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1. 发明申请

WO2005065708A3 FORMULATIONS OF HYDROPHOBIC PROTEINS IN AN IMMUNOGENIC COMPOSITION HAVING IMPROVED TOLERABILITY 审中-公开
公开(公告)号：WO2005065708A3
公开(公告)日：2005-07-21
申请号：PCT/US2004/043792
申请日：2004-12-28
申请人： WYETH , HOISETH, Susan, Kay , METCALF, Thomas, Newell, III , MATSUKA, Yury, Vladimirovich , HAGEN, Michael
发明人： HOISETH, Susan, Kay , METCALF, Thomas, Newell, III , MATSUKA, Yury, Vladimirovich , HAGEN, Michael
IPC分类号： A61K39/095
摘要： The present invention provides a method for producing a less-painful immunogenic composition of a hydrophobic protein in a pharmaceutically acceptable carrier suitable for administering to a mammal, comprising the steps of (a) solubilizing said hydrophobic protein with a zwitterionic detergent to make a first composition; (b) altering said first composition, such that the altered composition produces a reduction in pain as measured in the rat footpad model as compared to said first composition.

2. 发明申请

WO2004009600A1 1-HETEROCYCLYLALKYL-3-SULFONYLAZAINDOLE OR -AZAINDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS 审中-公开
标题翻译：作为5-羟基木聚糖-6配位体的1-环烷基亚甲基-3-磺酰基蓝或衍生物衍生物
公开(公告)号：WO2004009600A1
公开(公告)日：2004-01-29
申请号：PCT/US2003/022506
申请日：2003-07-17
申请人： WYETH , BERNOTAS, Ronald, Charles , LENICEK, Steven, Edward , ELOKDAH, Hassan, Mahmoud , LI, David, Zenan
发明人： BERNOTAS, Ronald, Charles , LENICEK, Steven, Edward , ELOKDAH, Hassan, Mahmoud , LI, David, Zenan
IPC分类号： C07D487/04
CPC分类号： C07D487/08 , A61K31/454 , A61K31/4745 , A61K31/498 , A61K31/503
摘要： The present invention provides a compound of formula (I) and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.
摘要翻译：本发明提供式（I）化合物及其用于治疗与5-HT 6受体相关或受其影响的中枢神经系统病症的用途。

3. 发明申请

WO2003104391A3 ANTIBACTERIAL TARGETS IN ALLOIOCOCCUS OTITIDIS 审中-公开
公开(公告)号：WO2003104391A3
公开(公告)日：2003-12-18
申请号：PCT/US2002/036122
申请日：2002-11-25
申请人： WYETH HOLDINGS CORPORATION , MURPHY, Ellen , PROJAN, Steven, Jay
发明人： MURPHY, Ellen , PROJAN, Steven, Jay
IPC分类号： C07H21/04 , C12N15/63 , C07K14/195 , C07K16/00 , C12P21/00 , A61K31/711 , G01N33/53 , C12P16/34
摘要： The present invention relates to the identification of polynucleotide sequences encoding polypeptides of Alloiococcus otitidis that are essential for the growth and survival of the bacteria. In particular, the invention relates to polypeptides encoded by the Alloiococcus otitidis open reading frames (ORFs), and to their use in pharmaceutical compositions, therapeutics, diagnostics and the like. The present invention also relates to methods for identifying pharmaceutical compounds that inhibit the activity of the polypeptides that are essential for the growth of Alloiococcus otitidis, to pharmaceutical compositions containing these compounds and to their use in treatment and amelioration of diseases caused by Alloiococcus otitidis

4. 发明申请

WO2003101962A1 1-(AMINOALKYL)-3-SULFONYLINDOLE AND -INDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS 审中-公开
标题翻译：作为5-羟基木聚糖-6配位体的1-（氨基甲酰基）-3-磺酰基吲哚衍生物
公开(公告)号：WO2003101962A1
公开(公告)日：2003-12-11
申请号：PCT/US2003/017472
申请日：2003-06-03
申请人： WYETH , BERNOTAS, Ronald, Charles , LENICEK, Steven, Edward , ANTANE, Schuyler, A. , ZHOU, Ping , LI, Yanfang
发明人： BERNOTAS, Ronald, Charles , LENICEK, Steven, Edward , ANTANE, Schuyler, A. , ZHOU, Ping , LI, Yanfang
IPC分类号： C07D209/30
CPC分类号： C07D209/48 , C07D209/08 , C07D209/30 , C07D231/56 , C07D403/12 , C07D409/12 , C07D513/04
摘要： The present invention provides compounds of formula (I) and the use thereof for the treatment of central nervous system disorders related to or affected by the 5-HT6 receptor.
摘要翻译：本发明提供式（I）化合物及其用于治疗与5-HT 6受体相关或受其影响的中枢神经系统疾病的用途。

