专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2018213514A2 OPTICAL CONNECTOR WITH FORWARD-BIASING PROJECTIONS 审中-公开
公开(公告)号：WO2018213514A2
公开(公告)日：2018-11-22
申请号：PCT/US2018/033063
申请日：2018-05-17
申请人： SENKO ADVANCED COMPONENTS, INC.
发明人： WONG, Yim , HO, Man, Ming , TAKANO, Kazuyoshi
摘要： An optical connector is provided having a ferrule configured to house one or more optical fibers. An inner housing is provided to hold the ferrule and has a distal end in a connection direction and a proximal end in a cable direction. An outer housing at least partially surrounds the inner housing. One or more resilient forward biasing projections extend from one or more of the outer housing or the inner housing for biasing the outer housing towards the distal end of the inner housing. The resilient forward biasing projection may be integrally formed with either the inner housing or with the outer housing.

2. 发明申请

WO2012148832A8 METHOD FOR REMOVING UNMODIFIED HEMOGLOBIN FROM CROSS-LINKED HEMOGLOBIN SOLUTIONS INCLUDING POLYMERIC HEMOGLOBIN WITH HIGH TEMPERATURES SHORT TIME HEAT TREATMENT APPARATUS 审中-公开
公开(公告)号：WO2012148832A8
公开(公告)日：2012-11-01
申请号：PCT/US2012/034608
申请日：2012-04-23
申请人： WONG, Bing Lou , KWOK, Sui Yi
发明人： WONG, Bing Lou , KWOK, Sui Yi
IPC分类号： C07K1/34 , C07K1/14 , C07K14/805 , C07K1/36
摘要： A method heat treatment of cross-linked hemoglobin solutions including polymeric hemoglobin is disclosed. The method involves contacting the hemoglobin solution with a high temperature short time heat treatment apparatus. The high temperature short time process thermally denatures unmodified tetrameric hemoglobin (hemoglobin dimer form), protein impurities (e.g. immunoglobin-G, serum albumin), bacteria, and viruses so that renal injury, vascular detrimental effects and other toxicity reactions can be avoided.

3. 发明申请

WO2011162863A1 A METHOD FOR THE PREPARATION OF A HEAT STABLE OXYGEN CARRIER-CONTAINING PHARMACEUTICAL COMPOSITION 审中-公开
标题翻译：一种制备含稳定含氧载体的药物组合物的方法
公开(公告)号：WO2011162863A1
公开(公告)日：2011-12-29
申请号：PCT/US2011/032595
申请日：2011-04-15
申请人： WONG, Bing, Lou , KWOK, Sui, Yi
发明人： WONG, Bing, Lou , KWOK, Sui, Yi
IPC分类号： A61K35/14
CPC分类号： A61K38/42
摘要： A highly purified and heat stable cross-linked nonpolymeric tetrameric hemoglobin suitable for use in mammals without causing renal injury and vasoconstriction is provided. A high temperature and short time (HTST) heat processing step is performed to remove undesired dimeric form of hemoglobin, uncross-linked tetrameric hemoglobin, and plasma protein impurities effectively. Addition of N-acetyl cysteine after heat treatment and optionally before heat treatment maintains a low level of met-hemoglobin. The heat stable cross-linked tetrameric hemoglobin can improve and prolong oxygenation in normal and hypoxic tissue. In another aspect, the product is used in the treatment of various types of cancer such as leukemia, colorectal cancer, lung cancer, breast cancer, liver cancer, nasopharyngeal carcinoma and esophageal cancer. The inventive tetrameric hemoglobin can also be used to prevent tumor metastasis and recurrence following surgical tumor excision. Further the inventive tetrameric hemoglobin can be administered to patients prior to chemotherapy and radiation treatment.
摘要翻译：提供了适用于哺乳动物而不引起肾损伤和血管收缩的高度纯化和热稳定的交联的非聚合四聚体血红蛋白。进行高温和短时间（HTST）热处理步骤以有效去除不期望的二聚体形式的血红蛋白，未交联的四聚体血红蛋白和血浆蛋白杂质。热处理后任选地加热N-乙酰半胱氨酸，维持低水平的血红蛋白。热稳定的交联四聚体血红蛋白可以改善并延长正常和缺氧组织的氧合作用。另一方面，该产品用于治疗各种类型的癌症如白血病，结肠直肠癌，肺癌，乳腺癌，肝癌，鼻咽癌和食管癌。本发明的四聚体血红蛋白也可用于预防手术切除肿瘤后的肿瘤转移和复发。此外，本发明的四聚体血红蛋白可以在化疗和放射治疗之前给予患者。

