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1. 发明申请

WO2014066808A1 INSULIN-MIMETIC LOCAL THERAPEUTIC ADJUNCTS FOR ENHANCING SPINAL FUSION 审中-公开
标题翻译：用于增强脊髓融合的INSULIN-MIMETIC局部治疗方法
公开(公告)号：WO2014066808A1
公开(公告)日：2014-05-01
申请号：PCT/US2013/066895
申请日：2013-10-25
申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
发明人： LIN, Sheldon, Suton , KOERNER, John , VIVES, Michael, J. , BENEVENIA, Joseph , BREITBART, Eric
IPC分类号： A61F2/30 , A61F2/44 , A61F2/46 , A61K35/32 , A61K38/28 , C12N15/17
CPC分类号： A61K33/30 , A61F2/4455 , A61F2002/30677 , A61F2310/00179 , A61F2310/00293 , A61F2310/00359 , A61F2310/0097 , A61K33/04 , A61K33/24 , A61K35/32 , A61K47/46 , A61L27/306 , A61L27/54 , A61L2300/102 , A61L2430/38
摘要： Bone tissue materials comprising insulin-mimetic agents, such as suitable zinc, vanadium, tungsten, molybdenum, niobium, selenium, and manganese compounds, for facilitating spinal fusion of vertebrae in spinal fusion surgical procedures, and methods thereof. Additionally provided is a bone tissue kit for facilitating fusion of vertebrae in a spinal fusion surgical procedure including a composition formulated for facile application in a spinal fusion procedure comprising an insulin-mimetic agent and a pharmaceutically acceptable carrier. Yet further provided is an implantable device for enhancing spinal fusion including a prosthetic implant configured to stabilize and promote the fusion of two adjacent vertebrae, wherein the bone tissue contacting surfaces of the prosthetic implant are coated with a composition comprising an insulin-mimetic agent.
摘要翻译：包括胰岛素模拟剂（例如合适的锌，钒，钨，钼，铌，硒和锰化合物）的骨组织材料，用于促进脊柱融合外科手术中椎骨的脊柱融合及其方法。另外提供了一种骨组织试剂盒，其用于促进椎骨融合外科手术中椎骨的融合，所述手术包括在包含胰岛素模拟剂和药学上可接受的载体的脊柱融合术中易于应用配制的组合物。还提供了一种用于增强脊柱融合的可植入装置，其包括被配置为稳定和促进两个相邻椎骨的融合的假体植入物，其中所述假体植入物的骨组织接触表面涂覆有包含胰岛素模拟剂的组合物。

2. 发明申请

WO2013006798A1 VANDIUM COMPOUNDS AS THERAPEUTIC ADJUNCTS FOR CARTILAGE REGENERATION AND REPAIR 审中-公开
标题翻译：作为治疗补体的维生素化合物用于再生和修复
公开(公告)号：WO2013006798A1
公开(公告)日：2013-01-10
申请号：PCT/US2012/045771
申请日：2012-07-06
申请人： UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY , LIN, Sheldon, Suton , PAGLIA, David, Naisby , O'CONNOR, John, Patrick , WEY, Aaron , TAN, Virak , BENEVENIA, Joseph
发明人： LIN, Sheldon, Suton , PAGLIA, David, Naisby , O'CONNOR, John, Patrick , WEY, Aaron , TAN, Virak , BENEVENIA, Joseph
IPC分类号： A61K33/24
CPC分类号： A61K31/555 , A61K33/24 , A61K45/06 , A61L31/08 , A61L31/16 , A61L2300/224 , A61L2420/04 , A61L2430/06
摘要： A method for repairing an injury of cartilage in a patient by local administration of an organovanadium agent or use of an implantable device for delivery of an organovanadium agent. Implantable devices containing an organovanadium agent and methods of making these implantable devices are also disclosed.
摘要翻译：通过局部施用有机钒剂或通过使用可植入装置来递送有机钒剂来修复患者软骨损伤的方法。还公开了含有有机体剂的可植入装置和制造这些可植入装置的方法。

3. 发明申请

WO2021081151A1 BINDER COMPOSITION FOR SOIL AND SOLIDIFICATION TREATMENT METHOD FOR SOIL 审中-公开
公开(公告)号：WO2021081151A1
公开(公告)日：2021-04-29
申请号：PCT/US2020/056759
申请日：2020-10-22
申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY , TAIHEIYO CEMENT CORPORATION
发明人： NOZAKI, Takahito , HIGO, Yasuhide , MISKEWITZ, Robert , MAHER, Ali
IPC分类号： A62D3/00 , B09C1/08 , C04B7/00
摘要： A binder composition for immobilizing a toxic-containing material. This composition has excellent strength developing properties at low temperature and is capable of solidifying soil to suppress the elution of toxic materials from the soil.

