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1. 发明申请

WO2020183222A1 A METHOD OF PROVIDING FEATURES ON AN IMPLANTABLE MATERIAL INVOLVING THE USE OF LASER, IMPLANTABLE CARDIOVASCULAR PROSTHESES AND IMPLANTABLE MATERIALS PROCESSED ACCORDING TO SAID METHOD 审中-公开
公开(公告)号：WO2020183222A1
公开(公告)日：2020-09-17
申请号：PCT/IB2019/051947
申请日：2019-03-11
申请人： SORIN GROUP ITALIA S.R.L.
发明人： STRASLY, Marina , GUALA, Carlo , VALLE, Francesco
IPC分类号： A61L27/36 , A61L27/38
摘要： Embodiments herein relate to a method of providing features (LCD, HD, HD_IN, HD_OUT) on an implantable material (ID), the method comprising: - providing an implantable material (ID) comprising a decellularized sterilized mammalian tissue having an extracellular matrix, wherein a plurality of interstitial spaces of the extracellular matrix include a solution of one or more polyols, - providing one or more features (LCD, HD, HD_IN, HD_OUT) on said implantable material (ID) by laser treatment.

2. 发明申请

WO2019224577A1 A CARDIAC VALVE PROSTHESIS 审中-公开
公开(公告)号：WO2019224577A1
公开(公告)日：2019-11-28
申请号：PCT/IB2018/053640
申请日：2018-05-23
申请人： SORIN GROUP ITALIA S.R.L.
发明人： CARLINO, Felice Giuseppe , BUSSONE, Marco , VALLE, Francesco , ACHILUZZI, Monica Francesca
IPC分类号： A61F2/24
摘要： A cardiac valve prosthesis including an armature for anchorage of the valve prosthesis at an implantation site. The armature defining a lumen for the passage of the blood flow and having a longitudinal axis, and a set of prosthetic valve leaflets supported by said armature and configured to move, under the action of blood flow, in a radially divaricated condition to enable the flow of blood through said lumen in a first direction, and in a radially contracted condition, in which said valve leaflets co-operate with one another and block the flow of blood through the prosthesis in the direction opposite said first direction. The armature including an annular part and a pattern of arched struts carried by said annular part, said pattern of arched struts having proximal ends connected to said annular part, and distal ends spaced axially from the proximal ends and opposite said annular part, a plurality of sets of anchoring formations configured to protrude radially outwardly of said annular part, each set being supported by at least one of said annular part and a corresponding arched strut, and a plurality of support posts, each support post being supported by adjacent arched struts, wherein the sets of anchoring formations alternate with the support posts around said longitudinal axis.

3. 发明申请

WO2016075514A1 ELASTIC PROTECTION TUBE FOR A HOLLOW FIBRE BLOOD PROCESSING APPARATUS 审中-公开
标题翻译：中空纤维加工设备的弹性保护管
公开(公告)号：WO2016075514A1
公开(公告)日：2016-05-19
申请号：PCT/IB2014/065987
申请日：2014-11-12
申请人： SORIN GROUP ITALIA S.R.L.
发明人： ZANIBONI, Andrea , MENOZZI, Sara , BENATTI, Francesco
IPC分类号： B01D53/22 , A61M1/16 , B01D63/02
CPC分类号： A61M1/1698 , B01D53/22 , B01D63/02 , B01D2313/23 , B01D2313/56
摘要： A blood processing apparatus includes a housing, a shell, a fiber bundle, and an elastic tube. The housing has a blood inlet and a blood outlet and the shell is situated in the housing and configured to receive blood through the blood inlet. The shell includes a surface and one or more apertures extending through the surface to permit the blood to flow to an exterior of the shell. The fiber bundle includes gas exchanger hollow fibers situated about the shell such that gas flows through and the blood flows across the gas exchanger hollow fibers. The elastic tube includes a fiber web situated about the fiber bundle and configured to elastically constrain and protect the gas exchanger hollow fibers during the insertion into the housing. The fiber web has a pore size that permits the blood to flow across the fiber web without filtering micro-emboli from the blood.
摘要翻译：血液处理装置包括壳体，壳体，纤维束和弹性管。壳体具有血液入口和血液出口，并且壳体位于壳体中并且构造成通过血液入口接收血液。壳体包括表面和延伸穿过表面的一个或多个孔，以允许血液流动到壳体的外部。纤维束包括位于壳体周围的气体交换器中空纤维，使得气体流过并且血液流过气体交换器中空纤维。弹性管包括围绕纤维束设置的纤维网，并且构造成在插入壳体期间弹性约束和保护气体交换器中空纤维。纤维网具有允许血液流过纤维网而不从血液中过滤微栓塞的孔径。

