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    • 3. 发明申请
    • DEVICE AND METHOD
    • 装置和方法
    • WO2017129964A1
    • 2017-08-03
    • PCT/GB2017/050175
    • 2017-01-24
    • NDM TECHNOLOGIES LIMITED
    • CHOWDHURY, Dewan Fazlul HoqueLUGHMANI, Waqas AkbarVOULGARIS, Savvas
    • A61M37/00
    • A61M37/0015A61M2037/0023A61M2037/003
    • A transdermal delivery device comprising a roller, at least one microneedle supported by the roller, and at least one reservoir for a liquid pharmaceutical composition; wherein movement of the roller over the skin of a patient will cause it to rotate and bring the at least one microneedle into contact with the skin of the patient and to bring the at least one microneedle into fluid communication with the at least one reservoir.A method of assembling a transdermal delivery device comprising attaching the at least one microneedle to the device and attaching the at least one reservoir to the device.A method of administering a liquid pharmaceutical composition to a patient using a transdermal delivery device.
    • 透皮递送装置,其包括辊,至少一个由所述辊支撑的微针以及至少一个用于液体药物组合物的储存器; 其中所述滚轮在患者皮肤上的移动将使其旋转并使所述至少一个微针与患者皮肤接触并使所述至少一个微针与所述至少一个储存器流体连通.A 组装透皮递送装置的方法,包括将所述至少一个微针附接到所述装置并将所述至少一个储库附接到所述装置.1。使用透皮递送装置将液体药物组合物给予患者的方法。
    • 5. 发明申请
    • A NEEDLE DELIVERY DEVICE
    • 一种送递装置
    • WO2018025017A1
    • 2018-02-08
    • PCT/GB2017/052211
    • 2017-07-28
    • NDM TECHNOLOGIES LIMITED
    • CHOWDHURY, Dewan Fazlul Hoque
    • A61M5/142A61M5/158
    • A61M5/14248A61M5/158A61M2005/14252A61M2005/1581A61M2005/1585A61M2005/1587
    • A needle delivery device (10; 100) comprises a device body (12) that has an opening (14) formed on a delivery surface (16) of the device body (12). The needle delivery device (10; 100) also includes a drive mechanism (28) which is configured to, in use, drive a needle (20; 120), at least a portion (22) of which is flexible, along a needle path (30) towards the opening (14). The needle path (30) changes direction as it reaches the opening (14). Furthermore, the needle delivery device (10; 100) includes a rigid support member (32) that is fixedly secured to the device body (12) at the opening (14). The rigid support member (32) is configured to guide the needle (20) as it leaves the opening (14) so as to prevent buckling of the needle (20; 120). The device also comprises a vial (40) for containing a pharmaceutical composition, the vial being in fluid communication with one end of the needle, wherein the vial is moveable in tandem with the needle as the needle is driven along the needle path.
    • 针输送装置(10; 100)包括具有形成在装置主体(12)的输送表面(16)上的开口(14)的装置主体(12)。 所述针输送装置(10; 100)还包括驱动机构(28),所述驱动机构构造成在使用中沿着针路径驱动针(20; 120),所述针的至少一部分(22)是柔性的 (30)朝向所述开口(14)。 针道(30)在到达开口(14)时改变方向。 此外,针输送装置(10; 100)包括在开口(14)处固定地紧固到装置主体(12)的刚性支撑构件(32)。 刚性支撑构件(32)被构造成在针(20)离开开口(14)时引导针(20),以防止针(20; 120)弯曲。 该装置还包括用于容纳药物组合物的小瓶(40),所述小瓶与所述针的一端流体连通,其中当所述针沿着所述针通道被驱动时,所述小瓶可以与所述针一前一后移动。 p>
    • 6. 发明申请
    • METHOD FOR THE TRANSFER OF GRAPHENE
    • 石墨转移方法
    • WO2017211992A1
    • 2017-12-14
    • PCT/EP2017/064037
    • 2017-06-08
    • UNIVERSITEIT LEIDEN
    • BELYAEVA, LiubovSCHNEIDER, Grégory F.
    • C01B32/194B82Y30/00
    • C01B32/194B82Y30/00B82Y40/00
    • The present invention relates to a method of transferring a graphene film to a substrate comprising providing a graphene film grown on a support and positioning the supported graphene film at the interface of a biphasic mixture, wherein the biphasic mixture comprises an aqueous phase and an organic phase, and wherein the phases are immiscible, wherein the aqueous phase further comprises an etchant which completely etches the graphene support from the graphene film. After the etching procedure has taken place, the biphasic mixture is cooled to a temperature such that the organic phase solidifies but the aqueous phase remains a liquid, wherein the graphene film sticks to the solidified organic phase. The solidified organic phase is then separated from the aqueous phase and the graphene of the solidified phase is applied to a substrate. The solidified organic phase is then removed by melting, subliming or evaporating the organic phase.
    • 本发明涉及一种将石墨烯膜转移到基底的方法,包括提供在支撑物上生长的石墨烯膜和将所述负载的石墨烯膜定位在两相混合物的界面处,其中所述两相混合物 包含水相和有机相,并且其中所述相是不混溶的,其中所述水相进一步包含从所述石墨烯膜完全蚀刻所述石墨烯载体的蚀刻剂。 蚀刻过程发生后,将两相混合物冷却至使有机相固化但水相保持液体的温度,其中石墨烯膜粘附于固化的有机相。 然后将固化的有机相与水相分离,并将固化相的石墨烯施加到基底上。 然后通过熔化,升华或蒸发有机相除去固化的有机相。
    • 10. 发明申请
    • IMPROVEMENTS IN OR RELATING TO TRANSDERMAL DELIVERY
    • 与经销递送相关的改进
    • WO2018015718A1
    • 2018-01-25
    • PCT/GB2017/052045
    • 2017-07-12
    • NDM TECHNOLOGIES LIMITED
    • CHOWDHURY, Dewan Fazlul HoqueBURNETT, Paul
    • A61M5/24A61M5/142
    • A61M5/24A61M5/14244A61M5/20A61M2005/14252A61M2005/1585A61M2005/2006A61M2005/206
    • It is known to deliver drugs through the skin, i.e. transdermally, by using a needle that is used in conjunction with a device. A device (10), for delivering a needle (110) to an injection site, comprises a rotation member (12) which is rotatable about a reference axis (A ref ), the reference axis (A ref ) being the central axis of the rotation member (12). The device (10) further including a needle support member (14) which is configured to support a needle (110) in use. The needle support member (14) being fixedly secured to the rotation member (12) such that rotation of the rotation member (12) results in the needle (110) supported by the needle support member (14) in use being delivered to an injection site. The central axis (A 0ffSet ) of the needle support member (14) is parallel to the reference axis (A ref ) such that the needle support member (14) is offset from the rotation member (12).
    • 已知通过皮肤递送药物,即透皮,通过使用与装置一起使用的针头。 用于将针(110)递送至注射部位的装置(10)包括可围绕参考轴(A ref)旋转的旋转构件(12),参考轴(A 1) )作为旋转构件(12)的中心轴线。 该装置(10)还包括构造成在使用中支撑针(110)的针支撑构件(14)。 针支撑构件(14)固定地固定到旋转构件(12),使得旋转构件(12)的旋转导致由使用中的针支撑构件(14)支撑的针(110)被递送到注射 现场。 针支撑构件(14)的中心轴线(A off)与参考轴线(A ref)平行,使得针支撑构件14(14)偏移 来自旋转构件(12)。