受的方法。衍生自其基因组中白细胞介素10（IL-10）同源物的病毒的表位，例如爱泼斯坦巴尔病毒和巨细胞病毒，特别适用于这些目的。特别优选使用EBV LMP1蛋白及其表位。

9. 发明申请

WO2003057378A1 FOOD PROCESSING SURFACE CLEANING SYSTEM AND METHOD 审中-公开
标题翻译：食品加工表面清洗系统及方法
公开(公告)号：WO2003057378A1
公开(公告)日：2003-07-17
申请号：PCT/GB2003/000046
申请日：2003-01-09
申请人： FOOD PRO SYTEMS LIMITED , SANDERS, Nigel
发明人： SANDERS, Nigel
IPC分类号： B08B3/02
CPC分类号： B65G45/22 , A61L2/02 , A61L2/04 , B08B3/02 , B08B3/022 , B08B3/024 , B08B5/026 , B08B2203/0229 , B08B2230/01
摘要： The invention provides food processing surface (40) cleaning system and related methods and uses. The system comprises: a vacuum source; a cleaning head (101), having walls (102, 106) defining a vacuum chamber (108) in communication via a vacuum line (150) with the vacuum source, the vacuum chamber (108) having an open vacuum mouth; and means for supplying a pressurised cleaning fluid via a fluid line (28) to one or more cleaning fluid outlets (26) within the vacuum chamber (108), the cleaning fluid outlets (26) being directed to spray cleaning fluid towards the vacuum mouth; whereby the vacuum mouth may in use be positioned near or against a food processing surface (40) to allow sprayed cleaning fluid to contact the surface and be removed under vacuum via the vacuum line (150). A preferred food processing surface (40) is a conveyor belt.
摘要翻译：本发明提供食品加工表面（40）清洁系统及相关方法和用途。该系统包括：真空源; 清洁头（101），其具有限定通过真空管线（150）与真空源连通的真空室（108）的壁（102,106），所述真空室（108）具有敞开的真空口; 以及用于经由流体管线（28）将加压清洁流体供应到所述真空室（108）内的一个或多个清洁流体出口（26）的装置，所述清洁流体出口（26）被引导以朝向所述真空口喷射清洁流体 ; 由此真空口可以在食品加工表面（40）附近或靠近食物处理表面（40），以允许喷射的清洁流体与表面接触并通过真空管线（150）在真空下去除。优选的食品加工表面（40）是传送带。

10. 发明申请

WO2004033695A2 A PROMOTER FROM STREPTOMYCES COELICOLOR 审中-公开
标题翻译：一种来自链霉菌的启动子
公开(公告)号：WO2004033695A2
公开(公告)日：2004-04-22
申请号：PCT/GB2003/004420
申请日：2003-10-13
申请人： UNIVERSITY OF SUSSEX , PAGET, Mark
发明人： PAGET, Mark
IPC分类号： C12N15/76
CPC分类号： C07K14/36
摘要： The invention provides an operator sequence (ROP), derived from S. coelicolor , that is sensitive to NAD+/NADH ratio. The invention further provides the cognate repressor, Rex. Naturally occurring and artificial homologues of the operator and repressor are also provided, including mutants with altered function, along with related methods, uses and materials.
摘要翻译：本发明提供了从S派生的操作符序列（ROP）。天蓝色，对NAD + / NADH比例敏感。本发明进一步提供了同源抑制剂Rex。还提供了操作者和阻遏物的天然存在的和人造的同源物，包括功能改变的突变体，以及相关的方法，用途和材料。

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