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1. 发明申请

WO2011022653A2 RECUPERATIVE COMBUSTION SYSTEM 审中-公开
标题翻译：再生燃烧系统
公开(公告)号：WO2011022653A2
公开(公告)日：2011-02-24
申请号：PCT/US2010/046174
申请日：2010-08-20
申请人： REILLY, Timothy J.
发明人： REILLY, Timothy J.
IPC分类号： F02B43/10 , F01K27/02 , F02G5/02 , C25B1/02 , F02M25/10
CPC分类号： F23L7/007 , F23C9/00 , Y02E20/14 , Y02E20/344
摘要： The methods and systems described herein relate to a recuperative combustion system that recuperates energy from fuel combustion that would otherwise be lost. The recuperative combustion system minimizes or eliminates the need for an air separator unit through the use of a clean water splitter section, consisting of a thermochemical cycle or high-temperature electrolysis. Water is split into its component hydrogen and oxygen, primarily with process heat from the combustion process. The oxygen produced by the water splitter provides oxygen necessary for oxy-fuel combustion, thereby reducing or eliminating the need for the power intensive air separator unit and/or external oxygen source, significantly increasing the efficiency of the oxy-fuel combustion cycle. Hydrogen produced by the water splitter may be used for a variety of industrial uses, or combined with carbon dioxide (captured from the flue gases produced by said combustion process) to produce methanol. Methanol can further be refined in a methanol to gasoline reactor to produce dimethyl ether, olefins or high grade gasoline. Described herein are methods and systems that 1) increase oxy-fuel combustion efficiency, 2) produce hydrogen for a suite of industrial/energy uses, and 3) capture carbon dioxide and convert it to high value hydrocarbons.
摘要翻译：本文描述的方法和系统涉及一种恢复燃烧系统，该系统能够恢复否则将丢失的来自燃料燃烧的能量。还原燃烧系统通过使用由热化学循环或高温电解组成的干净的水分离器部分来最小化或消除对空气分离器单元的需要。水分为氢和氧，主要是来自燃烧过程的过程热。由分水器产生的氧提供氧燃料燃烧所需的氧气，从而减少或消除了对功率密集型空气分离器单元和/或外部氧源的需要，显着提高了氧燃料燃烧循环的效率。由分水器产生的氢气可用于各种工业用途，或与二氧化碳（从由所述燃烧过程产生的烟道气捕获）结合以产生甲醇。甲醇可以在甲醇中进一步精制成汽油反应器，生产二甲醚，烯烃或高级汽油。这里描述的方法和系统是：1）增加氧燃料燃烧效率，2）为一套工业/能源用途生产氢气; 3）捕获二氧化碳并将其转化为高价烃。

2. 发明申请

WO2010144909A1 FUSED HETEROCYCLIC COMPOUNDS AND THEIR USES 审中-公开
标题翻译：熔融杂环化合物及其用途
公开(公告)号：WO2010144909A1
公开(公告)日：2010-12-16
申请号：PCT/US2010/038518
申请日：2010-06-14
申请人： NOVARTIS AG , CHOI, Hwan, Geun , SIM, Taebo , GRAY, Nathanael , ZHOU, Wenjun , CHANG, Jae, Won , ZHANG, Jianming , WEISBERG, Ellen
发明人： CHOI, Hwan, Geun , SIM, Taebo , GRAY, Nathanael , ZHOU, Wenjun , CHANG, Jae, Won , ZHANG, Jianming , WEISBERG, Ellen
IPC分类号： A01N43/78 , A61K31/425
CPC分类号： C07D513/04 , A61K31/437 , A61K31/496 , A61K31/4985 , A61K31/506 , A61K31/5377
摘要： The present application relates to therapeutic organic compounds, compositions comprising an effective amount of a therapeutic organic compound; and methods for treating and preventing disease comprising administering and effective amount of a therapeutic organic compound to a subject in need thereof.
摘要翻译：本申请涉及治疗性有机化合物，包含有效量的治疗性有机化合物的组合物; 以及治疗和预防疾病的方法，包括向有需要的受试者施用和有效量的治疗性有机化合物。

3. 发明申请

WO2009143345A3 NUCLEIC ACID SILENCING AGENT-PROTEIN CONJUGATES AND USE THEREOF FOR TREATING HCV-RELATED DISORDERS 审中-公开
公开(公告)号：WO2009143345A3
公开(公告)日：2009-11-26
申请号：PCT/US2009/044840
申请日：2009-05-21
申请人： UNIVERSITY OF MASSACHUSETTS , BABCOCK, Gregory, J. , AMBROSINO, Donna, M. , FINBERG, Robert, W. , ZAMORE, Phillip, D. , BROERING, Teresa
发明人： BABCOCK, Gregory, J. , AMBROSINO, Donna, M. , FINBERG, Robert, W. , ZAMORE, Phillip, D. , BROERING, Teresa
IPC分类号： A61K47/48 , A61P31/14
摘要： A method of using a complex or a molecule comprising a targeting moiety to deliver a second molecule effectively to HCV or to a cell being infected or having the potential to be infected by HCV, resulting in the prevention, immunization, inhibition or cure of HCV infection, or other beneficial effects related to HCV infection.