5. 发明申请

WO2005044861A1 POLYSACCHARIDES OF HELICOBACTER PYLORI 审中-公开
标题翻译： HELICOBACTER PYLORI的多糖
公开(公告)号：WO2005044861A1
公开(公告)日：2005-05-19
申请号：PCT/US2004/035492
申请日：2004-10-26
申请人： WYETH HOLDINGS CORPORATION , MONTEIRO, Mario, Artur , FULGINITI, James, Peter , DILTS, Deborah, Ann
发明人： MONTEIRO, Mario, Artur , FULGINITI, James, Peter , DILTS, Deborah, Ann
IPC分类号： C08B37/00
CPC分类号： A61K39/105 , A61K2039/55516 , C07K16/121 , C08B37/0006 , C08B37/0009 , C12P19/04 , G01N2333/205
摘要： The invention is directed to immunogenic compositions comprising polysaccharides and polysaccharide -protein conjugates that are useful to induce or detect the production of antibodies specific for H. pylori . The invention is also directed to methods of purifying the H. pylori polysaccharides from bacteria. The polysaccharide may be incorporated into an immunogenic composition or used in vitro to assay for the presence of H. pylori antibodies in a sample or biological fluid.
摘要翻译：本发明涉及包含多糖和多糖 - 蛋白质缀合物的免疫原性组合物，其可用于诱导或检测幽门螺杆菌特异性抗体的产生。本发明还涉及从细菌中纯化幽门螺杆菌多糖的方法。多糖可以掺入免疫原性组合物中或在体外用于测定样品或生物流体中幽门螺杆菌抗体的存在。

6. 发明申请

WO2005030216A1 5-ARYLPYRIMIDINES AS ANTICANCER AGENTS 审中-公开
标题翻译： 5-ARYLPYRIMININES作为反应剂
公开(公告)号：WO2005030216A1
公开(公告)日：2005-04-07
申请号：PCT/US2004/030682
申请日：2004-09-17
申请人： WYETH HOLDINGS CORPORATION , ZHANG, Nan , AYRAL-KALOUSTIAN, Semiramis , NGUYEN, Thai, Hiep
发明人： ZHANG, Nan , AYRAL-KALOUSTIAN, Semiramis , NGUYEN, Thai, Hiep
IPC分类号： A61K31/505
CPC分类号： C07D239/42 , A61K31/505 , A61K31/506 , C07D239/48 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04
摘要： This invention relates to certain 5-arylpyrimidine compounds or a pharmaceutically acceptable salt thereof, and compositions containing said compounds or a pharmaceutically acceptable salt thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals. This invention further relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and further provides a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or a pharmaceutically acceptable salt thereof. More specifically, the present invention relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof by promotion of microtubule polymerization which comprises administering to said mammal an effective amount of said compounds and pharmaceutically acceptable salts thereof.
摘要翻译：本发明涉及某些5-芳基嘧啶化合物或其药学上可接受的盐，以及含有所述化合物或其药学上可接受的盐的组合物，其中所述化合物是可用于治疗哺乳动物癌症的抗癌剂。本发明还涉及治疗或抑制哺乳动物中癌性肿瘤细胞和相关疾病的生长的方法，并进一步提供了治疗或预防表达多重耐药性（MDR）或耐多药耐药性的癌性肿瘤的方法在需要的哺乳动物中，所述方法包括向所述哺乳动物施用有效量的所述化合物或其药学上可接受的盐。更具体地，本发明涉及通过促进微管聚合来治疗或抑制有需要的哺乳动物中癌性肿瘤细胞和相关疾病的生长的方法，其包括向所述哺乳动物施用有效量的所述化合物和药学上可接受的盐它们。

7. 发明申请

WO2005012238A1 PROCESS FOR THE PREPARATION OF CPLA2 INHIBITORS 审中-公开
标题翻译：制备CPLA2抑制剂的方法
公开(公告)号：WO2005012238A1
公开(公告)日：2005-02-10
申请号：PCT/US2004/023247
申请日：2004-07-19
申请人： WYETH , WU, Yanzhong , RAVEENDRANATH, Panolil
发明人： WU, Yanzhong , RAVEENDRANATH, Panolil
IPC分类号： C07C303/40
CPC分类号： C07C303/38 , C07C303/40 , C07C311/13 , C07D209/14
摘要： A process for making a compound of formula (I) in which process the compound HC≡C-(CH 2 ) n -NH 2 is reacted with the compound R 1 -SO 2 Cl to produce an intermediate compound, which intermediate compound is then reacted with the compound of formula (II) to produce the compound of formula (I). The terms R 1 , R 2 , R 3 , R 4 and n have the definitions set forth in the claims. The compounds of formula (I) are useful in the preparation of indole derivatives of formula (V) which are cPLA 2 inhibitors.
摘要翻译：制备其中化合物HC = C-（CH 2）n -NH 2的方法与化合物R1-SO2Cl反应以制备中间体化合物的式（I）化合物的方法，然后将该中间体化合物与式（II）化合物制备式（I）化合物。术语R1，R2，R3，R4和n具有权利要求中阐述的定义。式（I）的化合物可用于制备作为cPLA2抑制剂的式（V）的吲哚衍生物。