4. 发明申请

WO2011149602A1 HIGH-TEMPERATURE STABLE OXYGEN-CARRIER-CONTAINING PHARMACEUTICAL COMPOSITION 审中-公开
标题翻译：高温稳定的含氧载体的药物组合物
公开(公告)号：WO2011149602A1
公开(公告)日：2011-12-01
申请号：PCT/US2011/032594
申请日：2011-04-15
申请人： WONG, Bing, Lou , KWOK, Sui, Yi
发明人： WONG, Bing, Lou , KWOK, Sui, Yi
IPC分类号： A61K35/14
CPC分类号： C07K14/805
摘要： A high temperature-stable and highly purified cross-linked (optionally > 70% β-β linked) tetrameric hemoglobin with high efficiency of oxygen delivery suitable for use in mammals without causing renal injury and vasoconstriction is provided. The dimeric form of hemoglobin is degenerated and purification processes are performed on red blood cells from whole blood. Controlled hypotonic lysis in an instant cytolysis apparatus prevents lysis of white blood cells. Nucleic acids from white blood cells and phospholipids impurities are not detected. Blocking of reactive sulfhydryl groups by a sulfhydryl reagent is performed in an oxygenated environment. Flowthrough column chromatography removes different plasma protein impurities. N-acetyl cysteine is added to the cross-linked tetrameric hemoglobin to maintain a low level of met-hemoglobin. The stabilized hemoglobin is preserved in an infusion bag with aluminum overwrap to prevent formation of inactive met-hemoglobin from oxygen intrusion. The product finds use in tissue oxygenation and cancer treatment.
摘要翻译：提供了适用于哺乳动物而不引起肾损伤和血管收缩的高温稳定且高度纯化的交联（任选> 70％ß连接的）四聚体血红蛋白，其具有高效率的氧输送。血红蛋白的二聚体形式是退化的，并且从全血对红细胞进行纯化过程。瞬时细胞裂解装置中的受控低渗溶解可防止白细胞裂解。没有检测到白细胞和磷脂杂质的核酸。通过巯基试剂阻断反应性巯基在氧合环境中进行。流式柱色谱法除去不同的血浆蛋白质杂质。将N-乙酰半胱氨酸加入到交联的四聚体血红蛋白中以维持低水平的血红蛋白。将稳定的血红蛋白保存在具有铝外包装的输液袋中，以防止氧气侵入形成无活性的血红蛋白。该产品用于组织氧合和癌症治疗。

5. 发明申请

WO2019014659A1 ULTRA-SMALL FROM FACTOR OPTICAL CONNECTORS 审中-公开
公开(公告)号：WO2019014659A1
公开(公告)日：2019-01-17
申请号：PCT/US2018/042202
申请日：2018-07-16
申请人： SENKO ADVANCED COMPONENTS, INC.
发明人： TAKANO, Kazuyoshi , CHANG, Jimmy, Jun-Fu
IPC分类号： G02B6/36
摘要： An optical connector holding two or more LC-type optical ferrules is provided. The optical connector includes an outer body, an inner front body accommodating the two or more LC-type optical ferrules, ferrule springs for urging the optical ferrules towards a mating receptacle, and a back body for supporting the ferrule springs. The outer body and the inner front body are configured such that four LC-type optical ferrules are accommodated in a small form-factor pluggable (SFP) transceiver footprint or eight LC- type optical ferrules are accommodated in a quad small form-factor pluggable (QSFP) transceiver footprint. A mating receptacle (transceiver or adapter) includes a receptacle hook and a housing with an opening that accommodates the receptacle hook in a flexed position as the optical connector makes connection with the mating receptacle by introducing the receptacle hook into an optical receptacle hook recess.