4. 发明申请

WO2009103076A1 METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY OF RTK INHIBITORS 审中-公开
标题翻译：用于增强RTK抑制剂效能的方法和组合物
公开(公告)号：WO2009103076A1
公开(公告)日：2009-08-20
申请号：PCT/US2009/034318
申请日：2009-02-17
申请人： OXIGENE, INC. , CHAPLIN, David, J. , SIIM, Bronwyn, G.
发明人： CHAPLIN, David, J. , SIIM, Bronwyn, G.
IPC分类号： A61K31/4412 , A61K31/517 , A61K31/66 , A61K31/661 , A61P35/00
CPC分类号： A61K31/66 , A61K31/44 , A61K31/517 , A61K31/661 , A61K2300/00
摘要： This invention relates to methods for treating, preventing and/or managing cancer in a subject including enhacing the efficacy of a Receptor Tyrosine Kinase inhibitor (e.g., a small molecule RTK inhibitor, e.g., Sorafenib or Erlotinib) by administering to the subject a Vascular Disrupting Agent (e.g., a Combretastatin or derivative thereof) sequentially or simultaneously in combination with said RTK inhibitor. Pharmaceutical compositions comprising a combination of a RTK inhibitor and a VDA are also provided.
摘要翻译：本发明涉及用于治疗，预防和/或控制受试者中的癌症的方法，所述方法包括通过向受试者施用受体酪氨酸激酶抑制剂（例如，小分子RTK抑制剂，例如索拉非尼或埃洛替尼）来实现血管破坏与所述RTK抑制剂组合，代理（例如，Combretastatin或其衍生物）顺序地或同时地。还提供了包含RTK抑制剂和VDA的组合的药物组合物。

5. 发明申请

WO2009091815A3 METHODS FOR MODULATING DE NOVO HEPATIC LIPOGENESIS BY MODULATING XBP-1 ACTIVITY 审中-公开
公开(公告)号：WO2009091815A3
公开(公告)日：2009-07-23
申请号：PCT/US2009/030976
申请日：2009-01-14
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , GLIMCHER, Laurie, H. , LEE, Ann-hwee
发明人： GLIMCHER, Laurie, H. , LEE, Ann-hwee
IPC分类号： A61K48/00 , A61K31/70 , C12N15/11
摘要： The invention provides methods and compositions for modulating the expression, processing, post-translational modification, stability and/or activity of XBP- 1 protein, or a protein in a signal transduction pathway involving XBP-I to treat dyslipidemias and steatosis disorders. The present invention also pertains to methods for identifying compounds that modulate the expression, processing, post-translational modification, and/or activity of XBP-I protein or a molecule in a signal transduction pathway involving XBP-1.

6. 发明申请

WO2009086550A1 PREDICTING LONG-TERM EFFICACY OF A COMPOUND IN THE TREATMENT OF PSORIASIS 审中-公开
标题翻译：化合物在治疗PSORIASIS中预测长期效力
公开(公告)号：WO2009086550A1
公开(公告)日：2009-07-09
申请号：PCT/US2008/088603
申请日：2008-12-31
申请人： ABBOTT LABORATORIES , PENG, Joanna, Z. , NOERTERSHEUSER, Peter, A.
发明人： PENG, Joanna, Z. , NOERTERSHEUSER, Peter, A.
IPC分类号： G01N33/48
CPC分类号： G06F19/704
摘要： The invention provides a method for predicting the efficacy of a compound for treating psoriasis based on a pharmacokinetic/pharmacodynamic model.
摘要翻译：本发明提供了一种基于药代动力学/药效学模型来预测化合物治疗牛皮癣的功效的方法。

7. 发明申请

WO2009015397A1 METHODS FOR IMAGING USING IMPROVED NANOPARTICULATE CONTRAST AGENTS 审中-公开
标题翻译：使用改进的纳米颗粒对比剂进行成像的方法
公开(公告)号：WO2009015397A1
公开(公告)日：2009-01-29
申请号：PCT/US2008/071391
申请日：2008-07-28
申请人： NANOSCAN IMAGING, LLC , SKERRETT, H. Donlon , PATTERSON, Joseph , LEE, Robert, W. , FAYAD, Zahi, A.
发明人： SKERRETT, H. Donlon , PATTERSON, Joseph , LEE, Robert, W. , FAYAD, Zahi, A.
IPC分类号： A61K9/14
CPC分类号： A61K49/0485 , B82Y5/00 , Y10T428/2982
摘要： The present invention also provides methods and compositions for imaging and evaluating, e.g., blood flow or inflammation in a subject. Such evaluations are important in a number of clinical diagnoses, including assessing organ damage associated with angina pectoris, heart attack, stroke, cancer, atherosclerosis, and the like, as well as assessing vessel leakages associated with aneurisms, diffuse bleedings after trauma, and the like.
摘要翻译：本发明还提供用于成像和评估例如受试者的血流或炎症的方法和组合物。这些评估在许多临床诊断中是重要的，包括评估与心绞痛，心脏病发作，中风，癌症，动脉粥样硬化等相关的器官损伤，以及评估与动脉瘤相关的血管渗漏，创伤后扩散出血，以及喜欢。