4. 发明申请

WO2017053481A1 MAGNESIUM ZINC OXIDE NANOSTRUCTURE MODIFIED BIOSENSOR AND MONITORING OF RESPONSE OF CELL POPULATION TO AN AGENT USING THE SAME 审中-公开
标题翻译：氧化镁氧化物纳米结构改性生物传感器和细胞群体对使用其的试剂的响应监测
公开(公告)号：WO2017053481A1
公开(公告)日：2017-03-30
申请号：PCT/US2016/052961
申请日：2016-09-21
申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
发明人： LU, Yicheng , REYES, Pavel , ZHENG, Steven , ZHENG, Andrew , YANG, Keyang
IPC分类号： C12M1/36 , C12M3/00 , G01N30/96 , H01L29/82 , H01L41/04 , H03H9/56
CPC分类号： H01L41/1871 , G01N29/022 , G01N29/46 , G01N2291/0256 , H01L41/1132 , H01L41/18
摘要： A magnesium zinc oxide (MZO) nano structure modified quartz crystal microbalance (MZO nano -QCM) takes advantage of the unique sensing ability and biocompatibility of MZO-based nanostructures, and combines them with the dynamic impedance spectrum capability of the bulk acoustic wave (BAW) devices including QCM, to form a real-time, noninvasive and label-free cell monitoring biosensor, specifically detecting the susceptibility and resistance of bacterial and fungal strains and cancer cells to various antibiotic and antifungal drugs and anticancer drugs, respectively.
摘要翻译：氧化锌氧化锌（MZO）纳米结构改性石英晶体微量天平（MZOnano-QCM）利用了基于MZO的纳米结构独特的传感能力和生物相容性，并将其与体声波（BAW）的动态阻抗谱能力相结合，设备包括QCM，以形成实时，无创和无标记的细胞监测生物传感器，分别专门检测细菌和真菌菌株和癌细胞对各种抗生素和抗真菌药物和抗癌药物的敏感性和抗性。

5. 发明申请

WO2017161288A1 TARGETING TUMOR CELLS WITH CHEMOTHERAPEUTIC AGENTS CONJUGATED TO ANTI-MATRIPTASE ANTIBODIES BY IN VIVO CLEAVABLE LINKING MOIETIES 审中-公开
标题翻译：靶向于抗MATRIPTASE抗体的化疗药物在体内可切割性连接时靶向肿瘤细胞
公开(公告)号：WO2017161288A1
公开(公告)日：2017-09-21
申请号：PCT/US2017/022993
申请日：2017-03-17
申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY , GEORGETOWN UNIVERSITY
发明人： LIN, Siang-Yo , BERTINO, Joseph, R. , LIN, Chen-Yong , SZEKELY, Zoltan
IPC分类号： A61K31/454 , A61K47/48 , A61K39/395 , C07K16/30 , C07K16/40 , C07K16/46
摘要： The present invention relates to anti-matriptase antibodies and immunoconjugates of anti- matriptase antibodies with cytotoxic agents and the use thereof for killing or inhibiting the growth of matriptase-expressing cancer cells, such as those of multiple myeloma and breast cancers. In particular, immunoconjugates comprising an anti-matriptase monoclonal antibody and anticancer agents such as auristatin, including monomethyl auristatin E (MMAE) and monomethyl auristatin F (MMAF) are introduced, which have potent antitumor activity in vivo. Moreover, importantly; there was no weight loss or other evidence of toxicity in the animals, indicating that no significant free drug was released into the circulation from the conjugate. The present invention also provides compositions comprising these new immunoconjugates and use of them for treatment of malignancies comprising cells that express matriptase. In addition, administration of an anti-matriptase antibody or immunoconjugates of an anti-matriptase antibody and a cytotoxic agent in combination with administration of an immunomodulatory agent, such as thalidomide or an analog thereof, provides a more effective treatment of these cancers.
摘要翻译：本发明涉及抗matriptase抗体和抗matriptase抗体与细胞毒性剂的免疫偶联物，及其用于杀死或抑制表达matriptase的癌细胞例如多发性骨髓瘤细胞的生长的用途和乳腺癌。具体而言，引入了包含抗matriptase单克隆抗体和抗癌剂如奥里斯他汀的免疫缀合物，包括单甲基奥里斯他汀E（MMAE）和单甲基奥里斯他汀F（MMAF），其在体内具有有效的抗肿瘤活性。而且，重要的是; 在动物中没有体重减轻或其他毒性证据，表明没有显着的游离药物从缀合物释放到循环中。本发明还提供了包含这些新型免疫缀合物的组合物以及它们用于治疗包含表达matriptase的细胞的恶性肿瘤的用途。另外，抗matriptase抗体或抗matriptase抗体和细胞毒性剂的免疫偶联物与施用免疫调节剂（例如沙利度胺或其类似物）组合提供了对这些癌症的更有效的治疗。 p>