4. 发明申请

WO2015019217A1 HEART VALVE PROSTHESIS 审中-公开
标题翻译：心脏瓣膜预防
公开(公告)号：WO2015019217A1
公开(公告)日：2015-02-12
申请号：PCT/IB2014/063176
申请日：2014-07-17
申请人： SORIN GROUP ITALIA S.R.L.
发明人： ACHILUZZI, Monica Francesca
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2436 , A61F2/2457 , A61F2220/0033 , A61F2230/0069 , A61F2250/006
摘要： A heart valve prosthesis (1) configured to be implanted at cardiac valve annulus located at an interface between a ventricle (LV) and an atrium (LA), the heart valve prosthesis (1) including: -a first portion (2) configured for enclosing a plurality of chordae tendineae (CT) in the ventricle (LV) and native valve leaflets (NVL) to which said chordae tendineae are connected, and -a second portion (4) including a radially expandable annular member (6) and a prosthetic heart valve (8) anchored to said radially expandable annular member (6), wherein said first portion (2) is configured to be implanted in the ventricle (LV), and wherein said second portion (4) is configured to be implanted and coupled to the first portion (2) at the cardiac valve annulus.
摘要翻译：一种心脏瓣膜假体（1），其构造成植入位于心室（LV）和心房（LA）之间的界面处的心脏瓣膜环处，心脏瓣膜假体（1）包括： - 第一部分（2）在所述心室（LV）中包围多个腱索（CT）和所述腱索连接到的天然瓣叶（NVL），以及包括径向可扩张的环形构件（6）和假体的第二部分锚定到所述可径向扩张的环形构件（6）的心脏瓣膜（8），其中所述第一部分（2）构造成植入心室（LV），并且其中所述第二部分（4）构造成植入和联接到心脏瓣膜环上的第一部分（2）。

5. 发明申请

WO2013150403A1 A SUPPORT DEVICE FOR HEART VALVE PROSTHESES 审中-公开
标题翻译：用于心脏瓣膜的支撑装置
公开(公告)号：WO2013150403A1
公开(公告)日：2013-10-10
申请号：PCT/IB2013/052080
申请日：2013-03-15
申请人： SORIN GROUP ITALIA S.R.L.
发明人： MARCHISIO, Andrea , ROLANDO, Giovanni , GASCHINO, Paolo
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2427
摘要： Herein described are various embodiments of a support device (1) for stentless heart valve prostheses (V) including: - a shaft (2) defining a manipulation axis (X1), a plurality of support formations (4) for a stentless heart valve prosthesis (V), and - a connection portion (6) flexibly connecting the shaft (2) and the support formations (4) to permit a displacement of the manipulation axis (X1, X1') with respect to the support formations (4), wherein the shaft (2), the plurality of support formations (4) and the connection portion (6) are formed in a single piece from a tubular element (T).
摘要翻译：这里描述了用于无支架心脏瓣膜假体（V）的支撑装置（1）的各种实施例，包括： - 限定操纵轴线（X1）的轴（2），用于无支架心脏瓣膜假体的多个支撑结构（4）（V），以及 - 柔性地连接所述轴（2）和所述支撑结构（4）的连接部分（6），以允许所述操纵轴线（X1，X1'）相对于所述支撑结构（4）的位移，其中所述轴（2），所述多个支撑结构（4）和所述连接部分（6）从管状元件（T）形成为单件。