8. 发明申请

WO2005001131A2 METHODS FOR DIAGNOSING MOOD DISORDERS 审中-公开
标题翻译：诊断疾病的方法
公开(公告)号：WO2005001131A2
公开(公告)日：2005-01-06
申请号：PCT/US2004/016548
申请日：2004-05-26
申请人： WYETH A CORPORATION OF THE STATE OF DELAWARE , KHAWAJA, Xavier, Zafar
发明人： KHAWAJA, Xavier, Zafar
IPC分类号： C12Q1/68
CPC分类号： C12N9/0008 , C07K14/47 , C07K14/4702 , C07K14/65 , C12N9/0004 , C12N9/10 , C12N9/1205 , C12N9/78 , C12Q1/6883 , C12Q2600/158
摘要： The present invention relates generally to the fields of neuroscience, proteomics and mood disorders. More particularly, the present invention relates to the identification of a group of proteins modulated in subjects with a mood disorder; methods for detecting or screening mRNA encoding these proteins and methods for diagnosing mood disorders.
摘要翻译：本发明一般涉及神经科学，蛋白质组学和情绪障碍领域。更具体地说，本发明涉及鉴定具有情绪障碍的受试者中调节的一组蛋白质; 用于检测或筛选编码这些蛋白质的mRNA的方法和用于诊断心境障碍的方法。

9. 发明申请

WO2003092623A2 CALICHEAMICIN DERIVATIVE-CARRIER CONJUGATES 审中-公开
标题翻译：卡利辛胺衍生物载体结合物
公开(公告)号：WO2003092623A2
公开(公告)日：2003-11-13
申请号：PCT/US2003/013910
申请日：2003-05-02
申请人： WYETH HOLDINGS CORPORATION , KUNZ, Arthur , MORAN, Justin, Keith , RUBINO, Joseph, Thomas , JAIN, Neera , VIDUNAS, Eugene, Joseph , SIMPSON, John, McLean , ROBBINS, Paul, David , MERCHANT, Nishith , DIJOSEPH, John, Francis , RUPPEN, Mark, Edward , DAMLE, Nitin, Krishnaji , POPPLEWELL, Andrew, George
发明人： KUNZ, Arthur , MORAN, Justin, Keith , RUBINO, Joseph, Thomas , JAIN, Neera , VIDUNAS, Eugene, Joseph , SIMPSON, John, McLean , ROBBINS, Paul, David , MERCHANT, Nishith , DIJOSEPH, John, Francis , RUPPEN, Mark, Edward , DAMLE, Nitin, Krishnaji , POPPLEWELL, Andrew, George
IPC分类号： A61K
CPC分类号： A61K31/704 , A61K47/48384 , A61K47/48407 , A61K47/48507 , A61K47/48561 , A61K47/6803 , A61K47/6809 , A61K47/6849 , C07K16/2803 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76
摘要： Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
摘要翻译：描述了具有显着高于先前报道的程序并且具有降低的聚集和低共轭分数（LCF）的药物负载的单体细胞毒性药物/载体缀合物的方法。还描述了细胞毒性药物衍生物/抗体缀合物，包含缀合物的组合物和缀合物的用途。还描述了单体加利车霉素衍生物/抗-CD22抗体缀合物，包含缀合物的组合物和缀合物的用途。

10. 发明申请

WO2003092619A2 PREVENTION AND TREATMENT OF TYPE 2 DIABETES 审中-公开
标题翻译：预防和治疗2型糖尿病
公开(公告)号：WO2003092619A2
公开(公告)日：2003-11-13
申请号：PCT/US2003/013820
申请日：2003-04-30
申请人： WYETH HOLDINGS CORPORATION , SIBER, George, Rainer , PILLAI, Subramonia, Padmanabha , FERNSTEN, Philip, David
发明人： SIBER, George, Rainer , PILLAI, Subramonia, Padmanabha , FERNSTEN, Philip, David
IPC分类号： A61K
CPC分类号： A61K39/0008 , A61K2039/6037
摘要： Methods and compositions are provided to prevent or treat Type 2 diabetes. Such methods entail administering an agent that induces in the patient a beneficial immune response against islet amyloid fibrils, protofibrils and/or amyloid plaque deposited in the islets of the human pancreas. In such methods, a suitable agent is an antigen that is surface-exposed only in islet amyloid fibrils, protofibrils, protofibrils and/or amyloid plaque but not in soluble, native islet amyloid polypeptide (IAPP), or an antibody thereto.
摘要翻译：提供了预防或治疗2型糖尿病的方法和组合物。这种方法需要施用在患者体内诱导胰岛淀粉样蛋白原纤维，沉积在胰腺胰岛中的原纤维和/或淀粉样蛋白斑的有益免疫应答的药剂。在这种方法中，合适的试剂是仅在胰岛淀粉样蛋白原纤维，原纤维，原纤维和/或淀粉样蛋白斑块中表面暴露但在可溶性天然胰岛淀粉样蛋白多肽（IAPP）或其抗体中不表达的抗原。

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