6. 发明申请

WO2016094539A1 THREE-DIMENSIONAL SCAFFOLD FOR BONE REGENERATION 审中-公开
标题翻译：用于骨再生的三维切割
公开(公告)号：WO2016094539A1
公开(公告)日：2016-06-16
申请号：PCT/US2015/064757
申请日：2015-12-09
申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY , VIRGINIA COMMONWEALTH UNIVERSITY
发明人： FREEMAN, Joseph , TAYLOR, Brittant, L. , ARAPOVIC, Tea , PATEL, Pushpendra, Pankaj
IPC分类号： A61F2/28 , A61K9/70
CPC分类号： A61F2/28 , A61F2002/2825 , A61F2002/30011 , A61F2002/30075 , A61F2002/30224 , A61F2002/3024 , A61F2310/00293 , A61F2310/00365 , A61K9/70
摘要： The present invention provides scaffolds comprising dual structural organization for bone and regeneration. Methods for fabricating and using the scaffold are also disclosed.
摘要翻译：本发明提供了包含用于骨和再生的双重结构组织的支架。还公开了制造和使用支架的方法。

7. 发明申请

WO2014117146A1 GROWTH MATRICES FOR STEM CELL PROPAGATION IN VITRO AND IN TISSUE REGENERATION 审中-公开
标题翻译：用于体细胞和组织再生中的干细胞传播的生长矩阵
公开(公告)号：WO2014117146A1
公开(公告)日：2014-07-31
申请号：PCT/US2014/013381
申请日：2014-01-28
申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
发明人： LEVISON, Steven , SKOP, Nolan , CALDERON, Frances , CHO, Cheul , GANDHI, Chirag
IPC分类号： C12N5/00
CPC分类号： C12N5/0623 , A61K9/0085 , A61K9/5078 , A61K35/28 , A61K35/30 , A61K35/51 , A61K35/545 , C12N5/0068 , C12N2501/115 , C12N2533/52 , C12N2533/72
摘要： The present invention provides a multifunctional 2-D and 3-D matrix for propagation of stein cells, in particular, a cliitosatv-based biomaieria! scaffold is engineered to promote CNS regeneration from primitive neural precursors by stabilizing a recombinant protein, fibroblast growth factor to preserve the cardinal properties of stem cells. The matrix, is further modified by the addition of either the extracellular matrix protein fibronectiii or the small peptide RGD or IK.VAV. A method to manu&eture an injectable multifunctional microsphere scaffold is also disclosed that is suitable as a vehicle for cell transplantation to repair traumatic brain injuries.
摘要翻译：本发明提供了一种多功能2-D和3-D基质，用于促进骨髓细胞，特别是基于cliitosatv的生物组织。支架被工程化以通过稳定重组蛋白质，成纤维细胞生长因子来保护干细胞的基础性质，从原始神经前体促进CNS再生。通过添加细胞外基质蛋白纤维结合蛋白或小肽RGD或IK.VAV进一步修饰基质。还公开了一种制备和注射可注射的多功能微球支架的方法，其适合作为细胞移植修复创伤性脑损伤的载体。