6. 发明申请

WO2013098739A1 A KIT FOR IMPLANTING PROSTHETIC VASCULAR CONDUITS 审中-公开
标题翻译：一种用于植入先天性血管瘤的套件
公开(公告)号：WO2013098739A1
公开(公告)日：2013-07-04
申请号：PCT/IB2012/057598
申请日：2012-12-21
申请人： SORIN GROUP ITALIA S.R.L.
发明人： ROLANDO, Giovanni , GASCHINO, Paolo , ACHILUZZI, Monica , CARLINO, Felice, Giuseppe
IPC分类号： A61F2/24 , A61F2/06
CPC分类号： A61F2/243 , A61F2/06 , A61F2/064 , A61F2/2409 , A61F2/2427 , A61F2/2436 , A61F2002/9522 , Y10T29/49412
摘要： A kit (1) for the implantation of a prosthetic vascular conduit (40) including: a prosthetic vascular conduit (40) for coupling to a prosthetic valve (V) having a terminal collar member (42) which includes a cuff (420) which is radially contractible to engage the annular portion (SR) of the valve (V) to couple the valve (V) to the conduit (40), a holder device (2) including a receiving portion (28) configured for housing a prosthetic valve (V), wherein said prosthetic vascular conduit (40) is fitted on said holder device (2) so that at least a portion (44; 46) of the conduit (40) adjacent to the cuff (420) wraps said receiving portion (28) of the hub (12), a sleeve member (48) onto which the cuff (420) is wrapped, wherein the sleeve member (48) is slidable away from said hub (12) to unwrap the cuff (420).
摘要翻译：一种用于植入假体血管导管（40）的套件（1），包括：用于联接到具有终端颈圈构件（42）的假体瓣膜（V）的假体血管导管（40），所述终端颈圈构件（42）包括袖带（420）径向收缩以接合所述阀（V）的所述环形部分（SR）以将所述阀（V）联接到所述导管（40）;保持器装置（2），包括接收部分（28），所述容纳部分构造成用于容纳人造瓣膜（V），其中所述假体血管导管（40）装配在所述保持器装置（2）上，使得邻近袖带（420）的导管（40）的至少一部分（44; 46）将所述接收部分轮毂（12）的一个（28），袖带（420）被包裹的套筒构件（48），其中套筒构件（48）可从所述轮毂（12）滑动以展开袖带（420）。

7. 发明申请

WO2012137086A1 DISPOSABLE DEVICE FOR CENTRIFUGAL BLOOD SEPARATION 审中-公开
标题翻译：用于离心血液分离的不可替代的装置
公开(公告)号：WO2012137086A1
公开(公告)日：2012-10-11
申请号：PCT/IB2012/051177
申请日：2012-03-13
申请人： SORIN GROUP ITALIA S.R.L. , GALAVOTTI, Andrea , MACULAN, Elisa , SIMONINI, Giampaolo
发明人： GALAVOTTI, Andrea , MACULAN, Elisa , SIMONINI, Giampaolo
IPC分类号： B04B5/04 , B04B7/08 , B04B11/06
CPC分类号： A61M1/3693 , A61M1/3696 , B04B5/0442 , B04B7/08 , B04B11/06 , B04B2005/0464
摘要： A continuous centrifugal blood separation device has a simple and reliable structure, like the Latham bowl, and avoids some functional difficulties observed with the Biofluid bowl. The continuous blood centrifugal device, in comparison with the Latham bowl, includes an RBC (red blood cell) collector (160) that is coaxial with a supernatant collector (162). The continuous blood centrifugal device includes an axial symmetric barrier (150) disposed between the RBC collector and the supernatant collector in order to avoid turbulence that can otherwise be caused by the supernatant collector.
摘要翻译：连续离心分离装置具有简单可靠的结构，如Latham碗，避免了生物流体碗观察到的一些功能障碍。与Latham碗相比，连续血液离心装置包括与上清液收集器（162）同轴的RBC（红细胞）收集器（160）。连续血液离心装置包括设置在RBC收集器和上清液收集器之间的轴向对称屏障（150），以避免由上清液收集器引起的湍流。