6. 发明申请

WO2019226575A1 5-AXIS THREE-DIMENSIONAL MANUFACTURING 审中-公开
公开(公告)号：WO2019226575A1
公开(公告)日：2019-11-28
申请号：PCT/US2019/033189
申请日：2019-05-20
申请人： 3D FLEXIBLE, INC.
发明人： YUN, Victor E. , LENG, Yongzhang , PARK, Donghun
IPC分类号： B22F3/105 , B29C64/393 , B29C64/153 , B29C64/209 , B33Y30/00 , B33Y10/00 , B33Y50/02
摘要： A multiple axis manufacturing platform for three-dimensional object fabrication in three dimensions and along at least two rotary axes. The platform includes one or more additive and one or more subtractive manufacturing tools. An automatic tool changer (ATC) holds the additive and subtractive manufacturing tools and selects among them. A movable substrate platform supports a workpiece. A programmable control system has programs for controlling the manufacturing tools, the automatic tool changer and the movable substrate platform, and includes machine code to control one or more relay switches to control the additive manufacturing tools. A machine vision system detects displacement between or features of deposited material. A vision camera mounting for the spindle housing allows viewing the manufacturing process. A laser displacement sensor extracts distance and position of the selected tool or the workpiece. A feedback system is used to dynamically control material flow from an additive manufacturing tool.

7. 发明申请

WO2019160654A1 ANTIDOTE FOR CHONDROITINASE 审中-公开
公开(公告)号：WO2019160654A1
公开(公告)日：2019-08-22
申请号：PCT/US2019/014653
申请日：2019-01-23
申请人： WONG, Bing Lou
发明人： WONG, Bing Lou
IPC分类号： A61K31/726 , A61P39/02
摘要： The present invention provides a method for inhibiting chondroitinase activity in a substrate by introducing a non-substrate glycosaminoglycan (GAG) to the substrate containing the chondroitinase. non-substrate GAG is undegradable by chondroitinase. GAG may be administered as a single dose or in multiple doses. chondroitinase may be Chondroitinase B, Chondroitinase C, Chondroitinase AC, or Chondroitinase ABC. substrate may be one or more of dermatan sulfate, hyaluronic acid, chondroitin sulfate, or derivatives thereof. non-substrate GAG may be from naturally unbranched homo-polysaccharide, unnaturally branched GAG, or a hybrid GAG molecule fused of two or three GAG chains, being produced by chemical synthesis or enzymatic reaction. non-substrate GAG may be heparin, heparan sulfate, and keratan sulfate. non-substrate GAG may bind to the active residue of the chondroitinase when being introduced to the substrate such that the chondroitinase is no longer enzymatically active.

8. 发明申请

WO2018213514A3 OPTICAL CONNECTOR WITH FORWARD-BIASING PROJECTIONS 审中-公开
公开(公告)号：WO2018213514A3
公开(公告)日：2018-11-22
申请号：PCT/US2018/033063
申请日：2018-05-17
申请人： SENKO ADVANCED COMPONENTS, INC.
发明人： WONG, Yim , HO, Man, Ming , TAKANO, Kazuyoshi
IPC分类号： G02B6/36
摘要： An optical connector is provided having a ferrule configured to house one or more optical fibers. An inner housing is provided to hold the ferrule and has a distal end in a connection direction and a proximal end in a cable direction. An outer housing at least partially surrounds the inner housing. One or more resilient forward biasing projections extend from one or more of the outer housing or the inner housing for biasing the outer housing towards the distal end of the inner housing. The resilient forward biasing projection may be integrally formed with either the inner housing or with the outer housing.

9. 发明申请

WO2018200290A1 PRODUCTION OF HIGH PURITY CHONDROITINASE ABC 审中-公开
公开(公告)号：WO2018200290A1
公开(公告)日：2018-11-01
申请号：PCT/US2018/028214
申请日：2018-04-19
申请人： ADVANTEK SERUM LABORATORIES LTD.
发明人： WONG, Bing Lou , CHUNG, Wai Hong
IPC分类号： C12N9/88 , B01D15/38
CPC分类号： B01D15/3823 , B01J20/286 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3274 , C12N9/88 , C12Y402/0202
摘要： The present invention provides a method for purifying Chondroitinase ABC (ChABC). The present method includes using a heparin-immobilized affinity chromatography column, and through chromatography method obtaining a purified ChABC from a matrix containing said ChABC. The present method is capable of obtaining ChABC in high purity with the advantages of simplicity in preparation and high yield.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式