8. 发明申请

WO2012174126A1 METHOD OF INHIBITING NONSENSE-MEDIATED mRNA DECAY 审中-公开
标题翻译：抑制非延迟mRNA降解的方法
公开(公告)号：WO2012174126A1
公开(公告)日：2012-12-20
申请号：PCT/US2012/042272
申请日：2012-06-13
申请人： UNIVERSYTY OF MEDICINE AND DENTISTRY OF NEW JESEY , PE'ERY. Tsafi , MATHEWS, Michael B. , HOQUE, Mainul , HANAUSKE-ABEL, Hartmut M
发明人： PE'ERY. Tsafi , MATHEWS, Michael B. , HOQUE, Mainul , HANAUSKE-ABEL, Hartmut M
IPC分类号： C12N15/11 , A01N43/40 , A61K31/44
CPC分类号： A61K31/4412 , A61K31/502 , A61K45/06 , A61K2300/00
摘要： Provided are methods for treating a NAD comprising administering to a patient suffering from a NAD an inhibitor of NMD and a nonsense suppressor, whereby degradation of NMD susceptible mRNA is decreased and translation termination at a misplaced nonsense codon is blocked.
摘要翻译：提供了用于治疗NAD的方法，包括对患有NMD的NMD抑制剂和无义抑制剂的患者施用，由此NMD敏感性mRNA的降解降低，并且在错放的无义密码子处的翻译终止被阻断。

9. 发明申请

WO2012118974A2 DETECTION OF HUMAN ENDOGENOUS RETROVIRUS EXPRESSION IN CANCER AND NORMAL CELLS 审中-公开
标题翻译：检测癌症和正常细胞中人类内源性逆转录酶表达
公开(公告)号：WO2012118974A2
公开(公告)日：2012-09-07
申请号：PCT/US2012/027289
申请日：2012-03-01
申请人： UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY , TSIAGBE, Vincent, K. , OLD, Lloyd , LI, Yu
发明人： TSIAGBE, Vincent, K. , OLD, Lloyd , LI, Yu
IPC分类号： C12Q1/70
CPC分类号： C07K16/1063 , C07K16/1036 , C07K16/30 , C07K2317/34 , C07K2317/55 , C12Q1/703 , G01N33/56988 , G01N33/574 , G01N33/57426
摘要： The invention relates to human endogenous retrovirus env (HERV-WL) polypeptides, nucleotide sequences, HERV-WL antibodies, methods to detect cancer, and methods to determine the effectiveness of the treatment of cancer.
摘要翻译：本发明涉及人内源性逆转录病毒env（HERV-WL）多肽，核苷酸序列，HERV-WL抗体，检测癌症的方法和确定癌症治疗有效性的方法。

10. 发明申请

WO2010107831A1 NANOCARRIER COMPOSITIONS AND METHODS 审中-公开
标题翻译： NANOCARRIER组合物和方法
公开(公告)号：WO2010107831A1
公开(公告)日：2010-09-23
申请号：PCT/US2010/027532
申请日：2010-03-16
申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY , SINKO, Patrick, J. , STEIN, Stanley , GUNASEELAN, Simi , POOYAN, Shahriar , PALOMBO, Matthew, Sean , ZHANG, Xiaoping
发明人： SINKO, Patrick, J. , STEIN, Stanley , GUNASEELAN, Simi , POOYAN, Shahriar , PALOMBO, Matthew, Sean , ZHANG, Xiaoping
IPC分类号： A61K47/42
CPC分类号： A61K47/42 , A61K9/5169
摘要： This invention provides multimeric nanocarrier for in vivo delivery of a bioactive agent, comprising at least two peptide monomers reversibly or irreversibly linked with one or more of said bioactive agents, wherein said two or more of said peptide monomers are covalently linked by a biodegradable difunctional moiety, as well as methods of using this nanocarrier.
摘要翻译：本发明提供用于体内递送生物活性剂的多聚体纳米载体，其包含与一种或多种所述生物活性剂可逆地或不可逆地连接的至少两种肽单体，其中所述两种或多种所述肽单体通过可生物降解的双官能部分共价连接，以及使用该纳米载体的方法。

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