8. 发明申请

WO2008084111A1 USE OF POLYMERIC RESINS FOR THE ADSORPTIVE EXTRACORPOREAL REMOVAL OF INFLAMMATORY MEDIATORS IN THE TREATMENT OF SYSTEMIC INFLAMMATION-RELATED DISEASES 审中-公开
标题翻译：在治疗系统性相关疾病中使用聚合树脂进行吸入性除去炎症介质
公开(公告)号：WO2008084111A1
公开(公告)日：2008-07-17
申请号：PCT/EP2008/050312
申请日：2008-01-11
申请人： SORIN GROUP ITALIA S.R.L. , ATTI, Mauro , WRATTEN, Mary Lou
发明人： ATTI, Mauro , WRATTEN, Mary Lou
IPC分类号： A61M1/34
CPC分类号： A61M1/3472 , A61M1/3486
摘要： It is described a kit for treating a systemic inf lammatatory related disease comprising a) a high permeability filter having a pore size designed to let inflammatory mediators to pass and b) means to retain said mediators but not serum albumin.
摘要翻译：描述了用于治疗全身性炎症相关疾病的试剂盒，其包括a）具有旨在使炎症介质通过的孔径的高渗透性过滤器，以及b）保留所述介质而不是血清白蛋白的方法。

9. 发明申请

WO2023286009A1 ORGAN PERFUSION AND PRESERVATION SYSTEM AND METHOD 审中-公开
公开(公告)号：WO2023286009A1
公开(公告)日：2023-01-19
申请号：PCT/IB2022/056504
申请日：2022-07-14
申请人： SORIN GROUP ITALIA S.R.L. , SORBONNE UNIVERSITE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , ASSISTANCE PUBLIQUE – HOPITAUX DE PARIS
发明人： MIGLIAZZA, John F. , SPIRITELLI, Sandra , SCATTON, Olivier , SAVIER, Eric , GOUMARD, Claire
IPC分类号： A01N1/02
摘要： An organ perfusion and preservation system for use in preserving an organ (80) from a donor, may include a fluid reservoir (10), a heat exchanger (50) in fluid communication with the fluid reservoir and configured to selectively raise and lower a temperature of a perfusion fluid, an oxygenator (40), an inflow pump (32) in fluid communication with the fluid reservoir and the oxygenator, a fluid inflow line (42) configured to transport perfusion fluid from the oxygenator to the organ, a fluid outflow line (44) configured to transport perfusion fluid away from the organ and back to the reservoir, an outflow pump (34) in fluid communication with the fluid outflow line and the fluid reservoir, and a controller (90) operatively connected to the inflow pump, the outflow pump, and the heat exchanger, wherein the controller is configured to select parameters to reversibly heat and reversibly cool the organ.

10. 发明申请

WO2019073279A1 BLOOD PROCESSING UNIT (BPU) WITH COUNTERCURRENT BLOOD/WATER FLOW PATHS IN THE HEAT EXCHANGER (HEX) 审中-公开
公开(公告)号：WO2019073279A1
公开(公告)日：2019-04-18
申请号：PCT/IB2017/056252
申请日：2017-10-10
申请人： SORIN GROUP ITALIA S.R.L.
发明人： TOMMASI, Gabriele
IPC分类号： A61M1/16 , A61M1/36
CPC分类号： A61M1/1698 , A61M1/3666 , A61M2205/36 , A61M2205/366 , A61M2206/14 , A61M2206/20
摘要： Described is a blood processing apparatus with a blood flow path and a heat exchanger fluid flow path overlapping the a heat exchanger chamber, in which the blood flows generally from a first end to a second end of the blood processing apparatus, and the heat exchanger fluid flows generally from the second end to the first end. Such "counter" or "countercurrent" flow improves heat transfer between the blood and the heat exchanger fluid. The blood processing apparatus includes a housing, a blood inlet, a heat exchanger fluid inlet and a heat exchanger fluid outlet, a heat exchanger core, a cylindrical shell having an annular shell aperture, a blood flow distributor, and a central chamber in fluid communication to a fluid flow distributor.

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