8. 发明申请

WO2008153814A2 MOLECULES INVOLVED IN REGULATION OF OSTEOBLAST ACTIVITY AND OSTEOCLAST ACTIVITY, AND METHODS OF USE THEREOF 审中-公开
标题翻译：参与OSTEOBLAST活动和OSTEOCLAST活动调节的分子及其使用方法
公开(公告)号：WO2008153814A2
公开(公告)日：2008-12-18
申请号：PCT/US2008/006783
申请日：2008-05-29
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , GLIMCHER, Laurie, H. , JONES, Dallas, C. , ALIPRANTIS, Antonios, O.
发明人： GLIMCHER, Laurie, H. , JONES, Dallas, C. , ALIPRANTIS, Antonios, O.
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2500/00
摘要： The present invention is based, at least in part, on the identification of molecules involved in the differentiation and/or activity of osteoblasts and osteoclasts. Accordingly, the present invention provides methods of identifying modulators of bone formation, mineralization, and/or osteoclastogenesis and methods for treating disorders that would benefit from modulation of bone formation, mineralization, and/or osteoclastogenesis using agents identified as described herein.
摘要翻译：本发明至少部分地基于涉及成骨细胞和破骨细胞的分化和/或活性的分子的鉴定。因此，本发明提供鉴定骨形成，矿化和/或破骨细胞发生的调节剂的方法以及用于治疗使用如本文所述鉴定的药剂调节骨形成，矿化和/或破骨细胞发生受益的疾病的方法。

9. 发明申请

WO2008108918A1 HUMAN ANTIBODIES AGAINST HEPATITIS C VIRUS (HCV) USES THEREOF 审中-公开
标题翻译：人类抗乙型肝炎病毒（HCV）用途的抗体
公开(公告)号：WO2008108918A1
公开(公告)日：2008-09-12
申请号：PCT/US2008/001922
申请日：2008-02-13
申请人： UNIVERSITY OF MASSACHUSETTS , BROERING, Teresa , SLOAN, Susan , BABCOCK, Gregory, J. , AMBROSINO, Donna , THOMAS, William, D., Jr.
发明人： BROERING, Teresa , SLOAN, Susan , BABCOCK, Gregory, J. , AMBROSINO, Donna , THOMAS, William, D., Jr.
IPC分类号： C07K16/10 , A61K39/395 , A61K39/00 , A61P31/14
CPC分类号： C07K16/109 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/505 , A61K2039/5258 , A61K2039/55566 , C07K14/005 , C07K2317/21 , C07K2317/34 , C12N2770/24222 , C12N2770/24234
摘要： Isolated human monoclonal antibodies which bind to hepatitis C virus (HCV), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译：公开了与丙型肝炎病毒（HCV）结合的分离的人单克隆抗体以及相关的基于抗体的组合物和分子。人抗体可以通过经历V-D-J重组和同种型转换而在能够产生人单克隆抗体多重同种型的转染瘤或非人转基因动物例如转基因小鼠中产生。还公开了包含人抗体，非人转基因动物和产生人抗体的杂交瘤的药物组合物，以及使用人抗体的治疗和诊断方法。

10. 发明申请

WO2008060540A3 METHODS OF IDENTIFYING COMPOSITIONS THAT MODULATE THE PROTEIN TYROSINE PHOSPHATASE, PTP-BL 审中-公开
公开(公告)号：WO2008060540A3
公开(公告)日：2008-05-22
申请号：PCT/US2007/023845
申请日：2007-11-13
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , GRUSBY, Michael, J.
发明人： GRUSBY, Michael, J.
IPC分类号： C12Q1/42 , G01N33/68
摘要： The present invention is based, at least in part, on the discovery that the tyrosine phosphatase, PTP-Basophil like (PTP-BL), physically interacts with multiple STAT proteins, e.g., STAT4, STAT1, and/or STAT6. The present invention is also based, at least in part, on the generation of Ptp-bt 1 - deficient non-human animals. Accordingly, the instant invention provides methods of identifying modulators of the interaction of STAT polypeptides and PTP-BL polypeptides, as well as Ptp-bt 1- deficient non-human animals, cells, derived therefrom, and methods of use thereof.

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