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1. 发明申请

WO2016009317A1 SYSTEM AND APPARATUS COMPRISING A MULTISENSOR GUIDEWIRE FOR USE IN INTERVENTIONAL CARDIOLOGY 审中-公开
标题翻译：包含用于传统心脏学的多传感器指南的系统和装置
公开(公告)号：WO2016009317A1
公开(公告)日：2016-01-21
申请号：PCT/IB2015/055240
申请日：2015-07-10
申请人： THREE RIVERS CARDIOVASCULAR SYSTEMS INC.
发明人： CARON, Eric
IPC分类号： A61B5/00 , A61B5/0205 , A61B5/0215 , A61B5/026 , A61B5/042 , A61F2/24
CPC分类号： A61B5/6851 , A61B5/02154 , A61B5/02158 , A61B5/042 , A61B2560/0462 , A61B2560/066 , A61B2562/228 , A61F2/24 , A61F2/2418 , A61F2/2427
摘要： A system (1) and apparatus comprising a multisensor guidewire (100/200/300) for use in interventional cardiology, e.g., Transcatheter Valve Therapies (TVT), comprises a plurality of optical sensors (10/20) for direct measurement of cardiovascular parameters, e.g. transvalvular blood pressure gradients and flow. A conventional outer coil wire (35) contains a shaped core wire (31) having a cross-section defining a channel surface (132), e.g. grooves (32), extending along its length, to position optical fibers (11) and optical sensors (10/20) in a channel (33). Advantageously, the core wire has a diameter that provides sufficient stiffness to the guidewire for use as a support guidewire for TVT, e.g. Transcatheter Aortic Valve Implantation (TAVI), while accommodating multiple sensors and fibers within a guidewire of outside diameter ≤0.89mm. An optical connector (112) couples the guidewire to a control system (150). Optionally, the guidewire includes a contact force sensor (60), a pre-formed tip (400-1/400-2) and a separable micro- connector (140).
摘要翻译：一种系统（1）和包括用于介入心脏病学的多传感器导丝（100/200/300）的装置，例如经导管阀治疗（TVT），包括用于直接测量心血管参数的多个光学传感器（10/20），例如跨瓣血压梯度和流量。常规的外部线圈线（35）包含具有限定通道表面（132）的横截面的成形芯线（31），例如，沿着其长度延伸的槽（32），以在通道（33）中定位光纤（11）和光学传感器（10/20）。有利地，芯线具有向引导线提供足够的刚度以用作TVT的支撑导丝的直径，例如，经导管主动脉瓣植入（TAVI），同时将多个传感器和纤维容纳在外径≤0.89mm的导丝内。光连接器（112）将导丝连接到控制系统（150）。可选地，导丝包括接触力传感器（60），预成形尖端（400-1 / 400-2）和可分离的微连接器（140）。

2. 发明申请

WO2016009317A4 SYSTEM AND APPARATUS COMPRISING A MULTISENSOR GUIDEWIRE FOR USE IN INTERVENTIONAL CARDIOLOGY 审中-公开
标题翻译：包括用于介入心脏病学的多传感器指导的系统和设备
公开(公告)号：WO2016009317A4
公开(公告)日：2016-03-10
申请号：PCT/IB2015055240
申请日：2015-07-10
申请人： THREE RIVERS CARDIOVASCULAR SYSTEMS INC
发明人： CARON ERIC , BILODEAU LUC
IPC分类号： A61B5/00 , A61B5/0205 , A61B5/0215 , A61B5/026 , A61B5/042 , A61F2/24
CPC分类号： A61B5/6851 , A61B5/02154 , A61B5/02158 , A61B5/042 , A61B2560/0462 , A61B2560/066 , A61B2562/228 , A61F2/24 , A61F2/2418 , A61F2/2427
摘要： A system (1) and apparatus comprising a multisensor guidewire (100/200/300) for use in interventional cardiology, e.g., Transcatheter Valve Therapies (TVT), comprises a plurality of optical sensors (10/20) for direct measurement of cardiovascular parameters, e.g. transvalvular blood pressure gradients and flow. A conventional outer coil wire (35) contains a shaped core wire (31) having a cross-section defining a channel surface (132), e.g. grooves (32), extending along its length, to position optical fibers (11) and optical sensors (10/20) in a channel (33). Advantageously, the core wire has a diameter that provides sufficient stiffness to the guidewire for use as a support guidewire for TVT, e.g. Transcatheter Aortic Valve Implantation (TAVI), while accommodating multiple sensors and fibers within a guidewire of outside diameter ≤0.89mm. An optical connector (112) couples the guidewire to a control system (150). Optionally, the guidewire includes a contact force sensor (60), a pre-formed tip (400-1/400-2) and a separable micro- connector (140).
摘要翻译：包括用于例如经导管瓣膜治疗（TVT）的介入心脏病学的多传感器导丝（100/200/300）的系统（1）和装置包括用于直接测量心血管参数的多个光学传感器（10/20），例如跨瓣血压梯度和流量。传统的外部线圈线（35）包含具有限定通道表面（132）的横截面的成形芯线（31），例如，沿着其长度延伸的槽（32），以将光纤（11）和光学传感器（10/20）定位在通道（33）中。有利的是，芯线的直径为导丝提供足够的硬度，以用作TVT的支撑导丝，例如，经导管主动脉瓣植入（TAVI），同时在外径≤0.89mm的导丝内容纳多个传感器和纤维。光学连接器（112）将导丝连接到控制系统（150）。可选地，导丝包括接触力传感器（60），预成型尖端（400-1 / 400-2）和可分离微型连接器（140）。

3. 发明申请

WO2019095049A1 DUAL SENSOR SYSTEM FOR CONTINUOUS BLOOD PRESSURE MONITORING DURING TRANSCATHETER HEART VALVE THERAPIES 审中-公开
公开(公告)号：WO2019095049A1
公开(公告)日：2019-05-23
申请号：PCT/CA2018/051430
申请日：2018-11-13
申请人： THREE RIVERS CARDIOVASCULAR SYSTEMS INC.
发明人： GLAWDEL, Tom , GLOVER, Christopher , CARON, Eric , ABEL, Sylvain
IPC分类号： A61B5/0215 , A61M25/14 , A61M25/18 , A61F2/24
CPC分类号： A61B5/0215 , A61B5/0084 , A61B5/6857 , A61F2/2427 , A61F2/2433
摘要： Dual sensor system for continuous blood pressure monitoring during transcatheter heart valve therapies (TVT), such as transcatheter aortic valve replacement (TAVR) or transcatheter mitral valve replacement (TMVR), comprises a controller, a support guidewire for TVT containing a first Fabry-Pérot (FP) optical pressure sensor near its distal end, and a pigtail catheter for delivery of contrast medium containing a second FP optical pressure sensor near its distal end. For example, for TAVR, the support guidewire is positioned to place the first optical pressure sensor within the left ventricle (LV) for monitoring LV pressure, the pigtail catheter is positioned in the aorta to place the second optical pressure sensor in the ascending aorta for direct measurement of pressure in the aorta, downstream of the aortic valve, enabling continuous monitoring of blood pressure at both sensor locations during TAVR. The controller may be configured to interface with standard patient monitoring systems.

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